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The Functiona. Redunda.cy of Neddyla.ion E2s a.d E3s in Modula.ing the Fitness of Regula.ory T Cells

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Resea.ch 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Ca.cer Institute(Key La.ora.ory of Ca.cer Prevention a.d Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Ca.cer Center of Zhejia.g University Hangzhou 310029China Zheja.g Provincia. Clinica. Resea.ch Center for Ca.cer Zhejang ProvinceChina Key La.ora.ory of Molecula. Biology in Medica. Sciences Zhejang ProvinceChina Resea.ch Center for Life Science a.d Huma. Hea.th Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddyla.ion is necessa.y for a.tiva.ion of Cullin-RING liga.es(CRLs),which degra.e va.ious immune regula.ory *** recent study showed tha. while depletion of neddyla.ion E2-E3 pa.r Ube2f-Sa. in regula.ory T(T_(reg))cells ha. no obvious phenotype,the sa.e depletion of either Ube2m or Rbx1 ca.sed infla.ma.ion disorders with different *** these E2s or E3s compensa.e ea.h other in functiona. regula.ions of T_(reg)cells is,however,previously *** this report,we genera.ed Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sa.^(fl/fl)double-null mice by simulta.eous deletion of both neddyla.ion E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe a.toimmune phenotypes tha. did Ube2m-null mice,indica.ing tha. Ube2m ma.kedly compensa.es Ube2f in T_(reg)*** minor worsened a.toimmune phenotypes seen a. the very ea.ly sta.e in Rbx1&Sa. double-null tha. Rbx1-null mice is likely due to a.rea.y severe phenotypes of the la.er,indica.ing a.minor compensa.ion of Rbx1 for *** RNa.profiling-ba.ed a.a.yses revea.ed tha. up-a.d down-regula.ions of few signa.ing pa.hwa.s in T_(reg)cells a.e a.socia.ed with the severity of a.toimmune ***,severer infla.ma.ion phenotypes seen in mice with double E3-null tha. with double E2-null T_(reg)cells indica.e a.neddyla.ion-independent mecha.ism of 2 E3s,a.so known to serve a. the RING component of CRLs in regula.ion of T_(reg)cell fitness.

关键词： Foxp3 infla.ma.ion ma.kedly

Tuning mecha.ica. beha.iors of highly enta.gled hydrogels with the ra.dom distribution of mobile enta.glements

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2024年第2期45卷 277-294页

作者： Jinlong LIU di LU Bin CHEN Depa.tment of Engineering Mecha.ics Zhejiang UniversityHangzhou 310027China Beijing System Design Institute of Electro-Mecha.ic Engineering Beijing 100854China Intelligent Robotic Resea.ch Center Zhejiang LaboratoryHangzhou 310027China Key La.ora.ory of Soft Ma.hines a.d Sma.t Devices of Zhejia.g Province Hangzhou 311100China

Highly enta.gled hydrogels exhibit excellent mecha.ica. properties,including high toughness,high stretcha.ility,a.d low *** considering the evolution of ra.domly distributed enta.glements within the polymer network upon mecha.ica. stretches,we develop a.constitutive theory to describe the la.ge stretch beha.iors of these *** the theory,we utilize a.representa.ive volume element(RVE)in the sha.e of a.cube,within which there exists a. a.era.ed cha.n segment a.ong ea.h edge a.d a.mobile enta.glement a. ea.h *** employing a. explicit method,we decouple the ela.ticity of the hydrogels from the sliding motion of their enta.glements,a.d derive the stress-stretch rela.ions for these *** present theoretica. a.a.ysis is in a.reement with experiment,a.d highlights the significa.t influence of the enta.glement distribution within the hydrogels on their *** a.so implement the present developed constitutive theory into a.commercia. finite element softwa.e,a.d the subsequent simula.ions demonstra.e tha. the exa.t distribution of enta.glements strongly a.fects the mecha.ica. beha.iors of the structures of these ***,the present theory provides va.ua.le insights into the deforma.ion mecha.ism of highly enta.gled hydrogels,a.d ca. a.d in the design of these hydrogels with enha.ced performa.ce.

关键词： highly enta.gled hydrogel constitutive theory enta.glement ga.ma.distribution

Effect of Modulus Heterogeneity on the Equilibrium Sha.e a.d Stress Field ofαPrecipita.e in Ti-6a.-4V

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1017-1028页

作者： di Qiu Rongpei Shi Ma.eria.s Genome Institute Shanghai UniversityShanghai200444China School of Ma.eria.s Science a.d Engineering Harbin Institute of TechnologyShenzhen518055China Sha.gha. Frontier Science Center of Mecha.oinforma.ics Shanghai UniversityShanghai200444China Zhejia.g La.ora.ory Hangzhou311100China

For media.with inclusions(e.g.,precipita.es,voids,reinforcements,a.d others),the difference in la.tice pa.a.eter a.d the ela.tic modulus between the ma.rix a.d inclusions ca.se stress concentra.ion a. the *** stress fields depend on the inclusions’size,sha.e,a.d distribution a.d will respond insta.tly to the evolving *** study develops a.pha.e-field model concerningmodulus *** effect of modulus heterogeneity on the growth process a.d equilibrium sta.e of theαpla.e in Ti-6a.-4V during precipita.ion is ***αprecipita.e exhibits strong a.isotropy in sha.e upon cooling due to the interpla. of the ela.tic stra.n a.d interfa.ia. *** ca.cula.ed orienta.ion of the ha.it pla.e using the homogeneous modulus ofαpha.e shows the sma.lest devia.ion fromtha. of the ha.it pla.e observed in the experiment,compa.ed to the ca.e where the homogeneous modulus ofβpha.e is *** a.dition,the equilibrium volume ofαpha.e within the systemusing homogeneousβmodulus exhibits the la.gest dependency on the a.plied *** stress fields a.ross theα/βinterfa.e a.e further ca.cula.ed under the a.sumption of modulus heterogeneity a.d compa.ed to those using homogeneous modulus of eitherαorβ*** study provides a. essentia. theoretica. ba.is for developing mecha.ics models concerning systems with heterogeneous structures.

关键词： Ela.tic heterogeneity ha.it pla.e stress field tita.ium pha.e-field simula.ion

Consistency of Tropospheric Wa.er Va.or between Rea.a.yses a.d Hima.a.i-8/a.I Mea.urements over Ea.t a.ia

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a.va.ces in a.mospheric Sciences 2024年第1期41卷 19-38页

作者： di di Jun LI Yunheng XUE Min MIN Bo LI Zhenglong LI Colla.ora.ive Innova.ion Center on Foreca.t a.d Eva.ua.ion of Meteorologica. disa.ters Nanjing University of Information Science and TechnologyNanjing 210044China Key La.ora.ory for a.rosol-Cloud-Precipita.ion China Meteorological AdministrationSchool of Atmospheric PhysicsNanjing University of Information Science and TechnologyNanjing 210044China FYSIC National Satellite Meteorological CenterChina Meteorological AdministrationBeijing 100081China Chengdu University of Informa.ion Science a.d Technology Chengdu 610225China School of a.mospheric Sciences a.d Gua.gdong Province Key la.ora.ory for Clima.e Cha.ge a.d Na.ura. disa.ter Studies Sun Yat-sen University and Southern Laboratory of Ocean Science and EngineeringZhuhai 519082China Coopera.ive Institute for Meteorologica. Sa.ellite Studies University of Wisconsin–MadisonMadison WI 53706WisconsinUSA Wuxi University Wuxi 214105China

High spa.iotempora. resolution ra.ia.ces from the a.va.ced ima.ers onboa.d the new genera.ion of geosta.iona.y wea.her sa.ellites provide a.unique opportunity to eva.ua.e the a.ilities of va.ious rea.a.ysis da.a.ets to depict multila.er tropospheric wa.er va.or(WV),thereby enha.cing our understa.ding of the deficiencies of WV in rea.a.ysis *** on da.ly mea.urements from the a.va.ced Hima.a.i Ima.er(a.I)onboa.d the Hima.a.i-8 sa.ellite in 2016,the bia. fea.ures of multila.er WV from six rea.a.ysis da.a.ets over Ea.t a.ia.a.e thoroughly *** a.sessments show tha. wet bia.es exist in the upper troposphere in a.l six rea.a.ysis da.a.ets;in pa.ticula.,these bia.es a.e much la.ger in ***,we find better depictions of WV in the middle troposphere tha. in the upper *** a.cura.y of WV in the ERa. da.a.et is the highest,in terms of the bia. ma.nitude,dispersion,a.d pa.tern *** cha.a.teristics of the WV bia. over the Tibeta. Pla.ea. a.e significa.tly different from those over other pa.ts of Ea.t *** a.dition,the rea.a.ysis da.a.ets a.l ca.ture the shift of the subtropica. high very well,with ERa. performing better overa.l.

关键词： a.I rea.a.ysis da.a.et multila.er wa.er va.or a.sessment ra.ia.ive tra.sfer model

Coordina.ion Mecha.ism a.d Empirica. Resea.ch on Ma.ine Science Technology Innova.ion a.d Ma.ine Eco-civiliza.ion:a.Ca.e Study of Coa.ta. a.ea. of China

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Chinese Geogra.hica. Science 2024年第3期34卷 468-486页

作者： CHEN Xia.long LIa.G Chenlu di Qia.bin School of Geogra.hica. Science Liaoning Normal UniversityDalian 116029China Institute of Ma.ine Susta.na.le Development Liaoning Normal UniversityDalian 116029China

Ma.ine science technology innova.ion provides power a.d gua.a.tees for ma.ine eco-civiliza.ion construction,which provides direction a.d ma.eria. support for ma.ine science technology ***,the coordina.ed development of the two is of grea. significa.ce to the ma.ine economy susta.na.le development in China.s coa.ta. *** the ba.is of cla.ifying the connota.ions of ma.ine science technology innova.ion a.d ma.ine eco-civiliza.ion in China.s coa.ta. a.ea. from 2006 to 2019,the mecha.ism for their coordina.ed development wa. a.a.ysed.a.comprehensive indica.or system ba.ed on the connota.ion of the two wa. constructed,a.d the coordina.ed development rela.ionship wa. empirica.ly tested using the coupled coordina.ion model a.d the pa.el vector a.toregressive(PVa.)*** results show tha.:1)the level of China.s coa.ta. ma.ine science technology innova.ion continues to improve,gra.ua.ly forming the core of the development of ma.ine science technology innova.ion in the north,ea.t a.d south of Sha.dong,Sha.gha. a.d Gua.gdong;the level of ma.ine eco-civiliza.ion development fluctua.ing upwa.d trend,showing obvious spa.ia. differentia.ion cha.a.teristics.2)The degree of coordina.ion of ma.ine science technology innova.ion a.d ma.ine eco-civiliza.ion is growing over *** is no ca.sa. rela.ionship between ma.ine science technology innova.ion a.d ma.ine eco-civiliza.ion in the northern ma.ine economic circle,but there is a.two-wa. ca.sa. rela.ionship between the two in the ea.tern a.d southern ma.ine economic circles.3)Ma.ine eco-civiliza.ion shows a.significa.t positive a.d continuous impa.t on ma.ine science technology innova.ion,a.d ma.ine science technology innova.ion shows a.long-term,continuous,fluctua.ing,a.d la.ging impa.t on ma.ine *** overa.l role of ma.ine eco-civiliza.ion on ma.ine science technology innova.ion is domina.t,a.d there a.e significa.t differences in the impa.t effects of the two ma.or ma.ine economic circles.

关键词： ma.ine science technology innova.ion ma.ine eco-civiliza.ion coordina.ed development coa.ta. a.ea. of China

Q-homotopy a.a.ysis method for time-fra.tiona. Newell–Whitehea. equa.ion a.d time-fra.tiona. genera.ized Hirota.Sa.suma.coupled KdV system

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Communica.ions in Theoretica. Physics 2024年第3期76卷 70-83页

作者： di Liu Qiongya.Gu Lizhen Wa.g Center for Nonlinea. Studies School of MathematicsNorthwest UniversityXi'an710127China

In this pa.er,two types of fra.tiona. nonlinea. equa.ions in Ca.uto sense,time-fra.tiona. Newell–Whitehea. equa.ion(FNWE)a.d time-fra.tiona. genera.ized Hirota.Sa.suma.coupled KdV system(HS-cKdVS),a.e investiga.ed by mea.s of the q-homotopy a.a.ysis method(q-Ha.).The a.proxima.e solutions of the proposed equa.ions a.e constructed in the form of a.convergent series a.d a.e compa.ed with the corresponding exa.t *** to the presence of the a.xilia.y pa.a.eter h in this method,just a.few terms of the series solution a.e required in order to obta.n better *** the sa.e of visua.iza.ion,the numerica. results obta.ned in this pa.er a.e gra.hica.ly displa.ed with the help of Ma.le.

关键词： fra.tiona. Newell-Whitehea. equa.ion fra.tiona. genera.ized Hirota.Sa.suma.coupled KdV system a.proxima.e solution q-homotopy a.a.ysis method

Recent progress of coba.t-ba.ed electroca.a.ysts for wa.er splitting: Electron modula.ion, surfa.e reconstitution, a.d a.plica.ions

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Na.o Resea.ch 2024年第4期17卷 2234-2269页

作者： Zhijia. Lia.g di Shen Lei Wa.g Hongga.g Fu Key La.ora.ory of Functiona. Inorga.ic Ma.eria. Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electroca.a.ytic wa.er splitting is a. essentia. a.d effective mea.s to produce green hydrogen energy structures,so it is necessa.y to develop non-precious meta. ca.a.ysts to repla.e precious ***-ba.ed ca.a.ysts present effective a.terna.ives due to the diverse va.ence sta.es,a.justa.le electronic structures,a.d plentiful *** this review,the ca.a.ytic mecha.isms of hydrogen evolution rea.tion(HER)a.d oxygen evolution rea.tion(OER)for electroca.a.ytic wa.er splitting a.e ***,the synthesis stra.egies of va.ious coba.t-ba.ed ca.a.ysts a.e systema.ica.ly summa.ized,followed by the rela.ionships between the structure a.d performa.ce ***,the effects of d-ba.d center a.d spin regula.ion for coba.t-ba.ed ca.a.ysts a.e a.so ***,the dyna.ic electronic a.d structura. devolution of coba.t-ba.ed ca.a.ysts a.e elucida.ed by combining a.series of in-situ ***,we highlight the cha.lenges a.d future developed directions of coba.t-ba.ed ca.a.ysts for electroca.a.ytic wa.er splitting.

关键词： coba.t-ba.ed electroca.a.ysts wa.er splitting electron modula.ion surfa.e reconfigura.ion

Time-va.ying pa.a.eters estima.ion with a.a.tive neura. network EKF for missile-dua. control system

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Journa. of Systems Engineering a.d Electronics 2024年第2期35卷 451-462页

作者： YUa. Yuqi ZHOU di LI Junlong LOU Cha.fei School of a.trona.tics Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Electronic System Engineering Beijing 100854China

In this pa.er, a.filtering method is presented to estima.e time-va.ying pa.a.eters of a.missile dua. control system with ta.l fins a.d rea.tion jets a. control va.ia.les. In this method, the long-short-term memory(LSTM) neura. network is nested into the extended Ka.ma. filter(EKF) to modify the Ka.ma. ga.n such tha. the filtering performa.ce is improved in the presence of la.ge model uncerta.nties. To a.oid the unsta.le network output ca.sed by the a.rupt cha.ges of system sta.es,a. a.a.tive correction fa.tor is introduced to correct the network output online. In the process of tra.ning the network, a.multi-gra.ient descent lea.ning mode is proposed to better fit the interna. sta.e of the system, a.d a.rolling tra.ning is used to implement a. online prediction logic. Ba.ed on the Lya.unov second method, we discuss the sta.ility of the system, the result shows tha. when the tra.ning error of neura. network is sufficiently sma.l, the system is a.ymptotica.ly sta.le. With its a.plica.ion to the estima.ion of time-va.ying pa.a.eters of a.missile dua. control system, the LSTM-EKF shows better filtering performa.ce tha. the EKF a.d a.a.tive EKF(a.KF) when there exist la.ge uncerta.nties in the system model.

关键词： long-short-term memory(LSTM)neura. network extended Ka.ma. filter(EKF) rolling tra.ning time-va.ying pa.a.eters estima.ion missile dua. control system

Comprehensive Exergoeconomic a.a.ysis a.d Optimiza.ion of a.Novel Zero-Ca.bon-Emission Multi-Genera.ion System ba.ed on Ca.bon dioxide Cycle

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Journa. of Therma. Science 2024年第3期33卷 1065-1081页

作者： SUN Ya. LI Hongwei Wa.G di DU Cha.ghe School of Energy a.d Power Engineering Northeast Electric Power UniversityJilin132012China School of a.toma.ion Engineering Northeast Electric Power UniversityJilin132012China Xi’a. Institute of Electromecha.ica. Informa.ion Technology Xi’an710065China

This pa.er a.ms to conduct a.comprehensive exergoeconomic a.a.ysis of a.novel zero-ca.bon-emission multi-genera.ion system a.d propose a.fa.t optimiza.ion method combined with ma.hine *** deta.led exergoeconomic a.a.ysis of a.novel combined power,freshwa.er a.d cooling multi-genera.ion system is performed in this *** exergoeconomic a.a.ysis model is esta.lished by exergy flow theory.a.comprehensive exergy,exergoeconomic a.d environmenta. a.a.ysis is ca.ried *** critica. decision va.ia.les a.e resea.ched to bring out effects on the multi-genera.ion system exergoeconomic performa.ce.a.novel fa.t optimiza.ion method combining genetic a.gorithm a.d Ba.ging neura. network is *** a.va.ced na.ure compa.ison is ma.e between the proposed system a.d four simila. *** displa. tha. increa.ing the turbine inlet tempera.ure ca. improve exergy efficiency a.d decrea.e the tota. product unit *** multi-genera.ion system exergy destruction directly determines exergy efficiency a.d tota. exergy destruction cost *** tota. product unit cost in the cost optima. design ca.e is reduced by 7.7%a.d 25%,respectively,compa.ed with exergy efficiency optima. design ca.e a.d ba.ic design *** with four simila. ca.es,the proposed multi-genera.ion system ha. grea. a.va.ta.es in thermodyna.ic performa.ce a.d exergoeconomic *** pa.er ca. provide resea.ch methods a.d idea. for performa.ce a.a.ysis a.d fa.t optimiza.ion of multi-genera.ion system.

关键词： wa.te hea. recovery exergoeconomic a.a.ysis supercritica. ca.bon dioxide optimiza.ion ma.hine lea.ning