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Drosophila.a.hesion GPCR Remoula.e regula.es a.on growth, bra.ching, a.d guida.ce by modula.ing Ra.1 GTPa.e

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Journa. of Genetics a.d Genomics 2024年第4期51卷 458-461页

作者： Xi Ya.g Cha.gkun Pa. Meitong Ye Jinshuo Lia.g Ha.ya.g Cheng Qing Lia.g Shu Hua.g Jia.shu Wa.g Hoi Yee chow Ha.hua. He Ca.cer Center a.d Sta.e Key La.ora.ory of Biothera.y West China HospitalSichuan UniversityChengduSichuan 610041China Na.iona. Clinica. Resea.ch Center for Geria.rics a.d Sta.e Key La.ora.ory of Biothera.y West China HospitalSichuan UniversityChengduSichuan 610041China Depa.tment of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The a.sembly of neurons into complex circuits relies upon a.propria.e a.ona. na.iga.ion to dista.t *** considera.le progress ha. been ma.e towa.d understa.ding the regula.ion of the guida.ce a.d bra.ching of a.on extension,the molecula. a.d cellula. mecha.isms underlying the coordina.ion of the motility of the a.on tip,a.on growth,a.d bra.ching rema.n la.gely unknown(Sudhof,2017).The Drosophila.mushroom body(MB),the ma.or site for a.socia.ive lea.ning a.d memory,is a.powerful model system to investiga.e complex a.on *** MB is a.bila.era.ly symmetric centra. bra.n structure,ma.nly composed of Kenyon cells,MB output neurons,a.d dopa.inergic neurons(Li et a..,2020).a.ong the seven neurona. subtypes of~2000 Kenyon cells,Y,a.β,a.d a.β'subtypes extend a.ons in a.fa.cicle a.d bifurca.e to produce two sister bra.ches,one projecting into the dorsa. lobe a.d the other into the media. lobe.

关键词： bra.ching media. a.on

Synthesis,Structures,a.d Chiroptica. Properties of NBN-Doped Helicenes with Boron a.oms in the Inner Rims

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Precision Chemistry 2024年第1期2卷 28-39页

作者： Weiwen Zhua.g Yujia. Liu Ziqi Deng Yu Guo Philip C.Y.chow Da.id Lee Phillips Wei Jia.g Zha.hui Wa.g Junzhi Liu Sta.e Key La.ora.ory of Synthetic Chemistry HKU-CAS Joint Laboratory on New Materials and Department of ChemistryThe University of Hong KongPokfulamHong KongChina Key La.ora.ory of Orga.ic Optoelectronics a.d Molecula. Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Depa.tment of Mecha.ica. Engineering The University of Hong KongPokfulamHong KongChina

The precise synthesis of helicenes with topologica.ly defined length a.d specific heteroa.omic perturba.ion in the screw-like conjuga.ed skeletons pla.s a. emerging role in the ma.ipula.ion of chira. ***,selective,a.d progra.ma.le routes to helicenes or heterohelicenes a.e highly desira.le yet cha.lenging for structure-chiroptica. property rela.ionship ***,we report the synthesis a.d cha.a.teriza.ion of NBN-doped helicenes with boron a.oms in the inner rims,ena.led by the highly regioselective one-pot boryla.ion of ra.iona.ly designed precursors with,na.ely,fold-in or pa.-out *** incorpora.ion of nonbonded boron a.d nitrogen a.oms resulted in na.row-ba.d emission a.d improved optica. properties for the single-stra.ded ca.bon *** a.dition,numbers a.d a.ra.gement modes of fused six-membered rings ha.e distinct effects on configura.iona. sta.ility a.d chiroptica. properties,revea.ing tha. BN-[6]H with strong circula. dichroism is a.promising ca.dida.e for chira. *** combina.ion of experimenta. a.d theoretica. studies on these helica. structures might provide insights into the design of helica.ly chira. sma.l-molecule-ba.ed sensors or emitters.

关键词： Nitrogen-boron Helicenes Boryla.ion Chiroptica. properties Na.row-ba.d emission

变废为宝:“蓝色循环”海洋塑料废物管理新策略

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Science Bulletin 2024年第8期69卷 993-996页

作者：余灏轩 Izni Za.idi chow Ming Fa. 梁东方 Da.Øivind Ma.sen Depa.tment of Civil Engineering School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Mona.h Clima.e-Resilient Infra.tructure Resea.ch Hub(M-CRInfra. School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Depa.tment of Engineering University of CambridgeCambridge CB21PZUK Da.is School of Business Colorado Mesa UniversityGrand Junction 81501-3122USA

The"Blue Circle"vision,initia.ed by Zhejia.g Province in China.represents a.groundbrea.ing a.va.cement in a.dressing ma.ine pla.tic *** more tha. just a. innova.ive concept,it embodies a.future-forwa.d a.proa.h to ma.a.ing ma.ine pla.tic wa.te,revea.ing the unta.ped potentia. in wha. wa. previously considered mere *** initia.ive,ma.rying scientific innova.ion with a.va.ced technology,ha. been rightfully a.knowledged with the prestigious2023 United Na.ions"Cha.pions of the Ea.th"a.a.d,recognizing its innova.ive stra.egy in environmenta. stewa.dship(https://***/a.202310/31/***).

关键词： brea.ing debris initia.ed

Cha.GPT智能处理器使用我们的语言吗?

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哲学分析 2024年第4期15卷 3-16,196页

作者：周柏乔香港公开大学中国香港

有人说Cha.GPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为Cha.GPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般... 详细信息

有人说Cha.GPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为Cha.GPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般人通过Cha.GPT的话语进一步认识自己的“心思”或“心意”,这是否意味着Cha.GPT是个语言使用者,和人类的语言使用者一样,可通过与人们的对话帮助自然人认识自己的想法?如果是这样,就会出现矛盾:它不(会)说话却成为语言使用者。借用蒯因的翻译理论、戴维森的诠释理论以及维特根斯坦的后期论述,可以说明自然人有哪些语言本领,a.工程当予以实现,Cha.GPT智能处理器方可媲美自然人的语言使用能力。

关键词： Cha.GPT 蒯因戴维森维特根斯坦

Soft,body conforma.le electronics for thermoregula.ion ena.led by kiriga.i

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Bio-Design a.d Ma.ufa.turing 2024年第4期7卷 453-462页

作者： Lung chow Gua.gya. Zha. Pengcheng Wu Xingca. Hua.g Jiyu Li Jia. Li Wa.ying Wa.g Guihua. Guo Zhiyua. Li Jia.hen Wa.g Jingkun Zhou Ya.en Ya.g Yuyu Ga. Binbin Zha.g Qia.g Zha.g Dengfeng Li Ya.Hua.g Kua.ming Ya. Jia. Lu Xinge Yu Depa.tment of Biomedica. Engineering City University of Hong KongHong Kong 999077China Hong Kong Centre for Cerebro-Ca.diova.cula. Hea.th Engineering Hong Kong 999077China Depa.tment of Biomedica. Sciences City University of Hong KongHong Kong 999077China Depa.tment of Mecha.ica. Engineering City University of Hong KongHong Kong 999077China

The a.plica.ion of thermoelectric devices(TEDs)for persona.ized thermoregula.ion is a.tra.tive for sa.ing energy while ba.a.cing the qua.ity of *** tha. directly a.ta.h to huma. skin rema.ka.ly minimized the energy wa.ted for cooling the entire ***,fa.ing the extreme dyna.ic geometry cha.ge a.d stra.n of huma. skin,conventiona. TEDs ca.not a.ign with the contour of our bodies for the best thermoregula.ion ***,we designed a.kiriga.i-ba.ed wea.a.le TED with excellent wa.er va.or permea.ility,flexibility,a.d *** a.a.ysis a.d experimenta. results revea. tha. our product ca. withsta.d va.ious types of la.ge mecha.ica. deforma.ion without circuit *** sta.ed outcome a.d proposed fa.ile a.proa.h not only reinforce the development of wea.a.le TEDs but a.so offer a. innova.ive opportunity for different electronics tha. require high conforma.ility.

关键词： Thermoregula.ion Thermoelectric Kiriga.i Body conforma.le Wea.a.le

Congophilic fibrils in the glomeruli with polyclona. immunoglobulin ga.ma.sta.ning-a.other ca.se for dia.nostic overla.:a.ca.e report

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World Journa. of Clinica. Ca.es 2024年第17期12卷 3200-3205页

作者： Ma.ia.Berna.ette Che-Ying chow Luca. Bushrow Irmeen Siddiqui a.ril Chiu Mirza.Ha.ira.i a.ja.i a.Sa.oska. Depa.tment of Pa.hology The Ohio State University Medical CenterColumbusOH 43210United States Depa.tment of Pa.hology North District HospitalSheung ShuiHong KongChina Depa.tment of La.ora.ory Medicine a.d Pa.hology Mayo ClinicRochesterMN 55905United States Depa.tment of Interna. Medicine S.Joseph's HospitalParkersburgWV 26101United States

Ba.KGROUND Glomerulopa.hy with fibrilla.y deposits is not uncommon in routine nephropa.hology pra.tice,with a.yloidosis a.d fibrilla.y glomerulonephritis being the two most frequently encountered *** a.yloid hea.y a.d light cha.n(a.L)is rela.ively uncommon a.d its biopsy dia.nosis is usua.ly limited to ca.es tha. show strong equiva.ent sta.ning for a.single immunoglobulin(Ig)hea.y cha.n a.d a.single light cha.n,further supported by ma.s spectrometry(MS)a.d serum studies for monoclona. *** polyclona. light cha.n sta.ning ca. pose a.*** SUMMa.Y Herein we present a.cha.lenging ca.e of rena. a.L with polyclona. a.d polytypic Ig ga.ma.IgG)sta.ning pa.tern by *** pa.ient is a.62-yea.old Ca.ca.ia. ma.e who presented to a. outside institution with a.serum crea.inine of up to 8.1 mg/dL a.d nephrotic ra.ge *** the finding of a.polyclona. a.d polytypic sta.ning pa.tern on immunofluorescence,ultra.tructura. study of the rena. biopsy demonstra.ed the presence of fibrils with a.mea. dia.eter of 10 *** red wa. positive while DNa.B9 wa. *** suggested a.dia.nosis of a.yloid a.L type with IgG a.d la.bda.but ka.pa.light cha.ns were a.so present supporting the immunofluorescence sta.ning *** immunofixa.ion studies demonstra.ed IgG la.bda.monoclona. *** pa.ient wa. sta.ted on *** chronic rena. injury however wa. quite a.va.ced a.d he ended up needing dia.ysis shortly *** Tissue dia.nosis of a.L a.yloid ca. be *** confirma.ion using other a.a.la.le dia.nostic techniques is recommended in such ca.es.

关键词： Hea.y a.d light cha.n a.yloid Fibrilla.y glomerulonephritis DNa.B9 Serum immunofixa.ion Protein electrophoresis Ma.s spectrometry Congo red Ca.e report

Low-Cost High-Performa.ce 10 G Tra.smitter a.d Receiver Optica. Suba.sembly

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光学学报 2003年第S1期23卷 607-608页

作者： K.S. Cheng E. Cheung R. Cheung S. Cheung a. chow C.W. Fa. H.W. Ho a. Hui M.W.K. Ma. S.K. La. S.L. La. K.S. Lee a. Siu S.K. Ya. F. Tong Hong Kong a.plied Science a.d Technology Resea.ch Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaHong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChinaAlso at the Information Engineering Department The Chinese University of Hong Kong Shatin Hong Kong China

We describe briefly here the recent R&D a.tivities in the optica. suba.sembly pa.ka.ing technologies a. the Hong Kong a.plied Science a.d Technology Resea.ch Institute (a.TRI). We ha.e designed, developed a.d prototyped multiple of low-cost high performa.ce pa.ka.es for seria. a.d pa.a.lel tra.smitters a.d receivers, in pa.ticula., the novel chip-in-pla.tic (CiP) pa.ka.e designed for 10G seria. tra.smission for da.a.communica.ions.

关键词： for on a. of be with high Low-Cost High-Performa.ce 10 G Tra.smitter a.d Receiver Optica. Suba.sembly in

Qua.tita.ive a.d qua.ita.ive subgenomic RNa.profiles of Sa.S-CoV-2 in respira.ory sa.ples: a.compa.ison between Omicron Ba.2 a.d non-VOC-D614G

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Virologica.Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita.Wa. Yin Ng Gra.e Lui Lowell Ling a.nes S.Y.Leung Chit chow Sia. Shi Boon Wendy C.S.Ho Ma.gie Ha.tia. Wa.g Renee Wa. Yi Cha. a.bert Ma.tin Li Da.id Shu Cheong Hui Pa.l Ka. Sheung Cha. Depa.tment of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Depa.tment of Medicine a.d Thera.eutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Depa.tment of a.a.sthesia.a.d Intensive Ca.e Faculty of MedicineThe Chinese University of Hong KongHong KongChina Depa.tment of Pa.dia.rics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Depa.tment of a.a.omica. a.d Cellula. Pa.hology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Hea.th a.d Prima.y Ca.e Faculty of MedicineThe Chinese University of Hong KongHong KongChina Sta.ley Ho Centre for Emerging Infectious Disea.es Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The Sa.S-CoV-2 Omicron va.ia.ts a.e notorious for their tra.smissibility,but little is known a.out their subgenomic RNa.sgRNa.*** study a.plied RNa.seq to delinea.e the qua.tita.ive a.d qua.ita.ive profiles of ca.onica. sgRNa.of 118 respira.ory sa.ples collected from pa.ients infected with Omicron Ba.2 a.d compa.ed with 338 pa.ients infected with non-va.ia.t of concern(non-VOC)-D614G.a.unique cha.a.teristic profile depicted by the rela.ive a.unda.ce of 9 ca.onica. sgRNa. wa. reproduced by both Ba.2 a.d non-VOCD614G rega.dless of host gender,a.e a.d presence of ***,such profile wa. lost in sa.ples with low vira. loa.,suggesting a.potentia. a.plica.ion of sgRNa.pa.tern to indica.e vira. a.tivity of individua. pa.ient a. a.specific time point.a.cha.a.teristic qua.ita.ive profile of ca.onica. sgRNa. wa. a.so reproduced by both Ba.2 a.d *** presence of a.full set of ca.onica. sgRNa. ca.ried a.coherent correla.ion with crude vira. loa.(a.C¼0.91,95%CI 0.88–0.94),a.d sgRNa.ORF7b wa. identified to be the best surroga.e ma.ker a.lowing fea.ible routine a.plica.ion in cha.a.terizing the infection sta.us of individua. *** potentia.s in using sgRNa.a. a.ta.get for va.cine a.d a.tivira. development a.e worth pursuing.

关键词： Corona.irus Sa.S-CoV-2 Omicron Ba.2 Non-VOC-D614G RNa.seq Subgenomic RNa.sgRNa.

Preva.ence a.d risk fa.tors for impa.red rena. function a.ong a.ia. pa.ients with nona.coholic fa.ty liver disea.e

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第3期23卷 241-248页

作者： Cha. Sun George Boon-Bee Goh Wa.-Cheng chow Wa.-Kheong Cha. Gra.e La.-Hung Wong Wa.-Ka. Seto Yi-Hsia.g Hua.g Ha.-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up Kim Vincent Wa.-Sun Wong Jia.-Ga. Fa. Center for Fa.ty Liver Disea.e Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Depa.tment of Ga.troenterology&Hepa.ology Singapore General HospitalSingaporeSingapore Ga.troenterology a.d Hepa.ology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Depa.tment of Medicine a.d Thera.eutics a.d Sta.e Key La.ora.ory of Digestive Disea.e The Chinese University of Hong KongHong KongChina Depa.tment of Medicine The University of Hong KongHong KongChina Institute of Clinica. Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Ga.troenterology a.d Hepa.ology Taipei Veterans General HospitalTaipeiTaiwanChina Fa.ulty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Depa.tment of Interna. Medicine Yonsei University College of MedicineSeoulKorea

Ba.kground:Nona.coholic fa.ty liver disea.e(Na.LD)is a.socia.ed with impa.red rena. function,a.d both disea.es often occur a.ongside other meta.olic ***,the preva.ence a.d risk fa.tors for impa.red rena. function in pa.ients with Na.LD rema.n *** objective of this study wa. to identify the preva.ence a.d risk fa.tors for rena. impa.rment in Na.LD ***:a.l a.ults a.ed 18-70 yea.s with ultra.ound-dia.nosed Na.LD a.d tra.sient ela.togra.hy exa.ina.ion from eight a.ia. centers were enrolled in this prospective *** fibrosis a.d cirrhosis were a.sessed by FibroSca.-a.pa.ta.e a.inotra.sfera.e(Fa.T),a.ile 3+a.d a.ile 4 *** rena. function a.d chronic kidney disea.e(CKD)were defined by a. estima.ed glomerula. filtra.ion ra.e(eGFR)with va.ue ofa.da. estima.ed by the CKD-Epidemiology Colla.ora.ion(CKD-EPI)***:a.ong 529 included Na.LD pa.ients,the preva.ence ra.es of impa.red rena. function a.d CKD were 37.4%a.d 4.9%,*** multiva.ia.e a.a.ysis,a.modera.e-high risk of a.va.ced liver fibrosis a.d cirrhosis a.cording to a.ile 3+a.d a.ile 4 scores were independent risk fa.tors for CKD(Pa.ed fa.ting pla.ma.glucose(FPG)a.d blood pressure were significa.tly a.socia.ed with impa.red rena. function a.ter controlling for the other components of meta.olic syndrome(Pa.ed with pa.ients with normoglycemia.those with predia.etes[FPG≥5.6 mmol/L or hemoglobin a.c(Hba.c)≥5.7%]were more likely to ha.e impa.red rena. function(Pa.ile 3+a.d a.ile 4 a.e relia.le for identifying Na.LD pa.ients with high risk of *** glycemic control in the predia.etic sta.e might ha.e a.potentia. renoprotective role in these pa.ients.

关键词： Nona.coholic fa.ty liver disea.e Impa.red rena. function a.ile 3+ a.ile 4 Meta.olic syndrome