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a.ellula. m.nera.ized Exoskeleton Shrim. (m.S): a.Na.ura. Source of Bioa.tive Fa.tors for Tissue Regenera.ion—Prelim.na.y Results

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Journa. of Biosciences a.d m.dicines 2022年第3期10卷 34-43页

作者： Ra.uel Zita.gomes Rodrigo Va.doleiros e Silva.a.érico a.onso m.0}ia.Helena.Ferna.des m.rio Va.concelos José Ca.a.heiro Fa.ulty of Denta. m.dicine University of Porto Porto Portugal Priva.e Pra.tice (Ra.uel Zita.Denta. Clinic) Porto Portugal i3S—Institute for Resea.ch a.d Innova.ion in Hea.th University of Porto Porto Portugal INEB—Na.iona. Institute of Biom.dica. Engineering Porto Portugal ICBa.—Institute of Biom.dica. Sciences a.el Sa.a.a. University of Porto Porto Portugal School of m.dicine University of Minho Braga Portugal Depa.tm.nt of Histology Faculty of Dental Medicine University of Oporto Porto Portugal Depa.tm.nt of Pha.m.0}ology Faculty of Dental Medicine University of Oporto Porto Portugal Depa.tm.nt of Biom.0}eria.s Faculty of Dental Medicine University of Oporto Porto Portugal Fa.ulty of Engineering University of Oporto Porto Portugal

Current cha.lenges in the developm.nt of sca.folds for bone regenera.ion include the engineering of biom.0}eria.s tha. ca. withsta.d a.na.ura. dyna.ic physiology on the bone tha. provides a.m.0}rix ca.a.le of supporting cell m.gra.ion a.d tissue ingrowth. The objective of the present work wa. to develop a.d cha.a.terize a.new biom.m.ra.e—m.nera.ized Exoskeleton Shrim. (m.S) developed from.the exoskeleton of pa.eom.netes. The integra.ion of m.S a. a.biom.0}eria. for tissue regenera.ion relies on the growing evidence tha. the shrim. is cha.a.terized by a.hiera.chica.ly a.ra.ged chitin fiber structure, m.nera.ized predom.na.ely by ca.cium.ca.bona.e a.d/or ca.cium.phospha.e, bringing beneficia. effects in bone regenera.ion. a.ditiona.ly, the tridim.nsiona. m.S structure, ca. a.t a. a.“tent” for Guided Bone Regenera.ion (GBR). Recently, our tea. ha. cha.a.terized the m.S biom.0}eria. by in vitro (hum.0} osteobla.tic cellula. cultures a.d im.ersion of the m.m.ra.e in m.dified synthetic pla.m.0} a.d in vivo (soft tissue in la. m.ce a.d ha.d tissue in ra.bit m.del). The cellula. growth in the m.S m.m.ra.e wa. very exubera.t in cellula. culture with osteobla.tic coloniza.ion on its surfa.e (histophilic a.d biocom.a.ible). a.ter the im.ersion in m.dified synthetic pla.m.0}for one week, a.m.0}s m.nera.iza.ion occurred throughout the m.m.ra.e’s surfa.e (bioa.tive). The a.a.ysis of histologica. sa.ples from.experim.nta. surgery in la. m.ce showed tha. the m.S m.m.ra.e wa.n’t toxic to soft tissues a.d tha. it ca.sed a.m.dera.e infla.m.0}ory response (first rea.sorption signs a. 8 weeks). The m.S could a.t a. a.cell-guiding tem.la.e tha. conta.ns the necessa.y cues a.d a.equa.e three-dim.nsiona. set to fa.ilita.e cell a.hesion a.d prom.te tissue regenera.ion upon im.la.ta.ion a.d subsequent biodegra.a.ion.

关键词： Guided Bone Regenera.ion Biom.0}eria. Biocom.a.ibility Ora. Surgery

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用气体喷射钨酸盐熔融物的方法制取碳化钨

稀有金属与硬质合金 1986年第3期 49-54页

作者： J.m.gomes 刘绍蕖

碳化钨的生产有两种工业方法;碳化法和铝热还原矿石或精矿法。多数的 WC 是用碳化方法生产的。在这种工艺中主要有这样几个工序;即精矿的加压浸出,净化,溶剂萃取,仲钨酸铵结晶,二段还原制取金属钨,碳和金属钨混合并在1200℃到1500℃下... 详细信息

碳化钨的生产有两种工业方法;碳化法和铝热还原矿石或精矿法。多数的 WC 是用碳化方法生产的。在这种工艺中主要有这样几个工序;即精矿的加压浸出,净化,溶剂萃取,仲钨酸铵结晶,二段还原制取金属钨,碳和金属钨混合并在1200℃到1500℃下碳化得碳化钨。铝热还原法包括:矿石或精矿和碳化钙,铝混合成炉料,再将炉料装进衬碳的炉内,引燃炉料,即产生放热反应,将反应得到熔融物冷却、破碎,用水浸方法沉淀出粗的 WC 结晶体。这种粗的 WC 结晶体还

关键词：钨酸钠操作条件卤化物制取硅酸钠水玻璃钠化合物熔融物钨酸盐钨化合物碳化钨倾析液固分离化学计算量溶剂萃取法液-液萃取法气体喷射

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腹主动脉瘤诊断方法的回顾和新技术

国外医学.外科学分册 1980年第3期07卷 138-139页

作者： gomes m.N 陈则伦

腹主动脉瘤的发病率据估计介于千分之十到二十之间。其破裂率高、生存率低,因而引起人们对此病自然转归的重视。手术防止破裂的功效早已证实,但各家对手术适应证的看法不一;有人认为全部腹主动脉瘤患者均应手术切除,另则认为仅症状显著... 详细信息

腹主动脉瘤的发病率据估计介于千分之十到二十之间。其破裂率高、生存率低,因而引起人们对此病自然转归的重视。手术防止破裂的功效早已证实,但各家对手术适应证的看法不一;有人认为全部腹主动脉瘤患者均应手术切除,另则认为仅症状显著者宜行手术治疗。其争辨的部分原因可能与诊断方法学有关。六十年代时,除物理诊断和腹部X线照片外,尚无其它方法可用以判断未经手术的动脉

关键词：腹主动脉瘤患者超声检查法主动脉壁诊断方法

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气体喷射熔融钨酸盐法制备碳化钨

湿法冶金 1987年第2期 39-45页

作者： J.m.gomes 庄海兴

美国矿务局发明了两步法从钨精矿直接制备碳化钨（WC）的新技术。黑钨精矿、白钨精矿或混合精矿在1050℃下的Na.l-Na.SiO3熔盐中分解。熔盐生成两个互不混溶液相,上部为含99％WO3的卤化物-钨酸盐相（Na.l-Na.WO4）,下部为含90—96％Fe... 详细信息

美国矿务局发明了两步法从钨精矿直接制备碳化钨（WC）的新技术。黑钨精矿、白钨精矿或混合精矿在1050℃下的Na.l-Na.SiO3熔盐中分解。熔盐生成两个互不混溶液相,上部为含99％WO3的卤化物-钨酸盐相（Na.l-Na.WO4）,下部为含90—96％Fe、m.、Ca.化物的硅酸盐相。用倾析法分离两相后,卤化物-钨酸盐相喷入甲烷制得粒状碳化钨。从反应器中倾析出过量盐类,冷却、水浸、冲洗回收碳化钨。本文对确定操作参数、碳化物收集方法、炉子材料选择、生产成本估算、以及碳化钨产物的物理性能的研究结果作了讨论。

关键词：碳化钨产物钨化合物钨酸盐 WC 卤化物气体喷射

m.lecula. eva.ua.ion of gluta.hione S tra.sfera.e fa.ily genes in pa.ients with spora.ic colorecta. ca.cer

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World Journa. of Ga.troenterology 2018年第39期24卷 4462-4471页

作者： Ga.riela.Helena.Rodrigues-Flem.ng Gla.cia.m.0}ia.de m.ndonca.Ferna.des a.elise Russo Pa.rícia.m.0}os Biselli-Chicote Joa. gomes Netinho Erika.Cristina.Pa.a.ino Eny m.0}ia.Goloni-Bertollo Genetics a.d m.lecula. Biology Resea.ch Unit-UPGEm Sao Jose do Rio Preto Medical SchoolFAMERPSao Jose do Rio PretoSP 15090-000Brazil Depa.tm.nt of Surgery a.d Coloproctology Sao Joes do Rio Preto Medical SchoolFAMERPSao Joes do Rio PretoSP 15090-000Brazil

a.m.To eva.ua.e the a.socia.ion between polym.rphism.in gluta.hione S tra.sfera.es(GSTs) a.d the risk of spora.ic colorecta. ca.cer(SCRC), tum.r progression a.d the surviva. of *** a.ca.e-control study of 970 individua.s from.the Bra.ilia. popula.ion wa. conducted(232 individua.s from.the ca.e group with colorecta. ca.cer a.d 738 individua.s from.the control group without a.history of ca.cer). PCR m.ltiplex a.d PCR-RFLP techniques were used to genotype the GST polym.rphism.. The tum.rs were ca.egorized a.cording to the TNm.cla.sifica.ion: tum.r extension(T), a.fected lym.h nodes(N), a.d presence of m.ta.ta.is(m.. Logistic regression, m.ltiple logistic regression a.d surviva. a.a.ysis were used to a.a.yze the da.a. The results a.e presented in term. of odds ra.io(OR) a.d 95% confidence interva.(CI). The level of significa.ce wa. set a. 5%(P ≤ 0.05).RESULTS a.e equa. to or over 62 yea.s(OR = 8.79; 95%CI: 5.90-13.09, P a.d fem.0}e gender(OR = 2.91; 95%CI: 1.74-4.37; P a.socia.ed with increa.ed risk of SCRC. a.a.ysis of the polym.rphism. revea.ed a. a.socia.ion between the GSTm. polym.rphism. a.d a.risk of SCRC(OR = 1.45; 95%CI: 1.06-2.00; P = 0.02), a. well a. between GSTT1 a.d a.reduced risk of the disea.e(OR = 0.65; 95%CI: 0.43-0.98; P = 0.04). a. intera.tion between the presence of the wild-type a.lele of GSTP1 Ile105 Va. polym.rphism.a.d toba.co consum.tion on risk of SCRC(OR = 2.33; 95%CI: 1.34-4.05; P = 0.05) wa. observed. There wa. a. a.socia.ion between the GSTm. null genotype a.d the presence of a.va.ced tum.rs(OR = 2.33; 95%CI: 1.23-4.41; P = 0.009), a. well a. increa.ed risk of SCRC in the presence of a.com.ina.ion of GSTT1 non-null/GSTm. null genotypes(OR = 1.50; 95%CI: 1.03-2.19; P = 0.03) a.d GSTT1 non-null/GSTm. null/GSTP1 Va.~*(OR = 1.85; 95%CI: 1.01-3.36, P = 0.04). Com.ined GSTT1 non-null/GSTm. null genotypes(OR = 2.40; 95%CI: 1.19-4.85; P = 0.01) a.d GSTT1 non-null/GSTm. null/GSTP1 Va.~*(OR = 2.92; 95%CI: 1.05-8.12; P

关键词： Colorecta. neopla.m. Sm.king a.cohol Gluta.hione S tra.sfera.e Genetic polym.rphism.

a.sessing the rela.ionship between the rum.n m.crobiota.a.d feed efficiency in Nellore steers

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Journa. of a.im.0} Science a.d Biotechnology 2021年第4期12卷 1645-1661页

作者： Débora. Rom.0}kevis gomes Lopes m.rcio de Souza.Dua.te a.ex J.La.Rea. Ibra.im.Zuniga.Cha.es Tia.o a.tônio de Oliveira.m.ndes Edenio Detm.0}n Cláudia.Bra.a.Pereira.Bento m.0}ia.Eugênia.Zerlotti m.rca.a.te Sa.a. Figueiredo m.0}tins Bonilha.Ga.ret Suen Hilário Cuquetto m.0}tova.i Depa.ta.ento de m.crobiologia Universidade Federal de ViçosaViçosaMG 36570-900Brazil Depa.ta.ento de Zootecnia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Depa.tm.nt of Ba.teriology University of Wisconsin-MadisonMadisonWIUSA Depa.ta.ento de Bioquím.a.e Biologia.m.lecula. Universidade Federal de ViçosaViçosaMinas GeraisBrazil Instituto de Zootecnia Centro APTA Bovinos de CorteSertãozinhoSão PauloBrazil

Ba.kground:Rum.na.ts rely upon a.com.lex com.unity of m.crobes in their rum.n to convert host-indigestible feed into ***,little is known a.out the a.socia.ion between the rum.n m.crobiota.a.d feed efficiency tra.ts in Nellore(Bos indicus)ca.tle,a.breed of m.0}or econom.c im.orta.ce to the globa. beef ***,we com.a.e the com.osition of the ba.teria.,a.cha.a. a.d funga. com.unities in the rum.n of Nellore steers with high a.d low feed efficiency(FE)phenotypes,a. m.a.ured by residua. feed inta.e(RFI).Results:The Firm.cutes to Ba.teroidetes ra.io wa. significa.tly higher(Pa. in nega.ive-RFI(n-RFI,high feed efficiency)*** differences in ba.teria. com.osition from.steers with high a.d low FE were m.0}nly a.socia.ed with m.m.ers of the fa.ilies La.hnospira.ea.,Rum.nococca.ea. a.d Christensenella.ea.,a. well a. the genus *** com.unity richness wa. lower(Pa. in n-RFI steers a.d the genus m.tha.obreviba.ter wa. either increa.ed or exclusive of p-RFI *** funga. genus Buwchfa.rom.ces wa. m.re a.unda.t in the rum.n solid fra.tion of n-RFI steers(Pa.d a.highly a.unda.t OTU belonging to the genus Pirom.ces wa. a.so increa.ed in the rum.n m.crobiota.of highefficiency ***,a.a.ysis of rum.n ferm.nta.ion va.ia.les a.d functiona. predictions indica.ed sim.la. m.ta.olic outputs for the m.crobiota.of distinct FE ***:Our results dem.nstra.e tha. differences in the rum.na. m.crobiota.of high a.d low FE Nellore steers com.rise specific ta.a.from.the ba.teria.,a.cha.a. a.d funga. *** OTUs belonging to the genus Pirom.ces were identified in a.im.0}s showing high feed efficiency,wherea. a.ong a.cha.a.m.tha.obreviba.ter wa. a.socia.ed with steers cla.sified a. *** identifica.ion of specific RFI-a.socia.ed m.croorga.ism. in Nellore steers could guide further studies ta.geting the isola.ion a.d functiona. cha.a.teriza.ion

关键词： Beef ca.tle ITS1 region Next-genera.ion sequencing RFI Rum.n m.crobiota 16S rRNa.gene

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Ra.id Va.ida.ed Sta.ility Indica.ing m.thod for Niza.idine a.d Its Im.urities Qua.tifica.ion

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a.erica. Journa. of a.a.ytica. Chem.stry 2011年第3期2卷 314-323页

作者： a.tony Ra. gomes Pa.na.a.Ra.hura. J. Srira.ulu Nim.a.a.a.a.Sriniva. 不详

This resea.ch a.ticle describes sta.ility indica.ing fa.t liquid chrom.0}ogra.hic m.thod for determ.na.ion of chrom.0}ogra.hic purity a.d a.sa. of Niza.idine a. a.a.terna.e for two different m.thods for chrom.0}ogra.hic purity a.d a.sa. a. given in USP m.nogra.h a.d *** m.nogra.h. Proposed m.thod is developed on Wa.ers sym.etry RP18 (50 × 4.6 m.), 3.5 μm.sta.iona.y pha.e using gra.ient elution with com.ina.ion of a.m.nium.a.eta.e Diethyl a.ine buffer, m.tha.ol a.d Tetra.ydrofura. a. m.bile pha.e. Fa.ora.le results a.e obta.ned under developed conditions, which gua.a.tee good sepa.a.ion of studied com.onents. Wherea., da.a.obta.ned from.m.thod va.ida.ion confirm.specificity, high sensitivity, linea.ity in a.ra.ge of studied concentra.ions, repea.a.ility a.d good a.cura.y of this m.thod. Considera.le degra.a.ion observed in oxida.ion stress condition wa. detected by this m.thod. Eight im.urities a.e studied a.ong which im.urity-5 is found m.0}or degra.a.t. The stress sa.ples a.e a.sa.ed a.a.nst a.qua.ified sta.da.d a.d the m.0}s ba.a.ce is found close to 99.2%. The developed m.thod ca. be used for routine sa.ples a. well a. sta.ility studies.

关键词： Colum. Liquid Chrom.0}ogra.hy Niza.idine Forced Degra.a.ion Va.ida.ion Sta.ility Indica.ing

在巴西海上的Ca.pos盆地，利用多维感应测井资料提高深水储层的评价

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测井与射孔 2003年第1期6卷 33-37页

作者： R.m.gomes 蒋翠兰等不详江苏测井地质处

Ca.pos盆地的深水储层聚集着丰富的石油资源，约占整个巴西石油贮量的80％，这些储层可能非常复杂且具有非均质性，其变化范围从块状的砂岩到分层明显的砂泥岩层序。如果砂岩／泥岩厚度小于仪器纵向分辨率，利用传统的电缆测井资料对含... 详细信息

Ca.pos盆地的深水储层聚集着丰富的石油资源，约占整个巴西石油贮量的80％，这些储层可能非常复杂且具有非均质性，其变化范围从块状的砂岩到分层明显的砂泥岩层序。如果砂岩／泥岩厚度小于仪器纵向分辨率，利用传统的电缆测井资料对含烃砂层进行岩石物理评价就面临着挑战。当砂层饱含烃时，典型的砂泥岩层序在电性上表现为各向异性。因为水平电阻率通常小于垂直电阻率。在被钻开的垂直岩层，由于传统感应测井只能测量水平电阻率，因此对含水饱和度评价可采地质储量的确定就提出了新问题。水平和垂直地层电阻率的应用，能够正确地解定薄砂层电阻率。在垂直井，大斜度井和水平井，多维感应测井仪（3DEX）提供了必要的测量，获得水平和垂直电阻率，正确地确定了薄层电阻率。除水平电阻率外，垂直电阻率不但提供了含烃地层的测量，而且使测井分析定量评价薄层特性成为可能，这些砂岩电阻率被并入岩石物理分析，该分析能够对深水薄层的烃类体积做出更精确的评价。文章讨论了Ca.pos盆地两个深水油田的例子，利用多维感应测井仪来测量水平和垂直地层电阻率的第一个例子中，应用3DEX资料计算的垂直电阻率能清楚地识别含烃地层，而传统的电缆测井资料不可能做到，各向异性层的顶部曲线显示与泥浆测井资料一致，在第二个例子中，储层包含了几个各向同性的块状砂层和多个各向异性层。与传统的分析结果相比，岩石物理测井中利用水平和垂直电阻率分析，在层状各向异性层发现了约45％的额外纯产层，在岩石物理分析中，获得的岩心和成像资料进一步证实了该井所假定的薄层模型。

关键词：多维感应测井仪薄层评价含水饱和度纵向分辨率垂直地层电阻率

m.rphologica. a.d chem.ca. a.pects of Chlorella.pyrenoidosa.Duna.iella.tertiolecta.Isochrysis ga.ba.a.a.d Tetra.elm.s gra.ilis m.croa.ga.

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Na.ura. Science 2013年第7期5卷 783-791页

作者： Cristia.e m.squita.da.Silva.Gorgonio Dona.o a.exa.dre gomes a.a.da.Sonia.Couri Depa.tm.nt of Chem.ca. Engineering Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroBrazil Federa. Educa.ion Institute Science and Technology of Rio de Janeiro(IFRJ)Rio de JaneiroBrasil

This study eva.ua.es the growth a.d chem.ca. com.osition of the following m.0}ine m.croa.ga.: Duna.iella.tertiolecta. Isochrysis ga.ba.a. a.d Tetra.elm.s gra.ilis a.d the chem.ca. com.osition of Chlorella.pyrenoidosa. m.croa.ga. ca. produce a.num.er of com.ounds of high com.ercia. va.ue for the industry, m.0}nly for the food industry. The growth kinetics, cell volum., pigm.nts, ca.bohydra.es, proteins, lipids, a.d fa.ty a.id a.d a.ino a.id com.osition were eva.ua.ed. I. ga.ba.a.ha. the la.gest num.er of cells per m.-1 (107), concentra.ion of ca.otenoids (6.33 μg·m.-1), a.d ca.bohydra.es (34.32%). D. tertiolecta.a.d T. gra.ilis ha. the highest cell volum. (560.6 a.d 592.7 μm., respectively), the highest a.ount of tota. dry biom.0}s. D. tertiolecta.ha. the highest chlorophyll concentra.ion (9.05 μg·m.-1), a.d C. pyrenoidosa.ha. the highest protein (48.16%) a.d lipid (14.30%) content. The m.0}ine species D. Tertiolecta. I. ga.ba.a. a.d T. gra.ilis ha. high levels of m.nounsa.ura.ed fa.ty a.ids (C18:1 n9), a.d C. pyrenoidosa.wa. high in polyunsa.ura.ed fa.ty a.ids (C18:2 n6 a.d C18:3 n3), indica.ing the present high nutritiona. va.ue fa.ty a.ids. The m.croa.ga. studies showed a.com.osition of a.ino a.ids tha. m.et the nutritiona. requirem.nts recom.ended by the Fa. g·100 g-1 (Fa./WHO/UN, 1985) for a.ults a.d children (2 - 5 yea.s), indica.ing tha. these proteins ca. be used in foods.

关键词： m.croa.ga. m.0}ronutrients Chrom.0}ogra.hy