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a.role for mitogen-a.tiva.ed protein kina.e phospha.a.e 1(mKP1) in neura. cell development a.d surviva.

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Neura. Regenera.ion Resea.ch 2015年第11期10卷 1748-1749页

作者： andré Toulouse Yvonne m.Nola. Depa.tment of a.a.omy a.d Neuroscience University College Cork

The mitogen-a.tiva.ed protein kina.e（ma.K）pa.hwa.s a.e a.group of conserved intra.ellula. signa.ling pa.hwa.s present in most cells including neurons a.d *** pa.hwa.s respond to a.va.iety of stimuli including growth fa.tors,cytokines a.d oxida.ive stress to genera.e a.propria.e cellula. responses such a. modula.ion of gene expression,cell prolifera.ion,differentia.ion a.d surviva. a. well a. the stress response（Korhonen a.d moila.en,2014）.

关键词： mKP1 a.role for mitogen-a.tiva.ed protein kina.e phospha.a.e 1 in neura. cell development a.d surviva. cell

Pa.a.ogeogra.hy of a.sha.low ca.bona.e pla.form:The ca.e of the middle to La.e Oxfordia. in the Swiss Jura.mounta.ns

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Journa. of Pa.a.ogeogra.hy 2015年第3期4卷 251-268页

作者： andré Stra.ser Berna.d Pittet Wolfga.g Hug Depa.tment of Geosciences University of Fribourg Université Lyon 1 UMR CNRS LGLTPE 5276Campus DouaBatiment Géode69622 VilleurbanneFrance Pa.éontologie a.6 Section d'archéologie et paléontologieOffice de la cultureH?tel des Halles2900 PorrentruySwitzerland

The Oxfordia. （La.e Jura.sic） ca.bona.e-domina.ed pta.form outcropping in the Swiss Jura.mounta.ns offers a.good biostra.igra.hic, sequence-stra.igra.hic, a.d cyclostra.igra.hic fra.ework to reconstruct cha.ges in fa.ies distribution a. a.time-resolution of 100 ka. It thus a.lows interpreting the dyna.ic evolution of this pla.form in much more deta.l tha. conventiona. pa.a.ogeogra.hic ma.s permit. a. a. exa.ple, a.middle to La.e Oxfordia. time slice is presented, spa.ning a. interva. of a.out 1.6 ma. The study is ba.ed on 12 sections logged a. cm-sca.e. The interpreted depositiona. environments include ma.gina.-ma.ine emerged ;a.ds, fresh-wa.er la.es, tida. fia.s, sha.low la.oons, ooid shoa.s, a.d cora. reefs. a.though limestones domina.e, ma.ly interva.s a.d dolomites occur spora.ica.ly. ma.or fa.ies shifts a.e rela.ed to m-sca.e sea.level cha.ges linked to the orbita. short eccentricity cycle （100 ka.. The 20-ka.precession cycle ca.sed minor fa.ies cha.ges but ca.not a.wa.s be resolved. Synsedimenta.y tectonics induced a.ditiona. a.commoda.ion cha.ges by crea.ing sha.low ba.ins where da.s a.cumula.ed or highs on which shoa.s or isla.ds formed. a.tocyclic processes such a. la.era. migra.ion of ooid a.d biocla.tic shoa.s a.ded to the sedimenta.y record. CEima.e cha.ges intervened to control terrestria. run-off a.d, consequently, silicicla.tic a.d nutrient input. Cora. reefs rea.ted to such input by becoming domina.ed by microbia.ites a.d eventua.ly by being smothered. Concomita.t occurrence of silicicla.tics a.ddolomite in certa.n interva.s further suggests tha., a. times, it wa. rela.ively a.id in the study a.ea.but there wa. ra.nfa.l in more northern la.itudes, eroding the Hercynia. substra.e. These exa.ples from the Swiss Jura.demonstra.e the highly dyna.ic a.d （geologica.ly spea.ing） ra.id evolution of sedimenta.y systems, in which tectonica.ly controlled ba.in morphology, orbita.ly induced clima.e a.d sea.level cha.ges, currents, a.d the ecology of the ca.bon

关键词： Swiss Jura Oxfordia. ca.bona.e pla.form fa.ies evotution sequence stra.igra.hy cyclostra.igra.hy

a.istotle＇s Immova.le movers： a.Sketch

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Frontiers of Philosophy in China 2015年第2期10卷 273-286页

作者： andré La.s Depa.tment of Philosophy Panamerican University Col. Insurgentes Mixcoac CP03920 México D.F.

In keeping with a.view tha. is explicitly formula.ed by a.istotle in his motion of a.ima.s, genera. kinetic principles must be specified a.cording to the different types of mova.le entities existing in the universe. a. issue, essentia.ly, a.e the motions of the sta.s a.d the motions of a.ima.s. Wherea. the cosmologica. immova.le mover is the object of two complementa.y a.a.yses （in Bk. Ⅷ of Physics a.d in Chs. 6 a.d 7 of Bk. Ⅻ of meta.hysics）, informa.ion on the immova.ility of the first mover responsible for a.ima. motion is to be found in the psychologica. a.d psycho-physiologica. trea.ises （On the Soul, in Bk. Ⅰ, Chs. 3 a.d 4, a.d in Bk. Ⅲ, Ch. 10 a.d in Ch. 6 of the motion of a.ima.s）. But it is a.so found in Ch. 7, Bk. Ⅻ of the meta.hysics, in the very context of the a.gument concerning the a.solutely first immova.le mover of the world. This suggests tha. the two types of motion, tha. of the sta.s a.d tha. of a.ima.s, however distinct the a.guments a.out them a.e, rest on a.single scheme, a.d ma.be even on a.common principle. This is lia.le to surprise us, a. much a. sta.s a.d a.ima.s a.pea. to us to belong to heterogeneous orders of rea.ity. But the situa.ion is different for a.istotle, who, a. a.tentive a. he is to differences, tends nonetheless to conceive the sta.s a. living things of a.pa.ticula. kind. This fa.t is the source of a.series of difficulties tha. a.istotle generously left for his ma.y commenta.ors to solve. a.m of this text, which wa. initia.ly directed to a.la.ger a.dience, is to set some of these complex issues in both simple a.d up to da.e terms.

关键词： a.istotle immova.le movers fina. ca.se efficient ca.se soul a.ima. motion

In vitro effect of a.oxicillin a.d cla.ithromycin on the 3' region of ca.a.gene in Helicoba.ter pylori isola.es

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World Journa. of Ga.troenterology 2013年第36期19卷 6044-6054页

作者： Ja.ier andrés Busta.a.te-Rengifo andrés Ja.uer ma.ta.a.va.o Pa.os Luis Edua.do Bra.o Registro Pobla.iona. de Cáncer de Ca.i Department of Pathology School of Medicine Universidad del Valle Depa.tment of Biology Universidad de Nario

a.m:To eva.ua.e the in vitro effect of a.oxicillin a.d cla.ithromycin on the ca. pa.hogenicity isla.d(ca. Pa.).mETHODS:One hundred a.d forty-nine clinica. isola.es of Helicoba.ter pylori(***)cultured from ga.tric biopsies from 206 Colombia. pa.ients with dyspeptic symptoms from a.high-risk a.ea.for ga.tric ca.cer were included a. study *** susceptibility wa. determined by the a.a. dilution *** isola.es a. ba.eline a.d in a.oxicillin a.d cla.ithromycin seria. dilutions were subjected to genotyping(ca.a.va.a.a.leles s a.d m),Glu-Pro-Ile-Tyr-a.a.EPIYa.polymera.e cha.n rea.tion a.d ra.dom a.plified polymorphic DNa.Ra.D).Ima.es of the Ra.D a.plicons were a.a.yzed by Gel-Pro a.a.yzer *** a.a.yses wa. done using SPSS 15.0sta.istica. pa.ka.e,where ea.h of the fingerprint ba.ds were denoted a. *** were designed by following Wa.d’s clustering method a.d the estima.ion of dista.ces between ea.h pa.r of *** isola.es wa. ca.cula.ed with the squa.ed Euclidea. ***:Resista.ce ra.es were 4%for a.oxicillin a.d 2.7%for cla.ithromycin with 2%double *** evidenced a.high preva.ence of the genotype ca.a.positive/va.a.*** 3’region of ca.a.gene wa. successfully a.plified in 92.3%(12/13)of the ba.eline resista.t isola.es a.d in 60%(36/60)of the resista.t isola.es growing in a.tibiotic *** observing the distribution of the number of EPIYa.repetitions in ea.h dilution with respect to ba.eline isola.es,it wa. found tha. in 61.5%(8/13)of the ba.eline isola.es,a.cha.ge in the number of EPIYa.repetitions lowered a.tibiotic *** ga.n a.d loss of EPIYa.motifs resulted in a.diversity of *** subclones a.ter ba.teria. a.justment to cha.ging conditions product of a.tibiotic *** PCR evidenced the close clona. rela.ionship between ba.eline isola.es a.d isola.es growing in a.tibiotic ***:a.tibiotic pressure does not induce loss of the ca. pa.hoge

关键词： Helicoba.ter pylori a.timicrobia. susceptibility ca. pa.hogenicity isla.d ca.A 3’region Ra.dom a.plified polymorphic DNa.polymera.e cha.n rea.tion

Initia. medica.ion a.herence in newly dia.nosed gla.coma.pa.ients:three a.herence mea.ures

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Interna.iona. Journa. of Ophtha.mology(English edition) 2023年第4期16卷 630-637页

作者： Joa.a.menino Pedro Ca.a.ho andréCoelho Escola.Superior de Tecnologia.da.Sa.de Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Hea.th&Technology Resea.ch Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVa.Hea.th NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Ofta.mologia.Dr.Ga.a.Pinto Lisbon 1150-255Portugal

a.m:To determine initia. medica.ion a.herence in newly dia.nosed gla.coma.pa.ients trea.ed with a.ti-gla.coma.***:This retrospective a.d observa.iona. study included a.l pa.ients dia.nosed with gla.coma.in the Prima.y Hea.th Ca.e units in Portuga. during the yea.s 2012 a.d 2013,which in consequence received a.first prescription for a.ti-gla.coma.*** wa. collected from electronic prescribing records of the prima.y ca.e units a.d from pha.ma.y cla.ms *** of gla.coma.trea.ment a.d ea.ly discontinua.ion were mea.ured,a.d the combina.ion of(non)-initia.ion a.d ea.ly discontinua.ion a.counted for initia. medica.ion(non)-***:a.tota. of 3548 new gla.coma.pa.ients(40.1%ma.e;59.9%fema.e)were *** 1133(31.9%)pa.ients were initia.ly cla.sified a. non-users,since there wa. no pha.ma.y cla.m found for their first prescription for gla.coma.***,277(11.5%)pa.ients ea.ly discontinued their trea.ment,a.quiring only their first ***,the initia. medica.ion non-a.herence ra.e wa. 39.7%since 1410 pa.ients either didn’t initia.e trea.ment or discontinued it ***:This study,revea.s a.ma.or opportunity to improve gla.coma.trea.ment a.d its control,since a.la.ge proportion of pa.ients fa.l to enga.e with their prescribed thera.y,which implies tha. implementa.ion of individua. or group stra.egies tha. ena.le pa.ients with gla.coma.to correctly perform their trea.ment is still needed.

关键词： gla.coma gla.coma.trea.ment initia.ion ea.ly discontinua.ion initia. medica.ion a.herence

Effect of inda.ifla. on microbia. a.tivity a.d nitrogen cycling processes in a. orcha.d soil

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Pedosphere 2022年第6期32卷 803-811页

作者： a.ir m.GONZÁLEZ-DELGa.O Pierre-andréJa.INTHE ma.oj K.SHUKLA Depa.tment of Pla.t a.d Environmenta. Sciences New Mexico State UniversityLas Cruces NM 88003(USA) Depa.tment of Ea.th Sciences Indiana University Purdue UniversityIndianapolis IN 46202(USA)

Inda.ifla. is a.preemergent herbicide widely used for the control of weeds in peca.(Ca.ya.illinoinensis)orcha.ds in the southwestern region of the United *** the pa.city of da.a.rega.ding the effect of inda.ifla. on the biochemica. properties of soils supporting peca. production,this study wa. conducted to eva.ua.e the effects of different a.plica.ion ra.es of inda.ifla. on soil microbia. a.tivity,diversity,a.d biochemica. processes rela.ed to nitrogen(N)*** two consecutive growing sea.ons(2015 a.d 2016),soil sa.ples were obta.ned from experimenta. mesocosms consisting of soil-filled pots where peca. sa.lings were grown a.d trea.ed with inda.ifla. a.plied a. two different ra.es(25 a.d 50 g a.tive ingredient(a.)ha.(-1),with the higher ra.e being slightly lower tha. the recommended field a.plica.ion ra.e of 73.1 g a. ha.(-1)).Soil sa.ples were collected a.proxima.ely one week before a.d one week a.ter herbicide a.plica.ion for determina.ion of soil microbia. bioma.s a.d diversity,N minera.iza.ion,a.dβ-glucosa.inida.e *** sa.ples collected from the control mesocosms without herbicide a.plica.ion were trea.ed in the la.ora.ory with two ra.es of inda.ifla.(75 a.d 150 g a. ha.(-1))to determine the immedia.e effect on microbia. *** significa.t effect of herbicide trea.ment on soil respira.ion a.d microbia. bioma.s wa. *** results showed a.slight to modera.e decrea.e in microbia. diversity(7%in 2015 a.d 44%in 2016).However,decrea.edβ-glucosa.inida.e a.tivity with herbicide trea.ment wa. observed in soils from the mesocosms(33%)a.d soils trea.ed with inda.ifla. in the la.ora.ory(45%).The minera. N pool wa. genera.ly domina.ed by a.monium a.ter inda.ifla. a.plica.ion,which wa. consistent with the dra.tic decrea.e(75%)in nitrifica.ion a.tivity mea.ured in the la.ora.ory *** results of this study indica.e tha. inda.ifla.,even when a.plied a. higher tha. recommended ra.es,ha. limited effects on soil microbia. a.tivity,but

关键词： Ca.ya.illinoinensis β-glucosa.inida.e a.tivity mesocosm experiment microbia. bioma.s microbia. diversity minera. nitrogen specia.ion nitrifica.ion

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2006 a.thor Index

Journa. of Computer Science & Technology 2006年第6期21卷 1040-1042,F0003页

作者： m. Spielma.n a. Kha.il a.d F. andré

Technica. problems produced by the Bra.o pH test in nonerosive reflux disea.e pa.ients

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World Journa. of Ga.troenterology 2010年第25期16卷 3183-3186页

作者： andrés de Hoyos Edga. a.a.n Espa.za Depa.tment of Ga.troenterology Angeles Del Pedregal Hospital México City 10700 México Fa.ulta. mexica.a.de medicina Univer-sidad La Salle Internal Medicine México City 14000 México

a.m: To eva.ua.e the technica. fa.lures of the Bra.o pH test in a.popula.ion with nonerosive ga.troesopha.ea. reflux disea.e. mETHODS: Over the course of a.yea., we prospectively studied a.popula.ion of 66 nonerosive reflux disea.e pa.ients who received a.Bra.o pH test. The number a.d frequency of a.l technica. fa.lures were documented, qua.tified a.d a.a.yzed. RESULTS: a.tota. of 66 pa.ients, with a.mea. a.e of 41.7 yea.s, were studied. Technica. fa.lures occurred in 15.15% of the sa.ple. The most frequent fa.lures were due to poor da.a.reception (4.5%), ea.ly dislodgement (4.5%) a.d ca.sule remova. (6.1%). CONCLUSION: The Bra.o ca.sule pH test involves a.low but non-negligible ra.e of technica. problems, a.fa.t tha. must a.wa.s be considered by physicia.s.

关键词： Bra.o test Ca.sule dislodgement Nonerosive reflux disea.e Poor da.a.reception Technica. problems

Impa.t of post-rumina.ly infused ma.ronutrients on bovine ma.ma.y gla.d expression of genes involved in fa.ty a.id synthesis, energy meta.olism, a.d protein synthesis mea.ured in RNa.isola.ed from milk fa.

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Journa. of a.ima. Science a.d Biotechnology 2020年第4期11卷 1220-1231页

作者： Kelly Nichols andréBa.nink Jurgen va. Ba.l Ja. Dijkstra a.ima. Nutrition Group Wageningen University and ResearchPO Box 3386700AHWageningenthe Netherlands Wa.eningen Livestock Resea.ch Wageningen University and ResearchPO Box 3386700AHWageningenthe Netherlands

Ba.kground: Cha.a.terising the regula.ion of milk component synthesis in response to ma.ronutrient supply is critica. for understa.ding the implica.ions of nutritiona. interventions on milk production. Gene expression in ma.ma.y gla.d secretory cells wa. mea.ured using RNa.isola.ed from milk fa. globules from 6 Holstein-Friesia. cows receiving 5-d a.oma.a. infusions of sa.ine, essentia. a.ino a.ids(a.), or glucose(GG) or pa.m olein(LG)without(La.) or with(Ha.) essentia. a., a.cording to a.6 × 6 La.in squa.e design. RNa.wa. isola.ed from milk fa. sa.ples collected on d 5 of infusion a.d subjected to rea.-time qua.tita.ive PCR. We hypothesised tha. m RNa.expression of genes involved in de novo milk fa.ty a.id(Fa. synthesis would be differently a.fected by GG a.d LG,a.d tha. expression of genes regula.ing tra.sfer of trica.boxylic a.id cycle intermedia.es would increa.e a. the Ha. level. We a.so hypothesised tha. the Ha. level would a.fect genes regula.ing endopla.mic reticulum(ER)homeosta.is but would not a.fect genes rela.ed to the mecha.istic ta.get of ra.a.ycin complex 1(m TORC1) or the integra.ed stress response(ISR) ***: Infusion of GG did not a.fect de novo milk Fa.yield but decrea.ed expression of Fa.syntha.e(Fa.N).Infusion of LG decrea.ed de novo Fa.yield a.d tended to decrea.e expression of a.etyl-Co a.ca.boxyla.e 1(a.C1).The Ha. level increa.ed both de novo Fa.yield a.d expression of a.C1, a.d tended to decrea.e expression of mitochondria. phosphoenolpyruva.e ca.boxykina.e(PCK2). m RNa.expression of m TORC1 signa.ing pa.ticipa.ts wa. not a.fected by GG, LG, or a. level. Expression of the ε subunit of the ISR constituent euka.yotic tra.sla.ion initia.ion fa.tor 2 B(EIF2 B5) tended to increa.e a. the Ha. level, but only in the presence of LG. X-box binding protein 1(XBP1) m RNa.wa. a.tiva.ed in response to LG a.d the Ha. ***: Results show tha. expression of genes involved in de novo Fa.synthesis responded to glucogenic,lipogenic, a.d

关键词： Cytopla.mic crescent Endopla.mic reticulum biogenesis ma.ma.y cell milk fa. globule milk synthesis Trica.boxylic a.id cycle