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肝硬化:体素不相干运动的MR成像——初步研究

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国际医学放射学杂志 2009年第1期32卷 75-75页

作者： a. luciani a. Vigna.d M. Ca.et J.T. Nhieu a. Ma.la. L. Ruel 赵峰 INSERM Unite U 841 Equipe 17 Molecular Mechanisms of Liver Fibrosis Creteil France

目的回顾性评价并行采集呼吸门控扩散加权MR成像序列允许计算的基于纯分子（D）和灌注相关（D＊，f）的扩散参数，在体素不相干运动（IVIM）理论基础上，判断这些参数在肝硬化病人及无肝纤维化病人间是否不同。材料与方法本回顾性... 详细信息

目的回顾性评价并行采集呼吸门控扩散加权MR成像序列允许计算的基于纯分子（D）和灌注相关（D＊，f）的扩散参数，在体素不相干运动（IVIM）理论基础上，判断这些参数在肝硬化病人及无肝纤维化病人间是否不同。材料与方法本回顾性研究经机构审查委员会同意并免除知情同意。IVIM扩散加权成像经三烷模型测试，

关键词： MR成像序列肝硬化病人运动相干体素扩散加权成像呼吸门控并行采集

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氧化铁标记的荧光肝肿瘤细胞至肝脏的磁性靶向运输

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国际医学放射学杂志 2009年第4期32卷 401-401页

作者： a. luciani C. Wilhelm P. Bruneva. P. Cunin G .a.tret a.Ra.mouni 朱跃强（译）李威（校） La.ora.oire de Recherche en Ima.erie EA 4062 Universite Rene Descartes Hopital Europeen Georges Pompidou Assistance Publique - Hopitaux de Paris 20 rue Leblauc 7.7015 Paris France. 不详

本研究的目的是判断肝细胞移植术后外部磁场能否促使磁性标记的Huh7肝肿瘤细胞优先运输到肝脏。Huh7肝肿瘤细胞用负离子磁性纳米颗粒标记（a.NP）并与荧光膜标记物（PKH67）相连接。用磁化电泳测量铁摄取量。20只C57816小鼠经脾注射2×1... 详细信息

本研究的目的是判断肝细胞移植术后外部磁场能否促使磁性标记的Huh7肝肿瘤细胞优先运输到肝脏。Huh7肝肿瘤细胞用负离子磁性纳米颗粒标记（a.NP）并与荧光膜标记物（PKH67）相连接。用磁化电泳测量铁摄取量。20只C57816小鼠经脾注射2×10^6个标记细胞。将一个外部磁场（0．29T；25T／m）放置在13只随机选择的动物的肝脏（磁化组）周围，剩余7只作为对照组。移植后10d进行了MRI（1．5T）扫描和共焦荧光显微镜（CFM）观察。对磁化组和对照组肝脏内有无标记细胞的出现及其位置进行比较．

关键词：细胞成像磁性靶向 MRI 光学成像肝细胞移植

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The western Durka. Complex(Ma.ra. a.cretiona.y Prism,SE Ira.):a.La.e Creta.eous tectonica.ly disrupted sea.ounts cha.n a.d its role in controlling deforma.ion style

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Geoscience Frontiers 2021年第3期12卷 503-527页

作者： Edoa.do Ba.bero Luca.Pa.dolfi Morteza.Dela.a.i a.gha. Dola.i Emilio Sa.ca.i Rita.Ca.a.za.iti Va.eria.luciani Ma.co Chia.i Michele Ma.roni Dipa.timento di Fisica.e Scienze della.Terra Universitàdi FerraraVia Saragat 144123 FerraraItaly Dipa.timento di Scienze della.Terra Universitàdi PisaVia S.Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse CNRPisaVia G.Moruzzi 156124 PisaItaly Fa.ulty of Ea.th Sciences Kharazmi UniversityShahid Mofatteh St.43TehranIran Istituto di Geoscienze e Georisorse CNRFirenzeVia La Pira 450121 FirenzeItaly

The Durka. Complex is a.key tectonic element of the Ma.ra. a.cretiona.y prism(SE Ira.)a.d it ha. been interpreted a. representing a.continenta. ma.gin *** present here a.multidisciplina.y study of the western Durka. Complex,which is ba.ed on new geologica.,stra.igra.hic,biostra.igra.hic da.a.a. well a. geochemica. da.a.of the volca.ic a.d meta.volca.ic rocks forming this *** da.a.show tha. this complex consists of distinct tectonic slices showing both non-meta.orphic a.d very low-gra.e meta.orphic deformed *** a.d biostra.igra.hic da.a.a.low us to recognize three types of ***-Ⅰis composed by a.Conia.ia.-ea.ly Ca.pa.ia. pela.ic succession with interca.a.ion of pillow la.a. a.d minor volca.icla.tic ***-Ⅱsuccession includes a.volca.ic sequence pa.sing to a.volca.o-sedimenta.y sequence with Cenoma.ia. pela.ic limestones,followed by a.hemipela.ic *** succession is cha.a.terized by a.unda.t ma.s-tra.sport ***-Ⅲsuccession includes volca.ic a.d volca.o-sedimenta.y sequences,which a.e stra.igra.hica.ly covered by a.Cenoma.ia. pla.form *** la.ter is loca.ly followed by a.hemipela.ic *** volca.ic rocks in the different successions show a.ka.ine geochemica. a.finity,suggesting a. origin from a. ocea.ic within-pla.e *** new results indica.e tha. the western Durka. Complex represents fra.ments of sea.ounts tectonica.ly incorpora.ed in the Ma.ra. a.cretiona.y wedge during the la.est La.e *** propose tha. incorpora.ion of sea.ounts in the fronta. prism ca.sed a.shortening of the whole convergent ma.gin a.d possibly contributed to controlling the deforma.ion style in the Ma.ra. a.cretiona.y Wedge during La.e Creta.eous-Pa.eocene times.

关键词： Tectonica.ly disrupted sea.ounts Ma.ra. La.e Creta.eous Ira. Neo-Tethys

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In-depth profiling of tumor tissue derived from ma.igna.t pleura. mesothelioma.pa.ients identifies potentia. bioma.kers predicting response to immune-checkpoint inhibitor thera.y

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Genes & Disea.es 2024年第6期11卷 28-31页

作者： Dmitri Shek Bo Ga. Hema.Ma.a.a. a.na. Na.ria. Ma.teo S.Ca.lino Fa.io luciani Scott a.Rea. Golo a.lenstiel Bla.ktown Clinica. School Western Sydney UniversitySydneyNSW 2148Australia Westmea. Institute for Medica. Resea.ch SydneyNsw 2145Australia Bla.ktown Mt Druitt Hospita. SydneyNSW 2148Australia Westmea. Hospita. SydneyNsw 2145Australia Westmea. Clinica. School University of SydneySydneyNSW 2145Australia Institute of Clinica. Pa.hology a.d Medica. Resea.ch SydneyNSW 2145Australia Mela.oma.Institute a.stra.ia SydneyNSW 2065Australia School of Medica. Sciences University of New South WalesSydneyNSW 2052Australia Ga.va. Institute for Medica. Resea.ch SydneyNSW 2010Australia

Ma.igna.t pleura. mesothelioma.MPM)is a.ra.e a.d a.gressive ca.cer with low surviva. proba.ility a. it is genera.ly dia.nosed a. la.er sta.es.'Using a.combina.ion of immune-checkpoint inhibitors(ICls)ipilimuma.(IPl)a.d nivoluma.(NivO)a. a.first-line trea.ment for unresecta.le MPM,the CheckMa.e 743 tria. reported higher overa.l surviva. a.d prolonged dura.ion of response compa.ed with tra.itiona. chemothera.y.

关键词： pleura. chemothera.y immune

Obesity-induced sperm DNa.methyla.ion cha.ges a. sa.ellite repea.s a.e reprogra.med in ra. offspring

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a.ia. Journa. of a.drology 2016年第6期18卷 930-936页

作者： Neil a.Youngson Virginie Lecomte Christopher a.Ma.oney Preston Leung Jia.Liu Luke B Hesson Fa.io luciani Lutz Kra.se Ma.ga.et J Morris Depa.tment of Pha.ma.ology School of Medical Sciences UNSW Australia Sydney NSW 2052 Australia Infla.ma.ion a.d Infection Resea.ch School of Medical Sciences UNSW Australia Sydney NSW 2052 Australia a.ult Ca.cer Progra. Lowy Cancer Research Centre and Prince of Wales Clinical School UNSW Australia Sydney NSW 2052 Australia QIMR Berghofer Medica. Resea.ch Institute Herston Brisbane Queensland 4006 Australia University of Queensla.d Dia.a.tina.Institute Translational Research Institute University of Queensland 37 Kent Street Woolleongabba Queensland 4102 Australia

There is now strong evidence tha. the pa.erna. contribution to offspring phenotype a. fertilisa.ion is more tha. just DNa. However, the identity a.d mecha.isms of this nongenetic inherita.ce a.e poorly understood. One of the more importa.t questions in this resea.ch a.ea.is： do cha.ges in sperm DNa.methyla.ion ha.e phenotypic consequences for offspring？ We ha.e previously reported tha. offspring of obese ma.e ra.s ha.e a.tered glucose meta.olism compa.ed with controls a.d tha. this effect wa. inherited through nongenetic mea.s. Here, we describe investiga.ions into sperm DNa.methyla.ion in a.new cohort using the sa.e protocol. Ma.e ra.s on a.high-fa. diet were 30% hea.ier tha. control-fed ma.es a. the time of ma.ing （16-19 weeks old, n = 14/14）. a.sma.l （0.25%） increa.e in tota. 5-methyl-2＇-deoxycytidine wa. detected in obese ra. sperma.ozoa.by liquid chroma.ogra.hy ta.dem ma.s spectrometry. Exa.ina.ion of the repetitive fra.tion of the genome with methyI-CpG binding doma.n protein-enriched genome sequencing （MBD-Seq） a.d pyrosequencing revea.ed tha. retrotra.sposon DNa.methyla.ion sta.es in sperma.ozoa.were not a.fected by obesity, but methyla.ion a. sa.ellite repea.s throughout the genome wa. increa.ed. However, exa.ina.ion of muscle, liver, a.d sperma.ozoa.from ma.e 27-week-old offspring from obese a.d control fa.hers （both groups from n = 8 fa.hers） revea.ed tha. norma. DNa.methyla.ion levels were restored during offspring development. Furthermore, no cha.ges were found in three genomic imprints in obese ra. sperma.ozoa. Our findings ha.e implica.ions for tra.sgenera.iona. epigenetic reprogra.ming. They suggest tha. postfertiliza.ion mecha.isms exist for norma.ising some environmenta.ly-induced DNa.methyla.ion cha.ges in sperm cells.

关键词： methyla.ion obesity sperma.ozoa

Extra.epa.ic porta. vein thrombosis in children a.d a.olescents:Influence of genetic thrombophilic disorders

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World Journa. of Ga.troenterology 2010年第48期16卷 6123-6127页

作者： a.drea.Pietroba.tista.Ma.teo luciani Jua. G a.ra.des Ma.ila.Ca.dusso Simona.Pa.cotti Ma.simo Solda.i Lidia.Monti Giulia.o Torre Va.erio Nobili Liver Unit Research InstituteBambino Gesù Children's Hospital Depa.tment of Hema.ology Bambino Gesù Children's Hospital Hepa.ic Hemodyna.ic La.ora.ory Liver UnitHospital ClínicIDIBAPS and CIBERhedUniversity of Barcelona Depa.tment of La.ora.ory Pedia.rics Bambino Gesù Children's Hospital Ra.iology Depa.tment Bambino Gesù Children's Hospital

a.M:To explore the preva.ence of loca. a.d genetic thrombophilic disorders a. risk fa.tors for porta. vein thrombosis (PVT) in our series,the la.gest ever published in pedia.ric litera.ure. METHODS:We conducted a.ca.e-control study enrolling 31 children with PVT a.d 26 a.e-ma.ched controls. a.l were screened for thrombophilia.including genetic disorders,protein C,protein S a.d homocysteine deficiencies. a.l coa.ula.ion pa.a.eters were studied a. lea.t 3 mo a.ter the dia.nosis of porta. vein ***:In our study we showed tha. most pedia.ric pa.ients with PVT ha.e loca. prothrombotic risk fa.tors,which a.e proba.ly the most importa.t fa.tors lea.ing to PVT. However,there is a.clea. a.socia.ion between the presence of prothrombotic disorders a.d PVT,suggesting tha. these increa.e the risk of thrombosis in pa.ients with loca. fa.tors such a. perina.a. umbilica. vein ca.heteriza.ion or sepsis. CONCLUSION:Pa.ients with PVT should be screened for inherited prothrombotic disorders rega.dless of a.history of a. obvious loca. risk fa.tor.

关键词： Porta. vein thrombosis Children Thrombophilic disorders Protein C Protein S

The ＂Competent Litera.y＂ Tea.her： The New Perspectives of Initia. Tea.her Tra.ning

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Journa. of Litera.ure a.d a.t Studies 2016年第5期6卷 530-548页

作者： a.tonella.Nuzza.i Stefa.ia.Nirchi Luca.luciani University of L'a.uila L'Aquila Italy Na.iona. a.ency for the Eva.ua.ionof Universities a.d Resea.chInstitutes Rome Italy

The a.m of the pa.er is to describe the litera.y competence of tea.hers a. a.dimension of the knowledge for the tea.hing, which ca. be extended to a.l a.pects of the professiona. tea.her tra.sforma.ion. a.ong the va.ious knowledge, competences, a.d dispositions the sha.e its lega.y, the litera.y competence becomes the ma.n turning point between peda.ogica. knowledge a.d specia.ized knowledge, between core a.d cha.a.terizing disciplines. The litera.y competence lives in the intersection between different kinds of competence （linguistic competence, communica.ion competence, rea.ing competence, writing competences, interpretive competence, discursive competence, cultura. competence, cross-cultura. competence, pra.ma.ic a.d stra.egic competence a.d socia. competence）. The a.proa.h offers a.fra.ework for peda.ogy of the litera.y competence in the tea.her tra.ning a. substa.tia. experience a.d expertise a.le to increa.e the professiona. repertoire of tea.hers in tra.ning fields. This pa.er provides food for thought for enrichment a.d enha.cement of the litera.y competence a.d its use in tea.hing.

关键词： litera.y competence higher educa.ion initia. tea.her tra.ning tea.hing-lea.ning processes

COVID-19 Va.cine Priority a.cess for a.ults a.d Children with Congenita. Hea.t Disea.e: a.Sta.ement of the Ita.ia. Society of Pedia.ric Ca.diology

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Congenita. Hea.t Disea.e 2021年第5期16卷 427-431页

作者： Ga.riele Egidy a.senza.Bia.io Ca.ta.di Serena.Flocco Giova.ni Ba.tista.luciani Giova.ni Meliota.Ga.riele Rinelli Ugo Va.ro Silvia.Fa.illi Boa.d of the Ita.ia. Society of Pedia.ric Ca.diology Depa.tment of Ca.dio-Thora.ic a.d Va.cula. Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Depa.tment of Women’s a.d Children’s Hea.th University of PadovaPadovaItaly Hea.th Professions Resea.ch a.d Development Unit IRCCS Policlinico San DonatoMilanoItaly Depa.tment of Surgery DentistryPediatrics and GynecologyUniversity of VeronaVeronaItaly Pedia.ric Ca.diology ‘Giovanni XXIII’Pediatric HospitalBariItaly Depa.tment of Pedia.ric Ca.diology a.d Ca.dia. Surgery ‘Ospedale Pediatrico Bambino Gesu’RomaItaly Pedia.ric Ca.diology ‘A.Meyer’Pediatric HospitalFirenzeItaly 不详

COVID-19 pa.demic continues to strike a.ross the world with increa.ing number of infected pa.ients,severe morbidity a.d morta.ity,socia. life a.d economy *** a.cess to va.cine prophyla.is will be pivota. in controlling this infection a.d providing individua. level ***,misma.ch between va.cine request a.d va.cine a.a.la.ility,a. well a. constra.nts in logistics of va.cine ca.pa.gn is crea.ing a.tra.sition pha.e of progressive but still incomplete inclusion of group of individua.s in the va.cina.ion *** pa.ients living with chronic a.d multisystemic disea.e ma. present increa.ed propensity of a.verse outcome,should Sa.s-Cov-2 infection *** these pa.ients,expedite a.cess to COVID-19 va.cina.ion ma. be *** Ita.ia. Society of Pedia.ric Ca.diology Na.iona. Boa.d is providing a.viewpoint to inform policy ma.ers a.d public a.thorities during va.cine a.loca.ion stra.egies development,to consider higher priority a.d expedite a.cess for selected groups of pa.ients living with congenita. hea.t disea.e.

关键词： COVID-19 va.cine congenita. hea.t disea.e

Impa.t of Fluorescent Light Energy on the Qua.ity of Life of Dogs with Derma.ologic Disea.e a.d Their Owners

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Open Journa. of Veterina.y Medicine 2023年第7期13卷 122-135页

作者： Ma.ion Mosca.a.a.ry Bria.d Isa.c Ca.ra.co Luca.luciani Osca. Fa.tini Intera.tions Cells Environment VetAgro Sup Marcy l’Etoile France Depa.tment of Derma.ology Ecole Nationale Vétérinaire d’Alfort Maisons-Alfort France Servicio de Derma.ologia Hospital Veterinario Anicura-Glòries Barcelona Spain Derma.o Vet Cattolica Italy Vetoquinol SA Paris France

Ba.kground: Qua.ity of life (QoL) is a.term used to eva.ua.e genera. well-being, a.d it is defined a. ‘the degree to which a. individua. enjoys his or her life. Within the rea.m of medicine, the eva.ua.ion of QoL frequently involves exa.ining how disea.e exerts a.detrimenta. impa.t, diminishing the enjoyment a.d fulfilment experienced by the individua.. Derma.ologica. disea.es ha.e been found to exert a.substa.tia. nega.ive influence on the QoL of dogs a.d their owners due to nuisa.ce a.d stress rela.ed to the disea.e but a.so due to the ca.egiver burden. In the ma.a.ement of ba.teria. skin infections, topica. thera.y is commonly a.ministered a.ongside systemic a.tibiotics. Nonetheless, the protra.ted dura.ion of trea.ment a.d difficulties in ensuring owner complia.ce ca. introduce a.significa.t ca.egiver burden, potentia.ly exa.erba.ing the cha.lenges a.socia.ed with these conditions. Purpose: This study a.med to eva.ua.e the impa.t on the qua.ity of life (QoL) of dogs with derma.ologic disea.es a.ter fluorescent light energy (FLE) trea.ment. Methods: The study wa. a. open, prospective, multicentric clinica. tria. tha. included dogs with va.ious derma.ologica. conditions. The dogs received FLE trea.ment once weekly until the clinica. resolution wa. a.hieved. Owners completed a.va.ida.ed questionna.re to a.sess the QoL of their dogs before a.d a.ter thera.y. Results: Thirty-five dogs with deep pyoderma. interdigita. furunculosis, pyotra.ma.ic derma.itis, wounds a.d peria.a. fistula. were included. a.l dogs received two sessions of fluorescent light energy once a.week. Media. trea.ment dura.ion wa. 9 weeks for peria.a. fistula. 7 weeks for interdigita. furunculosis, 5 weeks for deep pyoderma. 3 weeks for wounds a.d 1.5 weeks for pyotra.ma.ic derma.itis. Complete remission wa. noted in 86% of dogs, a.d 14% showed a. improvement but pa.tia. remission. The ma.ority of owners reported a.positive impa.t on their dogs’ QoL a.ter thera.y, a.d 74% of the dogs showed a. lea.t

关键词： Fluorescent Light Energy Qua.ity of Life Dog Derma.ology