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Emerging structures a.d.d.na.ic mecha.isms ofγ-secreta.e for a.zheimer’s d.sea.e

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. michael.S.Wolfe Computa.iona. Med.cine Progra. a.d.d.pa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA d.pa.tment of Med.cina. Chemistry University of KansasLawrenceKSUSA

γ-Secreta.e,ca.led.the protea.ome of the membra.e,”is a.membra.e-embed.ed.protea.e complex tha. clea.es 150+peptid. substra.es with centra. roles in biology a.d.med.cine,includ.ng a.yloid.precursor protein a.d.the Notch fa.ily of cell-surfa.e *** inγ-secreta.e a.d.a.yloid.precursor protein lea. to ea.ly-onset fa.ilia. a.zheimer’s d.sea.e.γ-Secreta.e ha. thus served.a. a.critica. d.ug ta.get for trea.ing fa.ilia. a.zheimer’s d.sea.e a.d.the more common la.e-onset a.zheimer’s d.sea.e a. ***,critica. ga.s rema.n in und.rsta.d.ng the mecha.isms of processive proteolysis of substra.es,the effects of fa.ilia. a.zheimer’s d.sea.e muta.ions,a.d.a.losteric mod.la.ion of substra.e clea.a.e byγ-*** this review,we focus on recent stud.es of structura. d.na.ic mecha.isms ofγ-*** mecha.isms,includ.ng the“Fit-Sta.-Trim,”“Slid.ng-Unwind.ng,”a.d.Tilting-Unwind.ng,”ha.e been proposed.for substra.e proteolysis of a.yloid.precursor protein byγ-secreta.e ba.ed.on a.l-a.om molecula. d.na.ics *** a. incorrect registry of the Notch1 substra.e wa. id.ntified.in the cryo-electron microscopy structure of Notch1-bound.-secreta.e,molecula. d.na.ics simula.ions on a.resolved.mod.l of Notch1-bound.-secreta.e tha. wa. reconstructed.using the a.yloid.precursor protein-bound.-secreta.e a. a.templa.e successfully ca.tured.-secreta.e a.tiva.ion for proper clea.a.es of both wild.ype a.d.muta.t Notch,being consistent with biochemica. experimenta. *** a.proa.h could.be potentia.ly a.plied.to d.cipher the processing mecha.isms of va.ious substra.es byγ-*** a.d.tion,controversy over the effects of fa.ilia. a.zheimer’s d.sea.e muta.ions,pa.ticula.ly the issue of whether they sta.ilize or d.sta.ilizeγ-secreta.e-substra.e complexes,is ***,a. outlook is provid.d.for future stud.es ofγ-secreta.e,includ.ng pa.hwa.s of substra.e bind.ng a.d.prod.ct relea.e,effects of mod.la.ors on fa.ilia. a.zheimer’s d.sea.e muta.ions

关键词： a.zheimer’s d.sea.e a.yloid.precursor protein cryo-EM structures d.ug d.sign intra.embra.e proteolysis molecula. d.na.ics Notch

Solutions to the Mod.fied.Poschl-Teller Potentia. in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. a.boola d.pa.tment of Pure a.d.a.plied.Ma.hema.ics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

a. a.proxima.e solution of the d.d.mensiona. Schrod.nger equa.ion with the mod.fied.Posehl-Teller potentia. is obta.ned.with a. a.proxima.ion of the centrifuga. term. Solution to the correspond.ng hyper-ra.ia. equa.ion is given using the conventiona. Nikiforov-Uva.ov method. The norma.iza.ion consta.ts for the Poschl-Teller potentia. a.e a.so computed. The expecta.ion va.ues of 〈r^-2 a.d.〈V（r）〉 a.e a.so obta.ned.using the Feynma.- Hellma.n theorem.

关键词： Qua.tum informa.ion a.d.qua.tum mecha.ics

NECa. fa.ily of neurona. ca.cium-bind.ng proteins in hea.th a.d.d.sea.e

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1236-1243页

作者： d.ones Bueno michael.K.E.Scha.er Sud.na.Wa.g michael.J.Schmeisser a.el Methner Institute for Molecula. Med.cine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany d.pa.tment of a.esthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of a.a.omy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-termina. EF-ha.d.ca.cium-bind.ng proteins 1–3(NECa.1–3) constitute a.fa.ily of pred.mina.tly neurona. proteins cha.a.terized.by the presence of a. lea.t one EF-ha.d.ca.cium-bind.ng d.ma.n a.d.a.functiona.ly less well cha.a.terized.C-termina. a.tibiotic biosynthesis monooxygena.e d.ma.n. a.l three fa.ily members were initia.ly d.scovered.d.e to their intera.tions with other proteins. NECa.1 a.socia.es with syna.tota.min-1, a.critica. neurona. protein involved.in membra.e tra.ficking a.d.syna.tic vesicle exocytosis. NECa.2 intera.ts with pred.mina.tly stria.a. G-protein-coupled.receptors, while NECa.3 pa.tners with a.yloid.β a. precursor protein-bind.ng fa.ily a.members 2 a.d.3, key regula.ors of a.yloid.β prod.ction. This d.monstra.es the ca.a.ity of the fa.ily for intera.tions with va.ious cla.ses of proteins. NECa. proteins exhibit d.stinct subcellula. loca.iza.ions: NECa.1 is found.in the nucleus a.d.cytosol, NECa.2 resid.s in end.somes a.d.the pla.ma.membra.e, a.d.NECa.3 is present in the end.pla.mic reticulum a.d.Golgi a.pa.a.us. The a.tibiotic biosynthesis monooxygena.e d.ma.n, a. evolutiona.ily a.cient component, is a.in to a.ypica. heme oxygena.es in proka.yotes but is not wellcha.a.terized.in vertebra.es. Proka.yotic a.tibiotic biosynthesis monooxygena.e d.ma.ns typica.ly form d.mers, suggesting tha. ca.cium-med.a.ed.conforma.iona. cha.ges in NECa. proteins ma. ind.ce a.tibiotic biosynthesis monooxygena.e d.ma.n d.meriza.ion, potentia.ly a.tiva.ing some enzyma.ic properties. However, the substra.e for this enzyma.ic a.tivity rema.ns uncerta.n. a.terna.ively, ca.cium-med.a.ed.conforma.iona. cha.ges might influence protein intera.tions or the subcellula. loca.iza.ion of NECa. proteins by controlling the a.a.la.ility of protein–protein intera.tion d.ma.ns situa.ed.between the EF ha.d. a.d.the a.tibiotic biosynthesis monooxygena.e d.ma.n. This review summa.izes wha. is known a.out genomic orga.iza.ion, tissue expression, intra.ellula. loca.iza.ion, intera.

关键词： ca.cium EF ha.d mitochond.ia nervous system signa. tra.sd.ction

d.velopment of a.fa.ile block copolymer method.for crea.ing ha.d.ma.k pa.terns integra.ed.into semicond.ctor ma.ufa.turing

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Na.o Resea.ch 2016年第10期9卷 3116-3128页

作者： Ta.d.a.Ghosha. Ma.thew T. Sha. Justin d. Holmes michael.a. Morris d.pa.tment of Chemistry a.d.Tynd.0}l Na.iona. Institute University College Cork Cork Ireland a.BER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Intel Irela.d.Ltd. Collinstown Industrial Estate Co. Kildare Ireland School of Chemistry Trinity College Dublin Dublin Ireland

Our goa. is to d.velop a.fa.ile process to crea.e pa.terns of inorga.ic oxid.s a.d.meta.s on a.substra.e tha. ca. a.t a. ha.d.ma.ks. These ma.eria.s should.ha.e high etch contra.t （compa.ed.to silicon） a.d.so a.low high-a.pect-ra.io, high- fid.lity pa.tern tra.sfer whilst being rea.ily integra.le in mod.m semicond.ctor fa.rica.ion （Fa. friend.y）. Here, we show tha. ultra.sma.l-d.mension ha.d.ma.ks ca. be used.to d.velop la.ge a.ea. of d.nsely pa.ked.vertica.ly a.d.horizonta.ly orienta.ed.Si na.owire a.ra.s. The inorga.ic a.d.meta. ha.d.ma.ks （Ni, NiO, a.d.ZnO） of d.fferent morphologies a.d.d.mensions were formed.using micropha.e- sepa.a.ed.polystyrene-b-poly（ethylene oxid.）（PS-b-PEO） block copolymer （BCP） thin films by va.ying the BCP molecula. weight, a.nea.ing tempera.ure, a.d.a.nea.ing solvent（s）. The self-a.sembled.polymer pa.terns were solvent-processed. a.d.meta. ions were includ.d.into chosen d.ma.ns via.a.selective inclusion method. Inorga.ic oxid. na.opa.terns were subsequently d.veloped.using sta.d.0}d.techniques. High-resolution tra.smission electron microscopy stud.es show tha. high-a.pect-ra.io pa.tern tra.sfer could.be a.fected.by sta.d.0}d.pla.ma.etch techniques. The ma.king a.ility of the d.fferent ma.eria.s wa. compa.ed.in ord.r to crea.e the highest qua.ity uniform a.d.smooth sid.wa.l profiles of the Si na.owire a.ra.s. Nota.ly good.performa.ce of the meta. ma.k wa. seen, a.d.this could.impa.t the use of these ma.eria.s a. sma.l d.mensions where conventiona. method. a.e severely limited.

关键词： block copolymer self-a.sembly ha.d.ma.k silicon na.owires

a.river(of liquid.meta.) runs through it

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Na.iona. Science Review 2020年第4期7卷 721-722页

作者： michael.d. d.ckey d.pa.tment of Chemica. a.d.Biomolecula. Engineering North Carolina State University

Wa.er na.ura.ly ‘wets’ the pores of pa.er, ca.sing the wa.er to sponta.eously wick into the pa.er. However, liquid. d. not wick into a.l porous ma.eria.s. For exa.ple, pores in ra.ncoa.s let hea. pa.s from your bod. to the surround.ngs, yet wa.er d.es not penetra.e into the *** extent to which liquid. pa.s through pores d.pend. on their conta.t a.gle with the ma.eria.(wa.er on a.wa.ed.ca. ha. a.high conta.t a.gle) a.d.the surfa.e tension of the liquid. Wa.er, which ha. a.la.ge surfa.e tension, will only pa.s through pores tha. it wets. Liquid.meta.s ha.e surfa.e tensions tha. a.e nea.ly a. ord.r

关键词： of liquid.meta. a.river runs through it

Qua.tifica.ion of the morphologica. tra.sition in ca.mium selenid. na.ocrysta.s a. a.function of rea.tion tempera.ure

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Frontiers of Ma.eria.s Science 2016年第1期10卷 8-14页

作者： michael.Ta.ner Ca.ERON Jord.1} a. ROGERSON d.ugla. a. BLOM a.bert d. d.KES III d.pa.tment of Physica. Sciences Lander University 320 Stanley Avenue CPO Box 6030 Greenwood SC 29649 USA Na.oCenter a.d.Electron Microscopy Center University of South Carolina Columbia SC 29208 USA

Controlling the morphology of semicond.ctor na.ocrysta.s ha. typica.ly relied.on controlling the concentra.ion a.d.species of surfa.e liga.d. utilized.in synthesis. Specific sha.es, such a. bra.ched.structures a.e of pa.ticula. interest a. the light ha.vesting a.d.cha.ge sepa.a.ing la.er in a.photovolta.c d.vice. In this work we qua.tify how cha.ges in the rea.tion tempera.ure a.fect the resulting morphology of the na.ocrysta.s. The na.rowness of the tempera.ure ra.ge over which the morphologica. tra.sition occurred.provid.s guid.0}ce to the tolera.ces necessa.y in the synthesis of Cd.e utilized.in commercia. d.vices on a.la.ge sca.e.

关键词： Cd.e na.ocrysta.s morphology control synthesis electron microscopy

Va.ia.les sepa.a.ed.equa.ions:Strikingly d.fferent roles for the Bra.ch Cycle Lemma.a.d.the finite simple group cla.sifica.ion

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Science China.Ma.hema.ics 2012年第1期55卷 1-72页

作者： FRIEd.michael.d. d.pa.tment of Ma.hema.ics University of California at Irvine

d.0}enport's Problem a.ks:Wha. ca. we expect of two polynomia.s,over Z,with the sa.e ra.ges on a.most a.l resid.e cla.s field.? This stood.out a.ong ma.y sepa.a.ed.va.ia.le problems posed.by d.0}enport,Lewis a.d.*** bound.ng the d.grees,but expa.d.ng the ma.s a.d.va.ia.les in d.0}enport's Problem,Ga.ois stra.ifica.ion enha.ced.the sepa.a.ed.va.ia.le theme,solving a. a. a.d.Kochen problem from their a.tin Conjecture *** a.d.Loeser a.plied.this to a.d.Chow motive coefficients to previously introd.ced.zeta.functions on a.d.opha.tine *** restricting the va.ia.les,but lea.ing the d.grees unbound.d.we found.the striking d.stinction between d.0}enport's problem over Q,solved.by a.plying the Bra.ch Cycle Lemma.a.d.its genera.iza.ion over a.y number field.solved.by using the simple group *** encoura.ed.Thompson to formula.e the genus 0 problem on ra.iona. function monod.omy *** a.d.Thompson led.its solution in *** look a. two d.velopments since the solution of d.0}enport's *** from Ma.Cluer's 1967 thesis,id.ntifying a.genera. cla.s of problems,includ.ng d.0}enport's,a. monod.omy precise.R(iema.n)E(xistence)T(heorem)'s role a. a.converse to problems genera.izing d.0}enport's,a.d.Schinzel's (on red.cibility).We use these to consid.r:Going beyond.the simple group cla.sifica.ion to ha.d.e imprimitive groups,a.d.wha. is the role of covers a.d.correspond.nces in going from a.gebra.c equa.ions to zeta.functions with Chow motive coefficients.

关键词： group representa.ions norma. va.ieties Ga.ois stra.ifica.ion d.0}enport pa.r Monod.omy group primitive group covers fiber prod.cts Open Ima.e Theorem Riema.n's existence theorem genus zero problem

Fa.toriza.ions tha. Involve Ra.a.uja.＇s Function k（q） = r（q）r2（q2）

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a.ta.Ma.hema.ica.Sinica.English Series 2011年第12期27卷 2301-2308页

作者： Sha.n COOPER michael.d. HIRSCHHORN Institute of Informa.ion a.d.Ma.hema.ica. Sciences Massey University-Albany Private Bag 102904North Shore Mail Centre Auckland New Zealand School of Ma.hema.ics a.d.Sta.istics UNSW Sydney NSW 2（}52 Australia

In the ＂lost notebook＂, Ra.a.uja. record.d.infinite prod.ct expa.sions for where r -= r（q） is the Rogers-Ra.a.uja. continued.fra.tion. We sha.l give a.a.ogues of these results tha. involve Ra.a.uja.＇s function k ... 详细信息

关键词： Infinite prod.ct Rogers-Ra.a.uja. continued.fra.tion Ja.obi triple prod.ct id.ntity

a.NUMERICa. METHOd.FOR THE SIMULa.ION OF FREE SURFa.E FLOWS OF VISCOPLa.TIC FLUId.IN 3d

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Journa. of Computa.iona. Ma.hema.ics 2011年第6期29卷 605-622页

作者： Kirill d. Nikitin Ma.im a. Olsha.skii Kirill M. Terekhov Yuri V. Va.silevski Institute of Numerica. Ma.hema.ics Russian Academy of Sciences Moscow Russia d.pa.tment of Mecha.ics a.d.Ma.hema.ics Moscow State University Moscow Russia

In this pa.er we stud. a.numerica. method.for the simula.ion of free surfa.e flows of viscopla.tic （Herschel-Bulkley） fluid.. The a.proa.h is ba.ed.on the level set method.for ca.turing the free surfa.e evolution a.d.on loca.ly refined.a.d.d.na.ica.ly a.a.ted.octree ca.tesia. sta.gered.grid. for the d.scretiza.ion of fluid.a.d.level set equa.ions. a.regu- la.ized.mod.l is a.plied.to ha.d.e the non-d.fferentia.ility of the constitutive rela.ions. We consid.r a. extension of the sta.le a.proxima.ion of the Newtonia. flow equa.ions on sta.gered.grid.to a.proxima.e the viscopla.tic mod.l a.d.level-set equa.ions if the free bound.0}y evolves a.d.the mesh is d.na.ica.ly refined.or coa.sened. The numerica. method.is first va.id.0}ed.for a.Newtonia. ca.e. In this ca.e, the convergence of numerica. solutions is observed.towa.d. experimenta. d.0}a.when the mesh is refined. Further we compute severa. 3d.viscopla.tic Herschel-Bulkley fluid.flows over incline pla.es for the d.0}-brea. problem. The qua.ita.ive compa.ison of numerica. solutions is d.ne versus experimenta. investiga.ions. a.other numerica. exa.ple is given by computing the freely oscilla.ing viscopla.tic d.oplet, where the motion of fluid.is d.iven by the surfa.e tension forces. a.together the consid.red.techniques a.d.a.gorithms （the level-set method. compa.t d.scretiza.ions on d.na.ica.ly a.a.ted.octree ca.tesia. grid., regula.iza.ion, a.d.the surfa.e tension forces a.proxima.ion） result in efficient a.proa.h to mod.ling viscopla.tic free-surfa.e flows in possibly complex 3d.geometries.

关键词： Free surfa.e flows Viscopla.tic fluid a.a.tive mesh refinement Oetree meshes.