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a. investiga.ion of non-Newtonia. fluid flow due to m.ta.hrona. bea.ing of cilia.in a.tube

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Interna.iona. Journa. of Biom.0}hem.0}ics 2015年第2期8卷 29-51页

作者： a. m. siddiqui a. a. Fa.ooq m. a. Ra.a Depa.tm.nt of m.0}hem.0}ics Pennsylvania State University York Campus York PA 17403-3398 USA Depa.tm.nt of Ba.ic Sciences Riphah International University Islamabad 44000 Pakistan Depa.tm.nt of m.0}hem.0}ics COm.a.S Institute of Inform.0}ion Technology Tobe Ca.p Abbottabad Pakistan

The a.m.of this study is to expla.n theoretica.ly the role of cilia.y m.tion on the tra.sport of epididym.0} fluid through the ductus efferentes of the m.0}e reproductive tra.k. For this purpose, a.m.0}hem.0}ica. m.del ha. been developed for the flow of a.non-Newtonia. fluid in a. a.isym.etric tube due to m.ta.hrona. wa.e of cilia.m.tion for the m.re rea.istic consequences. Ca.rea. viscous fluid m.del is considered to see the rheologica. effects on the pum.ing cha.a.teristics of the flow. Regula. perturba.ion m.thod ha. been em.loyed to obta.n the a.a.ytica. expressions for the strea. function, the velocity field a.d a.rela.ion between the pressure difference a.d the volum. flow ra.e. It is found tha. the volum. flow ra.e is influenced significa.tly by Weissenberg num.er We a.d the cilia.length pa.a.eter ε. The com.uta.iona. results a.e presented gra.hica.ly to see the effects of va.ious physica. pa.a.eters. Fina.ly, the a.a.ysis is a.plied a.d com.a.ed with the observed va.ue of the flow ra.e of sperm.0}ic fluid in the ductus efferentes of the m.0}e reproductive tra.k. The volum. flow ra.e is reported closed to the estim.0}ed va.ue 6 × 10^-3 m./h in the hum.0} ductus efferentes when We = 0.5 a.d e is nea. by 0.25.

关键词： Cilia.induced m.tion a.isym.etric tube m.ta.hrona. wa.e Ca.rea. fluid a.a.ytic solutions pum.ing a.d tra.ping.

PRESSURE FLOW OF a.SECOND GRa.E FLUID THROUGH a.CHa.NEL OF Va.YING WIDTH WITH a.PLICa.ION TO STENOSED a.TERY

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Interna.iona. Journa. of Biom.0}hem.0}ics 2013年第3期6卷 81-100页

作者： a. m. siddiqui T. Ha.OON Z. Ba.O S. ISLa. Pennsylva.ia.Sta.e University York Campus Edgecomb PA 1703 USA Depa.tm.nt of m.0}hem.0}ics COm.a.S Institute of Inform.0}ion TechnologyPa.k Roa. Chak Shehzad Islarnabad ~000 Pakistan Depa.tm.nt of m.0}hem.0}ics COm.a.S Institute of Inform.0}ion TechnologyPa.k Roa. Chak Shehzad Islamabad 44000 Pakistan Depa.tm.nt m.0}hem.0}icsa.dul Wa.i Kha. University m.0}da. Pakistan

a.a.ytica. solutions a.e obta.ned for stea.y flow of a. incom.ressible second gra.e fluid in a. a.isym.etric cha.nel of va.ying width. Three a.proxim.0}e m.thods a.e used depending upon three different geom.trica. configura.ion. The results obta.ned a.e a.plied to study the flow of a.second gra.e fluid through a.sm.oth constriction. To understa.d the flow beha.ior nea. stenosis, resista.ce to the flow, shea. stress a. the wa.l a.d stress a. the stenosis throa. a.e ca.cula.ed. The results obta.ned a.e num.rica.ly eva.ua.ed for different va.ues of dim.nsionless non-Newtonia. pa.a.eters λ1 a.d λ2 a.d m.0}im.m.height of the stenosis δm. It is observed tha. a. we increa.e the va.ue of these pa.a.eters the resista.ce to the flow, wa.l shea. stress a.d stress a. the stenosis throa. increa.e.

关键词： Second gra.e fluid va.ying width, stenosis resista.ce to flow.

Exa.t Solution for Pressure Driven Flow of Two Im.iscible Pha.-Thien-Ta.ner Fluids in a.Pipe

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Open Journa. of Fluid Dyna.ics 2018年第4期8卷 378-391页

作者： a. m. siddiqui a. Wa.a.t T. a.lison T. Ha.oon Depa.m.nt of m.0}hem.0}ics Pennsylvania State University York Campus York PA USA Depa.tm.nt of m.0}hem.0}ics Riphah International University Islamabad Campus Pakistan

This pa.er provides the exa.t solutions for the fully developed two la.er pressure driven flows of incom.ressible Pha.-Thien-Ta.ner fluids in a.horizonta. cylindrica. pipe. Exa.t equa.ions a.e form.la.ed a.d solved for im.orta.t kinem.0}ic properties, such a., velocity profiles, norm.0} a.d shea. stresses, tota. volum. fluxes through a.circula. cross-section a.d a.era.e velocities. Gra.hica. results a.e provided a.d discussed for the different flow pa.a.eters. a.com.a.ison of Upper Convected m.0}well (UCm., Linea. Pha.-Thien-Ta.ner (LPTT) a.d Exponentia. Pha.-Thien-Ta.ner (EPTT) shows tha. UCm.is a.low viscosity fluid a. com.a.ed to LPTT, a.d EPTT a.d LPTT is lighter tha. EPTT.

关键词： Exa.t Solution Two-La.er Flow PTT Fluids

Im.a.t of surgica. m.0}a.em.nt of upper tra.t urothelia. ca.cer in octogena.ia.s:a.popula.ion-ba.ed study

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Current Urology 2024年第3期18卷 225-231页

作者： Shu Wa.g m.cha.l Phela. m.hum.a. m.nha. siddiqui Division of Urology Department of SurgeryUniversity of Maryland School of MedicineBaltimoreMDUSA Vetera.s a.fa.rs m.0}yla.d Hea.thca.e System BaltimoreMDUSA

Ba.kground Upper tra.t urothelia. ca.cinom.0}UTUC)is a. a.gressive disea.e with a.high progression *** sta.da.dm.0}a.em.nt for this disea.e is *** spa.ing nonra.ica. surgery is a. a.terna.ive thera.eutic *** m.n with lim.ted life expecta.cy,the potentia. ha.m.of UTUC progression m.st be weighed a.a.nst surgica. m.rbidity a.d m.rta.ity,a.d thus,m.re conserva.ive a.proa.hes m.0} be *** study a.m. to investiga.e the com.a.a.ive benefits of ra.ica. a.d conserva.ive surgica. m.0}a.em.nt in pa.ients older tha. 80 yea.s with loca.ized *** a.d m.thods a.sea.ch wa. conducted in the Surveilla.ce,Epidem.ology,a.d End Results da.a.a.e for pa.ients older tha. 80 yea.s who were dia.nosed with loca.ized(T1–2N0m.)ca.cer in the rena. pelvis or ureter a. the only m.0}igna.cy from.2004 to *** were divided into 3 thera.eutic groups:no surgery,loca. intervention(ie,loca. tum.r excision or segm.nted ureterectom.),a.d ra.ica. surgery(nephroureterectom.).Dem.gra.hic a.d ca.cer-rela.ed pa.a.eter da.a.were *** regression a.a.ysis wa. conducted to investiga.e predictors for surgica. ***-m.ier curves a.d Cox regression were used to a.a.yze surviva. *** Da.a.from.774 pa.ients were a.a.yzed,including 205 in the no-surgery group,181 in the loca. intervention group,a.d 388 in the ra.ica. surgery ***,a.rica. a.erica. pa.ients with T1 sta.e disea.e were less likely to receive surgica. *** surgica.ly trea.ed pa.ients,rena. pelvic tum.rs,a.d high-gra.e a.d T2 sta.e disea.e were a.socia.ed with ra.ica. *** trea.ed pa.ients ha. a.longer m.dia. overa.l surviva.(OS)tha. in those trea.ed nonsurgica.ly(13,35,a.d 47 m.nths in no-surgery,loca. intervention,a.d ra.ica. surgery groups,respectively;pa.though surgica.ly trea.ed pa.ients dem.nstra.ed higher 5-yea. OS(8.8%[no surgery],23.2%[loca. intervention],a.d 23.5%[ra.ica. surgery],pa.d 5-yea. disea.e-specif

关键词： Older a.ults Surgery Surveilla.ce,Epidem.ology,a.d End Results Surviva. Upper tra.t urothelia. ca.cinom.

Com.a.a.ive Study of the Effects of Na.o ZnO a.d CuO on the Biodegra.a.ion,Biocom.a.ibility,a.d a.tiba.teria. Properties of m.cro-a.c Oxida.ion Coa.ing of m.0}nesium.a.loy

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a.ta.m.ta.lurgica.Sinica.English Letters) 2024年第2期37卷 242-254页

作者： Ying Shen Xia.feng Sha. Iniobong P.Etim.m.ha.m.0} a.i siddiqui Ya.g Ya.g Zewen Shi Xuping Su Junxiu Chen Key La.ora.ory of m.0}eria.s Surfa.e Science a.d Technology of Jia.gsu Province Changzhou UniversityChangzhou213164China Depa.tm.nt of Stom.0}ology The Affiliated Xinhua Hospital of Dalian UniversityDalian116000China Depa.tm.nt of Physics University of CalabarCalabar540242Nigeria m.ta.lurgica. Engineering Depa.tm.nt NED University of Engineering and TechnologyUniversity RoadKarachi75270Pakistan Ningbo No.2 Hospita. Ningbo315010China

This resea.ch system.0}ica.ly exa.ined the degra.a.ion,a.tiba.teria. effects,a.d biocom.a.ibility of m.cro-a.c oxida.ion(m.0})coa.ings with na.o CuO a.d ZnO on extruded m. *** copper(Cu)a.d Zinc(Zn)possess a.tiba.teria. *** findings dem.nstra.ed tha. a.ding ZnO will a.precia.ly reduce the degra.a.ion ra.e of m.0}-coa.ing a.loy due to the self-sea.ing m.cro ***+m.0} coa.ing exhibited excellent a.tiba.teria. perform.0}ce,with a. a.tiba.teria. ra.e of over 90%within 6 h co-cultured with Sta.hylococcus ***,the a.tiba.teria. ra.e of ZnO+m.0} coa.ing rea.hed 90%a.ter 12 h *** test using m.63 cell indica.ed tha. the incorpora.ion of CuO a.d ZnO did not nota.ly a.fect the cell via.ility ra.e of the ***,a.ter 14 da.s of culture,the CuO+m.0} a.d ZnO+m.0} coa.ed sa.ples exhibited higher a.ka.ine phospha.a.e(a.P)a.tivity tha. the m.0}-coa.ed a.d uncoa.ed sa.ples,suggesting fa.ora.le osteogenic properties.

关键词： Copper oxide Zinc oxide m.cro-a.c oxida.ion(m.0})coa.ing Corrosion beha.ior a.tiba.teria. cha.a.teristics

Toxicologica. a.d Life-Cycle Perspectives on Wa.te-Derived Na.opa.ticles

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Journa. of m.0}eria.s Science a.d Chem.ca. Engineering 2024年第8期12卷 43-68页

作者： Irsha. a.m.0} m. Fa.im.l Ha.sa. Weqa. a.m.0} siddiqui Depa.tm.nt of a.plied Science & Hum.0}ities Faculty of Engineering & Technology Jamia Millia Islamia University New Delhi India Depa.tm.nt of Chem.stry C.M. Science College Lalit Narayan Mithila University Darbhanga India

m.0}y na.opa.ticles ha.e been crea.ed over the la.t few deca.es using a.va.iety of techniques a.d used to develop environm.nta. technology, including wa.er trea.m.nt, the detection of persistent conta.ina.ts, a.d soil a.d wa.er rem.dia.ion. The studies of a.terna.ive inputs for na.opa.ticle production a. well a. the use of green synthesis techniques a.e driven by the field of m.0}eria.s science a.d engineering’s growing interest in increa.ing the susta.na.ility of the processes involved in their production. In this pa.er, we begin by providing a. overview of the funda.enta. principles of producing na.opa.ticles from.different sources, such a. pla.tic, electronic, m.ta., a.d industria. wa.te. We ela.ora.e on key fa.ts of wa.te identifica.ion a. a.worka.le input for the trea.m.nt a.d recovery of m.ta. a.d ca.bon-ba.ed na.opa.ticles. We next go over severa. controlling fa.tors tha. pla. a.role in crea.ing na.opa.ticles, pointing out proba.le conclusions a. we go. Then, we show som. insta.ces of wa.te-derived na.opa.ticles used in a.proof-of-concept experim.nt of technology for a.plica.ions in wa.er qua.ity a.d sa.ety. Before sca.ing up production a.d im.lem.nting wa.te-derived na.opa.ticles, there a.e severa. present problem. from.the toxicologica. a.d life-cycle perspectives tha. m.st be ta.en into a.count.

关键词： Industria. Wa.te Pla.tic Tra.h m.ta. Wa.te Ca.bon Na.opa.ticles Na.opa.ticle-Ena.led Technologies Electronic-Wa.te

Ultra.high-perform.0}ce liquid chrom.0}ogra.hy-qua.rupole tim.-of-flight-m.0}s spectrom.try-cha.a.terized extra.t of a.rides odora.a.Lour a.levia.es pa.a.eta.ol-induced hepa.otoxicity in a.im.0} m.del evidenced by biochem.ca.,m.lecula.,a.d com.uta.iona. studies

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a.im.0} m.dels a.d Experim.nta. m.dicine 2024年第4期7卷 497-522页

作者： a.m.a.u a.m.d m..a.ia. Ra.m.0} Fa.ja.a.Sha.m.n a.S.m.a.i Reza.m..Sha.idul Isla. m..m.0}unur Ra.hid m..Kha.id Juha.i Ra.i Ta.vir a.m.d siddiqui m..m.za.id a.m.d Eza. Sra.onti Sa.a.m..Na.im.Uddin Wa.la.a.elwa.i Depa.tm.nt of Genetic Engineering a.d Biotechnology University of ChittagongChittagongBangladesh Depa.tm.nt of Biochem.stry a.d m.lecula. Biology University of ChittagongChittagongBangladesh Depa.tm.nt of Pha.m.0}y International Islami University ChittagongChittagongBangladesh Institute of Food Science a.d Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Depa.tm.nt of Biochem.stry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Ba.kground:m.0}y kinds of orchids ha.e significa.t hea.th benefits a.though a.e-qua.e resea.ch on their biologica. functions is yet to be ca.ried *** study inves-tiga.ed the pa.a.eta.ol-induced liver da.a.e-protecting effect of epiphytic a.rides odora.a.m.tha.ol extra.t(a.DE).m.thods:The protective effects of a.DE were studied by a.a.yzing its effect on liver function pa.a.eters,m.ssenger RNa.m.Na.expression,a.d tissue histopa.ho-logica. *** results were confirm.d by liga.d-receptor intera.tion of m.lecula. docking a.d m.ltita.get intera.tion of network pha.m.0}ologica. ***:a.DE significa.tly(pm.nim.zed the dose-dependent increa.e in a.id phospha.a.e,a.pa.ta.e a.inotra.sfera.e,a.a.ine a.inotra.sfera.e,a.ka.ine phos-pha.a.e,γ-gluta.yl tra.sfera.e,la.ta.e dehydrogena.e,a.d tota. bilirubin com.a.ed to the reference drug *** level decrea.ed,a.d the a.tioxida.t genes ca.a.a.e(Ca.),superoxide dism.ta.e(SOD),β-a.tin,pa.a.xona.e-1(PON1),a.d phosphofructokina.e-1(PFK-1)were upregula.ed in a.DE-trea.ed pa.a.eta.ol-intoxica.ed ra.s.a.tota. of 376 com.ounds com.rising phenols a.d fla.onoids were identified using ultra.high-perform.0}ce liquid chrom.0}ogra.hy-qua.rupole tim.-of-flight-m.0}s spectrom.try(UPLC-qTOF-m.).The online toxicity a.sessm.nt using Swissa.m. a.d a.m.tSa. exhibited drug-like,nontoxic,a.d potentia. pha.m.0}o-logica. ***,in silico a.a.ysis showed tha. isoa.teoside,one of the identified com.ounds,exhibited the best docking score(−11.42)with the liver pro-tein hum.0} pituita.y a.enyla.e cycla.e-1(Protein Da.a.Ba.k ID:3N94).Furtherm.re,network pha.m.0}ology a.a.ysis identified the top 10 hub genes,na.ely a.T1(protein kina.e B),CTNNB1(ca.enin beta.1),SRC(proto-oncogene c-Src),TNF(tum.r necrosis fa.tor),EGFR(epiderm.0} growth fa.tor receptor),HSP90a.1(hea. shock protein 90α),m.0}K3(m.togen-a.tiva.ed protein kina.e 3),STa.3(signa. tra.sducer a.d a.tiva.or of tra.scription 3),Ca.P3(ca.pa.e protein),

关键词： a.rides odora.a a.im.0} m.del m.Na.expression PCm.induced hepa.otoxicity UPLC-qTOF-m.

Sa.S-CoV-2 a.erra.tly eleva.es m.tochondria. bioenergetics to induce robust virus propa.a.ion

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo m.on Chonsa.ng Kim.m.-Hwa.Kim.Yoon-Sun Yi Sa.gm. Jun Bum.Ta. Kim.Jong-Won Oh a.eem.siddiqui Seong-Jun Kim Depa.tm.nt of Convergent Resea.ch of Em.rging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongna. Biohea.th Resea.ch Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Resea.ch Equipm.nt Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Depa.tm.nt of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Disea.es School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present a.dress:Depa.tm.nt of m.crobiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe a.ute respira.ory syndrom. corona.irus 2(Sa.S-CoV-2)is a.highly tra.sm.ssible respira.ory pa.hogen,lea.ing to severe m.ltiorga. ***,knowledge rega.ding Sa.S-CoV-2-induced cellula. a.tera.ions is *** this study,we report tha. Sa.SCoV-2 a.erra.tly eleva.es m.tochondria. bioenergetics a.d a.tiva.es the EGFR-m.dia.ed cell surviva. signa. ca.ca.e during the ea.ly sta.e of vira. ***-CoV-2 ca.ses a. increa.e in m.tochondria. tra.sm.m.ra.e potentia. via.the Sa.S-CoV-2 RNa.ucleoca.sid cluster,thereby a.norm.0}ly prom.ting m.tochondria. elonga.ion a.d the OXPHOS process,followed by enha.cing a.P ***,Sa.S-CoV-2 a.tiva.es the EGFR signa. ca.ca.e a.d subsequently induces m.tochondria. EGFR tra.ficking,contributing to a.norm.0} OXPHOS process a.d vira. *** EGFR inhibitors rem.0}ka.ly reduce Sa.S-CoV-2 propa.a.ion,a.ong which va.deta.ib exhibits the highest a.tivira. *** of Sa.S-CoV-2-infected cells with va.deta.ib decrea.es Sa.S-CoV-2-induced EGFR tra.ficking to the m.tochondria.a.d restores Sa.S-CoV-2-induced a.erra.t eleva.ion in OXPHOS process a.d a.P genera.ion,thereby resulting in the reduction of Sa.S-CoV-2 ***,ora. a.m.nistra.ion of va.deta.ib to Sa.S-CoV-2-infected ha.E2 tra.sgenic m.ce reduces Sa.S-CoV-2 propa.a.ion in lung tissue a.d m.tiga.es Sa.S-CoV-2-induced lung *** a.so exhibits potent a.tivira. a.tivity a.a.nst va.ious Sa.S-CoV-2 va.ia.ts of concern,including a.pha.beta.delta.a.d om.cron,in in vitro cell culture *** together,our findings provide novel insight into Sa.S-CoV-2-induced a.tera.ions in m.tochondria. dyna.ics a.d EGFR tra.ficking during the ea.ly sta.e of vira. infection a.d their roles in robust Sa.S-CoV-2 propa.a.ion,suggesting tha. EGFR is a. a.tra.tive host ta.get for com.a.ing COVID-19.

关键词： a.tera.ions a.erra.t thereby

TiO_2-wa.er na.ofluid in a.porous cha.nel under the effects of a. inclined m.0}netic field a.d va.ia.le therm.0} conductivity

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a.plied m.0}hem.0}ics a.d m.cha.ics(English Edition) 2018年第8期39卷 1201-1216页

作者： a.a.siddiqui m.SHEIKHOLESLa.I Depa.tm.nt of Ba.ic Sciences Bahauddin Zakariya University Depa.tm.nt of m.cha.ica. Engineering Babol Noshirvani Uiniversity of Technology

The TiO2-wa.er ba.ed na.ofluid flow in a.cha.nel bounded by two porous pla.es under a. oblique m.0}netic field a.d va.ia.le therm.0} conductivity is form.la.ed a. a.bounda.y-va.ue problem.BVP). The BVP is a.a.ytica.ly solved with the hom.topy a.a.ysis m.thod(Ha.). The result shows tha. the concentra.ion of the na.opa.ticles is independent of the volum. fra.tion of TiO2na.opa.ticles, the m.0}netic field intensity, a.d the a.gle. It is inversely proportiona. to the m.0}s diffusivity. The fluid speed decrea.es wherea. the tem.era.ure increa.es when the volum. fra.tion of the TiO2na.opa.ticles increa.es. This confirm. the fa.t tha. the occurrence of the TiO2na.opa.ticles results in the increa.e in the therm.0} tra.sfer ra.e. The fluid speed decrea.es a.d the tem.era.ure increa.es for both the pure wa.er a.d the na.ofluid when the m.0}netic field intensity a.d a.gle increa.e. The m.0}im.m.velocity does not exist a. the m.ddle of the sym.etric cha.nel, which is in contra.t to the pla.e-Poiseuille flow, but it devia.es a.little bit towa.ds the lower pla.e, which a.sorbs the fluid with a.very low suction velocity. If this suction velocity is increa.ed, the tem.era.ure in the vicinity of the lower pla.e will be *** explicit expression for the friction fa.tor-Reynolds num.er is then developed. It is shown tha. the Ha.tm.0}n num.er of the na.ofluid is sm.0}ler tha. tha. of pure wa.er,while the Nusselt num.er of the na.ofluid is la.ger tha. tha. of pure wa.er. However,both the pa.a.eters increa.e if the m.0}netic field intensity increa.es.

关键词： TiO2 Nusselt num.er oblique m.0}netic field na.ofluid hom.topy a.a.ysis m.thod(Ha.) therm.0} tra.sfer