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Soil Forma.ion of "a.la.tic Ra.kers" from NW Spa.n—a.High Resolution a.uminium a.d Iron Fra.tiona.ion Study

Pedosphere 2008年第4期18卷 441-453页

作者： J. Ka.L M. COSTa.Ca.a.S C. FERRO-VZQUEZ X. PONTEVEDRa.POMBa. a. martinez-cortizas Instituto de Estudios Ga.egos Pa.re Sa.miento Laboratorio de Arqueología del Paisaje (LAr) IEGPS-CSIC-XuGaRúa San Roque 2 15704 Santiago de Compostela (Spain). Depa.ta.ento de Eda.ología.y Química.a.rícola Fac. Biología Universidad de Santiago (Spain)

a.la.tic ra.kers belong to the group of ＂cryptopodzolic ra.kers＂, which a.e ubiquitous in the mounta.nous cool/tempera.e humid regions of Western Europe. The ra.kers of Ga.icia.（NW Spa.n） formed by thousa.ds of yea.s of colluvia.ion. The prepondera.ce of a.-sta.ilised orga.ic ma.ter （OM） ma.ks the horizona.ion a.d polycyclic cha.a.ter （i.e., stra.ifica.ion） of these soils. Cryptopodzolic ra.kers a.e genera.ly thought to be the outcome of podzolisa.ion. This soil type is pa.t of the recent discussion on how to cla.sify soils developed from nonvolca.ic pa.ent ma.eria. ha.ing a.dic properties. To better understa.d the forma.ion processes of these soils, the a. a.d Fe fra.tiona.ion of four typica. a.la.tic ra.kers were studied by selective dissolution in a.id NH4-oxa.a.e, Na.pyrophospha.e a.d the chlorides of K, La.a.d Cu. a.high-resolution sa.pling a.proa.h a.lowed us to investiga.e the soils in grea.er deta.l tha. simply sa.pling by horizon. The ra.kers studied displa. a.distribution of Fe- a.d a.-OM complexes tha. is typica. of cryptopodzolic soils. However, these orga.ominera. a.socia.ions were proba.ly immobile due to the high a. sa.ura.ion. We a.gue tha. the soils owe their cha.a.teristic chemica. sta.us to externa. fa.tors ra.her tha. to tra.sloca.ion of orga.ominera. a.socia.ions： va.ia.ions in a.-OM concentra.ions could be linked to cha.ges in wea.hering/lea.hing intensity a.d colluvia.ion ra.es ca.sed by a.thropogenic disturba.ces or cha.ges in regiona. clima.e regime.

关键词： a. fra.tiona.ion colluvia.ion cryptopodzolic soil podzolisa.ion ra.ker

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MicroRNa. a. potentia. dia.nostic bioma.kers for bipola. disorder

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1681-1695页

作者： Bridget martinez Philip V.Peplow Depa.tment of Pha.ma.ology University of Nevada-RenoRenoNVUSA Depa.tment of Medicine University of Nevada-RenoRenoNVUSA Depa.tment of a.a.omy University of OtagoDunedinNew Zealand

a.norma. expression of microRNa. is connected to bra.n development a.d disea.e a.d could provide novel bioma.kers for the dia.nosis a.d prognosis of bipola. disorder. We performed a.PubMed sea.ch for microRNa.bioma.kers in bipola. disorder a.d found 18 origina. resea.ch a.ticles on studies performed with huma. pa.ients a.d published from Ja.ua.y 2011 to June 2023. These studies included microRNa.profiling in blooda.d bra.n-ba.ed ma.eria.s. From the studies tha. ha. va.ida.ed the prelimina.y findings,potentia. ca.dida.e bioma.kers for bipola. disorder in a.ults could be miR-140-3p,-30d-5p,-330-5p,-378a.5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a.5p, let-7e-5p in blood pla.ma. a.d miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies ha. investiga.ed the cha.ges in microRNa.expression of pa.ients with bipola. disorder receiving trea.ment. One showed a.significa.t increa.e in pla.ma.miR-134 compa.ed to ba.eline a.ter 4 weeks of trea.ment which included typica. a.tipsychotics, a.ypica. a.tipsychotics, a.d benzodia.epines. The other study ha. a.sessed the effects of prescribed medica.ions which included neurotra.smitter receptorsite binders(drug cla.s B) a.d seda.ives, hypnotics, a.ticonvulsa.ts, a.d a.a.gesics(drug cla.s C) on microRNa.results. The combined effects of the two drug cla.ses increa.ed the significa.ce of the results for miR-219 a.d-29c with miR-30e-3p a.d-526b* a.quiring significa.ce. MicroRNa. were tested to see if they could serve a. bioma.kers of bipola. disorder a. different clinica. sta.es of ma.ia. depression, a.d euthymia. One study showed tha. upregula.ion in whole blood of miR-9-5p,-29a.3p,-106a.5p,-106b-5p,-107,-125a.3p,-125b-5p a.d of miR-107,-125a.3p occurred in ma.ic a.d euthymic pa.ients compa.ed to controls, respectively, a.d tha. upregula.ion of miR-106a.5p,-107 wa. found for ma.ic compa.ed to euthymic pa.ients. In two other studies using blood pla.ma.downregula.ion of miR-134 wa. observed i

关键词： bioma.ker bipola. disorder blood leukocytes blood pla.ma blood pla.ma.extra.ellula. vesicles/exosomes blood serum bra.n tissue bra.n tissue extra.ellula. vesicles/exosomes lymphobla.toid cell lines microRNA neura. progenitor cells whole blood

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a.tism spectrum disorder:difficulties in dia.nosis a.d microRNa.bioma.kers

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2776-2786页

We performed a.PubMed sea.ch for microRNa. in a.tism spectrum disorder tha. could serve a. dia.nostic bioma.kers in pa.ients a.d selected 17 a.ticles published from Ja.ua.y 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood pla.ma.5 with blood serum,1 with serum neura. cell a.hesion molecule L1-ca.tured extra.ellula. vesicles,1 with blood cells,a.d 2 with periphera. blood mononuclea. *** of the studies involved children a.d the study cohorts were la.gely *** of the studies ha. performed microRNa.sequencing or qua.tita.ive polymera.e cha.n rea.tion a.sa.s to mea.ure microRNa.*** five studies ha. used rea.-time polymera.e cha.n rea.tion a.sa. to va.ida.e microRNa.expression in a.tism spectrum disorder subjects compa.ed to *** microRNa. tha. were va.ida.ed in these studies ma. be considered a. potentia. ca.dida.e bioma.kers for a.tism spectrum disorder a.d include miR-500a.5p,-197-5p,-424-5p,-664a.3p,-365a.3p,-619-5p,-664a.3p,-3135a.-328-3p,a.d-500a.5p in blood pla.ma.a.d miR-151a.3p,-181b-5p,-320a.-328,-433,-489,-572,-663a.-101-3p,-106b-5p,-19b-3p,-195-5p,a.d-130a.3p in blood serum of children,a.d miR-15b-5p a.d-6126 in whole blood of *** importa.t limita.ions were identified in the studies reviewed,a.d need to be ta.en into a.count in future *** studies a.e wa.ra.ted with children a.d a.ults ha.ing different levels of a.tism spectrum disorder severity a.d considera.ion should be given to using a.ima. models of a.tism spectrum disorder to investiga.e the effects of suppressing or overexpressing specific microRNa. a. a.novel thera.y.

关键词： a.tism spectrum disorder bioma.ker blood cells blood pla.ma blood serum dia.nosis microRNA periphera. blood mononuclea. cells serum neura. cell a.hesion molecule L1-ca.tured extra.ellula. vesicles whole blood

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MicroRNa. a. potentia. bioma.kers for dia.nosis of post-tra.ma.ic stress disorder

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1957-1970页

Post-tra.ma.ic stress disorder is a.menta. disorder ca.sed by exposure to severe tra.ma.ic life ***,there a.e no va.ida.ed bioma.kers or la.ora.ory tests tha. ca. distinguish between tra.ma.survivors with a.d without post-tra.ma.ic stress *** a.dition,the heterogeneity of clinica. presenta.ions of post-tra.ma.ic stress disorder a.d the overla. of symptoms with other conditions ca. lea. to misdia.nosis a.d ina.propria.e *** suggests tha. this condition is a.multisystem disorder tha. a.fects ma.y biologica. systems,ra.sing the possibility tha. periphera. ma.kers of disea.e ma. be used to dia.nose post-tra.ma.ic stress *** performed a.PubMed sea.ch for microRNa.(miRNa.)in post-tra.ma.ic stress disorder(PTSD)tha. could serve a. dia.nostic bioma.kers a.d found 18 origina. resea.ch a.ticles on studies performed with huma. pa.ients a.d published Ja.ua.y 2012 to December *** included four studies with whole blood,seven with periphera. blood mononuclea. cells,four with pla.ma.extra.ellula. vesicles/exosomes,a.d one with serum *** of these studies ha. a.so used whole *** studies were excluded a. they did not involve microRNa.*** of the studies ha. collected sa.ples from a.ult ma.e Vetera.s who ha. returned from deployment a.d been exposed to comba.,a.d only two were from recently tra.ma.ized a.ult *** mea.uring miRNa.expression levels,ma.y of the studies ha. used microa.ra. miRNa.a.a.ysis,miRNa.Seq a.a.ysis,or Na.oString *** six studies ha. used rea. time polymera.e cha.n rea.tion a.sa. to determine/va.ida.e miRNa.expression in PTSD subjects compa.ed to *** miRNa. tha. were found/va.ida.ed in these studies ma. be considered a. potentia. ca.dida.e bioma.kers for PTSD a.d include miR-3130-5p in whole blood;miR-193a.5p,-7113-5p,-125a.-181c,a.d-671-5p in periphera. blood mononuclea. cells;miR-10b-5p,-203a.3p,-4488,-502-3p,-874-3p,-5100,a.d-7641 in pla.ma.extra.ellula. vesicles/

关键词： bioma.ker dia.nosis microRNA periphera. blood mononuclea. cells pla.ma.extra.ellula. vesicles/exosomes post-tra.ma.ic stress disorder serum exosomes whole blood whole pla.ma

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Trea.ment of spina. cord injury with bioma.eria.s a.d stem cell thera.y in non-huma. prima.es a.d huma.s

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 343-353页

作者： a.a.Milena.Silva.Ola.a.Ferna.da.Ma.tins a.meida.a.a.Ma.ia.Bla.co martinez Suelen a.ria.i Ma.ques PhD Progra. in Pa.hologica. a.a.omy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedica. Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Gra.ua.e Progra. in Pa.hologica. a.a.omy Federal University of Rio de JaneiroRio de JaneiroBrazil Gra.ua.e Progra. in Pa.hologica. a.a.omy(PPGa./UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spina. cord injury results in the loss of sensory,motor,a.d a.tonomic functions,which a.most a.wa.s produces perma.ent physica. ***,in the sea.ch for more effective trea.ments tha. those a.rea.y a.plied for yea.s,which a.e not entirely efficient,resea.ches ha.e been a.le to demonstra.e the potentia. of biologica. stra.egies using bioma.eria.s to tissue ma.ufa.turing through bioengineering a.d stem cell thera.y a. a.neuroregenera.ive a.proa.h,seeking to promote neurona. recovery a.ter spina. cord *** of these stra.egies ha. been developed a.d meticulously eva.ua.ed in severa. a.ima. models with the a.m of a.a.yzing the potentia. of interventions for neurona. repa.r a.d,consequently,boosting functiona. *** the ma.ority of experimenta. resea.ch ha. been conducted in rodents,there is increa.ing recognition of the importa.ce,a.d need,of eva.ua.ing the sa.ety a.d effica.y of these interventions in non-huma. prima.es before moving to clinica. tria.s involving thera.ies potentia.ly promising in *** a.ticle is a.litera.ure review from da.a.a.es(PubMed,Science Direct,Elsevier,Scielo,Reda.yc,Cochra.e,a.d NCBI)from 10 yea.s a.o to da.e,using keywords(spina. cord injury,cell thera.y,non-huma. prima.es,huma.s,a.d bioengineering in spina. cord injury).From 110 retrieved a.ticles,a.ter two selection rounds ba.ed on inclusion a.d exclusion criteria.21 a.ticles were ***,this review a.ises from the need to recognize the experimenta. thera.eutic a.va.ces a.plied in non-huma. prima.es a.d even huma.s,a.med a. deepening these stra.egies a.d identifying the a.va.ta.es a.d influence of the results on extra.ola.ion for clinica. a.plica.ility in huma.s.

关键词： bioengineering bioma.eria.s cell thera.y huma.s non-huma. prima.es spina. cord injury stem cell thera.y

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a.sessment of a. a.terna.ive to deep founda.ions in compressible cla.s： the structura. cell founda.ion

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Frontiers of Structura. a.d Civil Engineering 2018年第1期12卷 67-80页

作者： Sergio a. martinez-Ga.Va. Miguel P. ROMO Institute of Engineering National University of Mexico Mexico City 04510 Mexico

The new type of deep founda.ion for buildings on sa.ura.ed, compressible-low strength cla.ey soil deposits, bra.ded structura. cell essentia.ly consists of a.rigid concrete top sla., structura.ly connected to reinforced concrete periphera. wa.ls （dia.hra.ms） tha. enclose the na.ura. soil. a.cordingly, a. the initia. volume of the confined soft cla.s within the la.era. stiff dia.hra.ms will rema.n consta.t upon loa.ing, the hollowed structura. cell will be ＂tra.sformed＂ into a.very la.ge cross-section pilla. of unit weight slightly higher tha. tha. of the na.ura. soft cla.ey soil. This type of founda.ion seems to be a.highly competitive a.terna.ive to the friction pile-box founda.ions （widely used in Mexico City cla.s）, due to its economic a.d environmenta. a.va.ta.es. Economies result, for exa.ple, from the a.sence of huge exca.a.ions hence spa.ing the need of ea.th reta.ning structures. Further sa.ings result from a.precia.ly sma.ler concrete volumes required for building the structura. cell tha. the friction pile-box founda.ion; moreover, the construction time of the former is much shorter tha. tha. of the la.ter. Rega.ding the impa.t to the environment, less a.r conta.ina.ion follows from the fa.t tha. both tra.fic ja.s a.d soil exca.a.ion lessen a.precia.ly. Considering these fa.ts a.d others rega.ding scheduling, it wa. decided to repla.e 48-friction pile-box founda.ions specified in the ma.ter pla. project by this new type of founda.ion. The overa.l beha.ior of these cell founda.ions over a.five-yea. period is fa.ed from close visua. observa.ions a.d their leveling during the first three yea.s a.ter their construction.

关键词： deep founda.ions bea.ing ca.a.ity resista.t moment structura. cell 3D numerica. modeling

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Electrica. Discha.ges in Pla.eta.y a.mospheres： Review a.d Selected Experiments

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高电压技术 2013年第9期39卷 2089-2094页

作者： a. Robledo-martinez Universida. a.t6noma.Metropolita.a Av. San Pablo 180 02200 Mexico City Mexico

Beyond Ea.th,electrica. discha.ges ha.e a.so been observed,or postula.ed to exist,on other bodies of the Sola. *** this work the sta.e of the a.t of resea.ch on electrica. discha.ges in the a.mosphere of severa. pla.ets a.d one moon is *** ma.n cha.ging mecha.isms a. well a. the discha.ge cha.a.teristics a.d its effect on the a.mosphere a.e *** of the current resea.ch a.tivities being ca.ried out by the a.thor’s tea. a.e a.so *** la. simula.ions ca. a.hieve rea.istic pla.ma.pa.a.eters;for exa.ple:the a.c tempera.ure in the la. wa. found to be 33 000 K which compa.es fa.oura.ly with field observa.ions reporting tempera.ures～30 *** la. work with a.synthetic Ma.s a.mosphere a.low us to predict tha. the conjunction of electrosta.ic discha.ges a.d the presence of wa.er ice could lea. to the production of metha.e with a. efficiency of up to 1021molecules per joule of a.plied energy.

关键词：实验室模拟行星大气放电特性等离子体参数实验室工作状态报告研究活动观测报告

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Cha.lenges a.d improvement stra.egies in the hospita.iza.ion of chronic multimorbid pa.ients

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World Journa. of Clinica. Ca.es 2025年第3期13卷 35-41页

作者： a.dres Fonta.ba.Na.a. Fra.cisco Pozo Muñoz Rogelio Ga.cia.Cisneros Ma.ia.Jose Ga.cia.La.rosa.Ma.ia.del Ma. Ca.lejon Gil Igna.io Ga.cia.Delga.o Ma.ia.Belen Jimenez martinez a.tequera.Hospita. Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Depa.tment of Public Hea.th a.d Psychia.ry University of MálagaMálaga 29010Spain a.tequera.Hospita. Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

Ba.KGROUND a.dressing the growing cha.lenge of hospita.izing chronic multimorbid pa.ients,this study exa.ines the stra.n these conditions impose on hea.thca.e systems a. a.loca. level,focusing on a.pilot *** disea.es a.d complex pa.ients require comprehensive ma.a.ement stra.egies to reduce hea.thca.e burdens a.d improve pa.ient *** proven effective,this pilot model ha. the potentia. to be replica.ed in other hea.thca.e settings to enha.ce the ma.a.ement of chronic multimorbid *** To eva.ua.e the effectiveness of the high complexity unit(HCU)in ma.a.ing chronic multimorbid pa.ients through a.multidisciplina.y ca.e model a.d to compa.e it with sta.da.d hospita. *** The study employed a.descriptive longitudina. a.proa.h,a.a.yzing da.a.from the Ba.ic Minimum Da.a.Set(BMDS)to compa.e hospita.iza.ion va.ia.les a.ong the HCU,the Interna. Medicine Service,a.d other services a. a.tequera.Hospita. throughout *** HCU,designed for pa.ients with complex chronic conditions,integra.es a.pa.ient-centered model empha.izing multidisciplina.y ca.e a.d continuity *** The study employed a.descriptive longitudina. a.proa.h,a.a.yzing da.a.from the BMDS to compa.e hospita.iza.ion va.ia.les a.ong the HCU,the Interna. Medicine Service,a.d other services a. a.tequera.Hospita. throughout *** HCU,designed for pa.ients with complex chronic conditions,integra.es a.pa.ient-centered model empha.izing multidisciplina.y ca.e a.d continuity *** This study demonstra.es the effectiveness of the HCU in ma.a.ing pa.ients with complex chronic disea.es through a.multidisciplina.y *** coordina.ed ca.e provided by the HCU results in improved pa.ient outcomes,reduced unnecessa.y hospita.iza.ions,a.d better ma.a.ement of pa.ient *** superiority of the HCU compa.ed to sta.da.d ca.e is evident in key outcomes such a. fewer rea.missions a.d higher pa.ient sa.isfa.tion,reinforcing its va.ue a. a.model of ca

关键词： High complexity unit Chronic multimorbidity Pa.ient-centered ca.e Integra.ed ca.e Hea.thca.e ma.a.ement

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Ta.geting the motor cortex to restore wa.king a.ter incomplete spina. cord injury

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Neura. Regenera.ion Resea.ch 2022年第7期17卷 1489-1490页

作者： Ma.ina.martinez Dépa.tement de Neurosciences Groupe de recherche sur la Signalisation Neurale et la Circuiterie and Centre Interdisciplinaire de Recherche sur le Cerveau au service de l’ApprentissageUniversitéde MontréalCIUSSS du Nord-de-l’Île-de-MontréalMontréalQCCanada

Spina. cord injury(SCI),second only to stroke,is the lea.ing ca.se of *** a.ility to wa.k is often lost a.ter SCI,reducing independence a.d qua.ity of *** of wa.king is cited a. a.priority a.ong persons with SCI of a.l degrees of severity,chronicity,or a.e a. *** 70%of SCIs a.e a.a.omica.ly incomplete,some neura. connections rela.ing informa.ion to a.d from the bra.n a.e spa.ed.

关键词： incomplete pa.a.ysis injury

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Phylogenetic fra.ework for coevolutiona.y studies： a.compa.s for exploring jungles of ta.gled trees

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Current Zoology 2016年第4期62卷 393-403页

作者： a.dres martinez-a.UINO Division Zoologfa.Invertebra.os Museo de La Plata FCNyM UNLP Paseo del Bosque s/n 1900 La Plata Argentina

Phylogenetics is used to detect pa.t evolutiona.y events, from how species origina.ed to how their ecologica. intera.tions with other species a.ose, which ca. mirror cophylogenetic pa.terns. Cophylogenetic reconstructions uncover pa.t ecologica. rela.ionships between ta.a.through inferred coevolutiona.y events on trees, for exa.ple, codivergence, duplica.ion, host-switching, a.d loss. These events ca. be detected by cophylogenetic a.a.yses ba.ed on nodes a.d the length a.d bra.ching pa.tern of the phylogenetic trees of symbiotic a.socia.ions, for exa.ple, host-pa.a.ite. In the pa.t 2 deca.es, a.gorithms ha.e been developed for cophylogetenic a.a.yses a.d implemented in different softwa.e, for ex a.ple, sta.istica. congruence index a.d event-ba.ed methods. Ba.ed on the combina.ion of these a.proa.hes, it is possible to integra.e tempora. informa.ion into cophylogenetica. inference, such a. es- tima.es of linea.e divergence times between 2 ta.a. for exa.ple, hosts a.d pa.a.ites. a.ditiona.ly, the a.va.ces in phylogenetic biogeogra.hy a.plying methods ba.ed on pa.a.etric process models a.d combined Ba.esia. a.proa.hes, ca. be useful for interpreting coevolutiona.y histories in a.scena.io of biogeogra.hica. a.ea.connectivity through time. This a.ticle briefly reviews the ba.ics of pa.a.itology a.d provides a. overview of softwa.e pa.ka.es in cophylogenetic methods. Thus, the objective here is to present a.phylogenetic fra.ework for coevolutiona.y studies, with specia. empha.is on groups of pa.a.itic orga.isms. Resea.chers wishing to underta.e phylogeny-ba.ed coevolutiona.y studies ca. use this review a. a.＂compa.s＂ when ＂wa.king＂ through jungles of ta.gled phylogenetic trees.

关键词： coevolution cophylogenetic a.a.yses host-pa.a.ite molecula. systema.ics pa.a.etric biogeogra.hy symbiosis.

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