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On the roa. towa.ds the globa. a.a.ysis of huma. syna.ses

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Neura. Regenera.ion Resea.ch 2017年第10期12卷 1586-1589页

作者： G.a.eph prieto Ca.l W.Cotma. Institute for Memory Impa.rments a.d Neurologica. Disorders University of CaliforniaIrvineCAUSA

Syna.ses a.e essentia. units for the flow of informa.ion in the *** the la.t 70 yea.s,syna.ses ha.e been widely studied in multiple a.ima. models including worms,fruit flies,a.d *** compa.ison,the study of huma. syna.ses ha. evolved significa.tly slower,ma.nly beca.se of technica. ***,three novel methods a.lowing the a.a.ysis of molecula.,morphologica.,a.d functiona. properties of huma. syna.ses ma. expa.d our knowledge of the huma. ***,we briefly describe these methods,a.d eva.ua.e how the informa.ion provided by ea.h unique a.proa.h ma. contribute to the functiona. a.d a.a.omica. a.a.ysis of the syna.tic component of huma. bra.n *** pa.ticula.,using tissue from cryopreserved huma. bra.ns,syna.tic pla.ticity ca. be studied in isola.ed syna.tosomes by fluorescence a.a.ysis of single-syna.se long-term potentia.ion（Fa.S-LTP）,a.d subpopula.ions of syna.ses ca. be thoroughly a.sessed in the ribbons of bra.n tissue by a.ra. tomogra.hy（a.）.Currently,it is a.so possible to qua.tify syna.tic density in the living huma. bra.n by positron emission tomogra.hy（PET）,using a.novel syna.tic ***,da.a.provided by Fa.S-LTP,a.,a.d PET ma. significa.tly contribute to the globa. understa.ding of syna.tic structure a.d function in both hea.thy a.d disea.ed huma. bra.ns,thus directly impa.ting tra.sla.iona. resea.ch.

关键词： fluorescence a.a.ysis of single-syna.se long-term potentia.ion a.ra. tomogra.hy positron emission tomogra.hy syna.tosomes flow cytometry microscopy [11C]UCB-J[(R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3 4 5-trifluorophenyl)pyrrolidin-2-one]

a.va.cing Ea.ly Detection of Colorecta. a.enoma.ous Polyps via.Genetic Da.a.a.a.ysis: a.Hybrid Ma.hine Lea.ning a.proa.h

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Journa. of Computer a.d Communica.ions 2024年第7期12卷 23-38页

作者： a.med S. Ma.la. Moha.ed a. Ma.dy a.er Ma.ki Noboru Niki a.da.la. a. Moha.ed Computer Science Depa.tment College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Informa.ion Systems Depa.tment Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Computer Science Depa.tment Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Institute of a.va.ced Science a.d Technology Tokushima University Tokushima Japan Informa.ion Systems Depa.tment College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Ma.hema.ics a.d Computer Science Depa.tment Faculty of Science Menoufia University Menoufia Egypt

In this study, a.hybrid ma.hine lea.ning (HML)-ba.ed a.proa.h, incorpora.ing Genetic da.a.a.a.ysis (GDa., is proposed to a.cura.ely identify the presence of a.enoma.ous colorecta. polyps (a.RP) which is a.crucia. ea.ly detector of colorecta. ca.cer (CRC). The present study develops a.cla.sifica.ion ensemble model ba.ed on tuned hyperpa.a.eters. Surpa.sing a.cura.y percenta.es of ea.ly detection a.proa.hes used in previous studies, the current method exhibits exceptiona. performa.ce in identifying a.RP a.d dia.nosing CRC, overcoming limita.ions of CRC tra.itiona. methods tha. a.e ba.ed on error-prone ma.ua. exa.ina.ion. Pa.ticula.ly, the method demonstra.es the following CRP identifica.ion a.cura.y da.a. 97.7 ± 1.1, precision: 94.3 ± 5, reca.l: 96.0 ± 3, F1-score: 95.7 ± 4, specificity: 97.3 ± 1.2, a.era.e a.C: 0.97.3 ± 0.02, a.d a.era.e p-va.ue: 0.0425 ± 0.07. The findings underscore the potentia. of this method for ea.ly detection of a.RP a. well a. clinica. use in the development of CRC trea.ment pla.ning stra.egies. The a.va.ta.es of this a.proa.h a.e highly expected to contribute to the prevention a.d reduction of CRC morta.ity.

关键词： Colorecta. a.enoma.Detection Colorecta. Ca.cer Dia.nosis Hybrid Ma.hine Lea.ning Genetics a.a.ysis

Combina.ion of Interlea.ed Single-input Multiple-output DC-DC Converters

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CSEE Journa. of Power a.d Energy Systems 2022年第1期8卷 132-142页

作者： Ela.io Dur´a. a.a.da.Sa.va.or P´erez Litr´a. Ma.´ıa.Bella.Ferrera.prieto Electronic Engineering Computer Systems and Automation DepartmentUniversity of HuelvaHuelvaSpain Electrica. a.d Therma. Engineering Design and Projects DepartmentUniversity of HuelvaHuelvaSpain

This pa.er a.a.yses,simula.es a.d verifies a. experimenta. prototype of a.four-pha.e interlea.ed DC-DC *** is ba.ed on a.SEPIC-Cuk *** developed prototype ha. been used in single-input multiple-output(SIMO)*** combined converter a.lows obta.ning dua. output volta.es of the sa.e va.ue,from a.single input DC volta.e a.d with only a.power *** interlea.ed DC-DC converters a.hieve a.better dyna.ic response a.d low ripple,ma.nta.ning their *** converter is connected in pa.a.lel,thereby ma.a.ing their losses by distributing them between more components,which fa.ilita.es the therma. ma.a.ement of the multipha.e converter a.d a.lows ha.dling high power va.ues in sma.l sizes with respect to solutions for a.single *** control stra.egies were a.plied:synchronous opera.ion mode(SOM)a.d interlea.ed opera.ion mode(IOM).The simula.ion results a.low the compa.ison of both opera.iona. modes,verifying tha. the IOM presents a.va.ta.es with respect to the ripple a. the input a.d output *** experimenta. prototype wa. designed for a.distributed power a.chitecture a.d bipola. DC microgrid(MG).

关键词： Bipola. DC DC-DC converter interlea.ed

Gene thera.y of liver ca.cer

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World Journa. of Ga.troenterology 2006年第38期12卷 6085-6097页

作者： Ruben Herna.dez-a.coceba.Bruno Sa.gro Jesus prieto Division of Gene Thera.y a.d Hepa.ology School of Medicine Foundation for Applied Medical Research-CIMA University of Navarra Spain Depa.tment of Medicine Clinica Universitaria University of Navarra Spain Division of Gene Thera.y a.d Hepa.ology School of Medicine Foundation for Applied Medical Research-CIMA University of Navarra Spain Department of Medicine Clinica Universitaria University of Navarra Spain

The a.plica.ion of gene tra.sfer technologies to the trea.ment of ca.cer ha. led to the development of new experimenta. a.proa.hes like gene directed enzyme/pro- drug thera.y (GDEPT), inhibition of oncogenes a.d restora.ion of tumor-suppressor genes. In a.dition, gene thera.y ha. a.big impa.t on other fields like ca.cer immunothera.y, a.ti-a.giogenic thera.y a.d virothera.y. These stra.egies a.e being eva.ua.ed for the trea.ment of prima.y a.d meta.ta.ic liver ca.cer a.d some of them ha.e rea.hed clinica. pha.es. We present a.review on the ba.is a.d the a.tua. sta.us of gene thera.y a.proa.hes a.plied to liver ca.cer.

关键词： Gene thera.y Ca.cer Liver Hepa.ocellula. ca.cinoma Vector Thera.eutic gene

短吻三线舌鳎、褐斑三线舌鳎和紫斑舌鳎种类的有效性厘定

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水产学报 2024年第3期48卷 109-117页

作者：孔晓瑜罗海容 THOMa. a. Munroe 中国科学院南海海洋研究所中国科学院热带海洋生物资源与生态重点实验室广东省应用海洋生物学重点实验室美国史密斯自然博物馆国家系统研究室

舌鳎属有些种类形态特征高度相似，导致了鉴定困难和种类的混乱，例如短吻三线舌鳎(Cynoglossusa.brevia.us, Gra., 1834)、褐斑三线舌鳎(C. trigra.mus, Günther,1862)和紫斑舌鳎(C. purpureoma.ula.us,Rega.,1905)的种类有效性和种间关系就存在三种观点：仅短吻三线舌鳎为有效种；短吻三线舌鳎和褐斑三线舌鳎均为有效种，而紫斑舌鳎是褐斑三线舌鳎的次同物异名；三个名义种均为有效种。为了解决这一分类混乱，本研究对三种舌鳎的原始描述、自测的模式标本和中国大陆沿海采集标本的28个形态特征和分子条形码进行了比较分析。结果显示，8个可数和16个可量特征的比例值以及2个描述性状在三个种之间为一致、包含、大部分重叠的关系；只有2个描述特征存在差异，一个是在吻长较上眼上缘距背鳍基部的长度特征上，短吻三线舌鳎和紫斑舌鳎为略长、等长或略短于的连续特征值，而褐斑三线舌鳎为明显大于；另一个差异是体表的花色差异，紫斑舌鳎体长一般小于200 mm，且具有明显的斑纹，短吻三线舌鳎体长一般大于200 mm，且随着体长增加，斑点逐渐淡化或者无斑，而不同体长的褐斑三线舌鳎在头后和身体前3/4均具有明显的零星褐色斑纹。COⅠ分子条形码结果显示，短吻三线舌鳎和紫斑舌鳎的遗传距离为0.000～0.002，为种内差异;褐斑三线舌与其他两种舌鳎之间的遗传距离为0.141～0.145，为种间差异。研究表明，短吻三线舌鳎和褐斑三线舌鳎是有效种，紫斑舌鳎是短吻三线舌鳎的次同物异名。本研究结果为鲽形目鱼类的正确分类提供了科学依据。

关键词：鲽形目舌鳎科形态特征有效性 COⅠ条形码

Improvement of a.tivities of Da.ly Living (a.L) for Pa.ients Trea.ed in Skilled Nursing Fa.ilities (SNFs)

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Open Journa. of Thera.y a.d Reha.ilita.ion 2024年第1期12卷 61-69页

作者： Ja.en a. Silver Sea. R. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Self-ca.e ta.ks or a.tivities of da.ly living (a.L)’s performa.ce a.e often disrupted a.ter a. older a.ult susta.ns a. injury or illness, which ca. be a.determining fa.tor for discha.ge pla.ement a.ter hospita.iza.ion, or it ca. determine the level of a.sista.ce required a.ter discha.ge from a.skilled nursing fa.ility (SNF). We believe tha. comprehensive reha.ilita.ion ca. improve a.pa.ient’s overa.l functioning during their short term sta. in SNFs. The purpose of this study is to determine if a. individua.’s level of independence improved a.ter a.mission to a.skilled nursing fa.ility a.d procurement of reha.ilita.ion services. Methods: This study retrospectively reviewed 4612 nursing home pa.ients in Ca.ifornia.who underwent reha.ilita.ive services a. skilled nursing fa.ilities to determine how the pa.ients responded to their environments, thera.y interventions, a.d a.y other a.ditiona. supportive mea.ures. The records of pa.ients who were a.mitted for short-term reha.ilita.ion were reviewed in a.blinded fa.hion, looking specifica.ly a. Section GG of the Minimum Da.a.Set (MDS). Self-Ca.e Section GG scores recorded by reha.ilita.ive sta.f provide objective da.a.a.d mea.ure pa.ients’ levels of a.sista.ce tha. were required. Ea.h a.tivity is scored from 1, being completely dependent, to 6, being entirely independent, with va.ying levels of a.sista.ce with scores in between. The a.mission scores versus the discha.ge scores ca. be compa.ed to determine if a.pa.ient improved their level of functioning upon discha.ge. Results: Utilizing the Pea.son’s correla.ion coefficient, a.strong correla.ion of improvement in a.L performa.ce on Section GG between the a.mission a.d discha.ge scores wa. identified, implying significa.t improvement in functiona. independence upon discha.ge. The a.era.e percent improvement for Ma.a.ed Ca.e pa.ients wa. ~35.4% a.d ~39.4% for Medica.e pa.ients. Conclusions: The results support the benefits of reha.ilita.ion services in skilled n

关键词： a.tivities of Da.ly Living Skilled Nursing Fa.ilities Reha.ilita.ion Independent Living

a.Review of Biochemica. Processes a.d Techniques for Soil Sta.iliza.ion a.d Resilience

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a.va.ces in Biologica. Chemistry 2024年第1期14卷 40-54页

作者： Jona.ha. a. Metuge Za.ha.y N. Senwo Depa.tment of Biologica. a.d Environmenta. Sciences Alabama A & M University Normal USA

Biochemica., chemica., a.d mecha.ica., techniques ha.e been employed to enha.ce soil resilience for deca.es. While the use of mecha.ica. techniques requires tra.sporting huge a.ounts of soil ma.eria.s, the cement used in chemica. techniques ma. lea. to increa.e a.mospheric ca.bon dioxide. Numerous studies indica.e tha. biochemica. techniques ma. be less expensive, cost effective, a.d environmenta.ly friendly. Biopolymers a.d enzymes derived from microorga.isms ha.e been suggested a. biologica. enha.cers in strengthening a.d fortifying soils used for ea.then structures. Lime a.d other trea.ment techniques used a. bioba.ed ma.eria.s ha.e been shown to be less effective for sta.ilizing soils. Here, we review biochemica. processes a.d techniques involved in the intera.tions of soil enzymes, microorga.isms, microbia. extra.ellula. polymeric substa.ces, a.d other biopolymers with soil pa.ticles, a.d the cha.lenges a.d stra.egies of their use a. bioba.ed ma.eria.s for sta.ilizing soils. This review provides their impa.ts on va.ious soil properties a.d the growth potentia.s of a.ricultura. crops. .

关键词： Biochemica. Ea.then Structures Soil Resilience Biopolymers Soil Enzymes a.riculture Microorga.isms Extra.ellula. Polymeric Substa.ces

Structura.-a.a.ta.ion Fea.ures of a.simila.ion Orga.s of the Species Sa.sola.inca.escens Ca.. in Conditions of Kyzylkum

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a.erica. Journa. of Pla.t Sciences 2024年第7期15卷 589-602页

作者： Guli a. Ibrokhimova.Gulja. M. Duscha.ova Depa.tment of Bota.y a.d Pla.t Physiology National University of Uzbekistan named after Mirzo Ulugbek Tashkent Uzbekistan Depa.tment of Bota.y a.d Ecology Tashkent State Pedagogical University named after Nizami Tashkent Uzbekistan

The a.ticle presents the results of the morpho-a.a.omica. structure of the a.simila.ion orga.s of the species Sa.sola.leptocla.a.Ga.d, which is widesprea. in the Kyzylkum desert region of Uzbekista., a.d revea.s the structura., dia.nostic a.d a.a.tive fea.ures. In the a.simila.ion orga.s, Kra.z type of mesophyll wa. found: in the cotyledons of the Kra.z-spherica. (a.riplicoid) type, a.d in the lea.—mesophylls of the Kra.z-centric (Sa.soloid) a.d Kra.z-ventrodorsa. type. These revea.ed dia.nostic fea.ures of the a.simila.ing orga.s of this species in a.id conditions noted C4-type photosynthesis. Ba.ed on the compa.a.ive biometric a.a.ysis of qua.tita.ive indices of the a.a.omica. fea.ures of the a.simila.ing orga.s, xero-ha.omorphic fea.ures predomina.e. Ha.omorphic fea.ures a.e in the cotyledons—thin outer wa.ls of the epiderma. cells;few stoma.a.of the a.omocytic a.d pa.a.ytic type;few rows of spongy cells (3 - 4 rows);few va.cula. bundles of the colla.era. type a.d xylem, in the lea.—la.ge a.d thin outer wa.ls of the epiderma. cells;succulence of the lea. mesophyll, the presence of a.uiferous cells;la.ge pa.isa.e, kera.in a.d a.uiferous cells. Xeromorphic fea.ures in the cotyledons—sma.l a.d numerous epiderma. cells a.d hemipa.a.ytic type stoma.a.a.so deep immersion;sma.l pa.isa.e cells a.d a.high pa.isa.e index, sma.l spongy, hypoderma. a.d kera.in cells;sma.l dia.eter of the xylem in va.cula. bundles;in the lea. numerous epiderma. cells a.d stoma.a.a.so deeply immersed;presence a.d numerous multicellula. nodula., denta.e trichomes;multi-row wa.er-bea.ing cells;high pa.isa.e index;sma.l a.d numerous xylem;numerous periphera. va.cula. bundles of the colla.era. type. These identified specific dia.nostic fea.ures showing a.a.ta.ion to a.id conditions ca. a.so serve in the identifica.ion of pla.t ma.eria.s.

关键词： Morphology a.a.omy Cotyledon Lea. Sa.sola.inca.escens South-West Kyzylkum

Exploring the Implica.ions of the Deforma.ion Pa.a.eter a.d Minima. Length in the Genera.ized Uncerta.nty Principle

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Journa. of Qua.tum Informa.ion Science 2024年第1期14卷 1-14页

作者： Ma.goub a. Sa.ih Ta.sir M. Elma.di Depa.tment of Physics Faculty of Science and Arts in Al-Miznab Qassim University Al Miznab Saudi Arabia

The brea.down of the Heisenberg Uncerta.nty Principle occurs when energies a.proa.h the Pla.ck sca.e, a.d the corresponding Schwa.zschild ra.ius becomes simila. to the Compton wa.elength. Both of these qua.tities a.e a.proxima.ely equa. to the Pla.ck length. In this context, we ha.e introduced a.model tha. utilizes a.combina.ion of Schwa.zschild’s ra.ius a.d Compton length to qua.tify the gra.ita.iona. length of a. object. This model ha. provided a.novel perspective in genera.izing the uncerta.nty principle. Furthermore, it ha. elucida.ed the significa.ce of the deforming linea. pa.a.eter β a.d its ra.ge of va.ia.ion from unity to its ma.imum va.ue.

关键词： Genera.ized Uncerta.nty Principle Deformed Heisenberg a.gebra Minima. Length