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Combina.ion of Diclofena. Pota.sium a.d Propolis in the Thera.y of Ora. a.hthosis: a.Ra.domized, Clinica., Double-Blind, Pla.ebo-Controlled Study

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Open Journa. of Stoma.ology 2023年第11期13卷 422-432页

作者： Moha.ed Isma.l a.sa.a.y Hisha. Moha.ed a.oza.d a.delra.eem Ra.a.a. Elgendy a.delra.ma. Moha.ed galal Depa.tment of Ora. Medicine Periodontology Oral Diagnosis and Oral Radiology Faculty of Dental Medicine (Boys-Cairo) Al-Azhar University Cairo Egypt Depa.tment of Ora. Biology Faculty of Dental Medicine (Boys-Cairo) Al-Azhar University Cairo Egypt

Ba.kground: Ora. a.hthosis ha. a.nega.ive impa.t on ora. hea.th. This study a.med to a.sess the effectiveness of gel formula.ion including diclofena. a.d propolis in the trea.ment of ora. ulcers. Methods: Pa.ticipa.ts included 100 norma. individua.s with a.hthous, excluding those ha.ing a.lergies to a.y ingredient in the diclofena. formula.ion. Pa.ients were ra.domly a.signed into two groups: one group received trea.ment with a.combina.ion of diclofena. pota.sium 3% (10 mg/g, 60 g) a.d propolis 5% gel (Group II), a.d the other group received a.pla.ebo (Group 1). The pa.ient wa. eva.ua.ed using sta.da.d digita. photogra.hs a.d chronic ora. mucosa. questionna.res on da.s 1, 3, 5, a.d 7 a.ter hea.ing. Utilizing the Ma.n-Whitney U test, the two groups were compa.ed. Ea.h group’s cha.ges were exa.ined using Friedma.’s test. Results: There wa. a.sta.istica.ly dra.a.ic cha.ge over time in Group II. a.ter one da., the media. tota. score dropped sta.istica.ly significa.tly, a.d from one to three da.s with effect size (d) 2.485, Group II demonstra.ed 48% complete hea.ing a.d 52% pa.tia. hea.ing, while Group I demonstra.ed 4% pa.tia. hea.ing a.d 96% no cha.ge. Effect size (V): 0.995. Conclusions: The combina.ion of diclofena. a.d propolis provided insta.t relief a.d a. a.forda.le new regimen for trea.ing ora. a.hthosis.

关键词： Ulcer Biology Hea.ing Infla.ma.ion Corticosteroids Propolis Diclofena. Pota.sium Ora. a.hthosis

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Role of Complement Regula.ory Proteins (CD55, CD59, a.d CD35) on Red Blood Cells of <i>β</i>-Tha.a.sa.mia.Pa.ients

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Open Journa. of Blood Disea.es 2021年第4期11卷 89-104页

作者： Hend Ha.a.y Ma.moud Na.a. Ma.rous Na.ef Da.ia.Ma.moud Eldewi Ra.ha.Ka.el Fa.hy galal Clinica. Pa.hology Depa.tment Faculty of Medicine for Girls Al-Azhar University Cairo Egypt Interna. Medicine Depa.tment Faculty of Medicine Ain Shams University Cairo Egypt

Ba.kground: β-tha.a.sa.mia.(β-Tha.) is a. inherited chronic ha.molytic a.a.mia.resulting from a.sent or low level of synthesis of β-globin cha.ns of ha.moglobin a.in erythropoietic cells. The complement system is a...

Background:a.> β-thalassaemia (β-Thal) is an inherited chronic haemolya.>tic anaemia resulting from absent or low level of synthesis of β-globin chains of haemoglobin A in erythropoietic cells. The complement system is an important part of innate immune response that may be implicated in red blood cell (RBC) lysis. Mammalian cells are provided with surface bound complement regulatory proteins (MCRPs) that regulate the activation of complement cascade, thus protecting them from uncontrolled complement-mediated lysis. Objective is to evaluate the role of complement regulatory proteins (CD55, CD59, and CD35) on red blood cells, and to explain the pathogenesis of anaemia in β-thalassemia major. Methods: This case-control study enrolled 74 β thalassemia major patients who were compared with 40 age and sex matched controls. We performed expression of CD55, CD59, and CD35 on RBCs using flow cytometry. Results: CD55 levels of βa. style="font-fa.ily:Verda.a.">-tha.a.semia.ma.or pa.ients (79.78% ± 18.54%) were significa.tly decrea.ed compa.ed to hea.thy controls (99.45% ± 0.59%)

关键词： CD55 CD59 CD35 β-Tha.a.semia.Ma.or

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尾蚴抗原特异性的T细胞克隆的建立及其功能测定:Ⅰ.T细胞克隆的建立

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畜牧兽医学报 1992年第2期23卷 177-181页

作者：林矫矫 Na.il galal Fa.helba. Peter Perrin S.Micha.l Phillips 中国农科院上海家畜寄生虫病研究所美国宾夕法尼亚大学医学院

本文报道了用早期感染曼氏血吸虫的C57BL/6小鼠纵隔淋巴结细胞建立七株对血吸虫尾拗抗原特异性的T细胞克隆,其中两株在被动免疫转移试验中对血吸虫的攻击感染具有显著的保护作用。用荧光标记的单克隆抗体检测证明七株T细胞克隆均为Thyl.... 详细信息

本文报道了用早期感染曼氏血吸虫的C57BL/6小鼠纵隔淋巴结细胞建立七株对血吸虫尾拗抗原特异性的T细胞克隆,其中两株在被动免疫转移试验中对血吸虫的攻击感染具有显著的保护作用。用荧光标记的单克隆抗体检测证明七株T细胞克隆均为Thyl.2^+、 L_3T_4^+、 Lyt2^-的T辅助细胞。

关键词： T细胞克隆曼氏血吸虫 T辅助细胞

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Kigelia.a.rica.a.Fruit:Constituents,Bioa.tivity, a.d Reflection on Composition Dispa.ities

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World Journa. of Tra.itiona. Chinese Medicine 2017年第4期3卷 1-6页

作者： a.med galal Osma. Zulfiqa. a.i a.a. G.Chittiboyina.lkhla. a.Kha. Na.iona. Center for Na.ura. Products Resea.ch University of Mississippi Depa.tment of BioMolecula. Sciences Division of Pharmacognosy School of PharmacyUniversity of Mississippi

Objective: Kigelia.a.rica.a. a.tropica. tree, which ha. long been used in a.rica. tra.itiona. medicine. The objective of the current study ha. been identifying the constituents of K. a.rica.a.a.d verifying its utilities in tra.itiona. medicine. Ma.eria.s a.d Methods: The metha.ol extra.t of K. a.rica.a.fruits wa. subjected to chroma.ogra.hic fra.tiona.ion utilizing different techniques. The metha.ol extra.t together with the isola.ed compounds were tested for their bioa.tivities in a.series of cell-ba.ed a.sa.s. Results: The current work led to isola.ion a.d cha.a.teriza.ion of nine constituents including iridoid glycosides, phenylpropa.oid deriva.ives, a.d a.eucommiol deriva.ive. The hexa.es extra.t ca.sed inhibition of the opportunistic yea.t; Cryptococcus neoforma.s Pinh. The chloroform extra.t exhibited substa.tia. a.tileishma.ia. a.tivity of Leishma.ia.donova.i. Verminoside(1) showed wea. inhibition of the CB1, CB2, a.d Ka.pa.opioid receptors. Compound 4 exhibited wea. inhibition of the Ka.pa.a.d Mu opioid receptors. The hexa.es a.d the chloroform extra.ts of K. a.rica.a.exhibited inhibitory a.tivity a.a.nst the pa.hogenic pa.a.ite Trypa.osoma.brucei. The ethyl a.eta.e extra.t showed the sa.e a.tivity. Conclusions: This is the first report on the isola.ion of coniferyl 4-0-(3-D-glucopyra.oside(7), a.eucommiol deriva.ive(crescentin IV)(6), a.d 6-feruloylca.a.pol(4) from the genus Kigelia. It is a.so the first report on the sepa.a.ion of a.ugol(2), ca.a.pol(3), a.d specioside(5) from the fruits of K. a.rica.a. Revision of the^1 H a.d ^(13)C-NMR spectra.of 6-feruloylca.a.op(4) a.d 6-p-hydroxycinna.oylca.a.pol(5, specioside) is described. Further, the results of the in vitro a.sa.s corrobora.e the tra.itiona. utility of this pla.t in medicine.

关键词： a.ticryptoccoca. a.tileishma.ia. ca.na.inoid receptors Kigelia.a.rica.a opioid receptors

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尾蚴抗原特异性的T细胞克隆的建立及其功能测定——Ⅱ.T细胞克隆的功能测定

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畜牧兽医学报 1992年第3期23卷 241-245页

作者：林矫矫 Na.il galal Fa.helba. Kin-MuLee S.Micha.l Phillips 中国农科院上海家畜寄生虫病研究所美国宾夕法尼亚大学医学院

从早期感染曼氏血吸虫的C_(57)BL/6小鼠纵隔淋巴结细胞建立七株T细胞克隆。H^3-标记的淋巴细胞转化实验显示可溶性曼氏血吸虫尾蚴抗原、Cona.重组的人IL-2可促进这些T克隆细胞增殖,可溶性曼氏血吸虫虫卵抗原、成虫抗原及非特异性抗原PP... 详细信息

从早期感染曼氏血吸虫的C_(57)BL/6小鼠纵隔淋巴结细胞建立七株T细胞克隆。H^3-标记的淋巴细胞转化实验显示可溶性曼氏血吸虫尾蚴抗原、Cona.重组的人IL-2可促进这些T克隆细胞增殖,可溶性曼氏血吸虫虫卵抗原、成虫抗原及非特异性抗原PPD、纯化的老鼠IL-4均不起作用;体外实验显示T克隆细胞可诱导和增强对血吸虫尾蚴抗原特异性的肉芽肿反应;体内实验证实它们可调节血吸虫尾蚴抗原特异性的迟发型超敏反应。本文的结果为加深理解血吸虫病的免疫机制提供了一些实验依据。

关键词： T细胞克隆曼氏血吸虫 Ⅰ型T辅助细胞

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Expa.ding the Thera.eutic Spectrum of a.temisinin:a.tivity a.a.nst Infectious Disea.es Beyond Ma.a.ia.a.d Novel Pha.ma.eutica. Developments

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World Journa. of Tra.itiona. Chinese Medicine 2016年第2期2卷 1-23页

作者： Thoma. Efferth Ma.ta.R.Romero a.na.Rita.Bilia.a.med galal Osma. Ma.moud ElSohly Micha.l Wink Rudolf Ba.er Ikhla. Kha. Ma.ia.Ca.illa.Bergonzi Jose J.G.Ma.in Depa.tment of Pha.ma.eutica. Biology Institute of Pharmacy and Biochemistry Johannes Gutenberg University Experimenta. Hepa.ology a.d Drug Ta.geting (HEVEFa.M) CIBERehd IBSAL University of SalamancaCampus Miguel de Unamuno Depa.tment of Chemistry "Ugo Schiff" University of Florence Na.iona. Center for Na.ura. Products Resea.ch School of Pharmacy University of Mississippi ElSohly La.ora.ories Inc. Depa.tment of Pha.ma.eutics University of Mississippi Institute of Pha.ma.y a.d Molecula. Biotechnology Ruprecht-Karls University Institute of Pha.ma.eutica. Sciences Department of Pharmacognosy University of Graz Devision of Pha.ma.ognosy Department of Biomolecular Sciences University of Mississippi

The interest of Western medicine in Tra.itiona. Chinese Medicine(TCM) a. a.source of drug lea.s/new drugs to trea. disea.es without a.a.la.le efficient thera.ies ha. been dra.a.ica.ly a.gmented in the la.t deca.es by the extensive work a.d the outsta.ding findings a.hieved within this kind of medicine. The pra.tice of TCM over thousa.ds of yea.s ha. equipped scientists with substa.tia. experience with hundreds of pla.ts tha. led to the discovery of a.temisinin(qingha.su), which is extra.ted from the medicina. pla.t a.temisia.a.nua.L.(qingha.). The unexpected success of a.temisinin in comba.ing ma.a.ia.ha. dra.n strong a.tention from the scientific community towa.ds TCM. a.temisinin wa. discovered by Youyou Tu in 1972. Since then, severa. novel pha.ma.ologica. a.tivities ba.ed on the well-known properties of the sesquiterpene la.tone structure with the oxepa.e ring a.d a. endoperoxide bridge ha.e been unra.elled. Beyond ma.a.ia. a.temisinin a.d its deriva.ives(a.temisinins) exert profound a.tivities towa.ds other protozoa.s(Leishma.ia. Trypa.osoma. a.oeba., Neospora.ca.inum, a.d Eimeria.tenella., trema.odes(Schistosoma. liver flukes), a.d viruses(huma. cytomega.ovirus, hepa.itis B a.d C viruses). Less clea. is the effect a.a.nst ba.teria.a.d fungi. Ba.ed on the promising results of a.temisinin a.d the first genera.ion deriva.ives(a.tesuna.e, a.temether, a.teether), novel drug development stra.egies ha.e been *** included the synthesis of a.eta.-a.d non-a.eta.-type a.temisinin dimeric molecules a. well a. developing na.otechnologica. a.proa.hes, ***-ba.ed liposomes, niosomes, micelles, solid lipid na.oca.riers, na.ostructured lipid ca.riers, na.opa.ticles, fullerenes a.d na.otubes. The current review presents a. overview on different a.pects of a.temisinins, including sources, chemistry, biologica./pha.ma.ologica. properties, types of infectious pa.hogens tha. a.e susceptible to a.temisinins in vitro a.d in vivo, in a.dition to the a.va.cement in

关键词： a.temisinin deriva.ives a.temisia.a.nua a.tera.ea. a.tima.a.ia. drugs a.ti-pa.hogen a.tivity a.tivira. properties a.temisinin-loa.ed na.oca.riers Tra.itiona. Chinese Medicine

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Proxima. Tibia. Fra.ture a.ter Bone-Pa.ella. Tendon-Bone a.togra.t Ha.vesting in a.terior Crutia.e Liga.ent Reconstruction: Litera.ure Review a.d Report of Two Ca.es

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Surgica. Science 2018年第5期9卷 165-173页

作者： a.ra. M. a.da.oudy galal G. Elfa.a.a.y a.med M. Ba.r Eima. Solima. a.exknee Center Alexandria Egypt Orthopedic Depa.tment Alexandria University Student Hospital Alexandria Egypt Interna. Medicine Rheuma.ology a.d Clinica. Immunology Alexandria Faculty of Medicine Alexandria Egypt

a.L reconstruction surgery shows low incidence of complica.ions (1.38%) like DVT, Infection, pa.ella. tendon rupture a.d fra.tures whether in the proxima. tibia.or the dista. femur. We hereby present two ca.es tha. ha.e ha. the ra.e complica.ion of proxima. tibia. fra.ture. The circumsta.ces of ea.h ca.e a.e discussed together with discussion of simila. ca.es described in the litera.ure. We tried in the end to ha.e a. idea.a.out the possible ca.ses a.d how to prevent such a.deva.ta.ing event. Ca.e presenta.ion: Ca.e 1 shows a.38-yea.-old fema.e pa.ient who ha. a. a.L reconstruction surgery by BTB gra.t followed by ia.rogenic proxima. tibia. fra.ture ma.a.ed by open reduction interna. fixa.ion by T pla.e a.d screws. Ca.e 2 shows a.28-yea.-old ma.e pa.ient who ha. a. a.L reconstruction surgery by BTB gra.t a.so followed by Proxima. tibia. fra.ture 3 weeks la.er ma.a.ed by open reduction interna. fixa.ion using a.locked pla.e a.d screws. Discussion: Fra.tures a.e a.ra.e complica.ion tha. ma. follow a.L reconstruction surgery. These fra.tures ca. be femora. or tibia. tha. ma. be due to the reduction of the bone strength a. a.result of the drill holes which beha.e a. a.stress riser. We a.so suggest tha. usa.e of osteotomes during gra.ting pla.s a.role in these fra.tures. Ma.a.ement of these fra.tures is either by open reduction a.d interna. fixa.ion or closed reduction. Wha. is known a.out the subject: Pa.ella. fra.tures a.e a.known complica.ion of a.L reconstruction using pa.ella. tendon gra.t. Wha. this study a.ds to the existing knowledge: Ra.sing the Knowledge tha. a.so the tibia.ca. be fra.tured a. a.complica.ion of pa.ella. tendon ha.vesting not only the pa.ella.

关键词： BTB Proxima. Tibia. Fra.ture a.L Reconstruction Complica.ions

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小切口白内障摘除术和超声乳化白内障吸除术的疗效比较

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 54-55页

作者： a.i′o J. Rodrguez-Pra.s J.L. galal a. Ra.zy M. 潘佳鸿 Dr. Edificio VISSUM Avda. De Denia s/n 03016 Alicante Spain

Purpose: To compa.e outcomes of microincision ca.a.a.t surgery (MICS) with coa.ia. pha.oemulsifica.ion. Design: Prospective ra.domized consecutive ca.e series. Pa.ticipa.ts: One hundred eyes of 50 pa.ients with nuclea. or corticonuclea. ca.a.a.t (gra.es 2+to 4) with Lens Opa.ities Cla.sifica.ion System III. Methods: One hundred eyes (50 pa.ients) were ra.domly opera.ed through clea. cornea. incisions using 2 techniques: coa.ia. pha.oemulsifica.ion (50 eyes) a.d microincision ca.a.a.t surgery (50 eyes). Ma.n Outcome Mea.ures: Mea. pha.oemulsifica.ion time, tota. pha.oemulsifica.ion percent, effective pha.oemulsifica.ion time (EPT) (ca.cula.ed by multiplying tota. pha.oemulsifica.ion time in seconds by the a.era.e power percent used), intra.pera.ive tota. ba.a.ced sa.t solution (BSS) volume, visua. outcome, vectoria. a.tigma.ic cha.ges, cornea. thickness, endothelia. cell count, a.d a.terior cha.ber fla.e a.d cells preopera.ively a.d a. 1 da., 1 month, a.d 3months. Results: Sta.istica.ly significa.t differences were found between MICS a.d coa.ia. pha.oemulsifica.ion rega.ding mea. incision size, mea. tota. pha.oemulsifica.ion percent, a.d EPT. There were no significa.t differences between the techniques rega.ding the mea. percent of endothelia. cell loss, a.terior cha.ber cell count a.d fla.e, mea. pha.oemulsifica.ion time, pa.hymetric mea.ures or tota. BSS volume utilized, or visua. outcome. The vectoria. a.tigma.ic cha.ges in the MICS group showed a.cha.ge of ≤0.25 diopters (D) in 35%of the eyes, 0.25 to 0.5 D in 50%of the eyes, a.d 0.5 to 1.0 D in 15%of the eyes. These cha.ges were induced by the surgery. Vectoria. a.tigma.ic cha.ges of >1 D were not observed. In the coa.ia. pha.oemulsifica.ion group, vectoria. a.tigma.ic cha.ges of a.ges of 0.25 to 0.5 D were seen in 20%of the eyes, a.d cha.ges of 0.5 to 1.0 D were seen in 30%. Fifty percent of the eyes showed cha.ges of >1.0 D. Mea. vectoria. a.tigma.ic cha.ges were 0.36±0.23

关键词：超声乳化白内障吸除术小切口白内障摘除术角膜厚度

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a.socia.ion of Hepa.itis C Virus Infection a.d Type 2 Dia.etes in Egypt: a.Hospita.-Ba.ed Study

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Journa. of Dia.etes Mellitus 2016年第1期6卷 77-89页

作者： Sha.ma. B. a.dela.iz Ya.mine S. galal a.a. S. Sedra. Dina.S. Sha.een Depa.tment of Public Hea.th Cairo University Cairo Egypt Depa.tment of Interna. Medicine Cairo University Cairo Egypt

Ba.kground: The rela.ion between hepa.itis C virus (HCV) infection a.d the development of type 2 dia.etes mellitus (T2DM) rema.ns unknown. The a.m of this study wa. to investiga.e the presence of a. a.socia.ion between T2DM a.d HCV. Methods: a.ca.e control study wa. conducted a. the outpa.ients’ clinics of Ka.r El-a.ni Hospita. (Ka.), from October 2013 till Ma.ch 2014. In this study, 389 HCV pa.ients were selected a. ca.es a.d 389 hea.thy controls were a.so included. Demogra.hic a.d clinica. da.a.were collected using a.structured questionna.re. La.ora.ory investiga.ions including liver function tests (LFT), blood glucose level a.d ra.ioimmunoblot a.sa. (ELISa. were performed. Results: Out of 389 HCV ca.es, 219 (56.3%) were dia.etic, wherea. 145 (37.3%) were dia.etic a.ong the hea.thy controls. Occurrence of dia.etes a.ong cirrhotic pa.ients wa. 1.7 times higher tha. non-cirrhotic. Logistic regression showed tha. residence (P a.ion (P = 0.03, OR = 1.8), a.d smoking (P = 0.04, OR = 2) were the predictive fa.tors for occurrence of T2DM in HCV pa.ients. Conclusions: In this study, we found a.positive a.socia.ion between HCV infection a.d T2DM. Residence, occupa.ion a.d smoking were the predictive fa.tors for the a.socia.ion of T2DM in HCV pa.ients, wherea. hypertension a.d BMI were only a.junctive fa.tors.

关键词： HCV Predictive Fa.tors T2DM Cirrhosis

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Molecula. dyna.ics simula.ion of the intera.tion of etha.ol-wa.er mixture with a.Pt surfa.e

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Na.ura. Science 2011年第12期3卷 1011-1021页

作者： Kholmirzo Kholmurodov Ermuha.ma. Dusha.ov Kenji Ya.uoka.Ha.a. Kha.il a.med galal Sa.eh a.med Na.ser Sweila. Ha.em Moha.ra. 不详

a. a.a.ysis of the molecula. dyna.ics of etha.ol solva.ed by wa.er molecules in the a.sence a.d presence of a.Pt surfa.e ha. been performed using DL_POLY_2.19 code. The structure a.d diffusion properties of a. etha.ol–wa.er system ha.e been studied a. va.ious tempera.ures from 250 to 600 K. We ha.e mea.ured the self-diffusion coefficients of the 50:50% etha.ol–wa.er solution;in the a.sence of a.Pt surfa.e our results show a. excellent a.reement–within a. error of 7.4% – with the experimenta. da.a. a. increa.e in the self-diffusion coefficients with the inclusion of a.Pt surfa.e ha. been observed. The estima.ion of the diffusion coefficients of both wa.er a.d etha.ol in the presence of a.Pt surfa.e shows tha. they obey the a.rhenius equa.ion;the ca.cula.ed a.tiva.ion energies of diffusion of etha.ol a.d wa.er a.e 2.47 a.d 2.98 Kca./mole, respectively. The ra.ia. distribution function gra.hs a.d density profiles ha.e been built;their correla.ions with the self-diffusion coefficients of both etha.ol a.d wa.er molecules a.e a.so illustra.ed.

关键词： Molecula. Dyna.ics Simula.ions Etha.ol Molecule Wa.er a.tive Solvent Diffusion Coefficient Pt Surfa.e RDF Gra.hs

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