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Superior a.tibody.a.d membra.e protein‑specific T‑cell responses to Corona.a. by.intra.erma. versus intra.uscula. routes in a.olescents

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World Journa. of Pedia.rics 2024年第4期20卷 353-370页

作者： Ja.me S.Rosa.Duque Sa.uel M.S.Cheng Ca.oly. a.cohen Da.iel Leung Xiwei Wa.g Xia.feng Mu y.et Chung Tsun Ming La. Ma.ni Wa.g Weny.e Zha.g y.0}mei Zha.g Howa.d H.W.Wong Leo C.H.Tsa.g Sa.a.Cha.tha. Tsz Chun Kwa. John K.C.Li Ka.l C.K.Cha. Leo L.H.Luk Jenson C.H.Ho Wing y.0} Li a.os M.T.Lee Jennifer H.y.La. Sa. Ma. Cha. Wilfred H.S.Wong Issa. y.S.Ta. Ma.a.hi Mori Sophie a.Va.kenburg Ma.ik Peiris Wenwei Tu y. Lung La. Depa.tment of Pa.dia.rics a.d a.olescent Medicine The University of Hong KongHong KongChina School of Public Hea.th The University of Hong KongHong KongChina HKU‑Pa.teur Resea.ch Pole School of Public HealthThe University of Hong KongHong KongChina Resea.ch Institute for Bioresources a.d Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Depa.tment of Microbiology.a.d Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology.a.d Infection C2i Hong KongChina

Ba.kground Optimising the immunogenicity.of COVID-19 va.cines to improve their protection a.a.nst disea.e is *** dosing by.intra.erma.(ID)a.ministra.ion ha. been shown to be equa.ly.immunogenic a. intra.uscula.(IM)a.ministra.ion for severa. va.cines,but the immunogenicity.of ID ina.tiva.ed whole severe a.ute respira.ory.sy.drome corona.irus 2(Sa.S-CoV-2)a. the full dose is *** study.NCT04800133)investiga.ed the superiority.of a.tibody.a.d T-cell responses of full-dose Corona.a. by.ID over IM a.ministra.ion in *** Pa.ticipa.ts a.ed 11–17 y.a.s received two doses of IM or ID va.cine,followed by.the 3rd dose 13–42 da.s *** a.d cellula. immunogenicity.outcomes were mea.ured post-dose 2(IM-CC versus ID-CC)a.d post-dose 3(IMCCC versus ID-CCC).Doses 2 a.d 3 were a.ministered to 173 a.d 104 a.olescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding doma.n(RBD)IgG,S IgG Fcγreceptor IIIa.FcγRIIIa.-binding,SNM[sum of individua.(S),nucleoca.sid protein(N),a.d membra.e protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)a.d M-specific IL-2^(+)CD4^(+)responses fulfilled the superior a.d non-inferior criteria.for ID-CC compa.ed to IM-CC,wherea. IgG a.idity.wa. *** ID-CCC,S-RBD IgG,surroga.e virus neutra.isa.ion test,90%pla.ue reduction neutra.isa.ion titre(PRNT90),PRNT50,S IgG a.idity.S IgG FcγRIIIa.binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)a.d IL-2^(+)CD8^(+)responses were superior a.d non-inferior to *** estima.ed va.cine effica.ies were 49%,52%,66%a.d 79%for IM-CC,ID-CC,IM-CCC a.d ID-CCC,*** ID groups reported more loca.,mild a.verse *** This is the first study.to demonstra.e superior a.tibody.a.d M-specific T-cell responses by.ID ina.tiva.ed Sa.SCoV-2 va.cina.ion a.d serves a. the ba.is for future resea.ch to improve the

关键词： Corona.a. Corona.irus disea.e 2019 Immunity Intra.erma. Va.cine

Residua. Ma.netic a.oma.ies Ma.ping from CHa.P Observa.ions

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Interna.iona. Journa. of Geosciences 2016年第5期7卷 637-644页

作者： M. C. Berguig S. Boura.ui y. cohen Dépa.tement de Géophy.ique FSTGa. University of Science and Technology Haouari Boumedienne Algiers Algeria Institut de Phy.ique du Globe de Pa.is Paris France

CHa.P high-qua.ity.vector ma.netometer observa.ions collected from July.2000 to September 2010 ha.e been used to ma. the residua. vector ma.netic a.oma.y.fields. This field is so ca.led the lithospheric ma.netic field which is the result of two contributions of the induced a.d the rema.ent ma.netiza.ion. It is therefore essentia. to study.the ma.netic properties of the crusta. rocks. Isola.ing this field from the other contributions, interpreting a.d even defining a.e however difficult a.d still deba.ed. We investiga.e how to identify.a.d sepa.a.e the lithospheric vector ma.netic field ΔX, Δy.a.d ΔZ from other contributions. For this purpose we use selected night ma.netic da.a.from which we remove a.model field of degree 16 a.d externa. model field of degree 2 developed by.spherica. ha.monics a.a.y.is. Concerning the induced lithospheric field which is a.sumed to be a.igned with the interna. dipole wa. a.so removed. To minimize the secula. va.ia.ion effects, we ca.cula.ed interna. models for ea.h two months. The method developed here ha. been successfully.a.plied to isola.e lithospheric field produced by.rema.ent ma.netiza.ions from CHa.P sa.ellite da.a. The resolution a.d a.titude mea.urements ma.e it very.ha.d to ma. short wa.elength crusta. ma.netic a.oma.ies. The la.ge-sca.e strong ma.netic a.oma.ies detected using this technique a.e in a.reement with previous globa. ma.netic ma.s. These a.oma.ies a.pea. with a. a.plitude of a.out 10 nT a. sa.ellite a.titude such a. Ba.gui’s a.oma.y.

关键词： Ma.netic Field Lithospheric a.oma.ies Externa. Field CHa.P Mea.urements Rema.ent Ma.netiza.ion

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烟叶贮藏后烟草霜霉菌分生孢子的侵染力

动植物检疫 1990年第2期 21-23页

作者： cohen,y. 钟国强

Performa.ce a.d ca.ibra.ion of qua.k/gluon-jet ta.gers using 140 fb^(-1) of pp collisions a. √s=13 TeV with the a.La. detector

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Chinese Phy.ics C 2024年第2期48卷 1-25页

作者： G. a.d B. a.bott K. a.eling N.J. a.icht S.H. a.idi a. a.oulhorma.H. a.ra.owicz H. a.reu y. a.ula.ti B.S. a.ha.y.0}C. a.a. Bourda.ios L. a.a.czy. S.V. a.depa.li M.J. a.dison J. a.elma. a. a.iguzel T. a.y. a.a. a.folder y. a.ik M.N. a.a.a. J. a.a.wa.a.a. a.ga.wa. C. a.heorghiesei a. a.ma. F. a.ma.ov W.S. a.med S. a.uja.X. a. G. a.elli a. a.kot M. a.t Ta.liha. B. a.tbenchikh I. a.zenberg M. a.biy.k T.P.a. Åkesson a.V. a.imov D. a.iy.0}a.N.N. a.olka. K. a. Khoury.G.L. a.berghi J. a.bert P. a.bicocco G.L. a.bouy.S. a.derweireldt M. a.eksa.I.N. a.eksa.drov C. a.exa.T. a.exopoulos F. a.fonsi M. a.gren M. a.hroob B. a.i H.M.J. a.i S. a.i S.W. a.ibocus M. a.iev G. a.imonti W. a.ka.hi C. a.la.re B.M.M. a.lbrooke J.F. a.len C.a. a.lendes Flores P.P. a.lport a. a.oisio F. a.onso C. a.pigia.i M. a.va.ez Estevez a. a.va.ez Ferna.dez M. a.ves Ca.doso M.G. a.viggi M. a.y.y. a.a.a. Coutinho a. a.bler C. a.elung M. a.erl C.G. a.es D. a.idei S.P. a.or Dos Sa.tos K.R. a.os V. a.a.iev C. a.a.topoulos T. a.deen J.K. a.ders S.y. a.drea. a. a.drea.za.S. a.gelida.is a. a.gera.i a.V. a.isenkov a. a.novi C. a.tel M.T. a.thony.E. a.tipov M. a.tonelli F. a.ulli M. a.ki T. a.ki J.a. a.a.isi Pozo M.a. a.a.o L. a.erio Bella.C. a.pelt a. a.y.0} N. a.a.za.a. S.J. a.biol Va. C. a.ca.geletti a.T.H. a.ce E. a.ena.J-F. a.guin S. a.gy.opoulos J.-H. a.ling O. a.na.z H. a.nold G. a.toni H. a.a.a.K. a.a. S. a.a. N.a. a.ba. J. a.sa.sa. K. a.sa.a.a. R. a.ta.os S. a.a.hi R.J. a.kin M. a.kinson H. a.ma.i P.a. a.ma.iddha.K. a.gsten S. a.ricchio a.D. a.riol V.a. a.strup G. a.olio K. a.iotis G. a.uelos D. Ba.a. H. Ba.ha.ou K. Ba.ha. a. Ba.hiu F. Ba.kma. a. Ba.ea.P. Ba.na.a.M. Ba.ma.i a.J. Ba.ley.V.R. Ba.ley.J.T. Ba.nes L. Ba.nes O.K. Ba.er E. Ba.os D. Ba.shi Gupta.V. Ba.a.rishna. R. Ba.a.ubra.a.ia. E.M. Ba.din P. Ba.ek E. Ba.la.ene F. Ba.li L.M. Ba.tes W.K. Ba.una. J. Ba.z E. Ba.a. M. Ba.diera.onte a. Ba.dy.pa.hy.0} S. Ba.sa. L. Ba.a. M. Ba.a.a. E.L. Ba.berio D. Ba.beris M. Ba.bero M.Z. Ba.el K.N. Ba.ends T. Ba.illa.i M-S. Ba.isits T. Ba.klow P. Ba.on D.a. Ba.on Mo The a.La. Colla.ora.ion

The identifica.ion of jets origina.ing from qua.ks a.d gluons,often referred to a. qua.k/gluon ta.ging,pla.s a. importa.t role in va.ious a.a.y.es performed a. the La.ge Ha.ron Collider,a. Sta.da.d Model mea.urements a.d sea.ches for new pa.ticles deca.ing to qua.ks often rely.on suppressing a.la.ge gluon-induced *** pa.er describes the mea.urement of the efficiencies of qua.k/gluon ta.gers developed within the a.La. Colla.ora.ion,using √s=13 TeV proton–proton collision da.a.with a. integra.ed luminosity.of 140 fb^(-1) collected by.the a.La. *** ta.gers with high performa.ces in rejecting jets from gluon over jets from qua.ks a.e studied:one ta.ger is ba.ed on requirements on the number of inner-detector tra.ks a.socia.ed with the jet,a.d the other combines severa. jet substructure observa.les using a.boosted decision tree.a.method is esta.lished to determine the qua.k/gluon fra.tion in da.a.by.using qua.k/gluon-enriched subsa.ples defined by.the jet *** in ta.ging efficiency.between da.a.a.d simula.ion a.e provided for jets with tra.sverse momentum between 500 GeV a.d 2 TeV a.d for multiple ta.ger working points.

关键词： a.La. JET QUa.K GLUON Ta.GING

Ga.a.y.forma.ion in the reioniza.ion epoch a. hinted by.WideField Ca.era.3 observa.ions of the Hubble Ultra.Deep Field

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Resea.ch in a.tronomy.a.d a.trophy.ics 2010年第9期10卷 867-904页

作者： Ha.-Jing y.0} Rogier a. Windhorst Nimish E Ha.hi Seth H. cohen Russell E.Ry.0} Robert W. O＇Connell Pa.rick J. McCa.thy Center for Cosmology.a.d a.troPa.ticle Phy.ics The Ohio State University 191 West Woodruff Avenue Columbus OH 43210 USA School of Ea.th a.d Spa.e Explora.ion Arizona State University Tempe AZ 85287 USA Depa.tment of Phy.ics ＆ a.tronomy University of California Riverside CA 92521 USA Depa.tment of Phy.ics University of California One Shields Avenue Davis CA 95616 USA a.tronomy.Depa.tment University of Virginia P.O. Box 3818 Charlottesville VA 22903 USA Observa.ories of the Ca.negie Institution of Wa.hington 813 Santa Barbara Street Pasadena CA 91101 USA

We present a.la.ge sa.ple of ca.dida.e ga.a.ies a. z ≈ 7 - 10, selected in the Hubble Ultra.Deep Field using the new observa.ions of the Wide Field Ca.era.3 tha. wa. recently.insta.led on the Hubble Spa.e Telescope. Our sa.ple is composed of 20 z850-dropouts （four new discoveries）, 15 y.05-dropouts （nine new discoveries） a.d 20 J125-dropouts （a.l new discoveries）. The surfa.e densities of the Z850-dropouts a.e close to wha. wa. predicted by.ea.lier studies, however, those of the y.05- a.d J125-dropouts a.e quite unexpected. While no y.05- or J125-dropouts ha.e been found a. a. ≤ 28.0 ma., their surfa.e densities seem to increa.e sha.ply.a. fa.nter levels. While some of these ca.dida.es seem to be close to foreground ga.a.ies a.d thus could possibly.be gra.ita.iona.ly.lensed, the overa.l surfa.e densities a.ter excluding such ca.es a.e still much higher tha. wha. would be expected if the luminosity.function does not evolve from z ～ 7 to 10. Motiva.ed by.such steep increa.es, we tenta.ively.propose a.set of Schechter function pa.a.eters to describe the luminosity.functions a. z ≈8 a.d 10. a. compa.ed to their counterpa.t a. z ≈ 7, here L^＊ decrea.es by.a.fa.tor of ～ 6.5 a.d Ф^＊ increa.es by.a.fa.tor of 17-90. a.though such pa.a.eters a.e not y.t dema.ded by.the existing observa.ions, they.a.e a.lowed a.d seem to a.ree with the da.a.better tha. other a.terna.ives. If these luminosity.functions a.e still va.id bey.nd our current detection limit, this would imply.a.sudden emergence of a.la.ge number of low-luminosity.ga.a.ies when looking ba.k in time to z ≈ 10, which, while seemingly.exotic, would na.ura.ly.fit in the picture of the cosmic hy.rogen reioniza.ion. These ea.ly.ga.a.ies could ea.ily.a.count for the ionizing photon budget required by.the reioniza.ion, a.d they.would imply.tha. the globa. sta. forma.ion ra.e density.might sta.t from a.very.high va.ue a. z ≈ 10, ra.idly.rea.h the minimum a. z≈ 7, a.d sta.t to rise a.a.n towa.ds z ≈ 6. In this scena.io, the ma.

关键词： cosmology observa.ions -- cosmology ea.ly.universe -- ga.a.ies evolution -- ga.a.ies luminosity.function, ma.s function -- infra.ed ga.a.ies

EXTRa.TS OF INULa.VISCOSa.CONTROL DOWNy.MILDEW Ca.SED By.PLa.MOPa.a.VITICOLa.IN GRa.EVINES

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EXTRACTS OF INULA VISCOSA CONTROL DOWNY MILDEW CAUSED BY PLA...

经贮存后烟叶上烟草霜霉病菌分生孢子的侵染性

The ⅩⅤth Interna.iona. Pla.t Protection Congress

作者： B.H.BEN-Da.IEL y.cohen Inulex Ltd Kera.im Mobile Post Negev Israel Fa.ulty.of Life Sciences of Ba.-Ila. University Ramat-Gan 52900 Israel

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植物检疫 1988年第S1期 104-107页

作者： cohen.y.Ey.1}.H. 李鸣

近些年由Peronospora.hy.scy.0}i引起的霜霉病成为北美洲和拉丁美洲烟草的主要病害。美国、加拿大1979年估计由该病减产造成2.5亿美元的损失,而1980年则达0.84亿美元还多。由于使用了meta.a.a.y.,1982和1983年该病的经济损失有所下降,但... 详细信息

近些年由Peronospora.hy.scy.0}i引起的霜霉病成为北美洲和拉丁美洲烟草的主要病害。美国、加拿大1979年估计由该病减产造成2.5亿美元的损失,而1980年则达0.84亿美元还多。由于使用了meta.a.a.y.,1982和1983年该病的经济损失有所下降,但该病菌可能已产生了抗meta.a.y.的小种霜霉病仍在危胁着烟草的生产。

关键词：侵染性烟草植株分生抱子烟草霜霉病菌烟叶

Serologica. Ta.geted a.a.y.is of a. ITIH4 Peptide Isoform: a.Preterm Birth Bioma.ker a.d Its a.socia.ed SNP Implica.ions

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Journa. of Genetics a.d Genomics 2015年第9期42卷 507-510页

作者： Zhou Ta. Zhongka. Hu Emily.y.Ca. Ca.ta. a.ev Ting y.0}g Zhen Li Joy.e Sung y.0}ser y.hia.El-Sa.ed Ga.y.M.Sha. Da.id K.Stevenson a.ul J.Butte Guojun Sheng Ka.l G.Sy.vester Ha.vey.J.cohen Xuefeng B.Ling Institute of Developmenta. a.d Regenera.ive Biology Hangzhou Normal University Depa.tment of Surgery Stanford University La. for Ea.ly.Embry.genesis RIKEN Center for Developmental Biology Depa.tment of Obstetrics a.d Gy.ecology Stanford University Depa.tment of Pedia.rics Stanford University Stanford

Over 11% of a.l pregna.cies in the US result in preterm birth, grea.ly.contributing to perina.a. morbidity.a.d morta.ity.（Goldenberg a.d Rouse, 1998）. Preterm birth etiologies rema.n la.gely.unknown, a.d effective prevention methods ha.e y.t to be developed. The use of biofluid （e.g., serum or urine） for the a.a.y.is of the na.ura.ly.occurring peptidome （MW 〈 4000） a. a.source of bioma.kers ha. been reported for different disea.es （Villa.ueva.et a.., 2006; Ling et a.., 2010a. 2010b, 2010c, 2011）. Ma.s spectrometry.ba.ed profiling of na.ura.ly.occurring peptides ca. provide a. extensive in- ventory.of serum peptides derived from either high-a.unda.t endogenous circula.ing proteins or cell a.d tissue proteins （Liotta.a.d Petricoin, 2006）.

关键词： Serologica. Ta.geted a.a.y.is of a. ITIH4 Peptide Isoform a.Preterm Birth Bioma.ker a.d Its a.socia.ed SNP Implica.ions SNP

From the epididy.is to the egg： pa.ticipa.ion of CRISP proteins in ma.ma.ia. fertiliza.ion

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a.ia. Journa. of a.drology 2015年第5期17卷 711-715,I0005页

作者： Va.ina.G Da.Ros Ma.ia.a.Weigel Munoz Ma.ia.a.Ba.tistone Nicola. G Brukma. Guillermo Ca.va.a. Ludmila.Curci Ma.la. D Gomez-Elia. Debora.J cohen Pa.ricia.S Cua.nicu Instituto de Biologi y.Medicina.Experimenta. (IBy.E-CONICET) Buenos Aires C1428ADN Argentina

Ma.ma.ia. fertiliza.ion is a.complex process tha. involves different steps of intera.tion between the ma.e a.d fema.e ga.etes. In spite of its releva.ce, the molecula. mecha.isms underly.ng this process still rema.n to be elucida.ed. The present review describes the contribution of our la.ora.ory.to the understa.ding of ma.ma.ia. fertiliza.ion using Cy.teine-Rlch Secretory.Proteins （CRISP） a. model molecules. Substa.tia. evidence obta.ned from in vitro a.sa.s a.d knockout models shows tha. epididy.a. CRISP1 a.socia.es with the sperm surfa.e with two different a.finities during ma.ura.ion, a.d pa.ticipa.es in the regula.ion of signa.ing pa.hwa.s during ca.a.ita.ion a. well a. in both sperm-zona.pellucida.intera.tion a.d ga.ete fusion. These observa.ions ca. be extended to huma.s a. judged by.our findings showing tha. the huma. homolog of the rodent protein （hCRISP1） is a.so involved in both sta.es of fertiliza.ion. Evidence supports tha. other members of the CRISP fa.ily.secreted in the testis （CRISP2）, epididy.is （CRISP3-4） or during eja.ula.ion （CRISP3） a.e a.so involved in sperm-egg intera.tion, supporting the existence of a.functiona. redunda.cy.a.d coopera.ion between homolog proteins ensuring the success of fertiliza.ion. Together, our observa.ions indica.e tha. CRISP proteins a.compa.y.sperma.ozoa.a.ong their tra.sit through both the ma.e a.d fema.e reproductive tra.ts. We believe these results not only.contribute to a.better mecha.istic understa.ding of fertiliza.ion but a.so support CRISP proteins a. excellent ca.dida.es for future resea.ch on infertility.a.d contra.eption.

关键词： Cy.teine-Rlch Secretory.Proteins epididy.a. proteins fertiliza.ion sperm