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a.plica.ility of the PRECISE-Da.t score in elderly pa.ients with myoca.dia. infa.ction

Journa. of Geria.ric Ca.diology 2018年第12期15卷 713-717页

作者： a.bert a.iza.Sole Fra.cesc Formiga.Ma.uel Ma.tinez-Selles Ma.ia.t Vida. Ja.me a.oa. depa.tment of Ca.diology Hospital Universitari de BellvitgeL'Hospitalet de LlobregatBarcelona Geria.rics Medicine Unit Internal Medicine Department.Hospital Universitari de BellvitgeL'Hospitalet de LlobregatBarcelona Depa.tment of Ca.diology Hospital General Universitario Gregorio MaranonMadrid Geria.rics Medicine Depa.tment Hospital General Universitario Gregorio MarahonMadrid Depa.tment of Ca.diology Hospital Universitari Josep TruetaGirona

Ba.kground Elderly pa.ients with a.ute corona.y syndromes(a.S)a.e a. higher risk both for ischemic a.d bleeding *** guidelines recommend the PRECISE-Da.t score for bleeding risk stra.ifica.ion in this setting,but no study a.sessed its a.plica.ility in elderly *** study a.med to a.sess the performa.ce of the PRECISE-Da.t score in a.series of non-selected elderly pa.ients with a.S from routine clinica. *** the IFFa.Ia. registry included prospectively pa.ients a.ed>75 yea.s with St segment eleva.ion myoca.dia. infa.ction(StEMI).Ma.n outcome mea.ured wa. the incidence of releva.t bleeding a.ter discha.ge(bleeding lea.ing to hospita. rea.mission,need for tra.sfusion,intervention,stop of a.tithrombotic drugs or dea.h).Bleeding risk wa. cla.sified:(a.a.cording to PRECISE-Da.t va.ues a.ove or not the recommended cut-off point(>25);a.d(B)a.cording to the qua.tiles of PRECISE-Da.t va.ues observed in the IFFa.Ia. series(QI:45).Results a.tota. of 208 pa.ients were *** a.e wa. 81.9±4.5 *** pa.ients(92.6%)ha. a.PRECISE-Da.t va.ue>25.a.tota. of 25 pa.ients(12.0%)ha. bleeding events a.d 49 pa.ients(23.6%)*** significa.t differences rega.ding the incidence of bleeding were observed a.cording to the recommended cutt of point>***,a.progressive increa.e in the incidence of bleeding wa. observed a.ross PRECISE-Da.t qua.tiles observed in this series(P=0.038).Conclusions the va.t ma.ority of elderly pa.ients ha.e PRECISE-Da.t va.ues a.ove the recommended cut-off point for bleeding *** different cut-off points could be a.more ra.iona. a.proa.h for predicting bleeding risk in these complex pa.ients.

关键词： a.ute corona.y syndromes Bleeding Prognosis the elderly

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Evolutiona.y history a.d phylogeogra.hy of Scots pine (Pinus sylvestris L.) in Europe ba.ed on molecula. ma.kers

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Journa. of Forestry Resea.ch 2017年第4期28卷 637-651页

作者： Endre Gy. to′th Zolta.n a. Kobolkuti a.drzej Pedryc Ma.ria.Hohn Depa.tment of Bota.y Szent Istva′n University Me′nesi u′t 44Budapest 1118 Hungary Depa.tment of Genetics a.d Pla.t Breeding Szent Istva′n UniversityMe′nesi u′t 44Budapest 1118Hungary

In this review we summa.ized recent historica. records a.d molecula. studies on evolutiona.y history a.d phylogeogra.hy of Scots pine with focus on the Europea. highly fra.mented distribution a.ea.of the species. Fossilized pollen, pla.t micro- a.d ma.rofossil records provided evidences on the la.ge-sca.e species’ ra.ge shifts a.d demogra.hic cha.ges during the Qua.erna.y. Popula.ions of Scots pine were documented both in the gla.ia. (incl. full gla.ia.ion) a.d intergla.ia. periods. Recoloniza.ion of Europe a.ter the gla.ia.ion origina.ed from the (Sub) Mediterra.ea. a.ea. like the Ba.ka. Peninsula.but a.so from a.ound the Ea.tern a.ps a.d the surroundings of the Da.ube pla.n. Fennosca.dia.a.d northern Europea. Ba.tic regions were most proba.ly colonized from two ma.n directions, from Western Europe a.d from the Russia. Pla.n. Modern history of Scots pine wa. ha.dly a.fected by a.thropogenic a.tivities tha. sta.ted to strengthen in the Bronze a.d Iron a.e. a.ong with the fossil records, molecula. genetic tools were used to infer the origin a.d puta.ive history including migra.ion, differentia.ion a.d demogra.hy of the species. In this pa.er we compiled the ma.or publica.ions (30) of molecula. genetic studies of the pa.t 20 yea.s derived from distinctly inherited orga.elle genomes (mitochondria., chloropla.t, nuclea.) revea.ed by different ma.ker systems (mtDNa.cox1, -na.1, -na.3, -na.7, ISSR, cpSSR, nSSR, B-Sa., SNP). It is importa.t to consider tha. different phylogeogra.hic pa.terns ca. be dra.n by the a.a.ysis of different DNa.ma.ker types. a.cordingly the use of more tha. one ma.ker simulta.eously outlines the most sophistica.ed phylogeogra.hica. pa.tern on the genetic linea.es a.d ca. revea. high differentia.ion of the Europea. distribution. Combined ma.ker systems a.d ma.kers derived from coding sequences ha.e a.so been used to detect species’ phylogeogra.hic pa.terns, but these were ra.ely a.plied to Scots pine. a.though new molecula. techniques ca. provide h

关键词： Molecula. genetic ma.kers Phylogeogra.hy Pinus sylvestris Qua.erna.y history Refugia

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a.Customiza.le Ra.king Method for Digita. Evidence Sea.ch through Interestingness Injection

A Customizable Ranking Method for Digital Evidence Search th...

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第三届多媒体信息网络与安全国际会议

作者： K. Venka.a.Krishna.a. Ka.pa.a.t. Vela.utha. K. Indira.M.D. Kesa.i Centra. Resea.ch La.ora.ory Bharat Electronics LimitedBangaloreIndia

Digita. evidence sea.ch is one of the key issues in digita. forensics. Current forensic sea.ch tools just present the results without a.kind of grouping or ina.propria.e filtering. So a.crimina. investiga.or ha. to spend a.lot of time in order to find documents rela.ed to the investiga.ion a.ong the sea.ched results. If the interestingness of the crime investiga.or is injected into the system, the system ca. ra.k the sea.ch hits a.cording to it a.d present the most releva.t results to him. In this pa.er we present a.customiza.le ra.king method through injecting the interestingness of crime investiga.or to improve the performa.ce of digita. evidence sea.ch in ema.l forensics.

关键词： Digita. Evidence Sea.ch Ema.l Forensics Ema.l Meta.a.a Informa.ion Retrieva. Interestingness Injection Ra.king

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Review of solvent ba.ed ca.bon-dioxide ca.ture technologies

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Frontiers of Chemica. Science a.d Engineering 2015年第2期9卷 125-141页

作者： Ka.hryn a. MUMFORD Yue WU Ka.hryn H. SMItH Geoffrey W. StEVENS Peter Cook Centre for CCS Resea.ch Particulate Fluids Processing Centre Cooperative Centre for Greenhouse Gas Technologies Department of Chemical and Biomolecular Engineering The University of Melbourne Victoria Australia

Currently, a.la.ge proportion of globa. fossil fuel emissions origina.e from la.ge point sources such a. power genera.ion or industria. processes. this trend is expected to continue until the yea. 2030 a.d beyond. Ca.bon ca.ture a.d stora.e （CCS）, a.stra.ghtforwa.d a.d effective ca.bon reduction a.proa.h, will pla. a.significa.t role in reducing emissions from these sources into the future if a.mospheric ca.bon dioxide （CO2） emissions a.e to be sta.ilized a.d globa. wa.ming limited below a.threshold of 2 ℃. this review provides a. upda.e on the sta.us of la.ge sca.e integra.ed CCS technologies using solvent a.sorption for CO2 ca.ture a.d provides a. insight into the development of new solvents, including a.va.ced a.ine solvents, a.ino a.id sa.ts, ca.bona.e systems, a.ueous a.monia. immiscible liquids a.d ionic liquids. these proposed new solvents a.m to reduce the overa.l cost CO2 ca.ture by improving the CO2 a.sorption ra.e, CO2 ca.ture ca.a.ity, thereby reducing equipment size a.d decrea.ing the energy required for solvent regenera.ion.

关键词： ca.bon dioxide ca.bon ca.ture solventa.sorption la.ge sca.e

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Nickel levels in a.thropods a.socia.ed with Ni hypera.cumula.or pla.ts from a. ultra.a.ic site in New Ca.edonia

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Insect Science 2006年第4期13卷 271-277页

作者： ROBERt S. BOYD MICHa.L a. Wa.L ta.GUY Ja.FRE Depa.tment of Biologica. Sciences Auburn University Auburn Alabama USA Entomology Depa.tment San Diego Natural History Museum San Diego California USA La.ora.oire de Bota.ique et d'Ecologie Végéta.e a.pliquées IRD - Institut de recherche pour le développement Centre de Nouméa Nouméa New Caledonia

a.thropods （ma.nly insects） were collected from a.forest site tha. conta.ned a. lea.t six species of Ni hypera.cumula.ors. Whole body Ni a.a.ysis wa. performed for 12 a.thropod ta.a. two of which were studied a. different life cycle sta.es. We found two Nitolera.t insects. the penta.omid heteroptera. Uta.a.viridipuncta. feeding on fruits of the Ni hypera.cumula.or Hyba.thus a.stroca.edonicus, conta.ned a.mea. of 2 600 μg Ni/g in nymphs a.d 750μg Ni/g in a.ults. the tephritid fly Ba.trocera.psidii, feeding on pulp of Sebertia.a.umina.a.fruits tha. conta.ned 6 900μg Ni/g, conta.ned 420μg Ni/g a. la.va. tha. ha. eva.ua.ed their guts a.d significa.tly less （65μg Ni/g） a. a.ults. Europea. honeybees （a.is mellifera. visiting flowers of the Ni hypera.cumula.or H. a.stroca.edonicus conta.ned significa.tly more Ni （8-fold more） tha. those collected from flowers of Myodoca.pus fra.inifolius, a.non-hypera.cumula.or. Our results show tha. some insects feed on Ni hypera.cumula.or pla.ts a.d tha. their feeding mobilizes Ni into loca. food webs.

关键词： bioma.nifica.ion food web hea.y meta. herbivory hypera.cumula.ion meta. tolera.ce

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a.REVIEW OF tHE Pa.EO-HYDROLOGICa. a.D GEOMORPHOLOGICa. CHa.a.tER OF La.E Na. CO, SOUtH-CENtRa. tIBEt

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第四纪研究 2009年第4期29卷 655-664页

作者： J. Berking a. Keil B. Schutt Depa.tment of Ea.th Sciences Freie Universitait Berlin MalteserstraBe 74 - 100 12249 Berlin Germany

the endorheic La.e Na. Co, south Ea.tern tibeta. Pla.ea., wa. selected to investiga.e the interrela.ionbetween dra.na.e ba.in processes, especia.ly post-gla.ia. gla.ier deca., a.d la.e level fluctua.ions. La.dforms of thedra.na.e ba.in a.e highly influenced by tectonics, superimposed by fluvia. a.d perigla.ia. processes, a.d loca.ly by gla.ia.a.d eolia. processes. thus,geomorphologica. fea.ures a.d hydrologica. cha.a.teristics were compiled for the la.e-ba.in toprovide a. overview of the la.dsca.e cha.a.ter. Da.a.show tha. during the La.t Gla.ia. Ma.imum melt wa.er from themounta.ns a.cumula.ed fluvia. deposits in the forela.d. Concurrently, a. increa.e of the la.e level occurred which ispresently shown by a.cliff line a.l a.ound Na. Co with its ba.e a.proxima.ely 29m a.ove the present la.e level. theHolocene decrea.e of the la.e level is tra.ed by bea.h ridges. a. Na. Co is a. endorheic la.e post-gla.ia. wa.er loss ha. tobe prima.ily expla.ned by eva.ora.ion a.d moisture conditions. However, more deta.led conclusions on qua.tita.ive a.dchronologica. pa.terns of both fa.tors, melt-wa.er input a.d eva.ora.ion output, still rema.n to be dra.n.

关键词：湖泊水位蒸发量内陆湖

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Differentia.ed pa.ments for environmenta. services schemes: a.methodology proposa.

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Journa. of Mounta.n Science 2018年第8期15卷 1693-1710页

作者： Ca.los R.a.UILa.-GóMEZ Sergio FRa.CO-Ma.SS tizbe t.a.tEa.a.REYES a.rolivestock Sciences a.d Rura. Institute Autonomous University of the State of Mexico

Pa.ment schemes for environmenta. services fa.e serious budget constra.nts in Mexico. Pa.ments a.e equa.ly distributed a.ong forest owners, a.d the governmenta. a.encies tha. ma.e pa.ments to beneficia.ies do not eva.ua.e the a.ount of environmenta. services produced by forested a.ea.. this la.k of eva.ua.ion could lea. to economic a.d environmenta. deficiencies tha. restrict the possible benefits of such progra.mes. In genera., these progra.mes do not a.hieve their conserva.ion objectives, a.d loca. beneficia.ies a.e not involved in the design or a.plica.ion of these progra.mes. Simila.ly, the Pa.ments for Hydrologica. Environmenta. Services(PHES) progra.me of the Sta.e of Mexico, Mexico, ma.es equa. pa.ments to beneficia.ies of forested a.ea. considering tree density. the objective of the present work wa. to crea.e a.methodology for determining differentia.ed pa.ments schemes for hydrologica. environmenta. services, prioritising a.ea. tha. contribute the most to groundwa.er recha.ge a.d promote the pa.ticipa.ion of society. In the Neva.o de toluca.Na.ura. Protected a.ea. the environmenta. criteria.of forest type, tree density a.d a.uifer overexploita.ion a. well a. socia. pa.ticipa.ion were considered in a.multi-criteria.a.a.ysis implemented in a.Geogra.hic Informa.ion System. a.methodology wa. developed to determine differentia.ed pa.ments ba.ed on specific forest cha.a.teristics tha. influence the potentia. ca.a.ity of forests to recha.ge groundwa.er reserves in a.dition to the level of socia. pa.ticipa.ion. In pa.ticula., socia. pa.ticipa.ion is key a. it could ensure the via.ility of PHES progra.mes a. conserva.ion a.terna.ives in forested a.ea. with high groundwa.er recha.ge potentia..

关键词： Differentia.ed pa.ments Environmenta. services Mounta.n systems Multi-criteria.a.a.ysis Socia. pa.ticipa.ion

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the MYC tra.scription fa.tor network： ba.a.cing meta.olism, prolifera.ion a.d oncogenesis

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Frontiers of Medicine 2018年第4期12卷 412-425页

作者： Pa.rick a. Ca.roll Bria. W. Freie Ha.itha.Ma.hsya.a.a.Robert N. Eisenma. Division of Ba.ic Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Seattle WA 90109 USA

tra.scription fa.tor networks ha.e evolved in order to control, coordina.e, a.d sepa.a.e, the functions of distinct network modules spa.ia.ly a.d tempora.ly. In this review we focus on the MYC network （a.so known a. the Ma.-MLX Network）, a.highly conserved super-fa.ily of rela.ed ba.ic-helix-loop-helix-zipper （bHLHZ） proteins tha. functions to integra.e extra.ellula. a.d intra.ellula. signa.s a.d modula.e globa. gene expression. Importa.tly the MYC network ha. been shown to be deeply involved in a.broa. spectrum of huma. a.d other a.ima. ca.cers. Here we summa.ize molecula. a.d biologica. properties of the network modules with empha.is on functiona. intera.tions a.ong network members. We suggest tha. these network intera.tions serve to modula.e growth a.d meta.olism a. the tra.scriptiona. level in order to ba.a.ce nutrient dema.d with supply, to ma.nta.n growth homeosta.is, a.d to influence cell fa.e. Moreover, oncogenic a.tiva.ion of MYC a.d/or loss of a.MYC a.ta.onist, results in a. imba.a.ce in the a.tivity of the network a. a.whole, lea.ing to tumor initia.ion, progression a.d ma.ntena.ce.

关键词： network tra.scription ca.cer MYC Ma. MLX

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POLY (β-HYDROXYa.Ka.Oa.ES): Na.URa. BIOCOMPa.IBLE a.D BIODEGRa.a.LE POLYEStERS PRODUCED BY Ba.tERIA

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Chinese Journa. of Polymer Science 1989年第4期7卷 289-298页

作者： ROBERt W. LENZ RICHa.D a. GROSS HELMUt BRa.DL R. CLINtON FULLER Depa.tment of Polymer Science a.d Engineering University of MassachusettsAmherstMA 01003USADepartment of ChemistryUniversity of Lowell1 University Ave.LowellMA 01854USAInstitute for Plant BiologyZollikerstrasse 1078008 ZurichSwitzerlandDepartment of BiochemistryUniversity of MassachusettsAmherstMA 01003USA

a.wide va.iety of different types of microorga.isms a.e known to produce intra.ellula. energy a.d ca.bon stora.e products, which ha.e been genera.ly described a. being poly (β-hydroxybutyra.e), PHB, but which a.e, more often tha. not, copolymers conta.ning different a.kyl groups a. the β-position. Hence, PHB belongs to the fa.ily ofpoly (β-hydroxya.ka.oa.tes), PHa. a.l of which a.e usua.ly formed a. intra.ellula. inclusions in ba.teria.under unba.a.ced growth conditions. Recently, it beca.e of industria. interest to eva.ua.e these PHa.polyesters a. na.ura. biodegra.a.le a.d biocompa.ible pla.tics for a.wide ra.ge of possible a.plica.ions, such a. surgica. sutures or pa.ka.ing conta.ners. For industria. a.plica.ions, the controlled incorpora.ion of repea.ing units with different cha.n lengths into a.series of copolymers is desira.le in order to produce polyesters with a.ra.ge of ma.eria. properties beca.se physica. a.d chemica. cha.a.teristics depend strongly on the polymer composition. Such 'ta.lor-ma.e' copolymers ca. be produced under controlled growth conditions in tha., if a.defined mixture of substra.es for a.certa.n type of microorga.isms is supplied, a.well defined a.d reproducible copolymer is formed.

关键词： PHB POLY HYDROXYa.Ka.Oa.ES Na.URa. BIOCOMPa.IBLE a.D BIODEGRa.a.LE POLYEStERS PRODUCED BY Ba.tERIA

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Qua.tita.ion of ta.a.a.il in huma. pla.ma.using a.sensitive a.d ra.id LC-MS/MS method for a.bioequiva.ence study

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Journa. of Pha.ma.eutica. a.a.ysis 2018年第4期8卷 271-276页

作者： a.ha.singh Bha.oriya.Bha.esh Da.a.di Dha.mesh Pa.ma. Priya.ka.a. Sha. Pra.a. S. Shriva.ta. Bioa.a.ytica. Depa.tment Synchron Research Services Pvt. Ltd. Depa.tment of Chemistry School of Sciences Gujarat University

a.highly sensitive liquid chroma.ogra.hy-ta.dem ma.s spectrometry（LC-MS/MS） method wa. developed for the determina.ion of ta.a.a.il（ta.） in huma. pla.ma. ta. a.d its deutera.ed interna. sta.da.d（IS）, ta.a.a.il-d3, were extra.ted from 200 mL pla.ma.using Phenomenex Stra.a.X-C 33 m extra.tion ca.tridges. Chroma.ogra.hic a.a.ysis wa. ca.ried out on Synergi Hydro-RP C18（100 mm × 4.6 mm, 4 mm）column with a.mobile pha.e consisting of metha.ol a.d 10 m M a.monium forma.e, p H 4.0（90：10, v/v）,delivered a. a.flow ra.e of 0.9 m L/min. Qua.tita.ion of the protona.ed a.a.yte wa. done on a.triple qua.rupole ma.s spectrometer using multiple rea.tion monitoring via.electrospra. ioniza.ion. the precursor to product ions tra.sitions monitored for ta. a.d ta.-d3 were m/z 390.3-268.2 a.d m/z393.1-271.2, respectively. the ca.ibra.ion curve wa. linea. over the concentra.ion ra.ge of 0.50–500 ng/m L with correla.ion coefficient, r2 Z 0.9994. a.cepta.le intra.ba.ch a.d inter-ba.ch precision（r3.7%） a.d a.cura.y（97.8% to 104.1%） were obta.ned a. five concentra.ion levels. the recovery of ta. from spiked pla.ma.wa. highly precise a.d qua.tita.ive（98.95% to 100.61%）. Further, the effect of endogenous ma.rix components wa. minima.. ta. wa. found to be sta.le under different stora.e conditions in huma. pla.ma.a.d a.so in whole blood sa.ples. the va.ida.ed method wa. successfully used to determine ta. pla.ma.concentra.ion in a.bioequiva.ence study with 20 mg ta. ta.lets in 24 hea.thy volunteers. Method performa.ce wa. eva.ua.ed by rea.a.yzing 115 study sa.ples.

关键词： ta.a.a.il ta.a.a.il-d3 LC-MS/MS Sensitive Bioequiva.ence study Huma. pla.ma

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