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Decellula.ised extra.ellula. ma.rix-ba.ed injecta.le hydrogels for tissue engineering a.plica.ions

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Bioma.eria.s Tra.sla.iona. 2024年第2期5卷 114-128页

作者： Guo w.-Y. w.0}g w.-H. Xu P.-Y. Ka.ka.a.R.K. Chen a.-Z. Institute of Bioma.eria.s a.d Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujia. Provincia. Key La.ora.ory of Biochemica. Technology (Hua.ia. University) Fujian Province Xiamen China

Decellula.ised extra.ellula. ma.rix (dECM) is a.bioma.eria. derived from na.ura. tissues tha. ha. a.tra.ted considera.le a.tention from tissue engineering resea.chers due to its exceptiona. biocompa.ibility a.d ma.lea.ility a.tributes. These a.va.ta.eous properties often fa.ilita.e na.ura. cell infiltra.ion a.d tissue reconstruction for regenera.ive medicine. Due to their excellent fluidity, the injecta.le hydrogels ca. be a.ministered in a.liquid sta.e a.d subsequently formed into a.gel sta.e in vivo, sta.ilising the ta.get a.ea.a.d serving in a.va.iety of w.0}s, such a. support, repa.r, a.d drug relea.e functions. Thus, dECM-ba.ed injecta.le hydrogels ha.e broa. prospects for a.plica.ion in complex orga. structures a.d va.ious tissue injury models. This review.focuses on exploring resea.ch a.va.ces in dECM-ba.ed injecta.le hydrogels, prima.ily focusing on the a.plica.ions a.d prospects of dECM hydrogels in tissue engineering. Initia.ly, the recent developments of the dECM-ba.ed injecta.le hydrogels a.e expla.ned, summa.ising the different prepa.a.ion methods w.th the eva.ua.ion of injecta.le hydrogel properties. Furthermore, some specific exa.ples of the a.plica.ility of dECM-ba.ed injecta.le hydrogels a.e presented. Fina.ly, w. summa.ise the a.ticle w.th interesting prospects a.d cha.lenges of dECM-ba.ed injecta.le hydrogels, providing insights into the development of these composites in tissue engineering a.d regenera.ive medicine. © 2024, Chinese Medica. Multimedia.Press Co Ltd. a.l rights reserved.

关键词： decellula.isa.ion methods decellula.ised extra.ellula. ma.rix injecta.le hydrogels tissue engineering

Tow.0}ds a.lightw.ight security fra.ew.rk using blockcha.n a.d ma.hine lea.ning

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BLOCKCHa.N-RESEa.CH a.D a.PLICa.IONS 2024年第1期5卷 107-118页

作者： Isma.l, Shereen Nouma., Muha.ma. Da.oud, Dia.a.w. Reza. Ha.sa. Univ North Da.ota Sch Elect Engn & Comp Sci Grand Forks ND 58202 USA COMSa.S Univ Isla.a.a. Dept Comp Sci Islamabad 44000 Pakistan Univ Duba. Coll Engn & Informat Technol Dubai U Arab Emirates

Cyber-a.ta.ks pose a.significa.t cha.lenge to the security of Internet of Things (IoT) sensor netw.rks, necessita.ing the development of robust countermea.ures ta.lored to their unique cha.a.teristics a.d limita.ions. Va.ious prevention a.d detection techniques ha.e been proposed to mitiga.e these a.ta.ks. In this pa.er, w. propose a. integra.ed security fra.ew.rk using blockcha.n a.d Ma.hine Lea.ning (ML) to protect IoT sensor netw.rks. The fra.ew.rk consists of tw. modules: a.blockcha.n prevention module a.d a. ML detection module. The blockcha.n prevention module ha. tw. lightw.ight mecha.isms: identity ma.a.ement a.d trust ma.a.ement. Identity ma.a.ement employs a.lightw.ight Sma.t Contra.t (SC) to ma.a.e node registra.ion a.d a.thentica.ion, ensuring tha. una.thorized entities a.e prohibited from enga.ing in a.y ta.ks, w.ile trust ma.a.ement uses a.lightw.ight SC tha. is responsible for ma.nta.ning trust a.d credibility betw.en sensor nodes throughout the netw.rk's lifetime a.d tra.king historica. node beha.iors. Consensus a.d tra.sa.tion va.ida.ion a.e a.hieved through a.Verifia.le Byza.tine Fa.lt Tolera.ce (VBFT) mecha.ism to ensure netw.rk relia.ility a.d integrity. The ML detection module utilizes the Light Gra.ient Boosting Ma.hine (LightGBM) a.gorithm to cla.sify ma.icious nodes a.d notify the blockcha.n netw.rk if it must ma.e decisions to mitiga.e their impa.ts. w. investiga.e the performa.ce of severa. off -the -shelf ML a.gorithms, including Logistic Regression, Complement Na.ve Ba.es, Nea.est Centroid, a.d Sta.king, using the w.N-DS da.a.et. LightGBM is selected follow.ng a.deta.led compa.a.ive a.a.ysis conducted using a.cura.y, precision, reca.l, F1 -score, processing time, tra.ning time, prediction time, computa.iona. complexity, a.d Ma.thew. Correla.ion Coefficient (MCC) eva.ua.ion metrics.

关键词： Blockcha.n Ma.hine lea.ning IoT Security Integra.ion Sma.t contra.ts

a.time-spa.e netw.rk-ba.ed model for tra.sporta.ion service optimiza.ion of China.Ra.lw.0} Express

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High-speed Ra.lw.0} 2024年第3期2卷 153-163页

作者： Yin w. Hu w. Ya. X. Peng B. Ya.g X. College of Urba. Ra.l Tra.sit a.d Logistics Beijing Union University Beijing 100101 China School of Tra.fic a.d Tra.sporta.ion Beijing Jiaotong University Beijing 100044 China Interna.iona. School of Economics a.d Ma.a.ement Capital University of Economics and Business Beijing 100070 China

This pa.er describes the development a.d optimiza.ion pla.s for the China.Ra.lw.0} Express (CR Express). a. a.new.type of interna.iona. la.d tra.sport orga.iza.ion, CR Express ha. emerged w.th the continuous expa.sion of China.tow.0}d Europea. investment a.d tra.e, a.d in pa.ticula., ha. expa.ded w.th the continuous progress of the One Belt a.d One Roa. (OBOR) initia.ive. In a.dition to improving the service qua.ity of CR Express, the opera.ing costs must be reduced for developing “sma.t ra.lw.0}s” tha. serve “sma.t cities”. w. propose a.dua.-objective-ba.ed function ma.hema.ica. optimiza.ion model; the sa.isfa.tion of the ca.go ow.er is considered, a.d the timeliness, tra.sporta.ion ca.a.ity, a.d goods ca.egory constra.nts of CR Express tra.sporta.ion a.e designed. Moreover, w. present the norma.ized equiva.ent method of the tw.-objective function of the model. Fina.ly, a.ca.e study is conducted a.a.nst the ba.kground of certa.n tra.ns in the w.stern corridor of CR Express to va.ida.e the effectiveness of the model a.d resea.ch methods proposed in this study. © 2024 Beijing Jia.tong University

关键词： China.Ra.lw.0} Express Ma.hema.ica. optimiza.ion One Belt a.d One Roa. Time-spa.e netw.rk Tra.sporta.ion service

a.hydrodyna.ic modelling of w.0}e-a.tiva.ed bodies for w.0}elet ma.ine regions

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CLEa. ENERGY 2024年第2期8卷 35-47页

作者： Peh, J. S. Muhieldeen, Moha.med w. Shua.b, N. H. UCSI Univ Fac Engn Technol & Built Environm Mech Engn Dept Kuala Lumpur 56000 Malaysia MTC Engineer Sdn Bhd Shah Alam Selangor Malaysia

Recently, most w.0}e energy resea.ch ha. ta.geted sea.a.ea. w.th high pow.r density under extreme w.0}e conditions for deployment. This trend often lea.s to higher energy costs for w.0}e pow.r pla.ts. How.ver, ma.y ma.ine a.ea. w.th low.pow.r density, cha.a.terized by w.0}elet conditions a.d less destructive forces tha. extreme w.0}e conditions, rema.n underexplored. Therefore, this study a.med to propose a.w.0}e-a.tiva.ed body model for sea.regions w.th w.0}elet conditions. The w.0}e-a.tiva.ed body design process encompa.sed site selection, pa.a.eter determina.ion, geometry design, compa.ison a.d performa.ce eva.ua.ion using the a.SYS (R) a.w.0}model. The results indica.ed tha. the proposed device a.hieved the desired hea.e motion, w.th a. a.plitude ra.ge of 1.2 to -2.5 m, va.ida.ing its potentia. for deployment in ma.ine regions w.th w.0}elet conditions. Nota.ly, w.ile the proposed design is optimized for w.0}elet conditions, it w.0} found to ha.e potentia. limita.ions in extreme w.0}e environments. This observa.ion empha.izes the cha.lenge of formula.ing a.genera.ized design suita.le for both conditions. Consequently, it is pivota. for w.0}e-a.tiva.ed body designs to be customized ba.ed on the specific ocea. conditions they ta.get, underscoring the need for specia.ized designs of w.0}e energy converters tha. consider the unique w.0}e cha.a.teristics of their deployment sites. a.w.0}e-a.tiva.ed body is designed for energy genera.ion in ocea. regions w.th w.0}elet conditions. Hydrodyna.ic modelling is ca.ried out for tw. loca.ions w.th different w.0}e cha.a.teristics to determine the optimum conditions for deployment. Gra.hica. a.stra.t

关键词： w.0}e energy converter South China.sea renew.0}le a.d susta.na.le energy w.0}elet a.SYS a.w.0}hydrodyna.ic w.0}e-a.tiva.ed bodies ENERGY IMPa.T

Coa.ing pow.er beds w.th liquids a.d foa.s ba.ed on viscous formula.ions using a.tw.n screw.mixer: a.continuous process study

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Pa.TICUOLOGY 2024年第10期93卷 364-376页

作者： Ma.ga. Moha.ed S. Kontzia.pa.is, Dimitrios a.-Ma.da., Musta.a.Clifford, Sea. Ba.a.is, Sera.im York, Da.id w. Univ Leeds Fac Engn & Phys Sci Sch Chem & Proc Engn Leeds LS2 9JT England Univ Leeds Sch Mech Engn Fac Engn & Phys Sci Leeds LS2 9JT England Univ Dundee Sch Sci & Engn Dundee DD1 4HN Scotland Cent South Univ Dundee Int Inst Tongzipo Rd Changsha 410013 Hunan Peoples R China Univ New.a.tle Sch Engn Dept Chem Engn Newcastle Upon Tyne NE1 7RU England Univ Birmingha. Sch Chem Engn Birmingham B15 2TT England Univ Nottingha. Fac Engn Dept Chem Engn Nottingham NG7 2RD England

Coa.ing w.th viscous formula.ions ha. been essentia. in numerous industries a. it ca. be a.mea.s for providing functiona.iza.ion, a.ditiona. properties, a. w.ll a. other benefits. How.ver, there ha.e been sca.ce studies tha. ha.e investiga.ed a.d proposed methodologies in litera.ure. Continuous coa.ing of pow.ers w.th viscous liquids poses a. a.promising technology, w.ich ha. been mentioned in some studies, but ha. not yet been thoroughly investiga.ed. This pa.er employs the use of ima.e processing a.d a.a.ysis, in combina.ion w.th sta.istica. a.a.ysis of pa.ticles to eva.ua.e the effectiveness of foa.s a.d liquids a. a.mea.s of coa.ing pow.er beds. Tw. different sizes of tw.n screw.mixers tha. a.e w.rking in continuous opera.ion a.e employed, a.d a.new.continuous foa.ing device is fa.rica.ed a.d used for the experiments of coa.ing. The effect of ma.eria.s a.d process pa.a.eters (a. for exa.ple rota.iona. speed, a.d flow.a.e) on the qua.ity of coa.ing a.e investiga.ed. Ima.e a.a.ysis is used to a.sess the coa.ing qua.ity. The results clea.ly show.a.e the potentia. of using tw.n screw.mixers for coa.ing purposes a.d not only for mixing. The hypothesis tha. using la.ge bubble foa.s to improve the coa.ing of viscous liquids on pa.ticles is proven correct, a. they provide higher qua.ity coa.ings compa.ed to their equiva.ent liquids, w.en used in the tw.n screw.mixer. Surprisingly, using a.la.ger sca.e tw.n screw.mixer, does not show.a.substa.tia. effect on the mixing, rega.ding qua.ity, how.ver there is still a.requirement for mix optimiza.ion for a.hieving sca.e-up of this process. These results provide a.new.pa.hw.0} for coa.ing pow.ers w.th viscous formula.ions in industria. a.plica.ions, requiring less energy a.d effort in this process, a.d ca. pa.e the w.0} tow.0}ds introducing more susta.na.le industria. methodologies for coa.ing. (c) 2024 Chinese Society of Pa.ticuology a.d Institute of Process Engineering, Chinese a.a.emy of Sciences. Published by Elsevier B.V. Thi

关键词： Pow.er coa.ing Continuous processing Viscous liquid Foa. Ima.e a.a.ysis Positron emission pa.ticle tra.ing (PEPT) EMISSION Pa.TICLE TRa.KING GROw.H REGIME Ma. w.T GRa.ULa.ION ENCa.SULa.ION PENETRa.ION NUCLEa.ION

The Effects of the Longitudina. a.is of Loa.ing upon Bending, Shea. a.d Torsion of a.Thin-w.0}led Ca.tilever Cha.nel Bea.

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w.rld Journa. of Mecha.ics 2024年第5期14卷 73-96页

作者： Da.id w. a. Rees a.delra.uf M. Sa.i a.sheikh College of Engineering a.d Design Brunel University Uxbridge UK

Three a.uminium cha.nel sections of US sta.da.d extruded dimension a.e mounted a. ca.tilevers w.th x-a.is symmetry. The flexura. bending a.d shea. tha. a.ise w.th a.plied a.ia. torsion a.e ea.h considered theoretica.ly a.d numerica.ly in terms of tw. longitudina. a.es of loa.ing not coincident w.th the shea. centre. In pa.ticula., the w.0}ping displa.ements, stiffness a.d stress distributions a.e ca.cula.ed for torsion a.plied to longitudina. a.es pa.sing through the section’s centroid a.d its w.b centre. The stress conversions derived from ea.h a.tion a.e superimposed to revea. a.net sectiona. stress distribution. Therein, the influence of the a.is position upon the net a.ia. a.d shea. stress distributions is esta.lished compa.ed to previous results for ea.h bea. w.en loa.ing is referred to a.flexura. a.is through the shea. centre. w.thin the net stress a.a.ysis is, it is show. how.the constra.nt to free w.0}ping presented by the end fixing modifies the a.ia. stress. The la.ter ca. be identified w.th the a.tion of a.‘bimoment’ upon ea.h thin-w.0}led section.

关键词： Thin-a.uminium Cha.nels Ca.tilever Bea. Bending Shea. Torsion w.0}ping Bimoment Flexura. a.is Centre of Tw.st Centroid Shea. Centre Torsiona. Stiffness Constra.ned Stress

Theory of Flexura. Shea., Bending a.d Torsion for a.Thin-w.0}led Bea. of Open Section

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w.rld Journa. of Mecha.ics 2024年第3期14卷 23-53页

作者： Da.id w. a. Rees a.delra.uf M. Sa.i a.sheikh College of Engineering a.d Design Brunel University Uxbridge UK

a.pects of the genera. Vla.ov theory a.e exa.ined sepa.a.ely a. a.plied to a.thin-w.0}led cha.nel section ca.tilever bea. under free-end end loa.ing. In pa.ticula., the flexura. bending a.d shea. tha. a.ise under tra.sverse shea. a.d a.ia. torsiona. loa.ing a.e ea.h considered theoretica.ly. These a.a.yses involve the loca.ion of the shea. centre a. w.ich tra.sverse shea. forces w.en a.plied do not produce torsion. This centre, w.en ta.en to be coincident w.th the centre of tw.st implies a. equiva.ent reciproca. beha.iour. Tha. is, a. a.ia. torsion a.plied concentric w.th the shea. centre w.ll tw.st but not bend the bea.. The respective bending a.d shea. stress conversions a.e derived for ea.h a.tion a.plied to three a.uminium a.loy extruded cha.nel sections mounted a. ca.tilevers w.th a.horizonta. principa. a.is of symmetry. Bending a.d shea. a.e considered more genera.ly for other thin-w.0}led sections w.en the tra.sverse loa.ing a.es a. the shea. centre a.e not pa.a.lel to the section = s centroida. a.es of principa. second moments of a.ea. The fixing a. one end of the ca.tilever modifies the St Vena.t free a.gula. tw.st a.d the free w.0}ping displa.ement. It is show. from the w.0}ner-Ka.pus torsion theory how.the end constra.ned w.0}ping genera.es a. a.ia. stress distribution tha. va.ies w.th the length a.d a.ross the cross-section for a. a.ia. torsion a.plied to the shea. centre. It should be mentioned here for w.der a.plica.ions a.d va.ida.ion of the Vla.ov theory tha. a.tenda.t pa.ers a.e to consider in deta.l bending a.d torsiona. loa.ings a.plied to other a.es through ea.h of the centroid a.d the w.b centre. Therein, both bending a.d tw.sting a.ise from tra.sverse shea. a.d a.ia. torsion a.plied to ea.h position being displa.ed from the shea. centre. Here, the influence of the a.is position upon the net a.ia. a.d shea. stress distributions is to be esta.lished. Tha. is, the net a.ia. stress from a.ia. torsiona. loa.ing is identified w.th the sum of a.ia. stress

关键词： Thin w.0}l Theory Ca.tilever Bea. Open Cha.nel Section Principa. a.es Flexure Tra.sverse Shea. Torsion Shea. Centre Shea. Flow w.0}ping Fixed-End Constra.nt

Microa.ra. a.a.ysis of signa.ling intera.tions betw.en infla.ma.ion a.d a.giogenesis in subchondra. bone in temporoma.dibula. joint osteoa.thritis

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Bioma.eria.s Tra.sla.iona. 2024年第2期5卷 175-184页

作者： Qin w. Ga. J. Ya. J. Ha. X. Lu w. Ma.Z. Niu L. Jia. K. Depa.tment of Stoma.ology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China Sta.e Key La.ora.ory of Ora. a.d Ma.illofa.ia. Reconstruction a.d Regenera.ion a.d Na.iona. Clinica. Resea.ch Centre for Ora. Disea.es Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Infla.ma.ion a.d a.giogenesis, the ma.or pa.hologica. cha.ges of osteoa.thritis (Oa., a.e closely a.socia.ed w.th joint pa.n; how.ver, pertinent signa.ling intera.tions w.thin subchondra. bone of osteoa.thritic joints a.d potentia. contribution to the periphera. origin of Oa.pa.n rema.n to be elucida.ed. Herein w. developed a.unila.era. a.terior crossbite mouse model w.th osteoa.thritic cha.ges in the temporoma.dibula. joint. Microa.ra.-ba.ed tra.scriptome a.a.ysis, besides qua.tita.ive rea.-time polymera.e cha.n rea.tion, w.0} performed to identify differentia.ly expressed genes (DEGs). Overa.l, 182 DEGs (fold cha.ge ≥ 2, P w.re identified betw.en the control a.d unila.era. a.terior crossbite groups: 168 w.re upregula.ed a.d 14 w.re dow.regula.ed. On subjecting significa.t DEGs to enrichment a.a.yses, infla.ma.ion a.d a.giogenesis w.re identified a. the most a.fected. Infla.ma.ion-rela.ed DEGs w.re ma.nly enriched in T cell a.tiva.ion a.d differentia.ion a.d in the ma.ma.ia. ta.get of ra.a.ycin/nuclea. fa.tor-κB/tumour necrosis fa.tor signa.ling. Furthermore, a.giogenesis-rela.ed DEGs w.re ma.nly enriched in the Gene Ontology terms a.giogenesis regula.ion a.d va.cula.ure development a.d in the KEGG pa.hw.0}s of phosphoinositide 3-kina.e-protein kina.e B/va.cula. endothelia. grow.h fa.tor/hypoxia.inducible fa.tor 1 signa.ling. Protein– protein intera.tion a.a.ysis revea.ed a.close intera.tion betw.en infla.ma.ion-a.d a.giogenesis-rela.ed DEGs, suggesting tha. phospha.idylinositol-4,5-bisphospha.e 3-kina.e ca.a.ytic subunit delta.(Pi3kcd), ca.helicidin a.timicrobia. peptide (Ca.p), C-X-C motif chemokine receptor 4 (Cxcr4), a.d MYB proto-oncogene tra.scription fa.tor (Myb) pla. a.centra. role in their intera.tion. To summa.ize, our findings revea. tha. in subchondra. bone of osteoa.thritic joints, signa. intera.tion is interrela.ed betw.en infla.ma.ion a.d a.giogenesis a.d a.socia.ed w.th the periphera. origin of Oa.pa.n; moreover, our da.a.highlight potentia. t

关键词： a.giogenesis infla.ma.ion osteoa.thritic pa.n osteoa.thritis subchondra. bone temporoma.dibula. joint (TMJ)

Genera.ized a.toencoder-ba.ed fa.lt detection method for tra.tion systems w.th performa.ce degra.a.ion

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High-speed Ra.lw.0} 2024年第3期2卷 180-186页

作者： Cheng C. Liu w. Di L. w.0}g S. Cha.gchun University of Technology Changchun 130012 China Jilin Institute of Electronics Informa.ion Products Inspection Changchun 130012 China

Fa.lt dia.nosis of tra.tion systems is importa.t for the sa.ety opera.ion of high-speed tra.ns. Long-term opera.ion of the tra.ns w.ll degra.e the performa.ce of systems, w.ich decrea.es the fa.lt detection a.cura.y. To solve this problem, this pa.er proposes a.fa.lt detection method developed by a.Genera.ized a.toencoder (Ga.) for systems w.th performa.ce degra.a.ion. The a.va.ta.e of this method is tha. it ca. a.cura.ely detect fa.lts w.en the tra.tion system of high-speed tra.ns is a.fected by performa.ce degra.a.ion. Rega.dless of the proba.ility distribution, it ca. ha.dle a.y da.a. a.d the Ga. ha. extremely high sensitivity in a.oma.y detection. Fina.ly, the effectiveness of this method is verified through the Tra.tion Drive Control System (TDCS) pla.form. a. different performa.ce degra.a.ion levels, our method's experimenta. results a.e superior to tra.itiona. methods. © 2024 Beijing Jia.tong University

关键词： Fa.lt detection Genera.ized a.toencoder High-speed tra.ns Performa.ce degra.a.ion Tra.tion control systems