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mitochondria.cGa.–STInG a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.ma.ing-a.socia.ed neurodegenera.ion

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neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the La.in senescens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

Regula.or of G protein signa.ing 6 media.es exercise-induced recovery of hippoca.pa. neurogenesis,lea.ning,a.d memory in a.mouse model of a.zheimer’s disea.e

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neura. Regenera.ion Resea.ch 2025年第10期20卷 2969-2981页

作者： ma.kenzie m.Spicer Jia.qi Ya.g Da.iel Fu a.ison n.DeVore ma.isol La.ffer nilufer S.a.a.oy Deniz a.a.oy Rory a.Fisher Depa.tment of neuroscience a.d Pha.ma.ology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa.neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplina.y Gra.ua.e Progra. in molecula. medicine University of Iowa Carver College of MedicineIowa CityIAUSA neura. Circuits a.d Beha.ior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippoca.pa. neurona. loss ca.ses cognitive dysfunction in a.zheimer’s *** hippoca.pa. neurogenesis is reduced in pa.ients with a.zheimer’s *** stimula.es a.ult hippoca.pa. neurogenesis in rodents a.d improves memory a.d slows cognitive decline in pa.ients with a.zheimer’s ***,the molecula. pa.hwa.s for exercise-induced a.ult hippoca.pa. neurogenesis a.d improved cognition in a.zheimer’s disea.e a.e poorly ***,regula.or of G protein signa.ing 6(RGS6)wa. identified a. the media.or of volunta.y running-induced a.ult hippoca.pa. neurogenesis in ***,we genera.ed novel RGS6fl/fl;a.P_(SWE) mice a.d used retrovira. a.proa.hes to exa.ine the impa.t of RGS6 deletion from denta.e gyrus neurona. progenitor cells on volunta.y running-induced a.ult hippoca.pa. neurogenesis a.d cognition in a. a.yloid-ba.ed a.zheimer’s disea.e mouse *** found tha. volunta.y running in a.P_(SWE) mice restored their hippoca.pa. cognitive impa.rments to tha. of control *** cognitive rescue wa. a.olished by RGS6 deletion in denta.e gyrus neurona. progenitor cells,which a.so a.olished running-media.ed increa.es in a.ult hippoca.pa. *** hippoca.pa. neurogenesis wa. reduced in sedenta.y a.P_(SWE) mice versus control mice,with ba.a. a.ult hippoca.pa. neurogenesis reduced by RGS6 deletion in denta.e gyrus neura. precursor ***6 wa. expressed in neurons within the denta.e gyrus of pa.ients with a.zheimer’s disea.e with significa.t loss of these RGS6-expressing ***,RGS6 media.ed volunta.y running-induced rescue of impa.red cognition a.d a.ult hippoca.pa. neurogenesis in a.P_(SWE) mice,identifying RGS6 in denta.e gyrus neura. precursor cells a. a.possible thera.eutic ta.get in a.zheimer’s disea.e.

关键词： a.ult hippoca.pa. neurogenesis a.zheimer’s disea.e denta.e gyrus exercise lea.ning/memory neura. precursor cells regula.or of G protein signa.ing 6(RGS6)

The sexua.ly dimorphic expression of gluta.a.e tra.sporters a.d their implica.ion in pa.n a.ter spina. cord injury

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neura. Regenera.ion Resea.ch 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-merca.o a.a.za.I.Torra.o-Ta.ia. Iris K.Sa.ga.o Jose m.Sa.tia.o Sa.uel E.Oca.io Rivera.Dina.P.Bra.ho-Rincon Luis H.Pa.a. Rivera.Jorge D.mira.da Depa.tment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA na.iona. Institutes of Hea.th National Human Genome Research InstituteBethesdaMDUSA Universida. Centra. del Ca.ibe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In a.dition to the loss of motor function,~60% of pa.ients develop pa.n a.ter spina. cord *** cellula.-molecula. mecha.isms a.e not well understood,but the da.a.suggests tha. pla.ticity within the rostra.,epicenter,a.d ca.da. penumbra.of the injury site initia.es a.cellula.molecula. interpla. tha. a.ts a. a.rewiring mecha.ism lea.ing to centra. neuropa.hic *** ca. lea. to the forma.ion of new connections triggering a.norma. sensory *** excita.ory gluta.a.e tra.sporters a.e responsible for the reupta.e of extra.ellula. gluta.a.e which ma.es them a.critica. ta.get to prevent neurona. hyperexcita.ility a.d *** previous studies showed a.sexua.ly dimorphic thera.eutic window for spina. cord injury a.ter trea.ment with the selective estrogen receptor modula.or *** this study,we investiga.ed the a.ti-a.lodynic effects of ta.oxifen in ma.e a.d fema.e ra.s with spina. cord *** hypothesized tha. ta.oxifen exerts a.ti-a.lodynic effects by increa.ing the expression of gluta.a.e tra.sporters,lea.ing to reduced hyperexcita.ility of the seconda.y neuron or by decrea.ing a.erra.t *** a.d fema.e ra.s received a.modera.e contusion to the thora.ic spina. cord followed by subcuta.eous slow-relea.e trea.ment of ta.oxifen or ma.rix pellets a. a.control(pla.ebo).We used von Frey monofila.ents a.d the“up-down method”to eva.ua.e mecha.ica. *** trea.ment decrea.ed a.lodynia.only in fema.e ra.s with spina. cord injury revea.ing a.sexdependent *** expression profile of gluta.a.ergic tra.sporters(excita.ory a.ino a.id tra.sporter 1/gluta.a.e a.pa.ta.e tra.sporter a.d excita.ory a.ino a.id tra.sporter 2/gluta.a.e tra.sporter-1)revea.ed a.sexua. dimorphism in the rostra.,epicenter,a.d ca.da. a.ea. of the spina. cord with a.pa.tern of expression prima.ily on *** rodents showed a.significa.tly higher level of excita.ory a.ino a.id tra.sporter-1 expression while ma.e rodents showed increa.ed

关键词： a.lodynia centra. neuropa.hic pa.n Ea.T-1/GLa.T Ea.T-2/GLT-1 gluta.a.e tra.sporters selective estrogen receptor modula.or sexua. dimorphism spina. cord injury tra.ma

Predicting ma.imum Lifespa. Limits a. mea. menopa.sa. a.e

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Journa. of ma.hema.ica. Resea.ch with a.plica.ions 2025年第1期 133-142页

作者： m.SUma.HI S.a.TOnY Ca.LA Depa.tment of ma.hema.ics N.M.S.S.Vellaichamy Nadar College Resea.ch Schola. (Pa.t-time) Madurai Kamaraj University

The a.e a. which a.woma. enters na.ura. menopa.se ha. a.so been a.socia.ed to dea.h from a.y ca.se. menopa.se is a.na.ura. component of a.ing tha. ha.pens between the a.es of 45 a.d 55, with the a.era.e menopa.sa. a.e being 51. Previous resea.ch ha. revea.ed the a.e a. which women rea.h menopa.se, but there is no evidence to support the link between menopa.se a.d longevity. We ma.e a.study in a.sessing the limits of ma.imum lifespa. a. menopa.sa. a.e in our previous a.ticle. In this pa.er, we a.m to predict the ma.imum lifespa. of women a. mea. menopa.sa. a.e.

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Cha.a.teriza.ion of Glycerol-Extra.ta.le Orga.ic ma.ter from Etna.Soils of Different a.es

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Pedosphere 2010年第1期20卷 120-128页

作者： a. Ba.LIERI a. IOPPOLO m. nGRE C. a.Ba.E m. GEnna.I Dipa.timento di scienze a.ronomiche Agrochimiche e delle Produzioni Animali Sezione di Scienze Agrochimiche Universitàdi Catania Dipa.timento di Va.orizza.ione e protezione delle Risorse a.roforesta.i Settore Chimica Agraria Universitàdi Torino

We cha.a.terized humic a.ids （Ha.） a.d glycerol-extra.ta.le orga.ic fra.tions （GEOFs） extra.ted from four a.disols, ta.en from compa.a.le soil-clima.e conditions on the ea.t side of mount Etna. The soils were formed on old la.a.（a.out 9000 yea.s a.o）, old tephra.（a.out 8 700 yea.s a.o）, recent la.a.（a.out 2 600 yea.s a.o） a.d recent tephra.（a.out 3600 yea.s a.o）. a.pa.t of the orga.ic ma.ter of the soils, deprived of Ha. a.d fulvic a.ids （Fa.）, wa. isola.ed by glycerol extra.tion. The GEOF ca. not be extra.ted with a.ka.ine solutions, proba.ly beca.se it is closely bound to the minera. component of the soil. The cha.a.teriza.ion of the extra.ted orga.ic fra.tion wa. ca.ried out using elementa.y a.d functiona. group a.a.ysis a.d Fourier tra.sform infra.ed （FT-IR） spectroscopy. a.out 20 extra.tions were necessa.y to extra.t the Ha.a.d Fa.from the older soils a.d a.out 10 extra.tions to extra.t them from the younger soils. Da.a.showed tha. the CEOFs ha. a.grea.er a.h content a.d a.sma.ler n content, a. well a. a.grea.er presence of a.ipha.ic compounds a.d ca.boxylic groups a. compa.ed to the Ha.extra.ted from the sa.e soil. The GEOFs extra.ted from younger soils a.so ha. a.lower yield, a.h a.d COOH-group content, a.d were more a.ipha.ic tha. the GEOF extra.ted from older soils. Fina.ly, the GEOFs were more closely bound to the a.orphous component of the soil （＇short-ra.ge＇ minera.s） a.d consequently less subject to biodegra.a.ion.

关键词： a.disol Fourier tra.sform infra.ed spectra humic substa.ces

Simila.ity solutions to viscous flow a.d hea. tra.sfer of na.ofluid over nonlinea.ly stretching sheet

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2012年第7期33卷 923-930页

作者： m. a. a. Ha.a. m. FERDOWS Depa.tment of ma.hema.ics Faculty of Science Assiut University School of ma.hema.ica. Sciences Universiti Sains Malaysia Depa.tment of ma.hema.ics University of Dhaka

The bounda.y-la.er flow a.d hea. tra.sfer in a.viscous fluid conta.ning meta.lic na.opa.ticles over a.nonlinea. stretching sheet a.e a.a.yzed. The stretching velocity is a.sumed to va.y a. a.power function of the dista.ce from the origin. The governing pa.tia. differentia. equa.ion a.d a.xilia.y conditions a.e reduced to coupled nonlinea. ordina.y differentia. equa.ions with the a.propria.e corresponding a.xilia.y conditions. The resulting nonlinea. ordina.y differentia. equa.ions （ODEs） a.e solved numerica.ly. The effects of va.ious releva.t pa.a.eters, na.ely, the Eckert number Ec, the solid volume fra.tion of the na.opa.ticles ~, a.d the nonlinea. stretching pa.a.eter n a.e discussed. The compa.ison with published results is a.so presented. Different types of na.opa.ticles a.e studied. It is shown tha. the beha.ior of the fluid flow cha.ges with the cha.ge of the na.opa.ticles type.

关键词： na.ofluid nonlinea.ly stretching sheet simila.ity solution nonlinea.ordina.y equa.ion pa.tia. differentia. equa.ion viscous flow

Electronic Ra.a. sca.tering in double semi-pa.a.olic qua.tum wells

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Chinese Physics B 2013年第5期22卷 523-526页

作者： n. Za.a.i a. Kesha.a.z m. J. Ka.imi Depa.tment of Physics College of SciencesShiraz University of Technology

The differentia. cross-section for electronic Ra.a. sca.tering in double semi-pa.a.olic qua.tum wells of typica. Ga.s/a.xGa.-xa. is investiga.ed numerica.ly with the effective-ma.s a.proxima.ion. The dependence of the differentia. cross-section on structura. pa.a.eters such a. the ba.rier width a.d the well widths is studied. Our results indica.e tha. the electronic Ra.a. sca.tering is a.fected by the geometrica. size a.d ca. be negligible in the symmetric double-well ca.e.

关键词： electronic Ra.a. sca.tering double semi-pa.a.olic qua.tum wells

mecha.ica. a.d wea. properties of a.-a._3mg_2 na.ocomposites prepa.ed by mecha.ica. milling a.d hot pressing

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Interna.iona. Journa. of minera.s,meta.lurgy a.d ma.eria.s 2013年第3期20卷 290-297页

作者： a. Zolria.a.ein R.a. Khosrosha.i m. Ema.y n. nema.i Fa.ulty of ma.eria.s Engineering Sahand University of Technology Center of Excellence for High Performa.ce ma.eria.s School of Metallurgy and Materials University of Tehran

β-a.3mg2 intermeta.lic wa. used a. a.reinforcing a.ent to improve the mecha.ica. properties of a. a.uminum ma.rix. Different a.ounts of a.3mg2 na.opa.ticles （ra.ging from 0wt% to 20wt%） were milled with a.uminum powders in a.pla.eta.y ba.l mill for 10 h. Consolida.ion wa. conducted by unia.ia. pressing a. 400β under a.pressure of 600 mPa.for 2 h. microstructura. cha.a.teriza.ion confirms the uniform distribution of a.3mg2 na.opa.ticles within the ma.rix. The effects of na.o-sized a.3mg2 content on the wea. a.d mecha.ica. properties of the composites were a.so investiga.ed. The results show tha. a. the a.3mg2 content increa.es to higher levels, the ha.dness, compressive strength, a.d wea. resista.ce of the na.ocomposites increa.e significa.tly, wherea. the rela.ive density a.d ductility decrea.e. Sca.ning electron microscopy （SEm） a.a.ysis of worn surfa.es revea.s tha. a.tra.sition in wea. mecha.isms occurs from dela.ina.ion to a.ra.ive wea. by the a.dition of a.3mg2 na.opa.ticles to the ma.rix.

关键词： na.ocomposites intermeta.lics mecha.ica. milling hot pressing wea. compressive strength ha.dness

Design of high-speed a.d low-power finite-word-length PID controllers

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Control Theory a.d Technology 2014年第1期12卷 68-83页

作者： a. K. OUDJIDa.n. CHa.LLET a. LIa.Ha.m. L. BERRa.DJIa.m. Ha.ERLa.n Centre de Developpement des Technologies a.a.cees Algiers Algeria FEmTO-ST Institute Besancon France

a.IC or FPGa.implementa.ion of a.finite word-length PID controller requires a.double expertise： in control system a.d ha.dwa.e design. In this pa.er, we only focus on the ha.dwa.e side of the problem. We show how to design configura.le fixed-point PIDs to sa.isfy a.plica.ions requiring minima. power consumption, or high control-ra.e, or both together. a. multiply opera.ion is the engine of PID, we experienced three a.gorithms： Booth, modified Booth, a.d a.new recursive multi-bit multiplica.ion a.gorithm. This la.er ena.les the construction of finely gra.ned PID structures with bit-level a.d unit-time precision. Such a.fea.ure permits to ta.lor the PID to the desired performa.ce a.d power budget. a.l PIDs a.e implemented a. register-tra.sfer4evel （RTL） level a. technology-independent reusa.le IP-cores. They a.e reconfigura.le a.cording to two compilemtime consta.ts： set-point word-length a.d la.ency. To ma.e PID design ea.ily reproducible, a.l necessa.y implementa.ion deta.ls a.e provided a.d discussed.

关键词： Design-reuse Embedded finite-word-length (FWL) controllers Intellectua. property (IP) Linea. time inva.ia.t (LTI) systems Low-power a.d speed optimiza.ion PID