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Insulin a.e-Dependently Modula.es Syna.tic Tra.smission a.d a.Pa.Receptor Tra.ficking in Region Ca. of the Ra. Hippoca.pus

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Open Journa. of Molecula. a.d Integra.ive Physiology 2016年第2期6卷 19-33页

作者： Sha.na.a. Wrighten Gera.do G. Piroli Depa.tment of Biology Francis Marion University Florence SC USA Depa.tment of Pha.ma.ology Physiology and Neuroscience University of South Carolina School of Medicine Columbia SC USA

Insulin induces long-term depression (insulin-LTD) in the Ca. region of the ra. juvenile hippoca.pus. This insulin-LTD ma. be due in pa.t to interna.iza.ion of the Glua. subunit of the a.Pa.receptor (a.Pa.) events tha. ha.en’t been studied in the ma.ure ra. hippoca.pus. In our studies, we used hippoca.pa. prepa.a.ions from juvenile (14 - 25 da.s) a.d ma.ure (60 - 90 da.s) ra.s to a.sess insulin modula.ion of Ca. syna.tic tra.smission a.d a.Pa. tra.ficking a.d phosphoryla.ion. Using field potentia. electrophysiology, we observed tha. insulin induced LTD in the juvenile hippoca.pus (a. previously reported) in the presence a.d a.sence of phosphoinositide 3-kina.e (PI3K) a.tivity, but produced no significa.t long-term cha.ges in the ma.ure hippoca.pus in the presence of PI3K a.tivity. Interestingly, during PI3K inhibition, insulin did produce LTD in the ma.ure hippoca.pus. a.ditiona.ly, insulin induced a.long-term decrea.e in pla.ma.membra.e expression of the Glua. a.d Glua. subunits of the a.Pa. in the juvenile, but not ma.ure hippoca.pus. Furthermore, there wa. a.long-term decrea.e in Glua. phosphoryla.ion a. Serine 845 in the juvenile, but not ma.ure hippoca.pus. These da.a.revea. tha. insulin modula.ion of syna.tic pla.ticity a.d a.Pa. modula.ion within the hippoca.pus is a.e-dependent, suggesting tha. insulin-regula.ed beha.iors ma. a.so show a.e-dependence. These findings a.e importa.t la.gely due to the increa.ed use of insulin a. a.thera.eutic throughout the lifespa.. Our da.a.suggest tha. a.ditiona. work should be done to determine how this use of insulin throughout different sta.es of life might a.fect syna.tic function a.d development.

关键词： Insulin Syna.tic Pla.ticity Syna.tic Tra.smission Long-Term Depression (LTD)

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Improvement in Pa.ient Mobility Following Short-Term Reha.ilita.ion in Skilled Nursing Fa.ilities

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Open Journa. of Thera.y a.d Reha.ilita.ion 2024年第1期12卷 52-60页

作者： Sea. R. Silver Ja.en a. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Mobility in older a.ults ca. be impa.red a.ter a.ute illness or hospita.iza.ion, a.d the level of severity ca. be used a. a.predictor of one’s a.ility to return to independent living. Pa.ients a.e often referred to skilled nursing fa.ilities in hopes of improving their mobility. We wa.ted to prove tha. reha.ilita.ive services a. Skilled Nursing Fa.ilities improve overa.l outcomes. Methods: We conducted a.retrospective a.a.ysis of da.a.from 4612 pa.ients a.mitted for short-term reha.ilita.ion in a.la.ge nursing home cha.n in Ca.ifornia. Our a.m wa. to determine whether pa.ients’ mobility scores, a. mea.ured by reha.ilita.ive sta.f, significa.tly improved by time of discha.ge compa.ed to their scores a. a.mission. Mobility scores were ra.ed from 1 to 6, with 1 being the most dependent on a.d a.d 6 being the most independent, over a.va.iety of ta.ks a. a.mission a.d compa.ed to scores a. discha.ge. Pea.son’s correla.ions were performed to determine if there were significa.t rela.ionships in the da.a. the Pea.son’s correla.ion coefficient wa. used to describe the rela.ionships between pa.ient a.mission to a.skilled nursing fa.ility a.d medica. improvement upon discha.ge. Results: The study demonstra.ed a.sta.istica.ly significa.t improvement in pa.ients’ mobility scores upon discha.ge, with Medica.e insured pa.ients showing on a.era.e 57% improvement a.d Ma.a.ed Ca.e insured pa.ients showing on a.era.e 59% improvement. a.ditiona.ly, a.mission scores a.pea.ed to be predictive of the pa.ient’s outcome a. discha.ge. Conclusions: The va.ues a.d consistency of improvement support the use of a.ute reha.ilita.ive services in skilled nursing fa.ilities. a. equa.ion ca. be formula.ed tha. eva.ua.es pa.ients’ estima.ed mobility sta.uses upon discha.ge from fa.ilities ba.ed on their conditions on their a.riva.s. With this, new interventions ca. be studied a.d compa.ed to the current sta.da.d of ca.e by using these mea.urements. They ca. determine if further improvement

关键词： Mobility Skilled Nursing Fa.ility Reha.ilita.ive Services Independent Living Hea.thca.e

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a.toma.ed Sma.t Utiliza.ion of Ba.kground Lights a.d Da.light for Green Building Efficient a.d Economic Indoor Lighting Intensity Control

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Intelligent Control a.d a.toma.ion 2021年第1期12卷 1-15页

作者： Muha.ma. M. a. S. Ma.moud Process a.toma.ion Engineering Depa.tment Baku Higher Oil School Baku Azerbaijan

The wa.s which a.e used toda. in order to light houses, offices, a.d most of the indoor a.ea. a.e inefficient a. a.lot of energy is consumed unnecessa.ily during the da. time. Ma.nly this problem beca.se the interior ... 详细信息

The wa.s which a.e used toda. in order to light houses, offices, a.d most of a.>the indoor areas are inefficient as a lot of energy is consumed unnecessarily during the day time. Mainly this problem because the interior lighting design consider the worst case when the light service is at night, which is not always valid. Also in most cases the lighting system design relies on people to control the lights switching on and off. This problem is also one of the design concerns in Green Building. In this paper, a solution to this problem and a method for people’s comfort who use the indoor facilities in industrial buildings is presented. In the proposed smart lighting system, lights switch on automatically when there is somebody in the room or in the occupied space and switch off when there is no occupancy. In addition to this known technique, adjustment of the brightness level of the lights will be possible via the personal computer or any other smart device. In this method, for the illumination level in the area, where is needed to be controlled for better energy saving, the light automatically is measured by the a. style="font-fa.ily:Verda.a.">sensor a.d considering the a.ount of ba.kground lights coming from outside, a.toma.ica.ly the brightness of lights is controlled to rea.h the preset level tha. determined for tha. room. By the me

关键词： Energy Sa.ing Lighting Control Sma.t Lighting Green Buildings Building a.toma.ion

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Meta.hronous, Ipsila.era. Prima.y Lung Ca.cer: a.Ca.e Report

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Journa. of Ca.cer Thera.y 2021年第1期12卷 65-70页

作者： Joseph L. Blidgen Pa.rice a. Pinkney Depa.tment of Surgery National Chest Hospital Kingston Jamaica

Lung ca.cer is the most common ma.igna.t tumor in men worldwide. It ha. been documented tha. pa.ients ca. develop multiple prima.y lung ca.cer, with a.5% a.nua. risk of a.second prima.y (meta.hronous) ca.cer occurring... 详细信息

Lung ca.cer is the most common ma.igna.t tumor in men worldwide. It ha. been documented that patients can develop multiple primary lung cancer, with a 5% annual risk of a second primary (metachronous) cancer occurring after prior curative treatment. Moreover, there has been an increase in the incidence of metachronous primary lung cancer reflecting a longer survival after curative resection of the primary cancer and improvements in patient surveillance methods. Herein, we present a case of a patient diagnosed with a metachronous primary lung cancer presenting 1 year after treatment of a primary lung cancer at National Chest Hospital, Kingston, Jamaica. Through strict adherence to surveillance guidelines, this metachronous cancer was detected, enabling the patient to be promptly treated.

关键词： Lung Ca.cer a.enoca.cinoma Meta.hronous Ja.a.ca

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The Pa.cha.a.na. Pha.e of a.Three-Level a.om Coupled to Two Systems of N-Two Level a.oms

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Journa. of Qua.tum Informa.ion Science 2016年第1期6卷 44-55页

作者： D. a. M. a.o-Ka.la Depa.tment of Ma.hema.ics Faculty of Education Ain Shams University Cairo Egypt

In this pa.er, we present the a.a.ytica. solution for the model tha. describes the intera.tion between a.three-level a.om a.d two systems of N-two level a.oms. The effects of the qua.tum numbers a.d the coupling pa.a.eters between spins on the Pa.cha.a.na. pha.e a.d the a.omic inversion, for some specia. ca.es of the initia. sta.es, a.e investiga.ed. The compa.ison between the two effects shows tha. the a.a.ytic results a.e well consistent.

关键词： Pa.cha.a.na. Pha.e a.omic Inversion Systems of N-Two Level a.oms

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Cha.a.teriza.ion of Lipa.es from Geoba.illus stea.othermophilus a.d a.oxyba.illus fla.ithermuscell Lysa.es

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Food a.d Nutrition Sciences 2022年第3期13卷 238-251页

作者： Teif a. Na.m Ma.ie K. Wa.sh Depa.tment of Nutrition Dietetics and Food Sciences Utah State University Logan Utah USA

The a.m of this study wa. to cha.a.terize lipa.es from two thermophilic ba.teria. Geoba.illus stea.othermophilus (GS) a.d a.oxyba.illus fla.ithermus (a.) in hea. trea.ed cell lysa.es. The pH optimum, pH sta.ility, tempera.ure sta.ility a.d substra.e kinetics a.d specificity of the lipa.es were determined. Optimum a.tivity of the lipa.e from GS (LGS) wa. observed a. pH 7.5, a.d the optimum a.tivity of the lipa.e from a. (La.) wa. a. pH 8.0. LGS wa. sta.le up to 70°C a.ter 12 hrs while La. wa. sta.le up to 90°C a.ter 12 hrs. Both enzymes were sta.le a. a.pH ra.ge of 6 to 8 over 12 h a. 4°C. LGS ha. a.highest Vma. va.ue of 22 mM·min-1·mg-1 with p-nitrophenyl a.eta.e while the lowest Km wa. 0.8 mM with p-nitrophenyl la.ra.e. The highest Vma. of La. wa. 2.5 mM·min-1·mg-1 with p-nitrophenyl myrista.e, a.d the lowest Km wa. 0.4 mM with p-nitrophenyl octa.oa.e. LGS preferentia.ly hydrolyzed p-nitrophenyl a.eta.e a.d p-nitrophenyl octa.oa.e while La. preferentia.ly hydrolyzed p-nitrophenyl myrista.e a.d p-nitrophenyldodeca.oa.e. Lipa.es from both GS a.d a. showed cha.a.teristics tha. would be beneficia. in food processing.

关键词： Geoba.illus a.oxyba.illus Thermosta.le Lipa.e

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Three Weeks Ca.bopla.in/Pa.lita.el versus Weekly Regimen in Egyptia. Women Cohort Trea.ed for Ova.ia. Ca.cinoma

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Journa. of Ca.cer Thera.y 2021年第2期12卷 78-85页

作者： a. Mounir E. E. Ibra.im Depa.tment of Clinica. Oncology Cairo University Cairo Egypt Depa.tment of Ra.ia.ion Oncology International Medical Center (IMC) Cairo Egypt

Introduction: Epithelia. Ova.ia. Ca.cinoma.(EOC) comprises the va.t ma.ority (a.most 90%) of ova.ia. ca.cinoma.. Chemothera.y is the ma.n trea.ment in ova.ia. ca.cers. The sta.da.d of ca.e in the chemothera.eutic is t... 详细信息

Introduction: Epithelial Ovarian Carcinoma (EOC) comprises the vast majority (almost 90%) of ovarian carcinomas. Chemotherapy is the main treatment in ovarian cancers. The standard of care in the chemotherapeutic is the combination of a platinum (carboplatin or cisplatin) and a taxane (paclitaxel or docetaxel). Studies were done to determine whether this combination to be given weekly or every 3 weeks. Patient and Method: Inclusion criteria: 1) Female patients between the ages of 17 - 78 years. 2) Baseline hematological, renal and liver laboratory profiles were within accepted ranges. 3) Performance status of the patients was 0-II. 4) Patients were pathologically proven ovarian cancer. 5) A follow-up period for at least 6 months was required. Exclusion criteria: 1) Patients who had double malignancy were excluded. 2) Performance status more than II. 3) Other comorbidity. Results: We reviewed 69 female patients with EOC, with 60% received every three weeks regimen. Mean age was 53.22 years. At a median follow up of 45.9 months, there was no significant different between the two protocols in terms of mean PFS, 62.35 months (95% CI: 50.08 - 74.63 months) for the three-weekly cohort, and 69.25 months (95% CI: 55.24 - 83.26 months) for weekly protocol (p = 0.613). The three weekly regimen patients had a higher incidence of hospital admission (40% vs 18.5% for the weekly protocol patients), but it didn’t reach a statistical significance (p = 0.063). The three weekly protocol had a significantly higher incidence of causing a neutropenic fever (p = 0.003). Conclusion: a. style="font-fa.ily:Verda.a.">In our cohort of Egyptia. women with EOC, no significa.t dif

关键词： Epithelia. Ova.ia. Ca.cinoma Ca.bopla.in/Pa.lita.el Weekly versus Every Three Weeks

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Compa.ison of Geogra.hica.ly Weighted Regression of Benthic Substra.e Modeling a.cura.y on La.ge a.d Sma.l Wa.ea.le Strea.s

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Journa. of Geogra.hic Informa.ion System 2021年第2期13卷 194-209页

作者： Ken R. Sheeha. Stua.t a. Welsh KnoWhere LLC 969 Ocean Blvd #3 Hampton NH USA U.S. Geologica. Survey West Virginia Cooperative Fish and Wildlife Research Unit West Virginia University Morgantown West Virginia USA

a.ua.ic ha.ita. a.sessments encompa.s la.ge a.d sma.l wa.ea.le strea.s which va.y from ma.y meters wide to ephemera.. Differences in strea. sizes within or a.ross wa.ersheds, however, ma. lea. to incompa.ibility of da.a.a. va.ying spa.ia. sca.es. Specifica.ly, issues ca.sed by moving between sca.es on la.ge a.d sma.l strea.s a.e not typica.ly a.dressed by ma.y forms of sta.istica. a.a.ysis, ma.ing the compa.ison of la.ge (>30 m wetted width) a.d sma.l strea. (a.ita. a.sessments difficult. Geogra.hica.ly weighted regression (GWR) ma. provide a.enues for efficiency a.d needed insight into strea. ha.ita. da.a.by a.dressing issues ca.sed by moving between sca.es. This study exa.ined the a.ility of GWR to consistently model strea. substra.e on both la.ge a.d sma.l wa.ea.le strea.s a. a. equiva.ent resolution. We performed GWR on two groups of 60 ra.domly selected substra.e pa.ches from la.ge a.d sma.l strea.s a.d used depth mea.urements to model substra.e. Our la.ge a.d sma.l strea. substra.e models responded equa.ly well to GWR. Results showed no sta.istica.ly significa.t difference between GWR R2 va.ues of la.ge a.d sma.l strea. strea.s. Results a.so provided a.much needed method for compa.ison of la.ge a.d sma.l wa.ea.le strea.s. Our results ha.e merit for a.ua.ic resource ma.a.ers, beca.se they demonstra.e a.ility to spa.ia.ly model a.d compa.e substra.e on la.ge a.d sma.l strea.s. Using depth to guide substra.e modeling by geogra.hica.ly weighted regression ha. a.va.iety of a.plica.ions which ma. help ma.a.e, monitor strea. hea.th, a.d interpret substra.e cha.ge over time.

关键词： Strea. Ha.ita. Modeling Geogra.hica.ly Weighted Regression Spa.ia. Sca.e Ha.ita. Interpola.ion Geogra.hic Informa.ion System

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Mea.urements &Detection Techniques in Na.otechnology in Roa. a.plica.ions

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World Journa. of Na.o Science a.d Engineering 2020年第3期10卷 37-50页

作者： Heba.a.ra.ma. a. Heba.a.ra.ma. Sa.id I. Za.i Dr. Eng Consulta.t in Ma.eria.s Science Egypt Strength a.d Testing of Ma.eria.s Housing and Building National Research Center Cairo Egypt

In recent yea.s, the world of science ha. sta.ted to produce a.va.ced ma.eria.s a.d technology in the na.osca.e, which known a. na.otechnology. The use of na.otechnology ha. become wide sprea. in a.l bra.ches of science, one of the importa.t bra.ches is the field of tra.sporta.ion. The a.plica.ion of na.otechnology in pa.ements showed grea. promise a.d the potentia. to cha.ge commonly used ma.eria.s, which ma.es tra.sporta.ion more efficient, sma.t looking, stronger a.d dura.le tha. a.l lea. to the extension of their life cycle of the roa.s. So, there is a. essentia. need to prepa.e a.va.ced na.otechnology tools a.d detection systems conta.n very recent instruments needed for na.otechnology studies, since the physica., chemica. a.d biologica. properties of the ma.eria. a. na.osca.e differ in funda.enta. a.d va.ua.le wa.s from tha. a. norma. sca.e. In this work the different techniques in mea.uring a.d detection techniques in na.otechnology will be discussed the method of opera.ion a.d a.cura.y of ea.h technique will be eva.ua.ed, the ma.n a.plica.ions of ea.h technique in industria. a.d construction field will be eva.ua.ed.

关键词： Na.otechnology Detection Equipment’s a.cura.y Tra.sporta.ion Pa.ements Roa.s

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历史中行进的中国女漫画家

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美术 2003年第8期 32-39页

作者：约翰.a.兰特许颖美国坦布尔大学 <国际漫画杂志>

本文简要描述13位中国女漫画家的职业生涯，更集中于1930至40年代的先驱梁白波和1950至70年代的陈今言，还有当代多产的乔玲和李建华等。

关键词：漫画家先驱年代集中历史职业生涯描述

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