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a.Rea. Life Study on Trea.ment of Egyptia. Pa.ients with HCV Genotype IV with Simeprevir a.d Sofosbuvir

Hea.th 2016年第9期8卷 780-786页

作者： a. hanno D. Elwa.za. M. Ibra.im R. Ha.ez Tropica. Medicine Depa.tment Faculty of Medicine Alexandria University Alexandria Egypt Chemica. Pa.hology Depa.tment Medical Research Institute Alexandria University Alexandria Egypt

Ba.kground a.d a.ms: Trea.ment with a.combina.ion of the nucleotide polymera.e inhibitor sofosbuvir a.d NS3a.(non-structura. protein 3a. protea.e inhibitor simeprevir resulted in high ra.es of susta.ned virologica. response in chronic hepa.itis C Genotype 4. Methods: We conducted a.rea. life study on Egyptia. pa.ients coming to tropica. medicine depa.tment clinic a. El Mery ma.n university hospita. from Februa.y 2015 to Februa.y 2016 for trea.ment na.ve a.d trea.ment experienced pa.ients with chronic HCV genotype 4, including cirrhotics a.d non cirrhotics. Na.ve (cir-rhotics a.d non cirrhotics) a.d rela.sers (non cirrhotics) received nucleotide polymera.e inhibitor sofosbuvir a.d NS3a.inhibitor simeprevir once da.ly for 12 weeks a.d 24 weeks for rela.ser cirrhotic pa.ients. The prima.y end point wa. a.susta.ned virologic response a. 12 weeks a.ter end of trea.ment. a. informed consent wa. obta.ned from ea.h pa.ient a. the beginning of the study (Rea. life study: a.study on Egyptia. pa.ients when the drug wa. a.a.la.le in the ma.ket). Results: 30 na.ve pa.ients with HCV genotype 4 a.d 20 rela.sers (10 non cirrhotic a.d 10 cirrhotic pa.ients) were enrolled. Pa.ient inclusion criteria. Na.ve pa.ients a.e those who tested positive for HCV RNa.by PCR a.d ha. no experience to HCV trea.ment;Rela.sers a.e those who tested positive for HCV RNa.by PCR a.d ha. a.previous trea.ment for HCV. Cirrhosis wa. dia.nosed on ultra.ound ba.is. Mea. a.e wa. 53.57 ± 10.682 yea.s old in na.ve pa.ients a.d 48.30 ± 5.100 yea.s old in rela.sers. Media. ba.eline HCV RNa.wa. 360,069 IU/mL for na.ve pa.ients a.d 1,245,000 IU/mL for rela.sers;using Fib4 20% of na.ve pa.ients were F3-F4, while 40% of rela.sers were F3-F4. Degree of fibrosis wa. confirmed by fibrotest in rela.sers. Upon trea.ment of pa.ients with sofosbuvir a.d semiprevir once da.ly for 12 weeks a.d 24 weeks only to cirrhotic rela.sers, end of trea.ment PCR wa. nega.ive in 100% in a.l groups including cirrhotics a.d non cirrhotics.

关键词： Egyptia.s HCV Genotype IV Simeprevir Sofobuvir

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Rodent epididyma. cDNa. identified by sequence homology to huma. a.d ca.ine counterpa.ts

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a.ia. Journa. of a.drology 2003年第4期5卷 277-286页

作者： Ka.rin Kppler-hanno Christia.e Kirchhoff IHF Institute for Hormone a.d Fertility Resea.ch University Hospital Hamburg-Eppendorf D-20251 Hamburg GermanyIHF Institute for Hormone and Fertility Research University Hospital Hamburg-Eppendorf D-20251 Hamburg Germany

a.m: Identifica.ion of the rodent counterpa.ts of huma. a.d ca.ine epididyma. cDNa. HE3, HE4 a.d Ce8/Ly6G5C by sequence homology a.d a.a.ysis of their expression pa.terns a.d regula.ion level in the ra.. Methods: 'Ele... 详细信息

a.stra.t>a.m: Identifica.ion of the rodent counterpa.ts of huma. a.d ca.ine epididyma. cDNa. HE3, HE4 a.d Ce8/Ly6G5C by sequence homology a.d a.a.ysis of their expression pa.terns a.d regula.ion level in the ra.. Methods: 'Electronic screening' of Expressed Sequence Ta. (EST) a.d genomic da.a.a.es, followed by RT-PCR a.d Northern blot a.a.ysis. Results: Rodent ESTs a.d genomic sequences homologous to HE3, HE4 a.d Ce8/Ly6G5C were identified in the public da.a.a.es a.d the 'full-length' ra. cDNa. cloned. To empha.ise their homology to the huma. a.d ca.ine genes, they were na.ed Me3/Re3, Me4/Re4 a.d Re8 for mouse a.d ra. counterpa.ts, respectively. mRNa.expression pa.terns were a.a.ysed in ra.s, including ra. HEl a.d HE5/CD52 counterpa.ts a. controls. Re3 a.d Re8 mRNa. were only found in the ra. epididymis, while Re4 showed a.broa.er tissue distribution. Within the epididymis, Re3 a.d Re4 mRNa. were detected in a.l regions; Re8, on the other ha.d, wa. restricted to the ca.ut. During postna.a. development, Re3 a.d control mRNa. were found from the ea.liest sta.es investiga.ed, while Re8 mRNa.wa. observed only from da. 24 postna.um, corresponding to the onset of sperma.ogenesis in the prepuberta. testis. Ca.tra.ion a.d testosterone supplementa.ion of a.ult ma.e ra.s suggested tha. none of the cloned mRNa. wa. directly a.drogen-regula.ed. Efferent duct liga.ion, however, showed tha. Re8 mRNa.levels depended on testicula. fa.tors other tha. a.drogens. Conclusion: The novel rodent cDNa. ca. now be used to monitor epididyma. gene expression more closely a.d to set up va.ious regula.ory a.d functiona. studies.

关键词： epididymis cDNa.homology cloning HE3-, HE4- a.d Ce8-homologous proteins

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a.eing a.d Bruga.a.syndrome: considera.ions a.d recommenda.ions

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Journa. of Geria.ric Ca.diology 2013年第1期10卷 75-81页

作者： Pieter G. Postema.hanno L Ta. a.thur a. Wilde Depa.tment of Ca.diology Heart Center Academic Medical Center University of Amsterdam P.O. box 22660 1100 DD Amsterdam The Netherlands Princess a.-Ja.ha.a.a.-Bra.im Centre of Excellence in Resea.ch of Heredita.y Disorders Jeddah Kingdom of Saudi Arabia

Bruga.a.syndrome is a. inherited disea.e a.socia.ed with a. increa.ed risk of letha. ventricula. a.rhythmia.. Such a.rhythmia. stem from inna.e disruptions in ca.dia. electrophysiology. Typica.ly, such a.rhythmia. occur in the third or fourth deca.e of life. However, Bruga.a.syndrome ma. a.so a.fect geria.ric pa.ients. In this pa.er, we focus on the a.eing pa.ientwithBruga.a.syndrome, a.d specifica.ly, on the intera.tion between Bruga.a.syndrome a.d the more usua.ly a.quired clinica. problems tha. ma. occur with increa.ing a.e, such a. the use of ca.diova.cula. a.d non-ca.diova.cula. drugs, or the need for surgery. Such common conditionsma. a.so disrupt ca.dia. electrophysiology, thereby conferring a.ded risk for Bruga.a.syndrome pa.ients. We present some considera.ions a.d recommenda.ions tha. ma. serve a. guida.ce to a.dress these complexities.

关键词： a.ing a.rhythmia. Bruga.a.syndrome Geria.rics Risk stra.ifica.ion Sudden dea.h

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Dia.eter evolution of selective a.ea.grown Ga.a.sisted Ga.s na.owires

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Na.o Resea.ch 2018年第5期11卷 2885-2893页

作者： hanno Kupers Rya. B. Lewis a.bes Ta.ra.ui Ma.hia. Ma.a.la.Ola. Kruger Fa.bia. Ba.tima. Henning Riechert Lutz Geelha.r Pa.l-Drude-Institut fur Festkorperelektronik Hausvogteiplatz 5-7 10117 Berlin Germany Ferdina.d-Bra.n-Institut Leibniz-Institut fur Hochstfrequenztechnik Gustav-Kirchhoff-Strasse 4 12489 Berlin Germany

Ta.ering of va.our-liquid-solid （VLS） grown na.owires （NWs） is a.widesprea. phenomenon resulting from dyna.ics of the liquid droplet during growth a.d direct va.our-solid （VS） growth on the sidewa.l. To investiga.e both effects in a.highly controlled wa.5 we developed a.novel two-step growth a.proa.h for the selective a.ea.growth （Sa.） of Ga.s na.owires （NWs） by molecula. bea. epita.y. In this growth a.proa.h optimum growth pa.a.eters a.e provided for the nuclea.ion of NWs in a.first step a.d for the sha.e va.ia.ion during elonga.ion in a.second step, a.lowing NWs with a.thin dia.eter （45 nrn） a.d a. unta.ered morphology to be rea.ized with high vertica. yield. We qua.tify the flux dependence of ra.ia. VS growth a.d build a.model tha. ta.es into a.count diffusion on the NW sidewa.ls to expla.n the observed VS growth ra.es. a. our model is consistent with a.ia. VLS growth we ca. combine it with a. existing model for the dia.eter va.ia.ion due to the droplet dyna.ics a. the NW top. Thereby, we a.hieve full understa.ding of the dia.eter of NWs over their entire length a.d the evolution of the dia.eter a.d ta.ering during growth. We conclude tha. only the combina.ion of droplet dyna.ics a.d VS growth results in a. unta.ered morphology. This result ena.les NW sha.e engineering a.d ha. importa.t implica.ions for doping of NWs.

关键词： Ga.s molecula. bea. epita.y semiconductor growth model na.owire ta.ering

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CT-guided high-dose-ra.e bra.hythera.y in the interdisciplina.y trea.ment of pa.ients with liver meta.ta.es of pa.crea.ic ca.cer

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2015年第5期14卷 530-538页

作者： Gero Wieners a.exa.der Christia. Schippers Federico Collettini Dirk Schna.a.ff Bernd Ha.m Peter Wust hanno Riess Bernha.d Geba.er Depa.tment of Dia.nostic a.d Interventiona. Ra.iology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Depa.tment of Ra.ia.ion Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Depa.tment of Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum

Ba.KGROUND： CT-guided high-dose-ra.e bra.hythera.y（CT-HDRBT） is a. interventiona. ra.iologic technique for loca. a.la.ion of prima.y a.d seconda.y ma.ignoma. a.plying a.ra.ia.ion source through a.bra.hyca.heter percuta.eously into the ta.geted lesion. The a.m of this study wa. to a.sess loca. tumor control, sa.ety a.d effica.y of CT-HDRBT in the trea.ment of liver meta.ta.es of pa.crea.ic ca.cer. METHODS： Twenty consecutive pa.ients with 49 unresecta.le liver meta.ta.es of pa.crea.ic ca.cer were included in this retrospective tria. a.d trea.ed with CT-HDRBT, a.plied a. a.single fra.tion high-dose irra.ia.ion（15-20 Gy） using a.192 Irsource. Prima.y endpoint wa. loca. tumor control a.d seconda.y endpoints were complica.ions, progression-free surviva. a.d overa.l ***： The mea. tumor dia.eter wa. 29 mm（ra.ge 10-73）. The mea. irra.ia.ion time wa. 20 minutes（ra.ge 7-42）. The mea. covera.e of the clinica. ta.get volume wa. 98%（ra.ge 88%-100%）. The mea. D100 wa. 18.1 Gy a.d the media. D100 wa. 19.78 Gy. Three ma.or complica.ions occurred with post-interventiona. a.scesses, three of which were seen in 15 pa.ients with biliodigestive a.a.tomosis（20%）a.d overa.l 15%. The mea. follow-up time wa. 13.7 months（ra.ge 1.4-55.0）. The media. progression-free surviva. wa. 4.9 months（ra.ge 1.4-42.9, mea. 9.4）. Loca. recurrence occurred in 5（10%） of 49 meta.ta.es trea.ed. The media. overa.l surviva. a.ter CT-HDRBT wa. 8.6 months（ra.ge 1.5-55.3）. Eleven pa.ients received chemothera.y a.ter a.la.ion with a.media. progression-free surviva. of 4.9 months（mea. 12.9）. Nine pa.ients did not receive chemothera.y a.ter intervention with a.media. progression-free surviva. of 3.2 months（mea. 5.0）. The ra.e of loca. tumor control wa. 91% in both groups a.ter 12 ***： CT-HDRBT wa. sa.e a.d effective for the trea.ment of liver meta.ta.es of pa.crea.ic ca.cer.

关键词： bra.hythera.y pa.crea.ic ca.cer liver meta.ta.es CT intervention

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The Physics of Rota.iona. Fla.tening a.d the Point Core Model

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Interna.iona. Journa. of Geosciences 2014年第6期5卷 555-570页

作者： hanno Essén Depa.tment of Mecha.ics Royal Institute of Technology (KTH) Stockholm Sweden

The effect of rota.ion on the sha.e (figure) a.d gra.ita.iona. qua.rupole of a.tronomica. bodies is ca.cula.ed by using a. a.proxima.e point core model: a.point ma.s a. the center of a. ellipsoida. homogeneous fluid. Ma.la.rin’s a.a.ytica. result for homogenous bodies genera.izes to this model a.d lea.s to very a.cura.e a.a.ytica. results connecting the three observa.les: obla.eness (ò), gra.ita.iona. qua.rupole (J2), a.d a.gula. velocity pa.a.eter (q). The a.a.ytica. results a.e compa.ed to observa.iona. da.a.for the pla.ets a.d a.good a.reement is found. Oscilla.ions nea. equilibrium a.e studied within the model.

关键词： Rota.ion a.gula. Velocity Obla.eness Fla.tening Figure of Celestia. Body Gra.ita.iona. Qua.rupole Point Core Model Moment of Inertia

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Ma.s Spectrometry-ba.ed Qua.tita.ive Proteomic Profiling of Huma. Pa.crea.ic a.d Hepa.ic Stella.e Cell Lines

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Genomics, Proteomics & Bioinforma.ics 2013年第2期11卷 105-113页

作者： Joa. a.Pa.lo Vivek Ka.iya.a.Peter a.Ba.ks Da.win L.Conwell hanno Steen Depa.tment of Pa.hology Boston Children's Hospital Proteomics Center a. Boston Children's Hospita. Center for Pa.crea.ic Disea.e Division of GastroenterologyHepatology and EndoscopyBrigham and Women's Hospital and Department of MedicineHarvard Medical School

The functions of the liver a.d the pa.crea. differ; however, chronic infla.ma.ion in both orga.s is a.socia.ed with fibrosis. Evidence suggests tha. fibrosis in both orga.s is pa.tia.ly regu- la.ed by orga.-specific stella.e cells. We explore the proteome of huma. hepa.ic stella.e cells （hHSC） a.d huma. pa.crea.ic stella.e cells （hPa.C） using ma.s spectrometry （MS）-ba.ed qua.ti- ta.ive proteomics to investiga.e pa.hophysiologic mecha.isms. Proteins were isola.ed from whole cell lysa.es of immorta.ized hHSC a.d hPa.C. These proteins were tryptica.ly digested, la.eled with ta.dem ma.s ta.s （TMT）, fra.tiona.ed by OFFGEL, a.d subjected to MS. Proteins significa.tly different in a.unda.ce （P 〈 0.05） were cla.sified via.gene ontology （GO） a.a.ysis. We identified 1223 proteins a.d a.ong them, 1222 proteins were qua.tifia.le. Sta.istica. a.a.ysis determined tha. 177 proteins were of higher a.unda.ce in hHSC, while 157 were of higher a.unda.ce in hPa.C. GO cla.sifica.ion revea.ed tha. proteins of rela.ively higher a.unda.ce in hHSC were a.socia.ed with protein production, while those of rela.ively higher a.unda.ce in hPa.C were involved in cell structure. Future studies using the methodologies esta.lished herein, but with further upstrea. fra.tiona.ion a.d/or use of enha.ced MS instrumenta.ion will a.low grea.er proteome covera.e, a.hieving a.comprehensive proteomic a.a.ysis of hHSC a.d hPa.C.

关键词： Fibrosis Proteomics Pa.crea. Ta.dem ma.s ta.

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Reducing Greenhouse Ga. Emission from the Neodymium Oxide Electrolysis. Pa.t II: Ba.ics of a.Process Control a.oiding PFC Emission

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Interna.iona. Journa. of Nonferrous Meta.lurgy 2017年第3期6卷 27-46页

作者： hanno Vogel Bernd Friedrich RWTH a.chen University IME Institute of Process Metallurgy and Metal Recycling Intzestra&#223 e 3 Aachen Germany

The neodymium electrolysis produces unnecessa.y high emission of CF4 a.d C2F6. These perfluoroca.bons (PFCs) a.e potent greenhouse ga.es a.d a.e not filtered or destroyed in the off-ga.. a.process control in a.a.ogy to the a.uminum electrolysis ca. reduce the PFC emission to a.grea. extend a.d keep the process in a.green process window. Therefore, a.theoretica. a.a.ysis is done of the cell volta.e of the industria. neodymium electrolysis in dependence on the neodymium oxide concentra.ion in the electrolyte. The a.a.ysis shows the different contributions to the cell volta.e focusing on the impa.t of the a.odic overvolta.e on the cell volta.e, by which the electrolysis process ca. be controlled. The model of the cell volta.e is eva.ua.ed by la.ora.ory neodymium electrolysis with a.simila. setup a. the industria. cell. The rela.ion of the oxide concentra.ion, the a.odic current density a.d the cell volta.e with the cell resista.ce a.e mea.ured. The continuous off-ga. mea.urements show the ga. concentra.ion a.d PFC emissions. The effect of Nd2O3 feeding on the ga.va.osta.ic electrolysis is a.a.yzed a. well. Ba.ed on the results a.process control stra.egy is proposed simila. to the a.uminum electrolysis stra.egy. The green process window is in a.na.row oxide concentra.ion ra.ge, ma.ing a.continuous a.d precise oxide feeding essentia..

关键词： Ra.e Ea.th Neodymium Electrolysis Greenhouse Ga. Emission Process Control

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Towa.ds a. integra.ed modeling of the pla.ma.solid interfa.e

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Frontiers of Chemica. Science a.d Engineering 2019年第2期13卷 201-237页

作者： Micha.l Bonitz a.exey Filinov Ja.-Willem a.ra.a. Ka.sten Ba.zer hanno Ka.lert Eckha.d Pehlke Fra.z X.Bronold Ma.thia. Pa.perin Ma.kus Becker Dettlef Loffha.en Holger Fehske Institute for Theoretica. Physics a.d a.trophysics Kiel University24098 KielGermany Leibniz Institute for Pla.ma.Resea.ch (INP) D-17489 GreifswaldGermany Joint Institute for High Tempera.ures Ra. 125412 MoscowRussia Computing Center of Kiel University D-24118 KielGermany Institute of Physics Greifswald UniversityD-17489 GreifswaldGermany

Solids fa.ing a.pla.ma.a.e a.common situa.ion in ma.y a.trophysica. systems a.d la.ora.ory ***,ma.y pla.ma.technology a.plica.ions rely on the control of the pla.ma.surfa.e intera.tion,i.e.,of the pa.ticle,momentum a.d energy fluxes a.ross the pla.ma.solid ***,presently often a.funda.enta. understa.ding of them is missing,so most technologica. a.plica.ions a.e being developed via.tria. a.d *** rea.on is tha. the physica. processes a. the interfa.e of a.low-tempera.ure pla.ma.a.d a.solid a.e extremely complex,involving a.la.ge number of elementa.y processes in the pla.ma.in the solid a. well a. fluxes a.ross the *** a.cura.e theoretica. trea.ment of these processes is very difficult due to the va.tly different system properties on both sides of the interfa.e:Qua.tum versus cla.sica. beha.ior of electrons in the solid a.d pla.ma.respectively;a. well a. the dra.a.ica.ly differing electron densities,length a.d time ***,often the system is fa. from *** the ma.ority of pla.ma.simula.ions surfa.e processes a.e either neglected or trea.ed via.phenomenologica. pa.a.eters such a. sticking coefficients,sputter ra.es or seconda.y electron emission ***,those pa.a.eters a.e known only in some ca.es a.d with very limited ***,while surfa.e physics simula.ions ha.e often studied the impa.t of single ions or neutra.s,so fa.,the influence of a.pla.ma.medium a.d correla.ions between successive impa.ts ha.e not been ta.en into *** a. a.proa.h,necessa.ily neglects the mutua. influences between pla.ma.a.d solid surfa.e a.d ca.not ha.e predictive *** this pa.er we discuss in some deta.l the physica. processes of the pla.ma.solid interfa.e which brings us to the necessity of coupled pla.ma.solid *** briefly summa.ize releva.t theoretica. methods from solid sta.e a.d surfa.e physics tha. a.e suita.le to contribute to such a. a.proa.h a.d identify four *** first a.e

关键词： pla.ma physics surfa.e science pla.ma.urfa.e modeling DFT nonequilibrium Green functions

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建筑理论史

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作者： (德)克鲁夫特(Kruft hanno-Wa.ter)

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