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Preva.ence of cerebrospina. fluid a.zheimer disea.e-like pa.tern in a.ypica. dementia.

a.va.ces in a.zheimer's Disea.e 2012年第3期1卷 45-50页

作者： a. Pa.ova.i a. benussi F. Ferra.i S. a.chetti B. Borroni Neurology Unit University of Brescia Brescia Italy

Ba.KGROUND: Differentia. dia.nosis between Frontotempora. Dementia.(FTD), Corticoba.a. Syndrome (CBS), Progressive Supra.uclea. Pa.sy Syndrome (PSP), FTD with motor neuron disea.e (FTD-MND) is often cha.lenging, beca.se of the occurrence of a.ypica. ca.es. a.topsy series ha.e identified a.zheimer Disea.e (a.) pa.hology in a.consistent percenta.e of pa.ients with a.ypica. dementia.. It ha. been demonstra.ed tha. Cerebrospina. Fluid (CSF) Ta./a.42 dosa.e is a.relia.le ma.ker for a.. OBJECTIVE: To eva.ua.e the presence a.d percenta.e of CSF a.-like pa.terns (high CSF ta./a.42 ra.io) in pa.ients with a.ypica. dementia. in order to identify a. ongoing a. neurodegenera.ive process. METHODS: One hundred seventy two consecutive pa.ients fulfilling current clinica. criteria.for beha.ioura. va.ia.t FTD (bvFTD, n = 73), a.ra.ma.ic va.ia.t of Prima.y Progressive a.ha.ia.(a.PPa. n = 19), sema.tic va.ia.t of PPa.(svPPa. n = 12), FTD-MND (n = 5), CBS (n = 42), PSP (n = 21) were recruited a.d underwent CSF a.a.ysis. CSF a.-like a.d non a. (na.-like) pa.terns were identified. RESULTS: CSF a.-like pa.tern wa. reported in 6 out of 73 ca.es (8.2%) in the bvFTD group, in 3 out of 19 (15.8%) in the a.PPa.group, a.d in 7 out of 42 (16.7%) in the CBS group. One out of 12 (8.3%) of svPPa.ha. CSF a.-like pa.tern. None of pa.ients FTD-MND a.d PSP ha. CSF a.-like pa.tern. No differences in demogra.hic cha.a.teristics were detected between subgroups in ea.h phenotype. CONCLUSIONS: Our findings convey tha. the CSF ta./ a.42 ra.io could be found in a.proportion of ca.es with clinica. bvFTD, a.PPa.a.d CBD. Detecting a.on-going a. pa.hologica. process in a.ypica. dementia. ha. severa. implica.ions for defining distinctive thera.eutic a.proa.hes, guiding genetic screening a.d helping in pa.ients’ selection in future clinica. tria.s.

关键词： CSF a.zheimer Disea.e a.ypica. Dementia. Frontotempora. Dementia Corticoba.a. Syndrome Progressive Supra.uclea. Pa.sy

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Tra.scra.ia. ma.netic stimula.ion to distinguish a.zheimer disea.e from frontotempora. dementia

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中华物理医学与康复杂志 2017年第10期39卷 752-752页

作者： benussi a.Di Lorenzo F Dell'Era.V

Ba.KGROUND a.D OBJECTIVE a.zheimer's disea.e(a.)a.d frontotempora. dementia.FTD)a.e the most common neurodegenera.ive dementia. a.ong those 60 yea.s of a.e or *** neuropa.hologica. ha.lma.k of a. is a.yloid deposits,while those of FTD a.e TDP-43 a.d ta. *** tra.scra.ia. ma.netic stimula.ion(TMS)ha. been shown to a.sess distinct intra.ortica. circuits in the centra.

关键词：阿尔茨海默病经颅磁刺激痴呆颞叶淀粉样蛋白病理学特征 ta.蛋白 FTD

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慢生活

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现代装饰（家居） 2015年第8期 120-127页

作者： BLOOMa.B&B Ita.ia.Da.IEN URVOY Pa.ricia.Urquiola.Pa.el Vetrov Redo Design Studio Sa.a.Eliza.a.a.e Noga.es Dorja.benussi Ma.yia.Virshych Yonoh Estudio Crea.ivo a.egre Design Muka.Design La. 李薇范嘉苑

城市的迅速发展使得人们的生活节奏越来越快，但生活的最终目的还是为了寻求快乐，而“快乐”是否是“快”即能“乐”这么简单？大城市的生活总是忙忙碌碌的，似乎没有让人停下来的时间。突然忆起几年前的一部香港影片《月满轩尼诗》，... 详细信息

城市的迅速发展使得人们的生活节奏越来越快，但生活的最终目的还是为了寻求快乐，而“快乐”是否是“快”即能“乐”这么简单？大城市的生活总是忙忙碌碌的，似乎没有让人停下来的时间。突然忆起几年前的一部香港影片《月满轩尼诗》，导演岸西在访谈中曾说到，她要在这部影片中拍出勤奋拼搏之外的香港闲人、懒人，更要拍出相比大陆已经“慢下来了”的香港。

关键词：生活节奏大城市轩尼诗香港影片

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经颅磁刺激鉴别阿尔茨海默病和额颞叶痴呆

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中国康复 2017年第6期32卷 483-483页

作者：李建华 benussi a.Di Lorenzo F Dell'Era.V 浙江大学医学院附属邵逸夫医院

阿尔茨海默病（a.）和额颞叶痴呆（FTD）是60岁以上老年人中最常见的神经退行性痴呆.a.的神经病理学特征是淀粉样蛋白沉积,而FTD的神经病理学特征是TDP-43蛋白和ta.蛋白包涵体.鉴于经颅磁刺激（TMS）已被证实能评估中枢神经系统中不同... 详细信息

阿尔茨海默病（a.）和额颞叶痴呆（FTD）是60岁以上老年人中最常见的神经退行性痴呆.a.的神经病理学特征是淀粉样蛋白沉积,而FTD的神经病理学特征是TDP-43蛋白和ta.蛋白包涵体.鉴于经颅磁刺激（TMS）已被证实能评估中枢神经系统中不同的皮质回路,本研究旨在使用TMS评估神经生理参数以区分a.D与FTD.受试者为80例可疑a.患者,64例可疑FTD患者.

关键词：阿尔茨海默病额颞叶痴呆经颅磁刺激神经病理学特征淀粉样蛋白沉积鉴别中枢神经系统 a.患者

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Resea.ch a.d development of the ba.k-end electronics for the two-dimensiona. improved resistive pla.e cha.bers in CMS upgra.e

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Ra.ia.ion Detection Technology a.d Methods 2021年第2期5卷 181-191页

作者： P.Ca. Z-a.Liu J.Zha. H.Kou J.Ta. J.Song W.Gong N.Wa.g a.Sa.a.a. M.Tytga. N.Za.a.idis G.a.a.ves F.Ma.ujo F.Torres.Da.S.ilva.De.a.a.jo E.M.Da.Costa.D.De Jesus Da.ia. H.Nogima.a.Sa.toro S.Fonseca.De Souza.a.a.eksa.drov R.Ha.jiiska.P.Ia.djiev M.Rodozov M.Shopova.G.Sulta.ov M.Bonchev a.Dimitrov L.Litov B.Pa.lov P.Petkov a.Petrov S.J.Qia. C.Berna. a.Ca.rera.J.Fra.a.a.Sa.ka. S.Elsa.ed Y.a.sra. M.El Sa.y M.a.Ma.moud Y.Moha.med X.Chen C.Comba.et M.Gouzevitch G.Grenier I.La.tineh L.Mira.ito K.Shcha.lo I.Ba.a.uria.D.Lomidze I.Lomidze V.Bha.na.a. R.Gupta.P.Kuma.i J.Singh V.a.oozega. B.Boghra.i M.Ebra.mi R.Gha.emi M.Moha.ma.i Na.a.a.a.i E.Za.eia. M.a.brescia.R.a.y W.Elmetena.ee N.De Filippis a.Gelmi G.Ia.elli S.Leszki F.Loddo I.Ma.gjeka.G.Pugliese D.Ra.os L.benussi S.Bia.co D.Piccolo S.Buontempo a.Di Crescenzo F.Fienga.G.De Lellis L.Lista.S.Meola.P.Pa.lucci a.Bra.hieri P.Sa.vini P.Monta.na.C.Ricca.di P.Vitulo B.Fra.cois T.J.Kim J.Pa.k S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.Eyserma.s C.Uribe Estra.a.I.Pedra.a.H.Ca.tilla.Va.dez a.Sa.chez-Herna.dez C.a.Mondra.on Herrera.D.a.Perez Na.a.ro G.a.a.a.a.Sa.chez S.Ca.rillo E.Va.quez a.Ra.i a.a.ma. I.a.gha. H.Hoora.i S.Muha.ma. M.a.Sha. I.Crotty Depa.tment of Physics a.d a.tronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Bra.ileiro Pesquisa. Fisica. R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil Dep.de Fisica.Nuclea. e a.ta. Energia. Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulga.ia. a.a.emy of Sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Fa.ulty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Institute of High Energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universida. de Los a.des Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia Egyptia. Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in Egypt(BUE) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt Suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt Depa.tment of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High Energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgia. Technica. University 77 Kostava Str.Tbilisi 0175Georgia Depa.tment of Physics Panjab UniversityChandigarh 160014India School of Pa.ticles a.d a.celera.ors Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Ha.ya.g University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement a.d ensure redunda.cy in the endca. muon system of the Compa.t Muon Solenoid(CMS)detector a.d to extend the Resistive Pla.e Cha.ber(RPC)system covera.e,improved RPCs(iRPCs)with either orthogona. la.er strips with one-end electronics or single la.er strips with two-end electronics providing more precise time mea.urement will be insta.led in the very forwa.d pseudora.idity region of|η|a.out system needs to support twodimensiona.(2D)or two-end *** a.dition,it must combine detector da.a.with Timing,Trigger a.d fa.t Control(TTC)a.d Slow Control(SC)into one da.a.strea. over a.bi-directiona. optica. link with a.line ra.e of 4.8 Gb/s between the Front-End Electronics(FEE)a.d the Ba.k-End Electronics(BEE).To fulfill these requirements,a.prototype BEE for the iRPC 2D cha.ber ha. been resea.ched a.d *** a.Micro-Telecommunica.ion a.d Computing a.chitecture(μTCa.-ba.ed processing ca.d wa. designed in this study to esta.lish a.prototype system together with a.TCa.*** Giga.Bit Tra.sceiver(GBT)protocol is integra.ed to provide bi-directiona. communica.ion between the FEE a.d BEE.a.server is connected with the BEE by a.Giga.it Ethernet(GbE)link for SC a.d a.10-GbE link for Da.a.a.Quisition(Da.).Results The Bit Error Ra.e(BER)test of the ba.k-end boa.d a.d a.joint test with the iRPC 2D prototype cha.ber were *** less tha. 1.331×10−16 wa. *** timemea.urement with a.resolution of 3.05 nswa. successfully rea.ized,a.d detector efficiencies of 97.7%for longitudina. strips a.d 96.0%for orthogona. strips were *** results demonstra.e the correctness a.d relia.ility of the prototype *** The BEE prototype sa.isfies the requirements for the iRPC 2D cha.ber,a.d it worked sta.ly a.d relia.ly during a.long-term joint test run.

关键词： CMS iRPC TTC SC BEE μTCA GBT Da.

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R&D of ba.k-end electronics for improved resistive pla.e cha.bers for the pha.e 2 upgra.e of the CMS end-ca.muon system

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Ra.ia.ion Detection Technology a.d Methods 2022年第3期6卷 306-316页

作者： H.Kou Z.-a.Liu J.Zha. J.Song Q.Hou W.Dia. P.Ca. W.Gong N.Wa.g a.Sa.a.a. M.Tytga. M.El Sa.y G.a.a.ves F.Ma.ujo E.a.Coelho F.Torres Da.Silva.De a.a.jo E.M.Da.Costa.H.Nogima.a.Sa.toro S.Fonseca.De Souza.D.De Jesus Da.ia. M.Thiel M.Ba.roso Ferreira.Filho K.Mota.a.a.ilo a.a.eksa.drov R.Ha.jiiska.P.Ia.djiev M.Rodozov M.Shopova.G.Sulta.ov a.Dimitrov L.Litov B.Pa.lov P.Petkov a.Petrov E.Shumka.S.J.Qia. C.a.ila.D.Ba.bosa.a.Ca.rera.a.Florez J.Fra.a.J.Reyes Y.a.sra. M.a.Ma.moud Y.Moha.med I.La.tineh G.Grenier M.Gouzevitch L.Mira.ito K.Shcha.lo C.Comba.et W.Tromeur G.Ga.bit a.Luciol X.Chen I.Ba.a.uria.I.Lomidze Z.Tsa.a.a.dze V.a.oozega. B.Boghra.i M.Ebra.mi E.Za.eia. M.Moha.ma.i Na.a.a.a.i M.a.brescia.G.Ia.elli G.Pugliese F.Loddo N.De Filippis R.a.y D.Ra.os W.Elmetena.ee S.Leszki I.Ma.gjeka.D.Pa.sa.i L.benussi S.Bia.co D.Piccolo S.Meola.S.Buontempo F.Ca.neva.i L.Lista.P.Pa.lucci F.Fienga.a.Bra.hieri P.Sa.vini P.Monta.na.C.Ricca.di P.Vitulo E.a.ila. J.Choi T.J.Kim S.Y.Choi B.Hong K.S.Lee H.Y.Oh J.Goh I.Yu C.Uribe Estra.a.I.Pedra.a.H.Ca.tilla.Va.dez R.L.Ferna.dez a.Sa.chez-Herna.dez E.Va.quez M.Ra.irez-Ga.cia.N.Za.a.idis a.Ra.i H.Hoora.i S.Muha.ma. a.a.ma. I.a.gha. M.a.Sha. W.a.Kha. J.Eyserma.s I.Crotty on beha.f of the CMS Muon Group Depa.tment of Physics a.d a.tronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium UniversitéLibre de Bruxelles Avenue Franklin Roosevelt50-1050 BruxellesBelgium Centro Bra.ileiro Pesquisa. Fisica. R.Dr.Xavier Sigaud150UrcaRio de JaneiroRio de Janeiro 22290-180Brazil Depa.tment de Fisica.Nuclea. e a.ta. Energia. Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524Rio de JaneiroRio de Janeiro 20559-900Brazil Bulga.ia. a.a.emy of Sciences Institute for Nuclear Researches and Nuclear EnergyTzarigradsko Shaussee Boulevard 721784 SofiaBulgaria Fa.ulty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Sta.e Key La.ora.ory of Pa.ticle Detection a.d Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese a.a.emy of Sciences B325Main BuildingNo.19(A)Yuquan RoadShijingshan DistrictBeijing 100049China Universida. de Los a.des Carrera 1No.18A-12BogotáColombia Egyptia. Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt Suez University SuezCairo RoadElsalam CitySuez 43522Egypt Center for High Energy Physics(CHEP-FU) Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgia. Technica. University 77 Kostava Str.0175 TbilisiGeorgia School of Pa.ticles a.d a.celera.ors Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531 TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso University Monte S.AngeloVia Cintia80126 NapoliItaly Dipa.timento di Ingegneria.Elettrica.e delle Tecnologie dell’Informa.ione UniversitàDegli Studi di Napoli Federico II80126 NapoliI

Purpose The La.ge Ha.ron Collider(LHC)a. Europea. Orga.iza.ion for Nuclea. Resea.ch is pla.ned to be upgra.ed to the high luminosity *** the luminosity ma.es muon triggering relia.le a.d ofﬂine reconstruction very *** enha.ce the redunda.cy of the Compa.t Muon Solenoid(CMS)Muon system a.d resolve the a.biguity of tra.k reconstruction in the forwa.d region,a. improved Resistive Pla.e Cha.ber(iRPC)with excellent time resolution will be insta.led in the Pha.e-2 CMS *** iRPC will be equipped with Front-End Electronics(FEE),which ca. perform high-precision time mea.urements of signa.s from both ends of the *** Ba.k-End Electronics(BEE)need to be resea.ched a.d developed to provide sophistica.ed functiona.ities such a. intera.ting with FEE with sha.ed links for fa.t,slow control(SC)a.d da.a.in a.dition to trigger primitives(TPs)genera.ion a.d da.a.a.quisition(Da.).Method The BEE prototype uses a.homema.e ha.dwa.e boa.d compa.ible with the MTCa.sta.da.d,the ba.k-end boa.d(BEB).BEE intera.ts with FEE via.a.bidirectiona. 4.8 Gbps optica. pa.red-link tha. integra.es clock,da.a.a.d control *** clock a.d fa.t/slow control comma.ds a.e distributed from BEB to the FEE via.the *** uplink is used for BEB to receive the time informa.ion of the iRPC’sﬁred strips a.d the responses to the fa.t/slow control *** ha.e a.pipelined detector da.a.for clusterﬁnding opera.ion,recover(DeMux)the time rela.ionship of which is cha.ged due to the tra.smission protocol for the continuous incoming MUXed da.a.from *** a. ea.h bunch crossing(BX),clusteringﬁred strips tha. sa.isfy time a.d spa.ia. constra.nts to genera.e *** incoming ra. MUXed detector da.a.a.d TPs in a.time window a.d la.ency ba.ed on the trigger signa. a.e rea. out to the Da. *** Ethernet(GbE)of SiTCP a.d commercia. 10-GbE a.e used a. link sta.da.ds for SC a.d Da.,respectively,for the BEB to intera.t with the *** The joint test results of

关键词： CMS iRPC BEE TP Da. SC

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