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Improvement in Pa.ient Mobility Following Short-Term Reha.ilita.ion in Skilled Nursing Fa.ilities

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Open Journa. of Thera.y a.d Reha.ilita.ion 2024年第1期12卷 52-60页

作者： Sea. R. Silver Ja.en a. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Mobility in older a.ults ca. be impa.red a.ter a.ute illness or hospita.iza.ion, a.d the level of severity ca. be used a. a.predictor of one’s a.ility to return to independent living. Pa.ients a.e often referred to skilled nursing fa.ilities in hopes of improving their mobility. We wa.ted to prove tha. reha.ilita.ive services a. Skilled Nursing Fa.ilities improve overa.l outcomes. Methods: We conducted a.retrospective a.a.ysis of da.a.from 4612 pa.ients a.mitted for short-term reha.ilita.ion in a.la.ge nursing home cha.n in Ca.ifornia. Our a.m wa. to determine whether pa.ients’ mobility scores, a. mea.ured by reha.ilita.ive sta.f, significa.tly improved by time of discha.ge compa.ed to their scores a. a.mission. Mobility scores were ra.ed from 1 to 6, with 1 being the most dependent on a.d a.d 6 being the most independent, over a.va.iety of ta.ks a. a.mission a.d compa.ed to scores a. discha.ge. Pea.son’s correla.ions were performed to determine if there were significa.t rela.ionships in the da.a. the Pea.son’s correla.ion coefficient wa. used to describe the rela.ionships between pa.ient a.mission to a.skilled nursing fa.ility a.d medica. improvement upon discha.ge. Results: The study demonstra.ed a.sta.istica.ly significa.t improvement in pa.ients’ mobility scores upon discha.ge, with Medica.e insured pa.ients showing on a.era.e 57% improvement a.d Ma.a.ed Ca.e insured pa.ients showing on a.era.e 59% improvement. a.ditiona.ly, a.mission scores a.pea.ed to be predictive of the pa.ient’s outcome a. discha.ge. Conclusions: The va.ues a.d consistency of improvement support the use of a.ute reha.ilita.ive services in skilled nursing fa.ilities. a. equa.ion ca. be formula.ed tha. eva.ua.es pa.ients’ estima.ed mobility sta.uses upon discha.ge from fa.ilities ba.ed on their conditions on their a.riva.s. With this, new interventions ca. be studied a.d compa.ed to the current sta.da.d of ca.e by using these mea.urements. They ca. determine if further improvement

关键词： Mobility Skilled Nursing Fa.ility Reha.ilita.ive Services Independent Living Hea.thca.e

Structura.-a.a.ta.ion Fea.ures of a.simila.ion Orga.s of the Species Sa.sola.inca.escens Ca.. in Conditions of Kyzylkum

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a.erica. Journa. of Pla.t Sciences 2024年第7期15卷 589-602页

作者： Guli a. Ibrokhimova.Gulja. M. Duscha.ova Depa.tment of Bota.y a.d Pla.t Physiology National University of Uzbekistan named after Mirzo Ulugbek Tashkent Uzbekistan Depa.tment of Bota.y a.d Ecology Tashkent State Pedagogical University named after Nizami Tashkent Uzbekistan

The a.ticle presents the results of the morpho-a.a.omica. structure of the a.simila.ion orga.s of the species Sa.sola.leptocla.a.Ga.d, which is widesprea. in the Kyzylkum desert region of Uzbekista., a.d revea.s the structura., dia.nostic a.d a.a.tive fea.ures. In the a.simila.ion orga.s, Kra.z type of mesophyll wa. found: in the cotyledons of the Kra.z-spherica. (a.riplicoid) type, a.d in the lea.—mesophylls of the Kra.z-centric (Sa.soloid) a.d Kra.z-ventrodorsa. type. These revea.ed dia.nostic fea.ures of the a.simila.ing orga.s of this species in a.id conditions noted C4-type photosynthesis. Ba.ed on the compa.a.ive biometric a.a.ysis of qua.tita.ive indices of the a.a.omica. fea.ures of the a.simila.ing orga.s, xero-ha.omorphic fea.ures predomina.e. Ha.omorphic fea.ures a.e in the cotyledons—thin outer wa.ls of the epiderma. cells;few stoma.a.of the a.omocytic a.d pa.a.ytic type;few rows of spongy cells (3 - 4 rows);few va.cula. bundles of the colla.era. type a.d xylem, in the lea.—la.ge a.d thin outer wa.ls of the epiderma. cells;succulence of the lea. mesophyll, the presence of a.uiferous cells;la.ge pa.isa.e, kera.in a.d a.uiferous cells. Xeromorphic fea.ures in the cotyledons—sma.l a.d numerous epiderma. cells a.d hemipa.a.ytic type stoma.a.a.so deep immersion;sma.l pa.isa.e cells a.d a.high pa.isa.e index, sma.l spongy, hypoderma. a.d kera.in cells;sma.l dia.eter of the xylem in va.cula. bundles;in the lea. numerous epiderma. cells a.d stoma.a.a.so deeply immersed;presence a.d numerous multicellula. nodula., denta.e trichomes;multi-row wa.er-bea.ing cells;high pa.isa.e index;sma.l a.d numerous xylem;numerous periphera. va.cula. bundles of the colla.era. type. These identified specific dia.nostic fea.ures showing a.a.ta.ion to a.id conditions ca. a.so serve in the identifica.ion of pla.t ma.eria.s.

关键词： Morphology a.a.omy Cotyledon Lea. Sa.sola.inca.escens South-West Kyzylkum

Va.ida.ion of a.Method for Cha.a.teriza.ion of Etha.ol in Wa.er by HS-GC-FID to Serve the Tra.ea.ility of Ha.a. Mea.urements

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Green a.d Susta.na.le Chemistry 2024年第2期14卷 17-28页

作者： a.el B. Sheha.a.a.dulra.ma. R. a. a.ka. Moha.med a. a. Ra.heed a.dulra.ma. M. a. Za.ra.y Fa.d a. a. Kha.ra. Sowa.lem a. a. Sowa.lem Chemistry Depa.tment/Na.iona. Mea.urement a.d Ca.ibra.ion Center (NMCC) Saudi Standards Metrology and Quality Organization (SASO) Riyadh Kingdom of Saudi Arabia

The determina.ion of the etha.ol content in food products is of funda.enta. importa.ce for Ha.a. certifica.ion. In this work, a. a.a.ytica. method for the determina.ion of etha.ol in wa.er by hea.spa.e ga. chroma.ogra.hy with fla.e ioniza.ion detector (HS-GC-FID) ha. been developed a.d va.ida.ed for the use in cha.a.teriza.ion of etha.ol reference ma.eria.s. The va.ida.ion study wa. ca.ried out in the linea. ca.ibra.ion ra.ge 100 - 1500 mg/kg using the NIST SRM 2900, nomina. 95.6%. The studied performa.ce cha.a.teristics of the method were the limit of detection, LOD, the limit of qua.tifica.ion LOQ, selectivity, linea.ity, precision, recovery a.d bia.. The va.ida.ion results showed tha. the method is selective, precise, a.cura.e a.d free from a.y significa.t bia.. The LOD a.d LOQ were 1.27 a.d 3.86 mg/kg respectively a.d the estima.ed expa.ded uncerta.nty wa. 2% indica.ing tha. the method is fit for the purpose of certifica.ion of etha.ol in wa.er reference ma.eria.s.

关键词： Etha.ol HS-GC-FID Va.ida.ion Linea.ity Precision Bia.

Utility of Preopera.ive Positron Emission Tomogra.hy (PET) in Loca.izing Perfora.or Vessels of a.terola.era. Thigh Free Fla.

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Interna.iona. Journa. of Otola.yngology a.d Hea. & Neck Surgery 2024年第4期13卷 275-284页

作者： a.exa.dra.McMilla. Sa.eer a. a.vi Za.d a.-Qura.shi Za.ha.y Fleisha.ker Nitin a. Pa.eda. Ma.isa.R. Bucha.jia. Depa.tment of Otola.yngology University of Iowa Hospitals and Clinics Iowa City IA USA Division of Otola.yngology-Hea. & Neck Surgery North Shore University Health System Evanston IL USA Pritzker School of Medicine The University of Chicago Chicago IL USA Holden Comprehensive Ca.cer Center University of Iowa Iowa City IA USA

Objectives: The a.terola.era. thigh (a.T) fla. is often considered the workhorse in soft tissue reconstruction of hea. a.d neck defects seconda.y to tra.ma. infection, or tumor resection. Despite its ma.y a.va.ta.es, a.T fla.s ha.e been criticized due to va.ia.ility in va.cula.ure, which ma. result in ina.equa.e or non-existent perfora.ors. This retrospective study a.ms to investiga.e the utility a.d va.idity of positron emission tomogra.hy (PET) sca. to identify the loca.ion a.d cha.a.teristics of perfora.ors to the a.T fla.. Methods: We performed a.10-yea. retrospective review of a.T fla.s a. our institution to identify pa.ients with preopera.ive PET sca.s a.a.la.le for a.a.ysis. Three reviewers (a.tending physicia., fellow, a.d resident) were a.ked to identify the number, loca.ion, a.d cha.a.teristics (myocuta.eous versus septocuta.eous) of a.T perfora.ors on ima.ing, a.d reviewer a.reement wa. a.sessed. Results were then compa.ed to a.a.la.le opera.ive da.a. Results: One hundred twenty-one pa.ients were identified who underwent a.T free fla. surgery. Thirty-eight preopera.ive PET sca.s were identified for review. a. lea.t one perfora.or wa. identified in 92.1% of sca.s. a.reement percenta.es rega.ding the number of perfora.ors ra.ged from 53% - 61% wherea. a.reement rega.ding the loca.ion of a.single perfora.or ra.ged from 79% - 90%. However, reviewers did not a.ree rega.ding the type of perfora.or, with a.reement ra.ging from 34% - 53%. Poor a.reement wa. observed when compa.ed to intra.pera.ive da.a. with the number of perfora.ors ra.ging from 26% - 34% a.d the type of perfora.or 11% - 24%. These findings a.e likely due to insufficient da.a.a.a.la.le in opera.ive reports. Conclusion: a.though initia. studies suggest tha. PET sca. shows promising evidence to support the ca.a.ity to preopera.ively identify a.T perfora.ors, future prospective studies a.e wa.ra.ted to fully va.ida.e these findings.

关键词： a.terola.era. Thigh Fla.s Positron Emission Tomogra.hy Hea. a.d Neck Defects Perfora.or Ma.ping

Emerging role of cellula. senescence in norma. lung development a.d perina.a. lung injury

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Chinese Medica. Journa. Pulmona.y a.d Critica. Ca.e Medicine 2024年第1期2卷 10-16页

作者： Phyllis a.Dennery Hongwei Ya. Depa.tment of Molecula. Biology Cell Biology&BiochemistryDivision of Biology and MedicineBrown UniversityProvidenceRI 02912USA Depa.tment of Pedia.rics Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA

Cellula. senescence is a.sta.us of irreversible growth a.rest,which ca. be triggered by the p53/p21cip1 a.d p16INK4/Rb pa.hwa.s via.intrinsic a.d externa. *** cells a.e typica.ly enla.ged a.d fla.tened,a.d cha.a.terized by numerous molecula. *** la.ter consists of increa.ed surfa.eome,increa.ed resid-ua. lysosoma. a.tivity a. pH 6.0(ma.ifested by increa.ed a.tivity of senescence-a.socia.ed beta.ga.a.tosida.e[Sa.𝛽-ga.]),senescence-a.socia.ed mitochondria. dysfunction,cytopla.mic chroma.in fra.ment,nuclea. la.in b1 exclusion,telomere-a.socia.ed foci,a.d the senescence-a.socia.ed secretory *** fea.ures va.y depending on the stressor lea.ing to senescence a.d the type of *** senescence pla.s pivota. roles in orga.isma. a.ing a.d in the pa.hogenesis of a.ing-rela.ed ***,senescence ca. a.so both promote a.d inhibit wound hea.ing *** recently report tha. senescence a. a.progra.med pro-cess contributes to norma. lung *** senescence is a.so observed in Down Syndrome,a. well a. in prema.ure infa.ts with bronchopulmona.y dyspla.ia.a.d in a.hyperoxia.induced rodent model of this ***,this senescence results in neona.a. lung *** this review,we briefly discuss the molecula. fea.ures of *** then focus on the emerging role of senescence in norma. lung development a.d in the pa.hogenesis of bronchopulmona.y dyspla.ia.a. well a. puta.ive signa.ing pa.hwa.s driving ***,we discuss potentia. thera.eutic a.proa.hes ta.geting senescent cells to prevent perina.a. lung disea.es.

关键词： Senescence Norma. lung development Bronchopulmona.y dyspla.ia Down syndrome Senolytics

Serum Immunoglobulin Concentra.ions in Juvenile Idiopa.hic a.thritis Ca.es during a.tive a.d Ina.tive Disea.e Sta.es

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Open Journa. of Rheuma.ology a.d a.toimmune Disea.es 2024年第2期14卷 49-59页

作者： Sa.ib Muha.ma. Ra.ha. Ka.rul La.la.Sha.a.a.a. Ra.ma. Consulta.t (Pa.dia.rics) Kalkini Upazila Health Complex Dhaka Bangladesh Depa.tment of Pa.dia.rics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Depa.tment of Pa.dia.rics (on PRL) Ba.ga.a.dhu Sheikh Mujib Medica. University Dhaka Bangladesh

Ba.kground: Juvenile idiopa.hic a.thritis (JIa. is the most common rheuma.ic disea.e in children. Both the humora. a.d cell media.ed immunities a.e involved in the pa.hogenesis of JIa. It is reported tha. overa.l immunoglobulin levels in JIa.pa.ients a.e significa.tly higher tha. their control during the a.tive sta.e of disea.e. Methodology: This prospective observa.iona. study wa. conducted over a.period of 18 months a.l the newly dia.nosed oligo-a.ticula. a.d poly-a.ticula. JIa.pa.ients ha.ing a.tive disea.e were included by purposive sa.pling. Da.a.were collected by a.semi-structured predesigned questionna.re. Result: Most of the study subjects (57.6%) belonged to a.e group > 3 - 9 yea.s. Oligo JIa.wa. dia.nosed in 66.7% a.d poly JIa.in 33.3% of JIa.children. The difference in mea. (±SD) ESR (33.52 ± 21.29 a.d 15.09 ± 7.71 mm in 1st hour) a. a.tive a.d ina.tive sta.es wa. highly significa.t. Mea. (±SD) difference of IgG, IgM a.d Iga.in a.tive a.d ina.tive sta.es of disea.e were highly significa.t. Conclusion: Higher a.d a.norma. levels of immunoglobulin (IgG, IgM, a.d Iga. were present a.ong JIa.pa.ients in a.tive disea.e sta.e which beca.e norma. during ina.tive disea.e sta.e a.ter trea.ment.

关键词： JIA Oligoa.ticula. JIA Polya.ticula. JIA Immunoglobulins a.itive Disea.e Ina.tive Disea.e

Observa.ion a.out the Cla.sica. Electroma.netic Ga.ge Tra.sforma.ion a.d Its Qua.tum Correspondence

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Journa. of Modern Physics 2024年第4期15卷 474-479页

作者： Gusta.o V. López Jorge a. Liza.ra.a Depa.ta.ento de Física Universidad de Guadalajara Guadalajara Mexico

Using the La.da. a.d symmetric ga.ges for the vector potentia. of a.consta.t ma.netic field a.d the qua.tum problem of a.cha.ged pa.ticle moving on a.fla. surfa.e, we show the cla.sica. electroma.netic ga.ge tra.sforma.ion does not correspond to a.one-dimensiona. unita.y group tra.sforma.ion U(1) of the wa.e function for the qua.tum ca.e. In a.dition, with the re-exa.ina.ion of the rela.ion between the ma.netic field B a.d its vector potentia. a. we found tha., in order to ha.e a.consistent formula.ion of the dyna.ics of the cha.ged pa.ticle with both expressions, we must ha.e tha. B=∇×a.if a.d only if B≠0.

关键词： Ga.ge Tra.sforma.ion Ha.monic Oscilla.or Qua.tum Ha.l Effect Electroma.netic Potentia.s

Investiga.ing the Influence of Gla.coma.on the Qua.ity of Life a.ong a.ult Pa.ients

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Interna.iona. Journa. of Clinica. Medicine 2024年第2期15卷 88-100页

作者： Pa.l Mwa.e Ka.en Ta.a.a.a.a.disha.ur a. Muse Ke Min Depa.tment of Ophtha.mology Zhongnan Hospital of Wuhan University Wuhan China

Ba.kground: Resea.ch exploring the influence of gla.coma.on qua.ity of life ha. ga.ned momentum in recent yea.s. Numerous studies ha.e investiga.ed the multifa.eted a.pects of qua.ity of life in gla.coma.pa.ients, utilizing va.ious a.sessment tools a.d methodologies. Objective: To determine the influence tha. gla.coma.ha. on the qua.ity of life a.ong a.ult pa.ients. Study site: kitwe tea.hing eye hospita., Za.bia. Method: It wa. a.cross-sectiona. study tha. wa. conducted from 30th June 2022 to 17th a.ril 2023. The study included 106 dia.nosed gla.coma.pa.ients who were a.ove the a.e of 55 yea.s. Da.a.wa. collected using va.ida.ed 25-item na.iona. eye institute visua. function Questionna.re (NEI VFQ-25). The da.a.wa. a.a.yzed using SPSS version 26 a.d Microsoft excel to present frequencies a.d percenta.es tha. genera.ed gra.hica. presenta.ion. Results: 62% of the pa.ticipa.ts worry a.out their eye sight most of the time, 26% sometimes a.d 12% a.little time. 9% of the pa.ticipa.ts ha. little difficulty to rea. ordina.y prints, 14% modera.e difficulties a.d 58% extremely difficult. 40% of the pa.ticipa.ts could drive despite gla.coma.da.a.ing their eyes while 60% could not. Ma.ority of the pa.ients sa.d it wa. difficult noticing things a.ound them while wa.king or sitted in one pla.e. There wa. a.significa.t difference between effects of gla.coma.on pa.ients a.d the existing rela.ionship between gla.coma.a.d qua.ity of life (a.OVa. p = 0.019 a.d a.OVa. p = 0.023). Conclusion: This study ha. demonstra.ed the ma.nitude of impa.t tha. gla.coma.ha. on the Qua.ity of Life (QoL) in dia.nosed pa.ients a.d the rela.ionship between gla.coma.a.d the Qua.ity of Life. Due to the progressive visua. loss, the a.ount of a.tivities these pa.ients would perform is nega.ively a.fected especia.ly where socia. a.d economic a.tivities a.e concerned which a.so a.fects their monthly ea.nings for those living in middle to low-income countries. Therefore, socia. welfa.e a

关键词： Gla.coma Qua.ity of Life Gla.coma.Pa.ients

Cha.ge in Functiona. Sta.us from Preopera.ive to One Yea. Postopera.ive in Pa.ients Who Ha.e Undergone Elective Open-Hea.t Surgery: a.Repea.ed-Mea.ures Study

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World Journa. of Ca.diova.cula. Disea.es 2024年第6期14卷 421-433页

作者： a. Ka.e Ma.Phedra. Da.id Ba.ker Ma.k Ma.bey Kiera. Foga.ty Physica. Thera.y Progra. Morosky College of Health Professions and Sciences Gannon University Erie PA USA Interdisciplina.y Hea.th Sciences PhD Progra. College of Health and Human Sciences Western Michigan University Kalamazoo MI USA Orga.iza.iona. Lea.ning a.d Lea.ership PhD Progra. College of Humanities Education and Social Sciences Gannon University Erie PA USA Ca.dia. Surgery Services AHN Saint Vincent Health Center Erie PA USA

Purpose: a.though pa.ient-rela.ed fa.tors a.fect surgica. outcomes, preopera.ive functiona. sta.us is not mea.ured by a.y ca.dia. risk score. Functiona. sta.us ca., however, be objectively mea.ured using va.ida.ed outcome tools such a. the La.e-Life Function a.d Disa.ility Instrument (LLFDI). The purpose of this study wa. to determine 1) if there wa. a.cha.ge over time in functiona. sta.us, a. mea.ured by the LLFDI, in pa.ients who underwent elective ca.dia. surgery, a.d if so, 2) wha. specific a.pect(s) of functiona. sta.us cha.ged. Methods: a.prospective longitudina. study of one yea. wa. conducted on elective ca.dia. surgery pa.ients (n = 43) using the self-reported LLFDI, which mea.ures Disa.ility Frequency (frequency of pa.ticipa.ion in socia. ta.ks), Disa.ility Limita.ion (a.ility to pa.ticipa.e in socia. ta.ks) a.d Function Tota. (ea.e in performing routine a.tivities). Higher scores indica.e increa.ed function a.d decrea.ed disa.ility. LLFDI scores were compa.ed a. three times (preopera.ive, six-week a.d one-yea. postopera.ive) using repea.ed mea.ures a.OVa. Post hoc pa.rwise compa.ison wa. conducted for specific intera.tions. Results: Both Function Tota. a.d Disa.ility Frequency significa.tly cha.ged over time (p = 0.047 a.d p = 0.013, respectively). Specifica.ly, pa.ients’ function level wa. significa.tly higher one-yea. postopera.ive compa.ed to preopera.ive (M difference = +3.48, SE = 1.48, p = 0.026). Likewise, Disa.ility Frequency scores were significa.tly higher (i.e. more a.tive) a. one-yea. postopera.ive versus preopera.ive (M difference= +5.98, SE = 2.19, p = 0.033). Disa.ility Limita.ion scores were not significa.tly different between a.y time points (p > 0.05). Conclusion: By one-yea. postopera.ive, pa.ients demonstra.ed increa.ed ea.e in their routine physica. a.tivities a.d were more pa.ticipa.ory in socia. life ta.ks. Individua.s who underwent elective ca.dia. surgery took more tha. six weeks to detect nota.le improvement in functiona. sta.us,

关键词： Functiona. Sta.us Elective Ca.dia. Surgery La.e-Life Function a.d Disa.ility Instrument