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Priming mesenchyma. stem cells to develop “super stem cells”

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World Journa. of Stem Cells 2024年第6期16卷 623-640页

作者： Kha.a.a.Husna.n haider Depa.tment of Ba.ic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia

The stem cell pre-trea.ment a.proa.hes a. cellula. a.d sub-cellula. levels encompa.s physica. ma.ipula.ion of stem cells to growth fa.tor trea.ment,genetic ma.ipula.ion,a.d chemica. a.d pha.ma.ologica. trea.ment,ea.h stra.egy ha.ing a.va.ta.es a.d *** of these pre-trea.ment protocols a.e *** editoria. is a.continuum of Li et a.’s published a.ticle a.d Wa. et a.’s editoria. focusing on the significa.ce of pre-trea.ment stra.egies to enha.ce their stemness,immunoregula.ory,a.d immunosuppressive *** ha.e ela.ora.ed on the intrica.ies of the combina.ive pre-trea.ment protocol using pro-infla.ma.ory cytokines a.d *** a.well-defined multi-pronged combina.oria. stra.egy of mesenchyma. stem cells(MSCs),pre-trea.ment ba.ed on the mecha.istic understa.ding is expected to develop“Super MSCs”,which will crea.e a.tra.sforma.ive shift in MSC-ba.ed thera.ies in clinica. settings,potentia.ly revolutionizing the *** optimized,the sta.da.dized protocols ma. be used with slight modifica.ions to pre-trea. different stem cells to develop“super stem cells”with a.gmented stemness,functiona.ity,a.d repa.a.ility for diverse clinica. a.plica.ions with better outcomes.

关键词： Cell surviva. Cell thera.y Preconditioning Pre-trea.ment Stem cells Super stem cells

Fuzzy inference system using genetic a.gorithm a.d pa.tern sea.ch for predicting roof fa.l ra.e in underground coa. mines

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Interna.iona. Journa. of Coa. Science & Technology 2024年第1期11卷 31-41页

作者： a.ush Sa.u Sa.ish Sinha.haider Ba.ka Depa.tment of CSE IIT(ISM)DhanbadJharkhand826004India Depa.tment of Susta.na.ility Adani universityAhmedabadGujrat382421India

One of the most da.gerous sa.ety ha.a.d in underground coa. mines is roof fa.ls during retrea. *** fa.ls ma. ca.se life-threa.ening a.d non-fa.a. injuries to miners a.d impede mining a.d tra.sporta.ion *** a.result,a.relia.le roof fa.l prediction model is essentia. to ta.kle such *** pa.a.eters tha. substa.tia.ly impa.t roof fa.ls a.e ill-defined a.d inta.gible,ma.ing this a. uncerta.n a.d cha.lenging resea.ch *** Na.iona. Institute for Occupa.iona. Sa.ety a.d Hea.th a.sembled a.na.iona. da.a.a.e of roof performa.ce from 37 coa. mines to explore the fa.tors contributing to roof *** a.quired for 37 mines is limited due to severa. restrictions,which increa.ed the likelihood of *** logic is a.technique for coping with a.biguity,incompleteness,a.d ***,In this pa.er,the fuzzy inference method is presented,which employs a.genetic a.gorithm to crea.e fuzzy rules ba.ed on 109 records of roof fa.l da.a.a.d pa.tern sea.ch to refine the membership functions of *** performa.ce of the deployed model is eva.ua.ed using sta.istica. mea.ures such a. the Root-Mea.-Squa.e Error,Mea.-a.solute-Error,a.d coefficient of determina.ion(R_(2)).Ba.ed on these criteria.the suggested model outperforms the existing models to precisely predict roof fa.l ra.es using fewer fuzzy rules.

关键词： Underground coa. mining Roof fa.l Fuzzy logic Genetic a.gorithm

Enha.cing Hea.thca.e Da.a.Security a.d Disea.e Detection Using Crossover-Ba.ed Multila.er Perceptron in Sma.t Hea.thca.e Systems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 977-997页

作者： Mustufa.haider a.idi Hisha. a.kha.efa. Moha.ed K.a.ouda.f Depa.tment of Industria. Engineering College of EngineeringKing Saud UniversityP.O.Box-800Riyadh11421Saudi Arabia

The hea.thca.e da.a.requires a.cura.e disea.e detection a.a.ysis,rea.-timemonitoring,a.d a.va.cements to ensure proper trea.ment for ***,Ma.hine Lea.ning methods a.e widely utilized in Sma.t Hea.thca.e Systems(SHS)to extra.t va.ua.le fea.ures fromheterogeneous a.d high-dimensiona. hea.thca.e da.a.for predicting va.ious disea.es a.d monitoring pa.ient *** methods a.e employed a.ross different doma.ns tha. a.e susceptible to a.versa.ia. a.ta.ks,necessita.ing ca.eful ***,this pa.er proposes a.crossover-ba.ed Multila.er Perceptron(CMLP)*** collected sa.ples a.e pre-processed a.d fed into the crossover-ba.ed multila.er perceptron neura. network to detect a.versa.ia. a.ta.ks on themedica. records of *** a. a.ta.k is detected,hea.thca.e professiona.s a.e promptly a.erted to prevent da.a.*** pa.er utilizes two da.a.ets,na.ely the synthetic da.a.et a.d the University of Queensla.d Vita. Signs(UQVS)da.a.et,from which numerous sa.ples a.e *** results a.e conducted to eva.ua.e the performa.ce of the proposed CMLP model,utilizing va.ious performa.cemea.ures such a. Reca.l,Precision,a.cura.y,a.d F1-score to predict pa.ient *** the proposed method with existing a.proa.hes,it a.hieves the highest a.cura.y,precision,reca.l,a.d ***,the proposedmethod a.hieves a.precision of 93%,a. a.cura.y of 97%,a. F1-score of 92%,a.d a.reca.l of 92%.

关键词： Sma.t hea.thca.e systems multila.er perceptron cybersecurity a.versa.ia. a.ta.k detection Hea.thca.e 4.0

Refined a.a.-Net:Lightweight Deep Lea.ning Model for Improved Segmenta.ion Performa.ce of Optic Cup a.d Disc for Gla.coma.Dia.nosis

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Computers, Ma.eria.s & Continua 2024年第7期80卷 1381-1405页

作者： Khursheed a.ra.gzeb Syed Irta.a.haider Musa.d a.hussein Depa.tment of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia

In this work,we a.m to introduce some modifica.ions to the a.a.-Net deep neura. network(DNN)model for segmenting optic cup(OC)a.d optic disc(OD)in retina. fundus ima.es to estima.e the cup-to-disc ra.io(CDR).The CDR is a.relia.le mea.ure for the ea.ly dia.nosis of *** this study,we developed a.lightweight DNN model for OC a.d OD segmenta.ion in retina. fundus *** DNN model is ba.ed on modifica.ions to a.a.-Net,incorpora.ing a. a.a.orphic depth embedding *** reduce computa.iona. complexity,we employ a.fixed filter size for a.l convolution la.ers in the encoder a.d decoder sta.es a. the network *** modifica.ion significa.tly reduces the number of tra.na.le pa.a.eters,ma.ing the model lightweight a.d suita.le for resource-constra.ned *** eva.ua.e the performa.ce of the developed model using two publicly a.a.la.le retina. ima.e da.a.a.es,na.ely RIM-ONE a.d *** results demonstra.e promising OC segmenta.ion performa.ce a.ross most sta.da.d eva.ua.ion metrics while a.hieving a.a.ogous results for OD *** used two retina. fundus ima.e da.a.a.es na.ed RIM-ONE a.d Drishti-GS tha. conta.ned 159 ima.es a.d 101 retina. ima.es,*** OD segmenta.ion using the RIM-ONE we obta.n a. f1-score(F1),Ja.ca.d coefficient(JC),a.d overla.ping error(OE)of 0.950,0.9219,a.d 0.0781,***,for OC segmenta.ion using the sa.e da.a.a.es,we a.hieve scores of 0.8481(F1),0.7428(JC),a.d 0.2572(OE).Ba.ed on these experimenta. results a.d the significa.tly lower number of tra.na.le pa.a.eters,we conclude tha. the developed model is highly suita.le for the ea.ly dia.nosis of gla.coma.by a.cura.ely estima.ing the CDR.

关键词： Refined a.a.-Net pa.a.eter tuning deep lea.ning optic cup optic disc cup-to-disc ra.io gla.coma.dia.nosis

Cellula. preconditioning a.d mesenchyma. stem cell ferroptosis

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World Journa. of Stem Cells 2024年第2期16卷 64-69页

作者： Doa. Hussein Zineldeen Ma.ha. Mushta. Kha.a.a.Husna.n haider Ba.ic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Depa.tment of Medica. Biochemistry a.d Molecula. Biology Faculty of MedicineTanta UniversityTanta 6632110Egypt

In this editoria.,we comment on the a.ticle published in the recent issue of the World Journa. of Stem *** focus on stem cell preconditioning to prevent ferroptosis by modula.ing the cysta.hionineγ-lya.e/hydrogen sulfide(H_(2)S)pa.hwa. a. a.novel a.proa.h to trea. va.cula. disorders,pa.ticula.ly pulmona.y *** stem cells a.e ga.ning popula.ity in regenera.ive medicine due to their unique a.ility to survive by resisting the ha.sh,unfa.ora.le microenvironment of the injured *** a.so secrete va.ious pa.a.rine fa.tors a.a.nst a.optosis,necrosis,a.d ferroptosis to enha.ce cell ***,a.regula.ed form of cell dea.h cha.a.terized by iron a.cumula.ion a.d oxida.ive stress,ha. been implica.ed in va.ious pa.hologies encompa.sing dege-nera.ive disorders to *** lipid peroxida.ion ca.ca.e initia.es a.d susta.ns ferroptosis,genera.ing ma.y rea.tive oxygen species tha. a.ta.k a.d da.a.e multiple cellula. *** these intertwined mecha.isms provi-des significa.t insights into developing thera.eutic moda.ities for ferroptosis-rela.ed *** editoria. prima.ily discusses stem cell preconditioning in modula.ing ferroptosis,focusing on the cysta.hiona.e ga.ma.H_(2)S ferroptosis *** presents a.significa.t cha.lenge in mesenchyma. stem cell(MSC)-ba.ed thera.ies;hence,the emerging role of H_(2)S/cysta.hiona.e ga.ma.H_(2) S signa.ing in a.roga.ing ferroptosis provides a.novel option for thera.eutic *** resea.ch into understa.ding the precise mecha.isms of H_(2)S-media.ed cytoprotection a.a.nst ferroptosis is wa.ra.ted to enha.ce the thera.peutic potentia. of MSCs in clinica. settings,pa.ticula.ly va.cula. disorders.

关键词： Cell surviva. Cell thera.y Hydrogen sulfide Ferroptosis Preconditioning Stem cells Umbilica. cord

High glucose microenvironment a.d huma. mesenchyma. stem cell beha.ior

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World Journa. of Stem Cells 2024年第3期16卷 237-244页

作者： Muha.ma. a.dul Ma.een Noura.sa.hin a.a.gib Kha.a.a.Husna.n haider Ba.ic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia Cellula. a.d Molecula. Pha.ma.ology Sulaiman AlRajhi Medical SchoolAl Bukairiyah 51941Saudi Arabia

High glucose(HG)culture conditions in vitro a.d persistent exposure to hyperglycemia.in dia.etes pa.ients a.e detrimenta. to stem cells,a.a.ogous to a.y other cell type in our *** interferes with diverse signa.ing pa.hwa.s,*** ta.get of ra.a.ycin(mTOR)-phosphoinositide 3-kina.e(PI3K)-a.t signa.ing,to impa.t physiologica. cellula. functions,lea.ing to low cell surviva. a.d higher cell a.optosis *** elucida.ing the underlying mecha.ism responsible for the a.optosis of a.ipose tissue-derived mesenchyma. stem cells(MSCs),a.recent study ha. shown tha. HG culture conditions dysregula.e mTORPI3K-a.t signa.ing in a.dition to mitochondria. ma.functioning due to defective mitochondria. membra.e potentia.(MtMP)tha. lowers a.P *** orga.elle-level dysfunction energy-sta.ves the cells a.d increa.es oxida.ive stress a.d ultra.tructura. *** of the mitochondria. electron tra.sport cha.n produces a. a.tered mitochondria. Na.+/Na.H redox sta.e a. evidenced by a.low Na.+/Na.H ra.io tha. prima.ily contributes to the reduced cell surviva. in *** previous studies ha.e a.so reported a.tered mitochondria. membra.e pola.ity(ca.sing hyperpola.iza.ion)a.d reduced mitochondria. cell ma.s,lea.ing to perturbed mitochondria. *** hostile microenvironment crea.ed by HG exposure crea.es structura. a.d functiona. cha.ges in the mitochondria.a.tering their bioenergetics a.d reducing their ca.a.ity to produce *** a.e significa.t da.a.a. MSCs a.e extensively studied for tissue regenera.ion a.d restoring their norma. functioning in cell-ba.ed ***,MSCs from hyperglycemic donors should be ca.tiously used in clinica. settings for cell-ba.ed thera.y due to concerns of their poor sur-viva. ra.es a.d increa.ed ra.es of post engra.tment *** hypergly-cemia.a.ters the bioenergetics of donor MSCs,rectifying the loss of MtMP ma. be a. excellent ta.get for future resea.ch to restore the norma. functioning of MSCs i

关键词： a.ipose tissue a.optosis Bioenergetics Cell surviva. Cell thera.y Hyperglycemia Mitochondria Mesenchyma. stem cells Stem cells

Deep Lea.ning a.proa.h for Ha.d Gesture Recognition:a.plica.ions in Dea. Communica.ion a.d Hea.thca.e

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Computers, Ma.eria.s & Continua 2024年第1期78卷 127-144页

作者： Khursheed a.ra.gzeb Kha.id Ja.eed Musa.d a.hussein Ima. Rida.Syed Irta.a.haider a.ubha.Pa.a.ha. Depa.tment of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Kingdom of Saudi Arabia Depa.tment of Computer Engineering College of Computing and InformaticsUniversity of SharjahSharjah27272United Arab Emirates La.ora.ory Biomecha.ics a.d Bioengineering University of Technology of CompiegneCompiegne60200France Depa.tment of Computer Science a.d Engineering Manipal University JaipurJaipur303007India

Ha.d gestures ha.e been used a. a.significa.t mode of communica.ion since the a.vent of huma. *** fa.ilita.ing huma.-computer intera.tion(HCI),ha.d gesture recognition(HGRoc)technology is crucia. for sea.less a.d error-free *** technology is pivota. in hea.thca.e a.d communica.ion for the dea. *** significa.t a.va.cements in computer vision-ba.ed gesture recognition for la.gua.e understa.ding,two considera.le cha.lenges persist in this field:(a.limited a.d common gestures a.e considered,(b)processing multiple cha.nels of informa.ion a.ross a.network ta.es huge computa.iona. time during discrimina.ive fea.ure ***,a.novel ha.d vision-ba.ed convolutiona. neura. network(CNN)model na.ed(HVCNNM)offers severa. benefits,nota.ly enha.ced a.cura.y,robustness to va.ia.ions,rea.-time performa.ce,reduced cha.nels,a.d ***,these models ca. be optimized for rea.-time performa.ce,lea.n from la.ge a.ounts of da.a.a.d a.e sca.a.le to ha.dle complex recognition ta.ks for efficient huma.-computer *** proposed model wa. eva.ua.ed on two cha.lenging da.a.ets,na.ely the Ma.sey University Da.a.et(MUD)a.d the a.erica. Sign La.gua.e(a.L)a.pha.et Da.a.et(a.La.).On the MUD a.d a.La. da.a.ets,HVCNNM a.hieved a.score of 99.23% a.d 99.00%,*** results demonstra.e the effectiveness of CNN a. a.promising HGRoc *** findings suggest tha. the proposed model ha.e potentia. roles in a.plica.ions such a. sign la.gua.e recognition,huma.-computer intera.tion,a.d robotics.

关键词： Computer vision deep lea.ning ga.t recognition sign la.gua.e recognition ma.hine lea.ning

Unknown Environment Mea.urement Ma.ping by Unma.ned a.ria. Vehicle Using Ka.ma. Filter-Ba.ed Low-Cost Estima.ed Pa.a.lel 8-Bea. LIDa.

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Computers, Ma.eria.s & Continua 2024年第9期80卷 4263-4279页

作者： Moha.ed Ra.ik Moha.ed Isma.l Muthura.a.inga. Tha.ga.a. Kha.a.Moiduddin Zeya. a.muta.ri Mustufa.haider a.idi Depa.tment of Mecha.ronics Engineering SRM Institute of Science and TechnologySRM NagarKattankulathurChengalpattu DistrictTamil Nadu603203India a.va.ced Ma.ufa.turing Institute King Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia Depa.tment of Mecha.ica. Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

The mea.urement a.d ma.ping of objects in the outer environment ha.e tra.itiona.ly been conducted using ground-ba.ed monitoring systems,a. well a. *** recently,unma.ned a.ria. vehicles ha.e a.so been employed for this *** a.cura.e detection a.d ma.ping of a.ta.get such a. buildings,trees,a.d terra.ns a.e of utmost importa.ce in va.ious a.plica.ions of unma.ned a.ria. vehicles(Ua.s),including sea.ch a.d rescue opera.ions,object tra.sporta.ion,object detection,inspection ta.ks,a.d ma.ping ***,the ra.id mea.urement a.d ma.ping of the object a.e not currently a.hieva.le due to fa.tors such a. the object’s size,the intrica.e na.ure of the sites,a.d the complexity of ma.ping *** present system introduces a.costeffective solution for mea.urement a.d ma.ping by utilizing a.sma.l unma.ned a.ria. vehicle(Ua.)equipped with a. 8-bea. Light Detection a.d Ra.ging(LiDa.)*** a.proa.h offers a.va.ta.es over tra.itiona. methods tha. rely on expensive ca.era. a.d complex a.gorithm-ba.ed *** reflective properties of la.er bea.s ha.e a.so been *** system provides prompt results in compa.ison to tra.itiona. ca.era.a.ed surveilla.ce,with minima. la.ency a.d the need for complex *** Ka.ma. estima.ion method demonstra.es improved performa.ce in the presence of *** mea.urement a.d ma.ping of externa. objects ha.e been successfully conducted a. va.ying dista.ces,utilizing different resolutions.

关键词： 8 bea. LiDa. Ua. mea.urement ma.ping Ka.ma. filter

a.-Driven Energy Optimiza.ion in Ua.-a.sisted Routing for Enha.ced Wireless Sensor Networks Performa.ce

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Computers, Ma.eria.s & Continua 2024年第9期80卷 4085-4110页

作者： Syed Ka.ra. haider a.ba. a.med Noma. Mujeeb Kha. a.i Na.ma. Sung Won Kim College of Internet of Things(IoT)Engineering Hohai UniversityChangzhou213001China Depa.tment of Electrica. a.d Electronics Engineering Beaconhouse International CollegeIslamabad44000Pakistan School of Computer Science a.d Engineering Yeungnam UniversityGyeongsan38428Republic of Korea

In recent a.va.cements within wireless sensor networks(WSN),the deployment of unma.ned a.ria. vehicles(Ua.s)ha. emerged a. a.groundbrea.ing stra.egy for enha.cing routing efficiency a.d overa.l network *** resea.ch introduces a.sophistica.ed fra.ework,driven by computa.iona. intelligence,tha. merges clustering techniques with Ua. mobility to refine routing stra.egies in *** proposed a.proa.h divides the sensor field into distinct sectors a.d implements a.novel weighting system for the selection of cluster hea.s(CHs).This system is prima.ily a.med a. reducing energy consumption through meticulously pla.ned routing a.d pa.h *** a.greedy a.gorithm for inter-cluster dia.ogue,our fra.ework orchestra.es CHs into a. efficient communica.ion *** compa.a.ive a.a.ysis,the proposed model demonstra.es a.ma.ked improvement over tra.itiona. methods such a. the cluster cha.n mobile a.ent routing(CCMa.)a.d the energy-efficient cluster-ba.ed dyna.ic a.gorithms(ECCRa..Specifica.ly,it showca.es a. impressive 15%increa.e in energy conserva.ion a.d a.20%reduction in da.a.tra.smission time,highlighting its a.va.ced ***,this pa.er investiga.es the impa.t of va.ious network pa.a.eters on the efficiency a.d robustness of the WSN,empha.izing the vita. role of sophistica.ed computa.iona. stra.egies in optimizing network opera.ions.

关键词： Ua. tra.ectory clustering next-genera.ion wireless sensor network(NGWSN) energy efficiency mobile sink