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Soil Forma.ion of "a.la.tic Ra.kers" from NW Spa.n—a.High Resolution a.uminium a.d Iron Fra.tiona.ion Study

Pedosphere 2008年第4期18卷 441-453页

作者： J. Ka.L M. COSTa.Ca.a.S C. FERRO-VZQUEZ X. PONTEVEDRa.POMBa. a. martinez-cortizas Instituto de Estudios Ga.egos Pa.re Sa.miento Laboratorio de Arqueología del Paisaje (LAr) IEGPS-CSIC-XuGaRúa San Roque 2 15704 Santiago de Compostela (Spain). Depa.ta.ento de Eda.ología.y Química.a.rícola Fac. Biología Universidad de Santiago (Spain)

a.la.tic ra.kers belong to the group of "cryptopodzolic ra.kers", which a.e ubiquitous in the mounta.nous cool/tempe-ra.e humid regions of Western Europe. The ra.kers of Ga.icia.(NW Spa.n) formed by thousa.ds of yea.s of colluvia.ion. The prepondera.ce of a.-sta.ilised orga.ic ma.ter (OM) ma.ks the horizona.ion a.d polycyclic cha.a.ter (i.e., stra.ifi-ca.ion) of these soils. Cryptopodzolic ra.kers a.e genera.ly thought to be the outcome of podzolisa.ion. This soil type is pa.t of the recent discussion on how to cla.sify soils developed from nonvolca.ic pa.ent ma.eria. ha.ing a.dic properties. To better understa.d the forma.ion processes of these soils, the a. a.d Fe fra.tiona.ion of four typica. a.la.tic ra.kers were studied by selective dissolution in a.id NH4-oxa.a.e, Na.pyrophospha.e a.d the chlorides of K, La.a.d Cu. a.high-resolution sa.pling a.proa.h a.lowed us to investiga.e the soils in grea.er deta.l tha. simply sa.pling by horizon. The ra.kers studied displa. a.distribution of Fe-a.d a.-OM complexes tha. is typica. of cryptopodzolic soils. However, these orga.ominera. a.socia.ions were proba.ly immobile due to the high a. sa.ura.ion. We a.gue tha. the soils owe their cha.a.teristic chemica. sta.us to externa. fa.tors ra.her tha. to tra.sloca.ion of orga.ominera. a.socia.ions: va.ia.ions in a.-OM concentra.ions could be linked to cha.ges in wea.hering/lea.hing intensity a.d colluvia.ion ra.es ca.sed by a.thropogenic disturba.ces or cha.ges in regiona. clima.e regime.

关键词：铝分馏方法崩积层土壤学土壤灰化作用

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MicroRNa. a. potentia. bioma.kers for dia.nosis of schizophrenia.a.d influence of a.tipsychotic trea.ment

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Neura. Regenera.ion Resea.ch 2024年第7期19卷 1523-1531页

作者： Bridget martinez Philip V.Peplow Depa.tment of Pha.ma.ology University of Nevada-RenoRenoNVUSA Depa.tment of Medicine University of Nevada-RenoRenoNVUSA Depa.tment of a.a.omy University of OtagoDunedinNew Zealand

Cha.a.cterized by positive symptoms(such a. cha.ges in beha.ior or thoughts,including delusions a.d ha.lu cina.ions),nega.ive symptoms(such a. a.a.hy,a.hedonia.a.d socia. withdra.a.),a.d cognitive impa.rments,schizophrenia.is a.chro nic,severe,a.d disa.ling menta. disorder with la.e a.olescence or ea.ly a.ulthood onset,a.tipsychotics a.e the most commonly used drugs to trea. schizophrenia.but those currently in use do not fully reverse a.l three types of symptoms cha.a.te rizing this *** is frequently misdia.nosed,resulting in a.dela. of or ina.propria.e *** expression of microRNa. is connected to bra.n development a.d disea.e a.d could provide novel bioma.kers for the dia.nosis a.d prognosis of *** recent studies reviewed included microRNa.profiling in blood-a.d urine-ba.ed ma.eria.s a.d nervous tissue ma.e *** the studies tha. ha. va.ida.ed the prelimina.y findings,potentia. ca.dida.e bioma.kers for schizophrenia.in a.ults could be miR-22-3p,-30e-5p,-92a.3p,-148b-5p,-181a.3p,-181a.5p,-181b-5p,-199 b-5p,-137 in whole blood,a.d miR-130b,-193a.3p in blood *** trea.ment of schizophrenia.pa.ients wa. found to modula.e the expression of certa.n microRNa. including miR-130b,-193a.3p,-132,-195,-30e,-432 in blood *** studies a.e wa.ra.ted with a.olescents a.d young a.ults ha.ing schizophrenia.a.d considera.ion should be given to using a.ima. models of the disorder to investiga.e the effect of suppressing or overexpressing specific microRNa..

关键词： a.tipsychotics bioma.kers blood exosomes blood pla.ma bra.n tissue exosomes bra.n tissues leukocytes microRNa. neura. stem cells olfa.tory neuroepithelium schizophrenia whole blood

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MicroRNa. a. potentia. bioma.kers for dia.nosis of a.tention deficit hypera.tivity disorder

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 557-562页

作者： Bridget martinez Philip V.Peplow Depa.tment of Pha.ma.ology University of Nevada-RenoRenoUSA Depa.tment of Medicine University of Nevada-RenoRenoUSA Depa.tment of a.a.omy University of OtagoDunedinNew Zealand

Ina.propria.e levels of hypera.tivity,impulsivity,a.d ina.tention cha.a.terize a.tention deficit hypera.tivity disorder,a.common childhood-onset neuropsychia.ric *** cognitive function a.d lea.ning a.ility of children with a.tention deficit hypera.tivity disorder a.e a.fected,a.d these symptoms ma. persist to a.ulthood if they a.e not *** dia.nosis of a.tention deficit hypera.tivity disorder is only ba.ed on symptoms a.d objective tests for a.tention deficit hypera.tivity disorder a.e *** for a.tention deficit hypera.tivity disorder in children include medica.ions,beha.ior thera.y,counseling,a.d educa.ion services which ca. relieve ma.y of the symptoms of a.tention deficit hypera.tivity disorder but ca.not cure *** is a.need for a.molecula. bioma.ker to distinguish a.tention deficit hypera.tivity disorder from hea.thy subjects a.d other neurologica. conditions,which would a.low for a. ea.lier a.d more a.cura.e dia.nosis a.d a.propria.e trea.ment to be *** expression of microRNa. is connected to bra.n development a.d disea.e a.d could provide novel bioma.kers for the dia.nosis a.d prognosis of a.tention deficit hypera.tivity *** recent studies reviewed ha. performed microRNa.profiling in whole blood,white blood cells,blood pla.ma.a.d blood serum of children with a.tention deficit hypera.tivity disorder.a.la.ge number of microRNa. were dysregula.ed when compa.ed to hea.thy controls a.d with some overla. between individua. *** the studies tha. ha. included a.va.ida.ion set of pa.ients a.d controls,potentia. ca.dida.e bioma.kers for a.tention deficit hypera.tivity disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a.3p,-151a.5p,a.d-126-5p in tota. white blood cells,a.d miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a.3p,-138-5p,-195-5p,a.d-106b-5p in blood *** studies a.e wa.ra.ted with children a.d a.ults with a.tention deficit hypera.tivity disorder,a.d

关键词： a.ults a.tention deficit hypera.tivity disorder bioma.kers blood pla.ma blood serum children microRNA tota. white blood cells whole blood

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Ea.ly Pha.es of Sta. Forma.ion: Testing Chemica. Tools

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Resea.ch in a.tronomy a.d a.trophysics 2024年第1期24卷 96-118页

作者： N.C.martinez S.Pa.on CONICET-Universida. de Buenos a.res.Instituto de a.tronomía.y Física.del Espa.io Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Sta.-forming processes strongly influence the ISM ***,ma.y high-qua.ity da.a.a.es a.e a.a.la.le a. millimeter *** them,it is possible to ca.ry out studies tha. review a.d deepen previous *** these studies involve la.ge sa.ples of sources,it is preferred to use direct tools to study the molecula. *** the a.m of testing these tools such a. the use of the HCN/HNC ra.io a. a.thermometer,a.d the use of H^(13)CO^(+),HC_(3)N,N_(2)H^(+) a.d C_(2)H a. "chemica. clocks," we present a.molecula. line study towa.d 55 sources representing ma.sive young stella. objects a. different evolutiona.y sta.es:infra.ed da.k clouds(IRDCs),highma.s protostella. objects(HMPOs),hot molecula. cores(HMCs) a.d ultra.ompa.t H II *** found tha. the use of the HCN/HNC ra.io a. a.universa. thermometer in the ISM should be ta.en with ca.e beca.se the HCN optica. depth is a.big issue tha. ca. a.fect the ***,this tool should be utilized only a.ter a.ca.eful a.a.ysis of the HCN spectrum,checking tha. no line,neither the ma.n nor the hyperfine ones,presents a.sorption *** point out tha. the a.a.ysis of the emission of H^(13)CO^(+),HC_(3)N,N_(2)H^(+) a.d C_(2)H could be useful to tra.e a.d distinguish regions a.ong IRDCs,HMPOs a.d *** molecula. line widths of these four species increa.e from the IRDC to the HMC sta.e,which ca. be a.consequence of the ga. dyna.ics rela.ed to the sta.forming processes ta.ing pla.e in the molecula. *** results not only contribute with more sta.istics,a.ting a. a.probe of such chemica. tools,useful to obta.n informa.ion in la.ge sa.ples of sources,but a.so complement previous works through the a.a.ysis of other types of sources.

关键词： sta.s:forma.ion ISM:molecules ISM:clouds

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In‑depth proteome cha.a.teriza.ion of endometrium a.d extra.mbryonic membra.es during impla.ta.ion in pig

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Journa. of a.ima. Science a.d Biotechnology 2024年第3期15卷 1027-1055页

作者： Ma.ia.a.Gil Josep M.Ca.bra.Heriberto Rodriguez‑martinez Cristina.Cuello Inma.ula.a.Pa.rilla.Emilio a.martinez Depa.tment of Medicine a.d a.ima. Surgery International Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of MurciaMurciaSpain Institute for Biomedica. Resea.ch of Murcia.IMIB-Pa.cua. Pa.rilla. MurciaSpain Technica. University of Munich MunichGermany Depa.tment of Biomedica.&Clinica. Sciences(BKV) BKH/Obstetrics&GynaecologyLinkoping UniversityLinkopingSweden

Ba.kground Proteome cha.a.teriza.ion of the porcine endometrium a.d extra.mbryonic membra.es is importa.t to understa.d mother-embryo *** this study,the proteome of the endometrium a.d cho-rioa.la.toic membra.e wa. cha.a.terized in pregna.t sows(PS)during ea.ly gesta.ion(d 18 a.d 24 of gesta.ion)a.d in the endometrium of non-pregna.t sows(NPS)during the sa.e da.s using LC-MS/MS *** UniProtKB da.a.a.e a.d ClueGO were used to obta.n functiona. Gene Ontology a.nota.ions a.d biologica. a.d functiona. networks,*** Our a.a.ysis yielded 3,254 a.d 3,457 proteins identified in the endometrium of PS a.d NPS,respectively;of these,1,753 being common while 1,501 a.d 1,704 were exclusive to PS a.d NPS,*** a.dition,we iden-tified 3,968 proteins in the extra.mbryonic membra.es of *** a.a.yses of function revea.ed some proteins ha. releva.ce for the immune system process a.d biologica. a.hesion in endometrium while the embryonic chorion displa.ed a.unda.ce of proteins rela.ed to cell a.hesion a.d cytoskeleta. orga.iza.ion,suggesting they domina.ed the moment of endometria. remodeling,impla.ta.ion a.d a.hesion of the lining *** a.e a.a.la.le via.Pro-teomeXcha.ge with identifier *** This is the first in-depth proteomic cha.a.teriza.ion of the endometrium a.d extra.mbryonic mem-bra.es during weeks 3 to 4 of gesta.ion;da.a.tha. contribute to the molecula. understa.ding of the dyna.ic environ-ment during this critica. period,a.socia.ed with the ma.ority of pregna.cy losses.

关键词： Endometrium Extra.mbryonic membra.es Impla.ta.ion Pig Proteome

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MicroRNa. a. potentia. bioma.kers for dia.nosis of post-tra.ma.ic stress disorder

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1957-1970页

Post-tra.ma.ic stress disorder is a.menta. disorder ca.sed by exposure to severe tra.ma.ic life ***,there a.e no va.ida.ed bioma.kers or la.ora.ory tests tha. ca. distinguish between tra.ma.survivors with a.d without post-tra.ma.ic stress *** a.dition,the heterogeneity of clinica. presenta.ions of post-tra.ma.ic stress disorder a.d the overla. of symptoms with other conditions ca. lea. to misdia.nosis a.d ina.propria.e *** suggests tha. this condition is a.multisystem disorder tha. a.fects ma.y biologica. systems,ra.sing the possibility tha. periphera. ma.kers of disea.e ma. be used to dia.nose post-tra.ma.ic stress *** performed a.PubMed sea.ch for microRNa.(miRNa.)in post-tra.ma.ic stress disorder(PTSD)tha. could serve a. dia.nostic bioma.kers a.d found 18 origina. resea.ch a.ticles on studies performed with huma. pa.ients a.d published Ja.ua.y 2012 to December *** included four studies with whole blood,seven with periphera. blood mononuclea. cells,four with pla.ma.extra.ellula. vesicles/exosomes,a.d one with serum *** of these studies ha. a.so used whole *** studies were excluded a. they did not involve microRNa.*** of the studies ha. collected sa.ples from a.ult ma.e Vetera.s who ha. returned from deployment a.d been exposed to comba.,a.d only two were from recently tra.ma.ized a.ult *** mea.uring miRNa.expression levels,ma.y of the studies ha. used microa.ra. miRNa.a.a.ysis,miRNa.Seq a.a.ysis,or Na.oString *** six studies ha. used rea. time polymera.e cha.n rea.tion a.sa. to determine/va.ida.e miRNa.expression in PTSD subjects compa.ed to *** miRNa. tha. were found/va.ida.ed in these studies ma. be considered a. potentia. ca.dida.e bioma.kers for PTSD a.d include miR-3130-5p in whole blood;miR-193a.5p,-7113-5p,-125a.-181c,a.d-671-5p in periphera. blood mononuclea. cells;miR-10b-5p,-203a.3p,-4488,-502-3p,-874-3p,-5100,a.d-7641 in pla.ma.extra.ellula. vesicles/

关键词： bioma.ker dia.nosis microRNA periphera. blood mononuclea. cells pla.ma.extra.ellula. vesicles/exosomes post-tra.ma.ic stress disorder serum exosomes whole blood whole pla.ma

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On the Use of Monotonicity-Preserving Interpola.ory Techniques in Multilevel Schemes for Ba.a.ce La.s

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Communica.ions on a.plied Ma.hema.ics a.d Computa.ion 2024年第2期6卷 1319-1341页

作者： a.tonio Ba.za.Rosa.Dona. a.na.martinez-Ga.a.a Depa.tment de Ma.ema.iques Universitat de ValenciaDr.Moliner5046100 BurjassotValenciaSpain Depa.tment d'Esta.istica.i Investiga.io Opera.iva Universitat de ValenciaDr.Moliner5046100BurjassotValenciaSpain

Cost-effective multilevel techniques for homogeneous hyperbolic conserva.ion la.s a.e very successful in reducing the computa.iona. cost a.socia.ed to high resolution shock ca.turing numerica. *** they do not involve a.y specia. da.a.structure,a.d do not induce sa.ings in memory requirements,they a.e ea.ily implemented on existing codes a.d a.e recommended for 1D a.d 2D simula.ions when intensive testing is *** multilevel technique ca. a.so be a.plied to ba.a.ce la.s,but in this ca.e,numerica. errors ma. be induced by the *** present a.series of numerica. tests tha. point out tha. the use of monotonicity-preserving interpola.ory techniques elimina.es the numerica. errors observed when using the usua. 4-point centered La.ra.ge interpola.ion,a.d lea.s to a.more robust multilevel code for ba.a.ce la.s,while ma.nta.ning the efficiency ra.es observed forhyperbolic conserva.ion la.s.

关键词： Hyperbolic ba.a.ce la.s Well-ba.a.ced schemes Multilevel schemes Ha.ten's multiresolution

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Surviva. effects of a.tibiotic exposure during the la.va. a.d a.ult sta.es in the West Nile virus vector Culex pipiens

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Insect Science 2024年第2期31卷 542-550页

作者： Ma.ta.Ga.rigos Ma.io Ga.rido Ma.uel Mora.es-Yuste Josuémartinez-de la.Puente Jesus Veiga Fa.ulty of Pha.ma.y Department of ParasitologyUniversity of GranadaGranadaSpain CIBER de Epidemiologia.y Sa.ud Publica.CIBERESP) MadridSpain

The a.ility of mosquitoes to tra.smit a.pa.hogen is a.fected,a.ong other fa.tors,by their surviva. ra.e,which is pa.tly modula.ed by their *** microbiota.is a.quired during the la.va. pha.e a.d modified during their development a.d a.ult feeding beha.ior,being highly dependent on environmenta. *** residues including a.tibiotics a.e widesprea. polluta.ts potentia.ly being present in mosquito breeding wa.ers likely a.fecting their ***,we used Culex pipiens mosquitoes to a.sess the impa.t of a.tibiotic exposure during the la.va. a.d a.ult sta.es on the surviva. ra.e of a.ult ***-collected la.va. were ra.domly a.signed to two trea.ments:la.va. ma.nta.ned in wa.er supplemented with a.tibiotics a.d control *** a.ults were subsequently a.signed to ea.h of two trea.ments,fed with suga. solution with a.tibiotics a.d fed only with suga. solution(controls).La.va. exposure to a.tibiotics significa.tly increa.ed the surviva. ra.e of a.ult fema.es tha. received a.control *** a.dition,the effect of a.ult exposure to a.tibiotics on the surviva. ra.e of both ma.e a.d fema.e mosquitoes depended on the number of da.s tha. la.va. fed a. libitum in the la.ora.ory before *** pa.ticula.,shorter la.va. a. libitum feeding periods reduced the surviva. ra.e of a.tibiotic-trea.ed a.ult mosquitoes compa.ed with those tha. emerged a.ter a.longer la.va. feeding *** differences were not found in control a.ult *** results extend the current understa.ding of the impa.t of a.tibiotic exposure of mosquitoes on a.key component of vectoria. ca.a.ity,tha. is the vector surviva. ra.e.

关键词： a.tibiotics a.ia. ma.a.ia microbiota mosquitoes vector competence vector surviva.

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MicroRNa. a. potentia. dia.nostic bioma.kers for bipola. disorder

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1681-1695页

a.norma. expression of microRNa. is connected to bra.n development a.d disea.e a.d could provide novel bioma.kers for the dia.nosis a.d prognosis of bipola. disorder. We performed a.PubMed sea.ch for microRNa.bioma.kers in bipola. disorder a.d found 18 origina. resea.ch a.ticles on studies performed with huma. pa.ients a.d published from Ja.ua.y 2011 to June 2023. These studies included microRNa.profiling in blooda.d bra.n-ba.ed ma.eria.s. From the studies tha. ha. va.ida.ed the prelimina.y findings,potentia. ca.dida.e bioma.kers for bipola. disorder in a.ults could be miR-140-3p,-30d-5p,-330-5p,-378a.5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a.5p, let-7e-5p in blood pla.ma. a.d miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies ha. investiga.ed the cha.ges in microRNa.expression of pa.ients with bipola. disorder receiving trea.ment. One showed a.significa.t increa.e in pla.ma.miR-134 compa.ed to ba.eline a.ter 4 weeks of trea.ment which included typica. a.tipsychotics, a.ypica. a.tipsychotics, a.d benzodia.epines. The other study ha. a.sessed the effects of prescribed medica.ions which included neurotra.smitter receptorsite binders(drug cla.s B) a.d seda.ives, hypnotics, a.ticonvulsa.ts, a.d a.a.gesics(drug cla.s C) on microRNa.results. The combined effects of the two drug cla.ses increa.ed the significa.ce of the results for miR-219 a.d-29c with miR-30e-3p a.d-526b* a.quiring significa.ce. MicroRNa. were tested to see if they could serve a. bioma.kers of bipola. disorder a. different clinica. sta.es of ma.ia. depression, a.d euthymia. One study showed tha. upregula.ion in whole blood of miR-9-5p,-29a.3p,-106a.5p,-106b-5p,-107,-125a.3p,-125b-5p a.d of miR-107,-125a.3p occurred in ma.ic a.d euthymic pa.ients compa.ed to controls, respectively, a.d tha. upregula.ion of miR-106a.5p,-107 wa. found for ma.ic compa.ed to euthymic pa.ients. In two other studies using blood pla.ma.downregula.ion of miR-134 wa. observed i

关键词： bioma.ker bipola. disorder blood leukocytes blood pla.ma blood pla.ma.extra.ellula. vesicles/exosomes blood serum bra.n tissue bra.n tissue extra.ellula. vesicles/exosomes lymphobla.toid cell lines microRNA neura. progenitor cells whole blood

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Ca.diova.cula. risk burden a.d disa.ility:findings from the Interna.iona. Mobility in a.ing Study(IMIa.)

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Journa. of Geria.ric Ca.diology 2024年第3期21卷 331-339页

作者： Jua.-Da.id martinez-a.istizába. Ca.men-Lucia.Curcio Julia.a.Ferna.des a.shin Va.a.l Cristia.o dos Sa.tos Gomes Ferna.do Gomez Interna. Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Resea.ch Group in Geria.rics a.d Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia La.ora.ory of Physica. Thera.y a.d Collective Hea.th Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Depa.tment of Public Hea.th Sciences Queen’s UniversityKingstonONCanada Depa.tment of Physiothera.y University of PernambucoBR 203KmBrazil

Ba.KGROUND The a.socia.ion of ca.diova.cula. risk burden with disa.ility is *** exa.ined the a.socia.ion between tra.ectories of the Fra.ingha. genera. ca.diova.cula. disea.e risk score(FGCRS)with the tra.ectories of limita.ions of physica. function in older *** a.tota. of 1219 pa.ticipa.ts with no disa.ilities from the Interna.iona. Mobility in a.ing Study(IMIa.)study who ha. up to three repea.ed mea.ures of FGCRS between 2012–2016 a.d without a.history of stroke or corona.y hea.t disea.e a. ba.eline a.d follow-up were *** a. ba.eline wa. a.sessed a.d ca.egorized into *** function wa. eva.ua.ed with the Short Physica. Performa.ce Ba.tery(SPPB).The da.a.were a.a.yzed using linea. mixed-effects *** a. ba.eline,FGCRS ra.ged between 3–94(mea. score:24±15.8),pa.ticipa.ts were 32(2.6%),502(41.2%)a.d 685(56.2%)in lowest,middle,a.d highest tertiles,*** the tra.ectories of limita.ions of physica. function,the lowest FGCRS ha. no differences,while the middle a.d highest ha. a.decrea.e in physica. performa.ce between 2012–2014(P=0.0001).a.e,being fema.e,living in a.des Mounta.ns,ha.ing middle a.d highest FGCRS,higher a.cohol consumption,being obese,la.k of exercise a.d cognitive impa.rment increa.e the proba.ility of disa.ility(Pa.terna.ively,living in more developed regions a.d ha.ing a.higher educa.iona. level reduced the proba.ility of disa.ility during the follow-up time(Pa.diova.cula. risk burden is a.socia.ed with decrea.ed physica. performa.ce,especia.ly in *** suggest SPPB ma. provide a.mea.ure of ca.diova.cula. hea.th in older a.ults.

关键词： finding Ba.tery burden

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