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a.va.cements a.d Cha.lenges in Bioma.kers for Colorecta. Ca.cer Detection:a.Comprehensive Review

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Proceedings of a.tica.cer Resea.ch 2024年第5期8卷 64-75页

作者： Ya.ir hameed Depa.tment of Biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

This study provides a. overview of the current la.dsca.e of bioma.kers for colorecta. ca.cer(CRC)detection,focusing on genetic,proteomic,circula.ing microRNa.miRNa.,a.d meta.olomic *** rema.ns a.significa.t globa. hea.th cha.lenge,ra.king a.ong the most preva.ent ca.cers worldwide a.d being a.lea.ing ca.se of ca.cer-rela.ed *** a.va.cements in screening methods such a. colonoscopy,sigmoidoscopy,a.d feca. occult blood tests(FOBT),the a.ymptoma.ic na.ure of ea.ly-sta.e CRC often results in la.e dia.noses,nega.ively impa.ting pa.ient *** bioma.kers like a.C,KRa.,TP53,a.d microsa.ellite insta.ility(MSI)pla. critica. roles in CRC pa.hogenesis a.d *** bioma.kers,detecta.le through polymera.e cha.n rea.tion,next-genera.ion sequencing,a.d other a.va.ced techniques,guide ea.ly detection a.d persona.ized trea.ment *** bioma.kers such a. CEa.Ca.19-9,a.d novel signa.ures offer insights into CRC’s physiologica. cha.ges a.d disea.e sta.us,a.ding prognosis a.d trea.ment response a.sessments through enzyme-linked immunosorbent a.sa. a.d ma.s *** miRNa.,including miR-21 a.d miR-92a.present promising non-inva.ive bioma.kers tha. ca. be detected in blood a.d stool sa.ples,reflecting CRC presence,progression,a.d thera.eutic *** bioma.kers,encompa.sing a.ino a.ids,lipids,a.d TCa.cycle intermedia.es,provide further insights into CRC-a.socia.ed meta.olic a.tera.ions,which a.e crucia. for ea.ly detection a.d trea.ment monitoring using ma.s spectrometry a.d nuclea. ma.netic *** these a.va.cements,cha.lenges such a. bioma.ker va.ida.ion,sta.da.diza.ion,a.d clinica. utility *** resea.ch directions include integra.ing multi-omics a.proa.hes a.d levera.ing technologies like liquid biopsies a.d a. for enha.ced bioma.ker discovery a.d clinica. *** a.dressing these cha.lenges a.d a.va.cing resea.ch in bioma.ker development,CRC screening a.d ma.a.ement could pote

关键词： Colorecta. ca.cer Bioma.ker Dia.nosis Detection

Modern Idea. of Ca.ing in Nursing Pra.tices

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Journa. of Clinica. a.d Nursing Resea.ch 2024年第6期8卷 247-255页

作者： Uka.ha.hameed Depa.tment of Microbiology Government College UniversityFaisalabad PunjabPakistan

For effective nursing pra.tice,it is essentia. to ha.e a.strong founda.ion in ethica. principles a.d a.sha.ed understa.ding of nursing a.d ca.ing *** compa.sion in nursing is *** study a.med to elucida.e the core idea.s of compa.sion,ethics,a.d ca.e in nursing *** ca. foster a.deeper sense of persona. significa.ce in their ca.egiving rela.ionships by demonstra.ing a.tentiveness,openness,a.d respect a.d trea.ing ea.h pa.ient a. a. *** self-reflection,nurses ca. develop a.grea.er understa.ding of nursing,compa.sion,a.d ethica. principles within the ca.egiving *** reflective pra.tice ena.les nurses to connect more profoundly with their pa.ients,enha.cing the qua.ity of *** integra.ing these core idea.s into their pra.tice,nurses not only improve pa.ient outcomes but a.so find grea.er persona. fulfilment in their professiona. ***,cultiva.ing compa.sion a.d ethica. a.a.eness is funda.enta. to the holistic a.d effective pra.tice of nursing.

关键词： Nursing Pa.ients Ethica. principles Ca.egiving Compa.sion

Dredged ma.ine soil sta.iliza.ion using ma.nesia.cement a.gmented with biocha./sla.

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2024年第3期16卷 1000-1017页

作者： Chikezie Chimere Onyekwena.Qi Li Yong Wa.g Ishra. hameed a.vi Wenta. Li Yunlu Hou Xia.wei Zha.g Min Zha.g Sta.e Key La.ora.ory of Geomecha.ics a.d Geotechnica. Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese a.a.emy of Sciences Beijing100049China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China School of Urba. Construction Wuhan University of Science and TechnologyWuhan430065China School of Civil Engineering a.d a.chtitecture Henan UniversityKaifeng475001China

Dredged ma.ine soils(DMS)ha.e poor engineering properties,which limit their usa.e in construction *** resea.ch exa.ines the a.plica.ion of rea.tive ma.nesia.rMgO)conta.ning supplementa.y cementitious ma.eria.s(SCMs)to sta.ilize DMS under a.bient a.d ca.bon dioxide(CO_(2))curing *** proprieta.y experimenta. tests were conducted to investiga.e the sta.ilized ***,the ca.bona.ion-induced minera.ogica.,therma.,a.d microstructura. properties cha.ge of the sa.ples were *** findings show tha. the compressive strength of the sta.ilized DMS fulfilled the 7-d requirement(0.7-2.1 MPa.for pa.ement a.d building *** rMgO with SCMs such a. biocha. or ground gra.ula.ed bla.t-furna.e sla.(GGBS)a.tered the engineering properties a.d pa.ticle pa.king of the sta.ilized soils,thus influencing their *** increa.ed the porosity of the sa.ples,fa.ilita.ing higher CO_(2) upta.e a.d improved ductility,while GGBS decrea.ed porosity a.d increa.ed the dry density of the sa.ples,resulting in higher *** a.dition of SCMs a.so enha.ced the wa.er retention ca.a.ity a.d modified the pH of the *** a.a.ysis revea.ed tha. the hydra.ed ma.nesium ca.bona.es precipita.ed in the ca.bona.ed sa.ples provided better cementa.ion effects tha. brucite formed during rMgO ***,incorpora.ing SCMs reduced the overa.l globa. wa.ming potentia. a.d energy dema.d of the rMgO-ba.ed *** biocha. mixes demonstra.ed lower toxicity a.d energy ***,the rMgO a.d biocha. blend ca. serve a. a. environmenta.ly friendly a.ditive for soft soil sta.iliza.ion a.d perma.ent fixa.ion of significa.t a.ounts of CO_(2) in soils through minera. ca.bona.ion,potentia.ly reducing environmenta. pollution while meeting urba.iza.ion needs.

关键词： Dredged ma.ine soil CO_(2)upta.e Rea.tive ma.nesia Biocha. Ground gra.ula.ed bla.t-furna.e sla.

a.Pa.-Ca.cer a.a.ysis of Ga.DH a. a.Common Bioma.ker for Va.ious Ca.cers

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Proceedings of a.tica.cer Resea.ch 2024年第5期8卷 105-120页

作者： Ya.ir hameed Depa.tment of Biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

Objective:To investiga.e the expression levels of glycera.dehyde-3-phospha.e dehydrogena.e(Ga.DH)a.d explore its prognostic va.ue a.ross 24 different huma. *** investiga.ion wa. conducted using comprehensive bioinforma.ics a.d in vitro a.proa.hes,incorpora.ing multiple la.ers of ***:Ga.DH expression a.d methyla.ion levels were a.sessed using bioinforma.ics tools a.d va.ida.ed in cell lines through RNa.seq a.d ta.geted bisulfite-seq *** potentia. prognostic significa.ce of Ga.DH wa. eva.ua.ed using the KM ***,cBioPorta. wa. employed to investiga.e genetic a.tera.ions a.socia.ed with this *** a.a.ysis wa. conducted using ***,a.correla.ion a.a.ysis between Ga.DH expression a.d CD8+T immune cells wa. performed using TIMER a.d ***,a.gene-drug intera.tion network a.a.ysis wa. conducted using Cytosca.e to exa.ine the rela.ionship between Ga.DH a.d va.ious ***:Ga.DH wa. found to be commonly upregula.ed in 24 types of huma. ca.cers,with its upregula.ion significa.tly correla.ed with poor rela.se-free surviva.(RFS)a.d overa.l surviva.(OS)in BLCa.CESC,HNSC,KIRP,LIHC,a.d *** suggests tha. Ga.DH pla.s a.significa.t role in the development of these *** upregula.ion wa. a.so a.socia.ed with va.ious clinicopa.hologica. fea.ures in pa.ients with BLCa.CESC,HNSC,KIRP,LIHC,a.d *** a.a.ysis revea.ed Ga.DH’s involvement in diverse ***,nota.le correla.ions were observed between Ga.DH expression a.d its promoter methyla.ion level,genetic a.tera.ions,a.d CD8+T immune cell ***,severa. regula.ory drugs ta.geting Ga.DH were identified,with the potentia. to modula.e its expression a.d potentia.ly prevent conditions such a. BLCa.CESC,HNSC,KIRP,LIHC,a.d ***:Ba.ed on our findings,Ga.DH emerges a. a.promising dia.nostic a.d prognostic bioma.ker for BLCa.CESC,HNSC,KIRP,LIHC,a.d LUa..

关键词： Ca.cer Expression Ga.DH Bioma.ker

a.lelic Va.ia.ion within Single Podded Gene Cha.a.terized by STMS Ma.ker in Chickpea

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分子植物育种 2007年第2期5卷 252-254页

作者： H. a.i M.a. Ha. N. Iqba. a. hameed T.M. Sha. B.M. a.ta Nuclea. Institute for a.riculture & Biology P.O.Box 128 Jhang Road Faisalabad Pakistan

Chickpea.(Cicer a.ietinum L.), is a. importa.t gra.n legume crop throughout the world especia.ly in developing countries. However the a.era.e yield worldwide is considered to be lower tha. its potentia. yield (Singh e... 详细信息

关键词：鹰嘴豆基因表达等位基因遗传学

Vision ba.ed intelligent tra.fic light ma.a.ement system using Fa.ter R‐CNN

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Ca.I Tra.sa.tions on Intelligence Technology 2024年第4期9卷 932-947页

作者： Syed Kona.n a.ba. Muha.ma. Usma. Gha.i Kha. Jia.Zhu Ra.eem Sa.wa. Na.f R.a.joha.i Ibra.im a.hameed Muha.ma. Uma.r Ha.sa. Depa.tment of Computer Science a.d Engineering University of Engineering and TechnologyLahorePakistan Zhejia.g Key La.ora.ory of Intelligent Educa.ion Technology a.d a.plica.ion Zhejiang Normal UniversityJinhuaChina OTHEM Manchester Metropolitan UniversityManchesterUK Fa.ulty of Computing a.d Informa.ion Technology King Abdulaziz UniversityJeddahSaudi Arabia Depa.tment of ICT a.d Na.ura. Sciences Norwegian University of Science and Technology(NTNU)ÅlesundNorway

Tra.sporta.ion systems prima.ily depend on vehicula. flow on roa.s. Developed coun-tries ha.e shifted towa.ds a.toma.ed signa. control, which ma.a.es a.d upda.es signa. synchronisa.ion a.toma.ica.ly. In contra.t, tra.fic in underdeveloped countries is ma.nly governed by ma.ua. tra.fic light systems. These existing ma.ua. systems lea. to numerous issues, wa.ting substa.tia. resources such a. time, energy, a.d fuel, a. they ca.not ma.e rea.‐time decisions. In this work, we propose a. a.gorithm to determine tra.fic signa. dura.ions ba.ed on rea.‐time vehicle density, obta.ned from live closed circuit television ca.era.feeds a.ja.ent to tra.fic signa.s. The a.gorithm a.toma.es the tra.fic light system, ma.ing decisions ba.ed on vehicle density a.d employing Fa.ter R‐CNN for vehicle detection. a.ditiona.ly, we ha.e crea.ed a.loca. da.a.et from live strea.s of Punja. Sa.e City ca.era. in colla.ora.ion with the loca. police a.thority. The proposed a.gorithm a.hieves a.cla.s a.cura.y of 96.6% a.d a.vehicle detection a.cura.y of 95.7%. a.ross both da. a.d night modes, our proposed method ma.nta.ns a. a.era.e precision, reca.l, F1 score, a.d vehicle detection a.cura.y of 0.94, 0.98, 0.96 a.d 0.95, respectively. Our proposed work surpa.ses a.l eva.ua.ion metrics compa.ed to sta.e‐of‐the‐a.t methodologies.

关键词： a.cess control a.tificia. intelligence computer vision intelligent control

GINS1 a. a.Novel Bioma.ker of Surviva. in Colon a.enoca.cinoma.Pa.ients-a.Seconda.y Publica.ion

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Proceedings of a.tica.cer Resea.ch 2024年第3期8卷 60-67页

作者： Muha.ma. Uma.r a.id Ya.ir hameed Depa.tment of Pla.t Breeding a.d Genetics University of Agriculture FaisalabadFaisalabadPakistan Depa.tment of Biochemistry a.d Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study focused on ela.ora.ing the role of GINS1 expression a.d its regula.ory mecha.isms in colon a.enoca.cinoma.(COa.). Using the Ua.Ca. informa.iona. index, GINS1 expression a.sessment unveiled a.critica. up- regula.ion in ma.igna.t cells tha. stood out from norma. controls, suggesting its contribution to COa. expa.sion. Further disma.tling GINS1 expression a.ross va.ious bounda.ies revea.ed unsurprising up-regula.ion in different ma.igna.t development sta.es, ra.ia. groups, genders, a.d a.e cla.ses in COa. pa.ients, cha.a.teristics for its impera.ive role in ca.cer progression. Moreover, this study investiga.ed the promoter methyla.ion sta.us of GINS1, uncovering a.critica. uniqueness between COa. sa.ples a.d norma. controls. a.a.yzing promoter methyla.ion a.ross va.ious clinica. bounda.ies uncovered powerful va.ia.ions, with pa.ticula. methyla.ion pa.terns seen a.ross ca.cer sta.es, ra.e groups, genders, a.d a.e groups. Surviva. a.a.ysis using the Ka.la.-Meier (KM) plotter tool showed a.colossa. connection between GINS1 expression levels a.d overa.l surviva. (OS) in COa. pa.ients, with low GINS1 expression interfa.ing with higher OS. a.ditiona.ly, muta.iona. exa.ina.ion using the cBioPorta. sta.e revea.ed tha. no critica. cha.ge wa. found in COa.. Overa.l, these findings revea.ed the complex contribution of GINS1 in COa. pa.hogenesis, underlining its a.tua. limit a. a.prognostic bioma.ker a.d supportive thera.eutic a.ent in COa. ma.a.ement.

关键词： Colon a.enoca.cinoma Dia.nosis Trea.ment

Comprehensive a.a.ysis of Estrogen Receptor 1 Dysregula.ion in Liver Hepa.ocellula. Ca.cinoma. Implica.ions for Prognosis a.d Thera.eutic Ta.geting - a.Seconda.y Publica.ion

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Proceedings of a.tica.cer Resea.ch 2024年第3期8卷 51-59页

作者： Syed Hussa.n Ra.a.Ya.ir hameed Depa.tment of Biochemistry a.d Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investiga.es the expression pa.tern a.d regula.ory mecha.isms of estrogen receptor 1 (ESR1) in liver hepa.ocellula. ca.cinoma.(LIHC) through comprehensive bioinforma.ics a.a.ysis. Utilizing Ua.Ca. a.d GEPIa. da.a.a.es, significa.t down-regula.ion of ESR1 expression is observed in LIHC sa.ples compa.ed to norma. controls, indica.ing its potentia. role in tumor progression. Further a.a.ysis revea.s consistent down-regula.ion a.ross different clinica. va.ia.les including pa.ient a.e, gender, ra.e, a.d va.ious sta.es of LIHC, a.firming the regula.ory role of ESR1 in tumor development a.d progression. a.ditiona.ly, promoter methyla.ion a.a.ysis demonstra.es hypermethyla.ion of ESR1 in LIHC sa.ples, nega.ively correla.ing with its expression. This a.socia.ion persists a.ross different clinica. pa.a.eters, empha.izing the inverse rela.ionship between ESR1 methyla.ion a.d expression levels. Surviva. a.a.ysis indica.es tha. up- regula.ion of ESR1 is a.socia.ed with better overa.l surviva., suggesting its potentia. a. a.prognostic bioma.ker in LIHC. Furthermore, genetic muta.ion a.a.ysis using cBioPorta. revea.s a.spectrum of a.tera.ions in ESR1, including a.plifica.ion, missense muta.ion, deep deletion, splice muta.ion, a.d trunca.ing muta.ion, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a.deeper understa.ding of ESR1 dysregula.ion in LIHC a.d its clinica. implica.ions a. a.potentia. thera.eutic ta.get a.d prognostic ma.ker.

关键词： Estrogen receptor 1 Liver hepa.ocellula. ca.cinoma Bioma.ker Prognosis

Toxicity Eva.ua.ion of Different Exposure Scena.ios of Roa. Dust Using Da.hnia.ma.na.a.d a.temia.sa.ina.a. a.ua.ic Orga.isms, a.d Prosopis cinera.ia.a.d Va.hellia.tortilis a. Na.ive Pla.t Species

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Open Journa. of a.r Pollution 2024年第3期13卷 73-86页

作者： Hila. K. a.-Shidi hameed Sula.ma. Depa.tment of Educa.iona. Studies University of Technology and Applied Sciences Khasab Oman Depa.tment of Biology Sultan Qaboos University Muscat Oman

Pa.ticula.e ma.ter (PM10) deposited a. roa. dust is considered a. importa.t source of conta.ina.ion from a.mosphere. However, there a.e limited studies on the toxicity of roa. dust a. such on different orga.isms. This study eva.ua.es the toxicity of roa. dust using different extra.tion scena.ios on Da.hnia.ma.na.a.d a.temia.sa.ina.a. a.ua.ic orga.isms a.d a.so on Prosopis cinera.ia.a.d Va.hellia.tortilis a. loca. pla.t species. Chemica. a.a.ysis of different extra.ts shows considera.le a.ount of tra.e meta.s, however the tra.e meta.s in the dust extra.t a.socia.ed with suspended sediment were not a.sorbed by the receptors. On the other ha.d, the concentra.ion of tra.e meta.s in the a.tificia. mixture wa. found bioa.a.la.le a.d a.sorbed ca.sing a.high percenta.e of morta.ity. In the pla.t a.sa., significa.t difference wa. obta.ned in the germina.ion percenta.e between the control a.d three different extra.tion exposures in both pla.t species. The mea. root length of P. cinera.ia.a.d V. tortilis were higher in 20% a.d 50% extra.ts tha. the control proba.ly due to the a.a.la.ility of nutrients from the dust extra.t. Interestingly however, the seedling vigor index wa. the opposite with higher index in the control a.d lower in dust extra.ts tha. conta.n hea.y meta.s.

关键词： Roa. Dust Hea.y Meta.s Toxicity Bioa.a.la.ility Holding Time