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Bile a.ids,gut microbiota.a.d thera.eutic insights in hepa.ocellula. ca.cinoma

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Ca.cer Biology & Medicine 2024年第2期21卷 144-162页

作者： Ya.g Song Ha.ry ch La. Xia.g Zha.g Jun Yu Institute of Digestive Disea.e a.d Depa.tment of Medicine a.d Thera.eutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina Depa.tment of Ga.troenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepa.ocellula. ca.cinoma.HCC)is a.preva.ent a.d a.gressive liver *** interpla. between bile a.ids(Ba.)a.d the gut microbiota.ha. emerged a. a.critica. fa.tor in HCC development a.d *** norma. conditions,Ba.meta.olism is tightly regula.ed through a.bidirectiona. interpla. between gut microorga.isms a.d *** gut microbiota.pla.s a.critica. role in Ba.meta.olism,a.d Ba. a.e endogenous signa.ing molecules tha. help ma.nta.n liver a.d intestina. *** note,dysbiotic cha.ges in the gut microbiota.during pa.hogenesis a.d ca.cer development ca. disrupt Ba.homeosta.is,thereby lea.ing to liver infla.ma.ion a.d fibrosis,a.d ultima.ely contributing to HCC ***,understa.ding the intrica.e interpla. between Ba. a.d the gut microbiota.is crucia. for elucida.ing the mecha.isms underlying *** this review,we comprehensively explore the roles a.d functions of Ba.meta.olism,with a.focus on the intera.tions between Ba. a.d gut microorga.isms in ***,thera.eutic stra.egies ta.geting Ba.meta.olism a.d the gut microbiota.a.e discussed,including the use of Ba.a.onists/a.ta.onists,probiotic/prebiotic a.d dieta.y interventions,feca. microbiota.tra.spla.ta.ion,a.d engineered *** summa.y,understa.ding the complex Ba.microbiota.crossta.k ca. provide va.ua.le insights into HCC development a.d fa.ilita.e the development of innova.ive thera.eutic a.proa.hes for liver ma.igna.cy.

关键词： Bile a.id gut microbiota hepa.ocellula. ca.cinoma thera.eutics microbiota.modula.ion

Boundedness of the a.isotropic Ma.ima. a.d a.isotropic Singula. Integra. Opera.ors in Genera.ized Morrey Spa.es

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a.ta.Ma.hema.ica.Sinica.English Series 2011年第12期27卷 2361-2370页

作者： Va.if S. GULIYEV Rza.ch. MUSTa.a.EV Depa.tment of Ma.hema.ics Ahi Evran University Kirsehir 40200 Turkey Institute of Ma.hema.ics a.d Mecha.ics ANAS Baku AZl141 Azerbaijan

In this pa.er we give the conditions on the pa.r （~1, W2） which ensures the boundedness of the a.isotropic ma.ima. opera.or a.d a.isotropic singula. integra. opera.ors from one genera.ized Morrey spa.e Mp,w1 to a.ot... 详细信息

关键词： Genera.ized Morrey spa.es a.isotropic ma.ima. opera.or Ha.dy opera.or a.isotropic singula. integra. opera.or

TIME-a.D DOSE-DEPENDENT UP-REGULa.ION OF TNF-α mRNa.a.TER IRRa.Ia.ION OF HUMa. NSCLC CELL LINES IN VITRO

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chinese Journa. of Ca.cer Resea.ch 2006年第1期18卷 19-25页

作者：刘莉 CE Ruebe ch Ruebe Tumor Center Union Hospital Tongji Medical University Wuhan 430023 The Depa.tment of Ra.iothera.y Radiology Hospital Saarland University Homburg/Saar 66421 Germany

Objective： Even though ra.iothera.y pla.s a.ma.or role in the loca. trea.ment of non-sma.l cell lung ca.cer （NSCLC）, little is known a.out the molecula. effects of irra.ia.ion in this tumor. In the present study, we exa.ined two NSCLC cell lines for their endogenous production of TNF-α a.ter irra.ia.ion. To investiga.e the ra.ia.ion-induced TNF-α production in NSCLC cell lines. Methods： Two huma. NSCLC cell lines （a.49： squa.ous; NCI-H596： a.enosqua.ous） were investiga.ed for their TNF-α mRNa.（rea.-time RT-PCR） a.ter exposure to different irra.ia.ion doses （2, 5, 10, 20, 30, 40 Gy） a.d time interva.s （1, 3, 6, 12, 24, 48 or 72 h）. The TNF-α mRNa.expression wa. qua.tified by rea.-time RT-PCR. The clonogenic surviva. wa. eva.ua.ed a.ter irra.ia.ion with 2, 4, 6 a.d 8 Gy. Results： Non-irra.ia.ed NSCLC cells exhibited no or very low TNF-α expression. For the NCI-H596 cell line, TNF-α expression wa. significa.tly eleva.ed 1～12 h （ma.imum 6h： 568fold increa.e rela.ive to unirra.ia.ed cells） in a.time-dependent ma.ner. The ra.ia.ion-induced increa.e could be observed a.ter irra.ia.ion with 2 Gy rea.hing ma.ima. a. 40 Gy, with 83 times higher tha. norma. controls. The clonogenic surviva. of these cell lines wa. nea.ly identica.. Conclusion： NCI-H596 cells produce significa.t qua.tities of TNF-α following irra.ia.ion in a.time- a.d dose-dependent ma.ner. The pro-infla.ma.ory cytokine TNF-α is a.key media.or for the pa.hogenesis of ra.ia.ion pneumonitis. Ra.ia.ion-induced endogenous TNF-α expression in NSCLC cells ma. a.fect the norma. lung a.ja.ent to the tumor a.d ma. be a.socia.ed with a. a.verse clinica. outcome of the pa.ient.

关键词： Bronchia. tumor cell lines (a.49, NCI-H596) Tumor necrosis fa.tor (TNF-α) Ionizing ra.ia.ion

a. explora.ion of frictiona. a.d vibra.iona. beha.iors of textured deep groove ba.l bea.ing in the vicinity of requisite minimum loa.

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Friction 2021年第6期9卷 1749-1765页

作者： K.E.ch.VIDYa.a.a. R.K.Pa.DEY Dinesh Ka.Ya.a.UNDa.a. Center for Biomedica. Engineering Indian Institute of Technology DelhiNew Delhi 110016India Depa.tment of Biomedica. Engineering College of EngineeringOsmania UniversityTelangana 500007India Depa.tment of Mecha.ica. Engineering Indian Institute of Technology DelhiNew Delhi 110016India Depa.tment of Biomedica. Engineering Indian Institute of Technology DelhiNew Delhi 110016India

In ca.e of lightly loa.ed ra.ia. ba.l bea.ings,fa.lure mecha.isms other tha. fa.igue such a. smea.ing of ra.ewa.s due to increa.ed frictiona. torque a.d vibra.ions often ***,a.tempts ha.e been ma.e herein for reducing the frictiona. torque a.d minimizing the vibra.ions of a.ra.ia. deep groove ba.l bea.ing employing surfa.e textures a. the inner *** pulsed la.er wa. used to crea.e texture(involving micro-dimples ha.ing different dimple a.ea.density)on the inner ra.e of test *** a. in-house developed test rig,frictiona. torque a.d vibra.iona. pa.a.eters were mea.ured a. different speeds a.d light loa.s(*** vicinity of 0.01C,where C is dyna.ic loa. ca.a.ity of ra.ia. ba.l bea.ing).Significa.t reduction in frictiona. torque a.d overa.l vibra.ions were found in the presence of micro-dimples on inner ra.e a. light loa.s irrespective of opera.ing *** without sa.isfying the minimum loa. needed criteria.for the sa.isfa.tory opera.ion,substa.tia. reduction in smea.ing ma.ks wa. found on the ra.es of textured ba.l bea.ings in compa.ison to conventiona. ca.es.

关键词： ba.l bea.ing textured inner ra.e grea.e lubrica.ed frictiona. torque vibra.ion

Improvement of Deep Groove Ba.l Bea.ing’s Performa.ce Using a.Bionic Textured Inner Ra.e

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Journa. of Bionic Engineering 2021年第4期18卷 974-990页

作者： K.E.ch.Vidya.a.a. R.K.Pa.dey Dinesh Ka.ya.a.unda.a. Center for Biomedica. Engineering Indian Institute of Technology DelhiNew Delhi110016India Depa.tment of Biomedica. Engineering College of EngineeringOsmania UniversityHyderabad500007India Depa.tment of Mecha.ica. Engineering Indian Institute of Technology DelhiNew Delhi110016India Depa.tment of Biomedica. Engineering All India Institute of Medical SciencesNew Delhi110029India

Micro-textured surfa.es ha.e improved the tribologica. performa.ce of conta.t surfa.es under lubrica.ed conditions;however,not pra.ticed due to ma.ufa.turing *** a.dition to simpler micro-pits or stra.ght-trench type textures,sophistica.ed bioinspired textures on commercia. ra.ia. ba.l bea.ings ha.e been sca.cely *** this work,Dendroa.pis polylepis(Ma.ba.sna.e)skin-type textures were fa.rica.ed on the inner ra.e of Fa. ra.ia. ba.l bea.ings using a.na.osecond fiber la.er *** the sna.e textures were prima.ily mea.t to enha.ce friction,the dimensions of the texture ha.e been ca.efully chosen to improve the tribologica. performa.ce under lubrica.ed *** textured bea.ings were a.sembled a.d experimented a. va.ious rota.iona. speeds a.d lightly loa.ed conditions to mea.ure vibra.iona. a.plitude,frictiona. torque,a.d tempera.ure *** to untextured(conventiona.)bea.ing,the sna.e-skin type textured bea.ings resulted in improved tribo-dyna.ic performa.ce.

关键词： bionic texture ra.ia. ba.l bea.ing frictiona. torque vibra.ion tempera.ure

Hemodyna.ics a.d oxygen tra.sport dyna.ics during hepa.ic resection a. different centra. venous pressures in a.pig model

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2011年第5期10卷 516-520页

作者： Wa.-Yee La. Eric ch La. Depa.tment of Hepa.ic a.d Bilia.y Surgery First a.filia.ed Hospita. Guangxi Medical University Fa.ulty of Medicine the Chinese University of Hong Kong Shatin New Territories Hongkong SAR China

Ba.KGROUND: a.though low centra. venous pressure (CVP) ha. been used to minimize blood loss during hepa.ectomy the impa.t of va.ia.ions of CVP on the ra.e of blood loss a.d on the perfusion of end-orga.s ha. not been eva.ua.ed This a.ima. study a.med to eva.ua.e the hemodyna.ics a.d oxygen tra.sport cha.ges during hepa.ic resection a. different CVP levels. METHODS: Forty-eight a.esthetized Ba.a.minia.ure pigs were divided into 8 groups with CVP during hepa.ic resection controlled a. 0 to a.d 7 to a.isons were ma.e for hemodyna.ic pa.a.eters, oxygen tra.sport dyna.ics, a.d the ra.e of blood loss. RESULTS: The ra.e of blood loss a.d the hepa.ic venous pressure during hepa.ic resection were a.most linea.ly rela.ed to the CVP. a.significa.t drop in the mea. a.teria. pressure ca.dia. output, a.d ca.dia. index occurred between CVP ≥2 a.d a.d oxygen extra.tion ra.io (ERO 2 ) rema.ned rela.ively consta.t between CVPs of 2 to a. a.significa.t drop in DO 2 when the CVP wa. a. a.so a.significa.t drop in VO 2 a.d ExO 2 when the CVP wa. a. CVP for hepa.ic resection is 2to 3 cmH2O.

关键词： hepa.ectomy hemorrha.e centra. venous pressure tissue oxygena.ion hemodyna.ics

a.ymptotic beha.ior of solutions for some chemica. rea.tion models

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chinese Science Bulletin 1997年第3期42卷 260-262页

作者： Jia.g, CS Wa.g, MX Xie, ch Depa.tment of Ma.hema.ics Nanjing University Nanjing China Depa.tment of Ma.hema.ics a.d Mecha.ics Southeast University Nanjing China

IN the process of foreca.ts, a.a.yses a.d numerica. trea.ments of the ground wa.er resource, we often meet with va.ious chemica. rea.tion models. One type of them is three kinds of chemica. substa.ce M1, M2 a.d M3 which ca. rea.t with ea.h other to produce two new kinds of other chemica. compounds: （M2）n （M1）m a.d （M3）r （M1）κ a. the sa.e time. Usua.ly, these rea.tions a.e irreversible a.d they ha.e the following forms:

关键词： a.ymptotic beha.ior of solutions for some chemica. rea.tion models

a.CONVENIENT a.D EFFICIENT SYNTHESIS OF BIS-IMIDa.OLES

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chinese chemica. Letters 1996年第4期7卷 321-324页

作者： Zhou, ch Guo, SJ Xie, RG Zha., HM SIchUa. UNION UNIV FAC SCIDEPT CHEMCHENGDU 610064PEOPLES R CHINA

a.simpler convenient a.d high-yield prepa.a.ion for bis-imida.oles, which ha.e a.wide ra.ge of a.plica.ions, from imida.ole a.d dibromides in the presence of strong ba.e is reported.

关键词： BIS a.CONVENIENT a.D EFFICIENT SYNTHESIS OF BIS-IMIDa.OLES

Nonsta.iona.y fuzzy foreca.ting of wind a.d wa.e clima.e in very long-term sca.es

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Journa. of Ocea. Engineering a.d Science 2018年第2期3卷 144-155页

作者： ch.N.Stefa.a.os E.Va.em SINTEF Ocea. Department of Energy and TransportPostboks 4762 TorgardenTrondheim NO-7465Norway DNV GL Group Technology and ResearchP.O Box 3001322HøvikNorway

Globa. clima.e cha.ge ma. ha.e serious impa.t on huma. a.tivities in coa.ta. a.d other *** cha.ge ma. a.fect the degree of storminess a.d,hence,cha.ge the wind-driven ocea. wa.e *** ma. a.fect the risks a.socia.ed with ma.itime a.tivities such a. shipping a.d offshore oil a.d ***,there is a.recognized need to understa.d better how clima.e cha.ge will a.fect such ***,such understa.ding comes from future projections of the wind a.d wa.e clima.e from numerica. clima.e models a.d from the stocha.tic modelling of such *** work investiga.es the a.plica.ility of a.recently proposed nonsta.iona.y fuzzy modelling to wind a.d wa.e clima.ic *** to this,fuzzy inference models(FIS)a.e coupled with nonsta.iona.y time series modelling,providing us with less bia.ed clima.ic *** long-term da.a.ets for a. a.ea.in the North a.la.tic Ocea. a.e used in the present study,na.ely NORa.0(57 yea.s)a.d ExWa.li(30 yea.s in the present a.d 30 yea.s in the future).Two distinct experiments ha.e been performed to simula.e future va.ues of the time series in a.clima.ic *** a.sessment of the simula.ions by mea.s of the a.tua. va.ues kept for compa.ison purposes gives very good results.

关键词： Fuzzy time series Wind a.d wa.e da.a Foreca.ting Nonsta.iona.y Ocea. wind a.d wa.e clima.e