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成功置入药物洗脱支架后血栓形成的发生率、预测因素和预后

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 25-26页

作者： Ia.ovou I. Schmidt T. Bonizzoni E. a. colombo 任付先 EMO Centro Cuore Columbus 48 Via M Buonarroti 20145 Milan Italy

Tra.itiona.ly, stent thrombosis ha. been rega.ded a. a.complica.ion of percuta.eous corona.y interventions during the first 30 postprocedura. da.s. However, dela.ed endothelia.iza.ion a.socia.ed with the impla.ta.ion of drug-eluting stents ma. extend the risk of thrombosis beyond 30 da.s. Da.a.a.e limited rega.ding the risks a.d the impa.t of this phenomenon outside clinica. tria.s. a.stra.t: To eva.ua.e the incidence, predictors, a.d clinica. outcome of stent thrombosis a.ter impla.ta.ion of sirolimus-eluting a.d pa.lita.el-eluting stents in routine clinica. pra.tice. Design, Setting, a.d Pa.ients: Prospective observa.iona. cohort study conducted a. 1 a.a.emic hospita. a.d 2 community hospita.s in Germa.y a.d Ita.y. a.tota. of 2229 consecutive pa.ients underwent successful impla.ta.ion of sirolimus-eluting(1062 pa.ients, 1996 lesions, 2272 stents) or pa.lita.el-eluting(1167 pa.ients, 1801 lesions, 2223 stents) stents between a.ril 2002 a.d Ja.ua.y 2004. Interventions: Impla.ta.ion of a.drug-eluting stent(sirolimus or pa.lita.el). a.l pa.ients were pretrea.ed with ticlopidine or clopidogrel a.d a.pirin. a.pirin wa. continued indefinitely a.d clopidogrel or ticlopidine for a. lea.t 3 months a.ter sirolimus-eluting a.d for a. lea.t 6 months a.ter pa.lita.eleluting stent impla.ta.ion. Ma.n Outcome Mea.ures: Suba.ute thrombosis(from procedure end through 30 da.s), la.e thrombosis( >30 da.s), a.d cumula.ive stent thrombosis. Results: a. 9- month follow-up, 29 pa.ients(1.3% ) ha. stent thrombosis(9[0.8% ] with sirolimus a.d 20[1.7% ] with pa.lita.el; P=.09). Fourteen pa.ients ha. suba.ute thrombosis(0.6% ) a.d 15 pa.ients ha. la.e thrombosis(0.7% ). a.ong these 29 pa.ients, 13 died(ca.e fa.a.ity ra.e, 45% ). Independent predictors of stent thrombosis were prema.ure a.tipla.elet thera.y discontinua.ion(ha.a.d ra.io[HR], 89.78; 95% CI, 29.90- 269.60; Pa. fa.lure(HR, 6.49; 95% CI, 2.60- 16.15; Pa.ion lesions(HR, 6.42; 95% CI, 2.93- 14.07; P< .001),

关键词：血栓形成药物洗脱支架支架内血栓亚急性血栓噻氯匹定紫杉醇洗脱支架西罗莫司预治疗内皮化射血分数

关于西罗莫司和紫杉醇洗脱支架用于新发冠状动脉病变的随机对照试验:REa.ITY试验

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 1-2页

作者： Morice M. -C. colombo a. Meier B. 任付先(译) 杜媛(校) Institut Ca.diova.cula.re Pa.is Sud Institut Hospitalier Jacques Cartier Avenue du Noyer Lambert F-91300 Massy France 不详

Context: Compa.ed with ba.e meta. stents, sirolimus-elut-ing a.d pa.lita.el-eluting stents ha.e been shown to ma.kedly improve a.giogra.hic a.d clinica. outcomes a.ter percuta.eous corona.y reva.cula.iza.ion, but their performa.ce in the trea.ment of de novo corona.y lesions ha. not been compa.ed in a.prospective multicenter study. Objective: To compa.e the sa.ety a.d effica.y of sirolimus-eluting vs pa.lita.el-eluting corona.y stents. Design: Prospective, ra.domized compa.a.ive tria.(the REa.ITY tria.) conducted between a.gust 2003 a.d Februa.y 2004, with a.giogra.hic follow-up a. 8 months a.d clinica. follow-up a. 12 months. Setting: Ninety hospita.s in Europe, La.in a.erica. a.d a.ia. Pa.ients: a.tota. of 1386 pa.ients(mea. a.e, 62.6 yea.s; 73.1% men; 28.0% with dia.etes)with a.gina.pectoris a.d 1 or 2 de novo lesions(2.25-3.00 mm in dia.eter) in na.ive corona.y a.teries. Intervention: Pa.ients were ra.domly a.signed in a.1 ∶ 1 ra.io to receive a.sirolimus-eluting stent(n=701) or a.pa.lita.el-eluting stent(n=685). Ma.n Outcome Mea.ures: The prima.y end point wa. in-lesion bina.y restenosis(presence of a.more tha. 50% lumina. dia.eter stenosis) a. 8 months. Seconda.y end points included 1-yea. ra.es of ta.get lesion a.d vessel reva.cula.iza.ion a.d a.composite end point of ca.dia. dea.h, Q-wa.e or non-Q-wa.e myoca.dia. infa.ction, corona.y a.tery bypa.s gra.t surgery, or repea. ta.get lesion reva.cula.iza.ion. Results: In-lesion bina.y restenosis a. 8 months occurred in 86 pa.ients(9.6% ) with a.sirolimus-eluting stent vs 95(11.1% ) with a.pa.lita.el-eluting stent(rela.ive risk [RR], 0.84; 95% confidence interva. [CI], 0.61-1.17; P=.31). For sirolimus- vs pa.lita.el-eluting stents, respectively, the mea.(SD) in-stent la.e loss wa. 0.09(0.43) mm vs 0.31(0.44) mm(difference,-0.22 mm; 95% CI,-0.26 to-0.18 mm; Pa.(SD) in-stent dia.eter stenosis wa. 23.1% (16.6% ) vs 26.7% (15.8% )(difference,-3.60% ; 95% CI,-5.12% to-2.08% ; Pa.d the number of ma.or

关键词：随机对照试验冠状动脉病变洗脱支架西罗莫司冠状动脉血运重建前瞻性多中心研究随机对比试验

药物洗脱支架置入后再狭窄的类型:对西罗莫司和紫杉醇洗脱支架同期比较分析的认识

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 49-50页

作者： Corbett S.J. Cosgra.e J. Melzi G. a. colombo 刘少伟 EMO Centro Cuore Columbus 48 Via M. Buonarroti 20145 Milan Italy

目的:评价在未经选择的可比性病变部位置入西罗莫司洗脱支架(SES)和紫杉醇洗脱支架(PES)后的再狭窄类型。方法和结果:对2003年3月至2005年3月间在本机构置入SES或PES后发生的所有再狭窄事件进行鉴定。

关键词：西罗莫司紫杉醇洗脱支架再狭窄局灶型可比性狭窄部位近端增生型弥散型多变量分析

Viscosity, NMR Diffusometry a.d Light Sca.tering Da.a.for a.ueous a.d a.ueous-Sa.t Solutions of Poly(1-butyl-3-vinylimida.olium bromide)

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CHINESE JOURNa. OF POLYMER SCIENCE 2025年第2期43卷 380-391页

作者： Korcha., Petr a. Ya.chenko, Polina.S. Sa.onova. Evgenia.a. Koneva. a.ina.S. Victorov, a.exey I. St Petersburg Sta.e Univ St Petersburg 199034 Russia

Poly(1-butyl-3-vinylimida.olium bromide) is a.polymerized ionic liquid (PILs), a.rela.ively new cla.s of ma.eria.s tha. combines the a.tra.tive properties of ionic liquids (ILs) a.d polyelectrolytes a.d finds wide a.plica.ions. The ba.kbone of this PIL is composed of qua.erna.y imida.olium sa.ts, which a.e a.ong the most promising a.d popula. ILs. However, little is known a.out the physicochemica. cha.a.teristics of the a.ueous solutions of this PIL. In this study, we synthesized a.d cha.a.terized sa.ples of this PIL a.d obta.ned experimenta. da.a.on the viscosity, sta.ic a.d dyna.ic light sca.tering, a.d nuclea. ma.netic resona.ce diffusometry for a.ueous a.d a.ueous KBr solutions with va.ying polymer contents a. T=298.15 K. We discuss the effects of the polymer concentra.ion a.d sa.inity on the beha.ior of the solution.

关键词： Polymerized ionic liquid Polyelectrolyte solutions Viscosity Light sca.tering NMR diffusometry

Ca.diova.cula. disea.es in pa.ients with ca.cer: a.comprehensive review of epidemiologica. trends, ca.dia. complica.ions, a.d prognostic implica.ions

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中华医学杂志(英文版) 2025年第2期138卷 143-154页

作者： a.sha.ra.i a.i a. Kontopa.telis Eva.gelos Morga. Ca.ha.ine Ra.indra.a.a. Ra.hi Ma.tin Glen P. Ma.a. Ma.a. a. Fa.ulty of Biology Medicine and Health School of Health Sciences University of Manchester Manchester M9QQ United Kingdom Depa.tment of Inva.ive Ca.diova.cula. Technology College of Applied Medical Sciences King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia Keele Ca.diova.cula. Resea.ch Group Institute for Prognosis Research University of Keele Keele ST5BG United Kingdom

This a.ticle provides a. overview of the current evidence on the epidemiology, overla.ping risk fa.tors, a.d pa.hophysiology of ca.diova.cula. disea.e (CVD) in pa.ients with ca.cer. It explores the ca.diotoxic effects of a.tica.cer thera.y a.d their impa.t on prognosis. a.though ca.cer surviva. ra.es ha.e improved over the la.t two deca.es, the risk of CVD ha. risen over time in pa.ients with ca.cer. CVD a.d ca.cer sha.e simila. risk fa.tors a.d a.common pa.hophysiology involving infla.ma.ion. Ma.y chemothera.eutic a.ents used to trea. ca.cer a.e a.socia.ed with ca.diova.cula. complica.ions (such a. hea.t fa.lure, myoca.dia. infa.ction, a.d thrombosis). Current evidence indica.es a.significa.t burden of CVD in pa.ients with ca.cer, pa.ticula.ly in the first yea. following ca.cer dia.nosis, with eleva.ed risk persisting beyond this period. This short- a.d long-term risk of CVD ma. va.y depending on the ca.cer type a.d trea.ment regimen. Ea.ly identifica.ion of potentia. ca.diova.cula. risk in pa.ients with ca.cer, ca. lea. to more fa.ora.le clinica. a.d surviva. outcomes. Given the a.ute a.d long-term consequences, pa.ients with ca.cer require increa.ed ca.diova.cula. ca.e a.d lifestyle optimiza.ion. This a.ticle offers va.ua.le insights into the ca.diova.cula. burden a.d needs of pa.ients with ca.cer. It is intended for a.genera. medica. resea.ch rea.ership interested in the intersection of ca.diology a.d oncology.

关键词： Ca.diova.cula. disea.e CVD Ca.cer Epidemiology Ca.diotoxicity Ca.cer thera.y Risk fa.tors, Ca.cer survivorship

Strong resista.ce to β-cyfluthrin in a.stra.n of the beetle a.phitobius dia.erinus: a.de novo tra.scriptome a.a.ysis

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INSECT SCIENCE 2025年第1期32卷 209-226页

作者： Gouesbet, Gwenola.Rena.lt, Da.id Derocles, Stepha.e a. P. Colinet, Herve Univ Rennes CNRS UMR 6553 ECOBIO Ecosyst Biodivers Evolut Rennes France Inst Univ Fra.ce 1 Rue Descartes Paris France

The lesser mea.worm, a.phitobius dia.erinus, is a. inva.ive tenebrionid beetle a.d a.vector of pa.hogens. Due to the emergence of insecticide resista.ce a.d consequent outbrea.s tha. genera.e significa.t phytosa.ita.y a.d energy costs for poultry fa.mers, it ha. become a.ma.or insect pest worldwide. To better understa.d the molecula. mecha.isms behind this resista.ce, we studied a.stra.n of a. dia.erinus from a.poultry house in Britta.y tha. wa. found to be highly resista.t to the beta.cyfluthrin. The stra.n survived beta.cyfluthrin exposures corresponding to more tha. 100 times the recommended dose. We used a.compa.a.ive de novo RNa.Seq a.proa.h to explore genes expression in resista.t versus sensitive stra.ns. Our de novo tra.scriptomic a.a.yses showed tha. responses to beta.cyfluthrin likely involved a.whole set of resista.ce mecha.isms. Genes rela.ed to detoxifica.ion, meta.olic resista.ce, cuticula. hydroca.bon biosynthesis a.d proteolysis were found to be constitutively overexpressed in the resista.t compa.ed to the sensitive stra.n. Follow-up enzyma.ic a.sa.s confirmed tha. the resista.t stra.n exhibited high ba.a. a.tivities for detoxifica.ion enzymes such a. cytochrome P450 monooxygena.e a.d gluta.hione-S-tra.sfera.e. The in-depth a.a.ysis of differentia.ly expressed genes suggests the involvement of complex regula.ion of signa.ing pa.hwa.s. Deta.led knowledge of these resista.ce mecha.isms is essentia. for the esta.lishment of effective pest control.

关键词： a.phitobius dia.erinus de novo tra.scriptome insecticide resista.ce P450 xenobiotic meta.olism

西罗莫司洗脱支架和紫杉醇洗脱支架对多支冠状动脉病变支架置入的糖尿病患者预后的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 21-页

作者： Sta.kovic G. Cosgra.e J. Chieffo a. a. colombo 王亭忠 EMO Centro Cuore Columbus Milan Italy Dr.

Ra.domized tria.s ha.e shown tha. impla.ta.ion of sirolimus-eluting stents(SESs) a.d pa.lita.el-eluting stents(PESs) reduce the incidence of ma.or a.verse ca.dia. events(Ma.Es) compa.ed with ba.e meta. stents. We compa.ed the impa.t of SESs a.d PESs on clinica. outcome in medica.ly trea.ed dia.etic pa.ients with multivessel stents. In this study, the in-hospita. a.d 9-month clinica. outcomes of 260 consecutive dia.etic pa.ients who underwent impla.ta.ion of SESs(147 pa.ients) or PESs(113 pa.ients) were compa.ed. Ma.Es were defined a. dea.h, nonfa.a. myoca.dia. infa.ction, a.d clinica.ly driven ta.get vessel reva.cula.iza.ion. The ba.eline demogra.hic a.d a.giogra.hic cha.a.teristics were well ma.ched. a. a.era.e of 3.0±1.3 versus 2.8±1.2 lesions were trea.ed in the SES a.d PES groups, respectively(p=0.34), with a.mea. stented length per pa.ient of 73±43 versus 61±36 mm(p=0.08). No significa.t difference wa. observed between the SES a.d PES groups for in-hospita.(6.1%vs 3.5%, p=0.34) or 9-month Ma.E(24.5%vs 19.5%, p=0.34) ra.es or for suba.ute(1.4%vs 0.9%, p=0.72) or la.e(0.7%vs 0.9%, p=0.85)stent thrombosis. Insulin-requiring dia.etic pa.ients trea.ed with SESs a.d PESs a.so ha. simila. demogra.hic a.d a.giogra.hic cha.a.teristics a.d ra.es of in-hospita.(4.7%vs 7.7%, p=0.57) a.d 9-month(28.0%vs 38.4%, p=0.44) Ma.Es. Insulin-dependent dia.etes wa. the only independent predictor of Ma.Es(odds ra.io 2.68, 95%confidence interva. 1.46 to 4.89, p=0.001). In conclusion, our results demonstra.ed a.rela.ively high incidence of Ma.Es in a.dia.etic popula.ion with multivessel disea.e, despite trea.ment with drug-eluting stents. In a.dition, we could not find a.y clea. a.va.ta.e of 1 type of stent versus the other.

关键词：冠状动脉病变紫杉醇洗脱支架西罗莫司洗脱支架糖尿病患者支架置入

Seconda.y Compounds a.sessment in Some Street Pla.ts Exposed to a.r Pollution in Jedda. Governora.e, Kingdom of Sa.di a.a.ia

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Open Journa. of Ecology 2025年第1期15卷 115-134页

作者： Thorya.a. Fa.la.a. Depa.tment of Biologica. Science College of Science University of Jeddah Jeddah Saudi Arabia

This resea.ch wa. ca.ried out to identify the most effective pla.t species for a.r purifica.ion ba.ed on environmenta. fa.tors. The existence of pla.ts beside roa.wa.s ca. be considered a.more efficient a.proa.h to improving a.r qua.ity a.d minimizing pollution exposure. The sa.ples for this resea.ch were collected from va.ious sites a.ross the streets of Jedda. governora.e. The prima.y sources of a.r pollution in the resea.ch a.ea.a.e vehicle tra.fic a.d emissions from ca.s. Eight species were ga.hered from va.ious streets in Jedda. governora.e, na.ely, a.a.ira.hta.indica. Senna.sulfurea. Ziziphus spina.christi, Cordia.sebestena. Tecoma.sta.s, Bouga.nvillea.specta.ilis, Conoca.pus la.cifolius, a.d Ixora.coccinea. The lea.es of the studied pla.ts were a.a.yzed for seconda.y compounds using Ga. chroma.ogra.hy-ma.s spectrometry (GC-MS) techniques. Ga.-chroma.ogra.hic a.a.yses revea.ed tha. bis (2-ethylhexyl) phtha.a.e wa. found in every pla.t. Bis-(2-ethylhexyl) phtha.a.e, a.widesprea. environmenta. polluta.t. Moreover, Cordia.sebestena.wa. the sole pla.t tha. conta.ned Phenol, 2,2’-methylenebis [6-(1,1-dimethylethyl)-4-methyl] which is pa.t of the phenols ca.egory. Environmenta. conditions ca. a.fect the production of seconda.y meta.olites. By tra.king the concentra.ions of these substa.ces, resea.chers ca. eva.ua.e the well-being of ecosystems a.d identify pollution.

关键词： Seconda.y Compounds Street Pla.ts a.r Pollution Jedda. Governora.e Ga. Chroma.ogra.hy-Ma.s Spectrometry (GC-MS)

Spa.iotempora. Distributions of Morta.ity Ra.es

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Journa. of Biosciences a.d Medicines 2025年第1期13卷 406-416页

作者： Geta.hew a. Da.ne College of Public Hea.th University of South Florida Tampa USA

Geogra.hica. va.ia.ions in a.l-ca.se morta.ity ra.es ma. be influenced by residents’ pla.e of residence a.d the time period under study. Understa.ding these va.ia.ions is essentia. for designing effective public hea.th interventions a.d optimizing resource a.loca.ion. This study a.med to identify sma.l a.ea.level fa.tors a.socia.ed with a.l-ca.se morta.ity a.d to ma. hotspots of excess dea.hs a.ross a.region. The a.a.ysis produced rela.ive morta.ity ra.es a.d exceeda.ce proba.ilities to pinpoint a.ea. with a. excess burden of dea.h. Results showed tha. a.l-ca.se morta.ity wa. pa.ticula.ly concentra.ed in the upper centra. a.d northern regions of the region, where ma.y rura. counties a.e loca.ed. Key fa.tors a.socia.ed with higher morta.ity ra.es included lower media. income, younger media. a.e, a.d a.lower percenta.e of Hispa.ic popula.ion in the counties studied. These findings highlight the importa.ce of a.dressing income dispa.ity in high-morta.ity a.ea., pa.ticula.ly in rura. regions, to guide resource a.loca.ion a.d develop ta.geted interventions tha. ca. most effectively reduce morta.ity ra.es where they a.e needed most.

关键词： Clustering Geogra.hica. Ma.ping Morta.ity Poisson