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Effect of Wa.e Nonlinea.ity on the Insta.ta.eous Sea.ed Liquefa.tion

China.Ocea. Engineering 2024年第1期38卷 93-103页

作者： Wa.G Zha.-jun SUI ti-ti ZHa.G Chi Pa. Jun-ning Key La.ora.ory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key La.ora.ory of Coa.ta. Disa.ter a.d Protection(Hoha. University) Ministry of EducationNanjing 210098China The Na.iona. Key La.ora.ory of Wa.er Disa.ter Prevention Nanjing 210098China

The nonlinea. va.ia.ion of wa.e is commonly seen in nea.shore a.ea.a.d the resulting sea.ed response a.d liquefa.tion a.e of high concern to coa.ta. *** this study,a. a.a.ytica. formula.considering the nonlinea. wa.e skewness a.d a.ymmetry is a.opted to provide wa.e pressure on the sea.ed *** liquefa.tion depth a.tenua.ion coefficient a.d width growth coefficient a.e defined to qua.tita.ively cha.a.terize the nonlinea. effect of wa.e on sea.ed *** on the 2D full dyna.ic model of wa.e-induced sea.ed response,a.deta.led pa.a.etric study is ca.ried out in order to eva.ua.e the influence of the nonlinea. va.ia.ion of wa.e loa.ings on sea.ed ***,new empirica. prediction formula. a.e proposed to fa.t predict the ma.imum liquefa.tion under nonlinea. *** indica.e tha.(1)Due to the influence of wa.e nonlinea.ity,the vertica. tra.smission of nega.ive pore wa.er pressure in the sea.ed is hindered,a.d therefore,the a.plitude decrea.es significa.tly.(2)In genera.,with the increa.e of wa.e nonlinea.ity,the liquefa.tion depth of sea.ed decrea.es *** under a.ymmetric a.d skewed wa.e loa.ing,the a.tenua.ion of ma.imum sea.ed liquefa.tion depth is the most significa.t a.ong a.l the nonlinea. wa.e ***,highly skewed wa.e ca. ca.se the liquefa.tion depth of sea.ed grea.er tha. tha. under linea. wa.e.(3)The a.ymmetry of wa.e pressure lea.s to the increa.e of liquefa.tion width,wherea. the influence of skewedness is not significa.t.(4)Compa.ed with the nonlinea. wa.eform,sea.ed liquefa.tion is more sensitive to the va.ia.ion of nonlinea. degree of wa.e loa.ing.

关键词： nonlinea. wa.e sea.ed response sea.ed liquefa.tion numerica. simula.ion liquefa.tion prediction

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Tumor microenvironment reprogra.ming by na.omedicine to enha.ce the effect of tumor immunothera.y

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a.ia. Journa. of Pha.ma.eutica. Sciences 2024年第2期19卷 1-37页

作者： Yu Hua.g Hui Fa. Huihui ti School of Chinese Ma.eria.Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Gua.gdong Province Precise Medicine Big Da.e of Tra.itiona. Chinese Medicine Engineering Technology Resea.ch Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pha.ma.y Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the ra.id development of the fields of tumor biology a.d immunology, tumor immunothera.y ha. been used in clinica. pra.tice a.d ha. demonstra.ed significa.t thera.eutic potentia., pa.ticula.ly for trea.ing tumors tha. do not respond to sta.da.d trea.ment options. Despite its a.va.ces, immunothera.y still ha. limita.ions, such a. poor clinica. response ra.es a.d differences in individua. pa.ient responses, la.gely beca.se tumor tissues ha.e strong immunosuppressive microenvironments. Ma.y tumors ha.e a.tumor microenvironment (TME) tha. is cha.a.terized by hypoxia. low pH, a.d substa.tia. numbers of immunosuppressive cells, a.d these a.e the ma.n fa.tors limiting the effica.y of a.titumor immunothera.y. The TME is crucia. to the occurrence, growth, a.d meta.ta.is of tumors. Therefore, numerous studies ha.e been devoted to improving the effects of immunothera.y by remodeling the TME. Effective regula.ion of the TME a.d reversa. of immunosuppressive conditions a.e effective stra.egies for improving tumor immunothera.y. The use of multidrug combina.ions to improve the TME is a. efficient wa. to enha.ce a.titumor immune effica.y. However, the ina.ility to effectively ta.get drugs decrea.es thera.eutic effects a.d ca.ses toxic side effects. Na.odrug delivery ca.riers ha.e the a.va.ta.eous a.ility to enha.ce drug bioa.a.la.ility a.d improve drug ta.geting. Importa.tly, they ca. a.so regula.e the TME a.d deliver la.ge or sma.l thera.eutic molecules to decrea.e the inhibitory effect of the TME on immune cells. Therefore, na.omedicine ha. grea. potentia. for reprogra.ming immunosuppressive microenvironments a.d represents a.new immunothera.eutic stra.egy. Therefore, this a.ticle reviews stra.egies for improving the TME a.d summa.izes resea.ch on synergistic na.omedicine a.proa.hes tha. enha.ce the effica.y of tumor immunothera.y.

关键词： Tumor immunothera.y Tumor micr oenvir onment Na.omedicine Tumor repr ogra.ming

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a.a.ytica. libra.ion control la. for electrodyna.ic tether system with current constra.nt

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a.trodyna.ics 2024年第2期8卷 237-246页

作者： Shidong Xu ti Chen Ha. Wen Dongping Jin Sta.e Key La.ora.ory of Mecha.ics a.d Control for a.rospa.e Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

This study focuses on sta.ilizing the libra.ion dyna.ics of a. electrodyna.ic tether system(EDTS)using genera.ized torques induced by the Lorentz *** contra.t to existing numerica. optimiza.ion methods,a.novel a.a.ytica. feedba.k control la. is developed to sta.ilize the in-pla.e a.d out-of-pla.e motions of a.tether by modula.ing the electric current *** sa.ura.ion constra.nt on the current is a.counted for by a.ding a. a.xilia.y dyna.ic system to the *** enha.ce the robustness of the proposed controller,multiple perturba.ions of the orbita. dyna.ics,modeling uncerta.nties,a.d externa. disturba.ces a.e a.proxima.ed using a.neura. network in which the weighting ma.rix a.d a.proxima.ion error a.e estima.ed simulta.eously,such tha. these perturba.ions a.e well compensa.ed for during the control design of the ***,a.dyna.ica.ly sca.ed genera.ized inverse is utilized to a.dress the singula. ma.rix in the control *** closed-loop system is proven to be ultima.ely bounded ba.ed on Lya.unov sta.ility ***,numerica. simula.ions a.e performed to demonstra.e the effectiveness of the proposed a.a.ytica. control la..

关键词： electrodyna.ic tether system(EDTS) libra.ion dyna.ics a.a.ytica. control current constra.nt

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Cyber-physica. Colla.ora.ive Restora.ion Stra.egy for Power Tra.smission System Considering Ma.ntena.ce Scheduling

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CSEE Journa. of Power a.d Energy Systems 2024年第3期10卷 1331-1341页

作者： Ba.zhong ti Chua.yun Zha.g Jingfei Liu Zha.yua. Wu Ziya.g Hua.g North China.Bra.ch of Sta.e Grid Corpora.ion of China Beijing 100053China Sta.e Grid Beijing Electric Power Compa.y Beijing 100031China Sta.e Key La.ora.ory of a.terna.e Electrica. Power System with Renewa.le Energy Sources School of Electrical and Electronic EngineeringNorth China Electric Power UniversityBeijing 102206China IEEE CSEE

In order to improve the a.ility of power tra.smission system to cope with compound fa.lts on the communica.ion side a.d power side,a.cyber-physica. colla.ora.ive restora.ion stra.egy is ***,a.cording to the informa.ion system’s role in fa.lt dia.nosis,remote control of equipment ma.ntena.ce a.d a.toma.ic output a.justment of genera.or restora.ion,a.cyber-physica. coupling model is *** this ba.is,a.colla.ora.ive restora.ion model of power tra.smission system is esta.lished by studying intera.tions a.ong ma.ntena.ce schedule pa.hs,informa.ion system opera.ion,a.d power system *** on power flow linea.iza.ion a.d the la.ge M-ε method,the a.ove model is tra.sformed into a.mixed integer linea. progra.ming model,whose computa.iona. burden is reduced further by the clustering *** to the pa.a.eters of IEEE39 New Engla.d system,the geogra.hic wiring dia.ra. of the cyber-physica. system is *** results show the proposed restora.ion stra.egy ca. consider the support function of the informa.ion system a.d spa.e-time coordina.ion of equipment ma.ntena.ce a. both sides comprehensively to speed up loa. recovery progress.

关键词： Clustering method colla.ora.ive restora.ion cyber-physica. power system ma.ntena.ce scheduling power tra.smission system restora.ion

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Network Configura.ion Entity Extra.tion Method Ba.ed on Tra.sformer with Multi-Hea. a.tention Mecha.ism

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Computers, Ma.eria.s & Continua 2024年第1期78卷 735-757页

作者： Ya.g Ya.g Zhenying Qu Zefa. Ya. Zhipeng Ga. ti Wa.g Sta.e Key La.ora.ory of Networking a.d Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Product Development Depa.tment China Unicom Smart City Research InstituteBeijing100044China

Nowa.a.s,ensuring thequa.ity of networkservicesha. become increa.ingly *** a.e turning toknowledge gra.h technology,with a.significa.t empha.is on entity extra.tion in the identifica.ion of device *** resea.ch pa.er presents a.novel entity extra.tion method tha. levera.es a.combina.ion of a.tive lea.ning a.d a.tention ***,a. improved a.tive lea.ning a.proa.h is employed to select the most va.ua.le unla.eled sa.ples,which a.e subsequently submitted for expert *** a.proa.h successfully a.dresses the problems of isola.ed points a.d sa.ple redunda.cy within the network configura.ion sa.ple *** the la.eled sa.ples a.e utilized to tra.n the model for network configura.ion entity ***,the multi-hea. self-a.tention of the tra.sformer model is enha.ced by introducing the a.a.tive Weighting method ba.ed on the La.la.e mixture *** enha.cement ena.les the tra.sformer model to dyna.ica.ly a.a.t its focus to words in va.ious positions,displa.ing exceptiona. a.a.ta.ility to a.norma. da.a.a.d further eleva.ing the a.cura.y of the proposed *** compa.isons with Ra.dom Sa.pling(Ra.DOM),Ma.imum Norma.ized Log-Proba.ility(MNLP),Lea.t Confidence(LC),Token Entrop(TE),a.d Entropy Query by Ba.ging(EQB),the proposed method,Entropy Query by Ba.ging a.d Ma.imum Influence a.tive Lea.ning(EQBMIa.),a.hieves compa.a.le performa.ce with only 40% of the sa.ples on both da.a.ets,while other a.gorithms require 50% of the ***,the entity extra.tion a.gorithm with the a.a.tive Weighted Multi-hea. a.tention mecha.ism(a.-MHa.is compa.ed with BILSTM-CRF,Mutil_a.tention-Bilstm-Crf,Deep_Neura._Model_NER a.d BERT_Tra.sformer,a.hieving precision ra.es of 75.98% a.d 98.32% on the two da.a.ets,*** tests demonstra.e the sta.istica. significa.ce a.d effectiveness of the proposed a.gorithms in this pa.er.

关键词： Entity extra.tion network configura.ion knowledge gra.h a.tive lea.ning tra.sformer

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Mecha.ica. response of a.tunnel subjected to strike-slip fa.lting processes,ba.ed on a.multi-sca.e modeling method

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Frontiers of Structura. a.d Civil Engineering 2024年第8期18卷 1281-1295页

作者： Guoguo LIU Ping GENG tia.qia.g Wa.G Xia.gyu GUO Jia.ia.g Wa.G ti DING Key La.ora.ory of Tra.sporta.ion Tunnel Engineering Ministry of EducationChengdu 610031China College of Civil Engineering Huaqiao UniversityXiamen 361021China China.Ra.lwa. Design Corpora.ion Tianjin 300308China

The stick-slip a.tion of strike-slip fa.lts poses a.significa.t threa. to the sa.ety a.d sta.ility of underground *** this study,the north-ea.t a.ea.of the Longmensha. fa.lt,Sichua.,provides the geologica. ba.kground;the rheologica. cha.a.teristics of the crusta. lithosphere a.d the nonlinea. intera.tions between pla.es a.e described by Burger’s viscoela.tic constitutive model a.d the friction constitutive model,respectively.a.la.ge-sca.e globa. numerica. model for pla.e squeezing a.a.ysis is esta.lished,a.d the seemingly periodic stick-slip a.tion of fa.lts a. different crust depths is *** a.second model a. a.sma.ler sca.e,a.loca. finite element model(sub-model),the time history of displa.ement a. a.ground level loca.ion on the Longmensha. fa.lt pla.e in a.stick-slip a.tion is considered a. the displa.ement *** integra.ion of these models,crea.ing a.multi-sca.e modeling method,is used to eva.ua.e the cra.k propa.a.ion a.d mecha.ica. response of a.tunnel subjected to strike-slip *** determina.ions of the recurrence interva. of stick-slip a.tion a.d the cra.king cha.a.teristics of the tunnel a.e in substa.tia. a.reement with the previous field investiga.ion a.d experimenta. results,va.ida.ing the multi-sca.e modeling *** ca. be concluded tha.,rega.dless of stra.um stiffness,initia. cra.ks first occur a. the inverted a.ch of the tunnel in the footwa.l,on the squeezed side under strike-slip *** sma.ler the stra.um stiffness is,the sma.ler the included a.gle between the cra.k expa.sion a.d longitudina. direction of the tunnel,a.d the more extensive the cra.k expa.sion *** the tunnel in a.high stiffness stra.um,both shea. a.d bending fa.lures occur on the lining under strike-slip fa.lting,while for tha. in the low stiffness stra.um,only bending fa.lure occurs on the lining.

关键词： stick-slip a.tion pla.e squeezing a.a.ysis multi-sca.e modeling method lining cra.king mecha.ica. response

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Liver-bra.n a.is with a.cohol:Role of fibrobla.t growth fa.tor 21(FGF21)

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Genes & Disea.es 2024年第2期11卷 509-511页

作者： Ke Zha.g Elena.Blokhina.Evgeny Krupitsky Ma.ina.Vetrova.ti-Fei Yua. Hua.Wa.g Sha.gha. Key La.ora.ory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Pa.lov University Valdman Institute of PharmacologySt.Petersburg 197022Russia Bekhterev Na.iona. Medica. Resea.ch Center for Psychia.ry a.d Neurology St.Petersburg 192019Russia Co-innova.ion Center of Neuroregenera.ion Nantong UniversityNantongJiangsu 226007China Depa.tment of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032China

Fibrobla.t growth fa.tor21(FGF21)is a.hormone tha. ca. ba.a.ce nutrient fluctua.ions,control meta.olic processes,a.d ma.nta.n energy *** FGF21 is produced by a.va.iety of cell types,including hepa.ocytes,a.ipocytes,bone cells,myoca.dia. cells,a.d pa.crea. cells,a.d a.t on va.ious effector tissues such a. bra.n,a.ipose tissue,liver,hea.t,a.d skeleta. muscle.1 The ta.get tha. FGF21 intera.ts with is the cell-surfa.e receptor composed of FGF receptors in complex with the single-pa.s tra.smembra.e proteinβ-*** receptors a.e a.unda.tly expressed,both in periphera. tissues a.d some regions of the CNS,such a. the hypotha.a.us a.d a.ygda.a.a.d the locus coeruleus(LC).2 Physiologica.ly,FGF21 ca. be induced by va.ious meta.olic stresses,including hunger,protein deficiency,monosa.cha.ides,a.d a.cohol,by a.ting onβ-Klotho receptor in corresponding tissues,ultima.ely exerting regula.ory effects(Fig.1)

关键词： Klotho homeosta.is a.cohol

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Fa.t X-ra. ima.ing bea.line a. SSRF

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Nuclea. Science a.d Techniques 2024年第9期35卷 68-81页

作者： Ke Li Hong-La. Xie Ya.Na. Fu Fei-Xia.g Wa.g Guo-Ha. Du Jia.-Feng ji Bia. Deng ti-Qia. Xia. Sha.gha. Synchrotron Ra.ia.ion Fa.ility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

The fa.t X-ra. ima.ing bea.line(BL16U2)a. Sha.gha. Synchrotron Ra.ia.ion Fa.ility(SSRF)is a.new bea.line tha. provides X-ra. micro-ima.ing ca.a.ilities a.ross a.wide ra.ge of time sca.es,spa.ning from 100 ps toμs a.d *** bea.line ha. been specifica.ly designed to fa.ilita.e the investiga.ion of a.wide ra.ge of ra.id phenomena.such a. the deforma.ion a.d fa.lure of ma.eria.s subjected to intense dyna.ic *** a.dition,it ena.les the study of high-pressure a.d high-speed fuel spra. processes in a.tomotive *** light source of this bea.line is a.cryogenic perma.ent ma.net undula.or(CPMU)tha. is cooled by liquid *** CPMU ca. genera.e X-ra. photons within a. energy ra.ge of 8.7-30 *** bea.line offers two modes of opera.ion:monochroma.ic bea. mode with a.liquid nitrogen-cooled double-crysta. monochroma.or(DCM)a.d pink bea. mode with the first crysta. of the DCM out of the bea. *** X-ra. ima.ing methods were implemented in BL16U2:single-pulse ultra.a.t X-ra. ima.ing,microsecond-resolved X-ra. dyna.ic ima.ing,millisecond-resolved X-ra. dyna.ic micro-CT,a.d high-resolution qua.tita.ive ***,BL16U2 is equipped with va.ious in situ impa.t loa.ing systems,such a. a.split Hopkinson ba. system,light ga. gun,a.d fuel spra. *** the completion of the fina. commissioning in 2021 a.d subsequent tria. opera.ions in 2022,the bea.line ha. been officia.ly a.a.la.le to users from 2023.

关键词： Multiple time-sca.e X ra. ima.ing Single-pulse X ra. ima.ing Dyna.ic 2D ima.ing Dyna.ic micro-CT

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Cemented vertebra.a.d a.ja.ent vertebra.refra.tured in a.chronic kidney disea.e-minera. a.d bone disorder pa.ient: a.ca.e report

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World Journa. of Clinica. Ca.es 2024年第10期12卷 1804-1809页

作者： ti-Dong Zha.g Shua. Ca. Hui-Yong Ren Yu-Min Li Yi-Ming Yua. Depa.tment of Orthopedics Civil Aviation General HospitalBeijing 100123China

Ba.KGROUND a.though percuta.eous vertebra. a.gmenta.ion(PVa.is a.commonly used procedure for trea.ing vertebra. compression fra.ture(VCF),the risk of vertebra. refra.ture should be *** kidney disea.e-minera. a.d bone disorder(CKD-MBD)is a.systemic disea.e of minera. a.d bone *** is a.socia.ed with a. increa.ed risk of *** studies ha.e reported the use of PVa.in pa.ients with *** herein report a.ra.e ca.e wherein the cemented vertebra.a.d the a.ja.ent vertebra.refra.tured simulta.eously in a.CKD-MBD pa.ient a.ter *** SUMMa.Y a.74-yea.-old ma. suffered from low ba.k pa.n a.ter ta.ing a.fa.l a.out 3 wk *** to physica. exa.ina.ion,ima.ing a.d la.ora.ory findings,dia.noses of T12 VCF,CKD-MBD,a.d chronic kidney disea.e sta.e 5 were *** then received percuta.eous vertebropla.ty a. T12 *** weeks la.er,he presented with T12 a.d L1 vertebra. refra.tures ca.sed by lumba. *** a.a.n,he wa. given PVa.which wa. optimized for the refra.tured *** the short-term postopera.ive effect wa. sa.isfa.tory,he reported chronic low ba.k pa.n a.a.n a. the 3-month *** It is necessa.y tha. pa.ients with CKD-MBD who ha.e received PVa.a.e a.a.e of the a.verse effects of *** ma. increa.e the risk of vertebra. ***,the PVa.surgica. technique needs to be optimized a.cording to the condition of the *** medium-a.d long-term effects of PVa.rema.n uncerta.n in pa.ients with CKD-MBD.

关键词： Chronic kidney disea.e-minera. a.d bone disorder Percuta.eous vertebra. a.gmenta.ion Vertebra. compression fra.ture Vertebra. refra.ture Cemented vertebra a.ja.ent vertebra Ca.e report

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Better use of experience from other reservoirs for a.cura.e production foreca.ting by lea.n-to-lea.n method

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Petroleum Science 2024年第1期21卷 716-728页

作者： Ha.-Chen Wa.g Ka. Zha.g Na.cy Chen Wen-Sheng Zhou Chen Liu Ji-Fu Wa.g Li-Ming Zha.g Zhi-Ga.g Yu Shi-ti Cui Mei-Chun Ya.g China.University of Petroleum(Ea.t China. 66 Changjiang West RoadQingdao West Coast New AreaQingdao266580ShandongChina University of Ca.ga.y 2500 University Dr NWCalgaryT2N 1N4AlbertaCanada Qingda. University of Technology Qingdao266071ShandongChina Sta.e Key La.ora.ory of Offshore Oil Exploita.ion Beijing100028China CNOOC Resea.ch Institute Ltd. Beijing100028China CNPC Ta.im Oilfield Bra.ch Compa.y Korla841000XinjiangChina Na.iona. Engineering La.ora.ory for Explora.ion a.d Development of Low-Permea.ility Oil a.d Ga. Fields Xi'an710000ShaanxiChina Sinopec Ma.rix Co. LTDQingdao266000ShandongChina

To a.sess whether a.development stra.egy will be profita.le enough,production foreca.ting is a.crucia. a.d difficult step in the *** development history of other reservoirs in the sa.e cla.s tends to be studied to ma.e predictions ***,the permea.ility field,well pa.terns,a.d development regime must a.l be simila. for two reservoirs to be considered in the sa.e *** results in very few a.a.la.le experiences from other reservoirs even though there is a.lot of historica. informa.ion on numerous reservoirs beca.se it is difficult to find such simila. *** pa.er proposes a.lea.n-to-lea.n method,which ca. better utilize a.va.t a.ount of historica. da.a.from va.ious ***,the proposed method first lea.ns how to lea.n sa.ples before directly lea.ning rules in ***,by utilizing gra.ients from networks with independent pa.a.eters a.d copied structure in ea.h cla.s of reservoirs,the proposed network obta.ns the optima. sha.ed initia. pa.a.eters which a.e rega.ded a. tra.sfera.le informa.ion a.ross different *** on tha.,the network is a.le to predict future production indices for the ta.get reservoir by only tra.ning with very limited sa.ples collected from reservoirs in the sa.e *** ca.es further demonstra.e its superiority in a.cura.y to other widely-used network methods.

关键词： Production foreca.ting Multiple pa.terns Few-shot lea.ning Tra.sfer lea.ning

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