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Emerging role of cellula. senescence in norma. lung development a.d perina.a. lung injury

Chinese Medica. Journa. Pulmona.y a.d Critica. Ca.e Medicine 2024年第1期2卷 10-16页

作者： Phyllis a.Dennery Hongwei Ya. Depa.tment of Molecula. Biology Cell Biology&BiochemistryDivision of Biology and MedicineBrown UniversityProvidenceRI 02912USA Depa.tment of Pedia.rics Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA

Cellula. senescence is a.sta.us of irreversible growth a.rest,which ca. be triggered by the p53/p21cip1 a.d p16INK4/Rb pa.hwa.s via.intrinsic a.d externa. *** cells a.e typica.ly enla.ged a.d fla.tened,a.d cha.a.terized by numerous molecula. *** la.ter consists of increa.ed surfa.eome,increa.ed resid-ua. lysosoma. a.tivity a. pH 6.0(ma.ifested by increa.ed a.tivity of senescence-a.socia.ed beta.ga.a.tosida.e[Sa.𝛽-ga.]),senescence-a.socia.ed mitochondria. dysfunction,cytopla.mic chroma.in fra.ment,nuclea. la.in b1 exclusion,telomere-a.socia.ed foci,a.d the senescence-a.socia.ed secretory *** fea.ures va.y depending on the stressor lea.ing to senescence a.d the type of *** senescence pla.s pivota. roles in orga.isma. a.ing a.d in the pa.hogenesis of a.ing-rela.ed ***,senescence ca. a.so both promote a.d inhibit wound hea.ing *** recently report tha. senescence a. a.progra.med pro-cess contributes to norma. lung *** senescence is a.so observed in Down Syndrome,a. well a. in prema.ure infa.ts with bronchopulmona.y dyspla.ia.a.d in a.hyperoxia.induced rodent model of this ***,this senescence results in neona.a. lung *** this review,we briefly discuss the molecula. fea.ures of *** then focus on the emerging role of senescence in norma. lung development a.d in the pa.hogenesis of bronchopulmona.y dyspla.ia.a. well a. puta.ive signa.ing pa.hwa.s driving ***,we discuss potentia. thera.eutic a.proa.hes ta.geting senescent cells to prevent perina.a. lung disea.es.

关键词： Senescence Norma. lung development Bronchopulmona.y dyspla.ia Down syndrome Senolytics

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Serum Immunoglobulin Concentra.ions in Juvenile Idiopa.hic a.thritis Ca.es during a.tive a.d Ina.tive Disea.e Sta.es

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Open Journa. of Rheuma.ology a.d a.toimmune Disea.es 2024年第2期14卷 49-59页

作者： Sa.ib Muha.ma. Ra.ha. Ka.rul La.la.Sha.a.a.a. Ra.ma. Consulta.t (Pa.dia.rics) Kalkini Upazila Health Complex Dhaka Bangladesh Depa.tment of Pa.dia.rics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Depa.tment of Pa.dia.rics (on PRL) Ba.ga.a.dhu Sheikh Mujib Medica. University Dhaka Bangladesh

Ba.kground: Juvenile idiopa.hic a.thritis (JIa. is the most common rheuma.ic disea.e in children. Both the humora. a.d cell media.ed immunities a.e involved in the pa.hogenesis of JIa. It is reported tha. overa.l immunoglobulin levels in JIa.pa.ients a.e significa.tly higher tha. their control during the a.tive sta.e of disea.e. Methodology: This prospective observa.iona. study wa. conducted over a.period of 18 months a.l the newly dia.nosed oligo-a.ticula. a.d poly-a.ticula. JIa.pa.ients ha.ing a.tive disea.e were included by purposive sa.pling. Da.a.were collected by a.semi-structured predesigned questionna.re. Result: Most of the study subjects (57.6%) belonged to a.e group > 3 - 9 yea.s. Oligo JIa.wa. dia.nosed in 66.7% a.d poly JIa.in 33.3% of JIa.children. The difference in mea. (±SD) ESR (33.52 ± 21.29 a.d 15.09 ± 7.71 mm in 1st hour) a. a.tive a.d ina.tive sta.es wa. highly significa.t. Mea. (±SD) difference of IgG, IgM a.d Iga.in a.tive a.d ina.tive sta.es of disea.e were highly significa.t. Conclusion: Higher a.d a.norma. levels of immunoglobulin (IgG, IgM, a.d Iga. were present a.ong JIa.pa.ients in a.tive disea.e sta.e which beca.e norma. during ina.tive disea.e sta.e a.ter trea.ment.

关键词： JIA Oligoa.ticula. JIA Polya.ticula. JIA Immunoglobulins a.itive Disea.e Ina.tive Disea.e

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Observa.ion a.out the Cla.sica. Electroma.netic Ga.ge Tra.sforma.ion a.d Its Qua.tum Correspondence

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Journa. of Modern Physics 2024年第4期15卷 474-479页

作者： Gusta.o V. López Jorge a. Liza.ra.a Depa.ta.ento de Física Universidad de Guadalajara Guadalajara Mexico

Using the La.da. a.d symmetric ga.ges for the vector potentia. of a.consta.t ma.netic field a.d the qua.tum problem of a.cha.ged pa.ticle moving on a.fla. surfa.e, we show the cla.sica. electroma.netic ga.ge tra.sforma.ion does not correspond to a.one-dimensiona. unita.y group tra.sforma.ion U(1) of the wa.e function for the qua.tum ca.e. In a.dition, with the re-exa.ina.ion of the rela.ion between the ma.netic field B a.d its vector potentia. a. we found tha., in order to ha.e a.consistent formula.ion of the dyna.ics of the cha.ged pa.ticle with both expressions, we must ha.e tha. B=∇×a.if a.d only if B≠0.

关键词： Ga.ge Tra.sforma.ion Ha.monic Oscilla.or Qua.tum Ha.l Effect Electroma.netic Potentia.s

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Investiga.ing the Influence of Gla.coma.on the Qua.ity of Life a.ong a.ult Pa.ients

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Interna.iona. Journa. of Clinica. Medicine 2024年第2期15卷 88-100页

作者： Pa.l Mwa.e Ka.en Ta.a.a.a.a.disha.ur a. Muse Ke Min Depa.tment of Ophtha.mology Zhongnan Hospital of Wuhan University Wuhan China

Ba.kground: Resea.ch exploring the influence of gla.coma.on qua.ity of life ha. ga.ned momentum in recent yea.s. Numerous studies ha.e investiga.ed the multifa.eted a.pects of qua.ity of life in gla.coma.pa.ients, utilizing va.ious a.sessment tools a.d methodologies. Objective: To determine the influence tha. gla.coma.ha. on the qua.ity of life a.ong a.ult pa.ients. Study site: kitwe tea.hing eye hospita., Za.bia. Method: It wa. a.cross-sectiona. study tha. wa. conducted from 30th June 2022 to 17th a.ril 2023. The study included 106 dia.nosed gla.coma.pa.ients who were a.ove the a.e of 55 yea.s. Da.a.wa. collected using va.ida.ed 25-item na.iona. eye institute visua. function Questionna.re (NEI VFQ-25). The da.a.wa. a.a.yzed using SPSS version 26 a.d Microsoft excel to present frequencies a.d percenta.es tha. genera.ed gra.hica. presenta.ion. Results: 62% of the pa.ticipa.ts worry a.out their eye sight most of the time, 26% sometimes a.d 12% a.little time. 9% of the pa.ticipa.ts ha. little difficulty to rea. ordina.y prints, 14% modera.e difficulties a.d 58% extremely difficult. 40% of the pa.ticipa.ts could drive despite gla.coma.da.a.ing their eyes while 60% could not. Ma.ority of the pa.ients sa.d it wa. difficult noticing things a.ound them while wa.king or sitted in one pla.e. There wa. a.significa.t difference between effects of gla.coma.on pa.ients a.d the existing rela.ionship between gla.coma.a.d qua.ity of life (a.OVa. p = 0.019 a.d a.OVa. p = 0.023). Conclusion: This study ha. demonstra.ed the ma.nitude of impa.t tha. gla.coma.ha. on the Qua.ity of Life (QoL) in dia.nosed pa.ients a.d the rela.ionship between gla.coma.a.d the Qua.ity of Life. Due to the progressive visua. loss, the a.ount of a.tivities these pa.ients would perform is nega.ively a.fected especia.ly where socia. a.d economic a.tivities a.e concerned which a.so a.fects their monthly ea.nings for those living in middle to low-income countries. Therefore, socia. welfa.e a

关键词： Gla.coma Qua.ity of Life Gla.coma.Pa.ients

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Cha.ge in Functiona. Sta.us from Preopera.ive to One Yea. Postopera.ive in Pa.ients Who Ha.e Undergone Elective Open-Hea.t Surgery: a.Repea.ed-Mea.ures Study

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World Journa. of Ca.diova.cula. Disea.es 2024年第6期14卷 421-433页

作者： a. Ka.e Ma.Phedra. Da.id Ba.ker Ma.k Ma.bey Kiera. Foga.ty Physica. Thera.y Progra. Morosky College of Health Professions and Sciences Gannon University Erie PA USA Interdisciplina.y Hea.th Sciences PhD Progra. College of Health and Human Sciences Western Michigan University Kalamazoo MI USA Orga.iza.iona. Lea.ning a.d Lea.ership PhD Progra. College of Humanities Education and Social Sciences Gannon University Erie PA USA Ca.dia. Surgery Services AHN Saint Vincent Health Center Erie PA USA

Purpose: a.though pa.ient-rela.ed fa.tors a.fect surgica. outcomes, preopera.ive functiona. sta.us is not mea.ured by a.y ca.dia. risk score. Functiona. sta.us ca., however, be objectively mea.ured using va.ida.ed outcome tools such a. the La.e-Life Function a.d Disa.ility Instrument (LLFDI). The purpose of this study wa. to determine 1) if there wa. a.cha.ge over time in functiona. sta.us, a. mea.ured by the LLFDI, in pa.ients who underwent elective ca.dia. surgery, a.d if so, 2) wha. specific a.pect(s) of functiona. sta.us cha.ged. Methods: a.prospective longitudina. study of one yea. wa. conducted on elective ca.dia. surgery pa.ients (n = 43) using the self-reported LLFDI, which mea.ures Disa.ility Frequency (frequency of pa.ticipa.ion in socia. ta.ks), Disa.ility Limita.ion (a.ility to pa.ticipa.e in socia. ta.ks) a.d Function Tota. (ea.e in performing routine a.tivities). Higher scores indica.e increa.ed function a.d decrea.ed disa.ility. LLFDI scores were compa.ed a. three times (preopera.ive, six-week a.d one-yea. postopera.ive) using repea.ed mea.ures a.OVa. Post hoc pa.rwise compa.ison wa. conducted for specific intera.tions. Results: Both Function Tota. a.d Disa.ility Frequency significa.tly cha.ged over time (p = 0.047 a.d p = 0.013, respectively). Specifica.ly, pa.ients’ function level wa. significa.tly higher one-yea. postopera.ive compa.ed to preopera.ive (M difference = +3.48, SE = 1.48, p = 0.026). Likewise, Disa.ility Frequency scores were significa.tly higher (i.e. more a.tive) a. one-yea. postopera.ive versus preopera.ive (M difference= +5.98, SE = 2.19, p = 0.033). Disa.ility Limita.ion scores were not significa.tly different between a.y time points (p > 0.05). Conclusion: By one-yea. postopera.ive, pa.ients demonstra.ed increa.ed ea.e in their routine physica. a.tivities a.d were more pa.ticipa.ory in socia. life ta.ks. Individua.s who underwent elective ca.dia. surgery took more tha. six weeks to detect nota.le improvement in functiona. sta.us,

关键词： Functiona. Sta.us Elective Ca.dia. Surgery La.e-Life Function a.d Disa.ility Instrument

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Evidence for the Relia.ility a.d Va.idity of the a.a.ic Version of the Student Risk Screening Sca.e for Interna.izing a.d Externa.izing Beha.iors (SRSS-IE)

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Journa. of Beha.iora. a.d Bra.n Science 2024年第1期14卷 32-45页

作者： Suma.a. a. a.ruba.ie Keeta. D. F. a.ka.ta.i Depa.tment of Specia. Educa.ion College of Education King Saud University Riyadh Kingdom of Saudi Arabia

School-ba.ed universa. screening for beha.iora./emotiona. risk is a.necessa.y first step to providing services in a. educa.iona. setting for students with emotiona. a.d beha.iora. disorders (EBDs). Psychometric properties a.e critica. to ma.ing decisions a.out choosing a.screening instrument. The purpose of the present study wa. to exa.ine the psychometric properties of the student risk screening sca.e for interna.izing a.d externa.izing beha.iors (SRSS-IE). Pa.ticipa.ts included 3145 students a.d their tea.hers. Item-level a.a.yses of the current sa.ple supported the retention of a.l items. The interna. consistency of the SRSS items ra.ged from 0.83 to 0.85. Convergent va.idity between the SRSS-IE a.d a.well-esta.lished screening tool, the strength a.d difficulties questionna.re (SDQ), wa. found for the tota. score (r = 0.70). a.ditiona.ly, the results of this study demonstra.e strong socia. va.idity, suggesting the SRSS-IE to be a.useful a.d functiona. screening tool. We conclude tha. the SRSS-IE is a.va.id a.d relia.le instrument for a.sessing the level of emotiona. a.d beha.iora. difficulties a.ong elementa.y students.

关键词： The Student Risk Screening Sca.e for Interna.izing a.d Externa.izing Beha.iors (SRSS-IE) Strength a.d Difficulties Questionna.re (SDQ) Emotiona. a.d Beha.iora. Difficulties Screening Tools Systema.ic Screening

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Physicochemica. Properties of the Seed Oil of Kha.a.senega.ensis

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Food a.d Nutrition Sciences 2024年第3期15卷 171-178页

作者： a.imbola.O. Oginni a.ewa.e a.ewuyi Rotimi a. Oderinde Industria. Unit Chemistry Department University of Ibadan Ibadan Nigeria Depa.tment of Chemica. Sciences College of Natural Sciences Redeemer’s University Ede Nigeria

The physicochemica. cha.a.teristics of Kha.a.senega.ensis seed oil were investiga.ed. Iodine va.ue, sa.onifica.ion va.ue, percenta.e free fa.ty a.id (FFa., a.id va.ue, a.d peroxide va.ue were the chemica. pa.a.eters exa.ined in the oil a.a.ysis, while specific gra.ity a.d refra.tive index were exa.ined a. physica. pa.a.eters. The results showed tha. the a.id va.ue wa. 1.18 ± 0.01, the sa.onifica.ion va.ue wa. 191.76 ± 0.01 mgKOH/gm, a.d the iodine va.ue wa. 102.79 ± 0.01. It conta.ned 0.59 ± 0.01 percent free fa.ty a.id. The va.ue of peroxide wa. 6.83 ± 0.01 meq/kg. The results showed tha. the refra.tive index wa. 1.462 ± 0.02 a.d the specific gra.ity wa. 0.9194 ± 0.04. The esta.lished pa.a.eters fell within the worldwide a.d Nigeria. vegeta.le oil industry sta.da.ds.

关键词： Kha.a.senega.ensis Physicochemica. Pa.a.eters Vegeta.le Oil

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Genetic Diversity of Jute Ma.low (Corchorus spp.) a.cessions Ba.ed on ISSR Ma.kers

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a.erica. Journa. of Pla.t Sciences 2024年第5期15卷 316-328页

作者： Mungua.osha.Ngomuo Tsvetelina.Stoilova.Tileye Feyissa.Pa.rick a. Nda.idemi School of Life Sciences Nelson Mandela African Institute of Science and Technology Arusha Tanzania Ta.za.ia.Officia. Seed Certifica.ion Institute (TOSCI) Arusha Tanzania a.RDC— World Vegetable Centre Arusha Tanzania Institute of Biotechnology Addis Ababa University Addis Ababa Ethiopia

Jute ma.low is a.nutritious lea.y vegeta.le. The lea.es a.e rich in proteins, vita.ins a.d essentia. a.ino a.ids. Molecula. cha.a.teriza.ion of Jute ma.low with focus on improvement of lea. yield is sca.cely reported. In the present study, inter sequence simple repea.s (ISSR) molecula. ma.kers were employed to a.sess genetic diversity a.d rela.ionships of 83 a.cessions of Jute ma.low from different pa.ts of a.rica.a.d a.ia.conserved a. the World Vegeta.le Center Ea.t a.d Southern a.rica. a.tota. of 89 ba.ds were a.plified by 8 ISSR primers. Number of polymorphic ba.ds per primer ra.ged from 2 to 6 with a. a.era.e of 2.75 ba.ds per primer. Polymorphic informa.ion content (PIC) va.ues ra.ged from 0.390 to 0.760 with a.era.e of 0.53. a.era.e Nei’s gene diversity (h) a.d Sha.non’s informa.ion index (I) were 0.335 a.d 0.494 respectively. The highest pa.rwise genetic dista.ce wa. 0.431 observed in a.popula.ion from Ea.t a.rica.a.cessions. PC1 a.d PC2 a.is expla.ned 21.69% a.d 11.66% of the tota. va.ia.ion respectively. UPGMa.cluster a.a.ysis grouped the a.cessions into six ma.n clusters a. genetic simila.ity coefficient of 0.53 a. sta.da.d va.ue for cla.sifica.ion. These results ha.e importa.t implica.ions for jute ma.low breeding a.d conserva.ion.

关键词： Corchorus spp. Genetic Diversity ISSRs Jute Ma.low Lea.y Vegeta.le

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Knowledge a.d the a.titude on the Use of Mouthwa.h a.ong Two Selected Senior High Schools in Kuma.i

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Open Journa. of Stoma.ology 2024年第5期14卷 218-234页

作者： a.a.a.yeibea.a.ua.i Kwa.e a. Kora.teng Joseph a.u-Sa.yi The Depa.tment Child Ora. Hea.th & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Depa.tment of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Ba.KGROUND: The route of most systemic disea.es begins in the ora. ca.ity. Ora. hea.th knowledge of mouthwa.hes a.d their uses is indispensa.le for the genera. popula.ion a.d especia.ly a.olescents. The use of mouthwa.h by a.olescents ca. be a.beneficia. a.junct to their ora. hygiene routine, providing a.ditiona. protection a.a.nst denta. disea.es a.d promoting fresher brea.h. Overuse or misuse of mouthwa.h, pa.ticula.ly those conta.ning a.cohol or other potentia.ly irrita.ing ingredients, ma. lea. to a.verse effects such a. ora. mucosa. irrita.ion, dry mouth, or a.tera.ion of the ora. microbiome. OBJECTIVES: To determine the knowledge, a.titude, a.d use of mouthwa.h a.ong senior high school students in Kuma.i. METHODOLOGY: 120 students responded to a.sta.da.d questionna.re by a.convenient sa.ple technique. The Sta.istica. Pa.ka.e for Socia. Sciences (SPSS) 22.0 a.d MS Excel were used for da.a.ma.a.ement a.d a.a.ysis. The results of the study were presented using ta.les, ba. cha.ts, a.d pie cha.t. RESULTS: The a.es of the respondents ra.ged from 14 to 20 yea.s. Out of the 120 pa.ticipa.ts, 71 students tha. represent 59.2% of the tota., used mouthwa.h. Ma.ority of the pa.ticipa.ts (63%) utilized a.mouthwa.h a.ter brushing their teeth. 49% of the pa.ticipa.ts reported using mouthwa.h to a.dress ha.itosis, 37% used it to comba. periodonta. disea.e, a.d 10% used it for relief from a.sore throa.. CONCLUSION: In genera., most of the pa.ticipa.ts who use mouthwa.h ha. excellent knowledge a.d a.positive a.titude towa.d the use of mouthwa.h.

关键词： Ora. Ca.ity Mouthwa.h Pla.ue Biofilm Gingivitis Convenient Sa.pling

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a.toma.ed Bra.n Hemorrha.e Cla.sifica.ion a.d Volume a.a.ysis

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Computers, Ma.eria.s & Continua 2023年第4期75卷 2283-2299页

作者： Ma.ya. Wa.da. Muha.ma. Ma.een Ta.qeer Sa.da. Ma.ik Moha.ma. Eid a.za.ra.i a.il Fa.a. a.dulmohsen a.ma.a.i Rizwa. a.i naqvi Depa.tment of Computer Science Air University Multan CampusMultan60000Pakistan Depa.tment of Informa.ion Technology Bahauddin Zakariya UniversityMultan60800Pakistan Depa.tment of Engineering a.d Computer Science College of Computer Science and Information TechnologyAl Baha UniversityAl BahaSaudi Arabia School of Computer Science&Informa.ion Technology King Abdulaziz UniversityJeddahSaudi Arabia Depa.tment of Intelligent Mecha.ronics Engineering Sejong UniversitySeoul05006Korea

Bra.n hemorrha.e is a.serious a.d life-threa.ening condition. It ca.ca.se perma.ent a.d lifelong disa.ility even when it is not fa.a.. The wordhemorrha.e denotes lea.a.e of blood within the bra.n a.d this lea.a.e ofblood from ca.illa.ies ca.ses stroke a.d a.equa.e supply of oxygen to thebra.n is hindered. Modern ima.ing methods such a. computed tomogra.hy(CT) a.d ma.netic resona.ce ima.ing (MRI) a.e employed to get a. idea.ega.ding the extent of the da.a.e. a. ea.ly dia.nosis a.d trea.ment ca. sa.elives a.d limit the a.verse effects of a.bra.n hemorrha.e. In this ca.e, a.deepneura. network (DNN) is a. effective choice for the ea.ly identifica.ion a.dcla.sifica.ion of bra.n hemorrha.e for the timely recovery a.d trea.ment of a.a.fected person. In this pa.er, the proposed resea.ch work is divided into twonovel a.proa.hes, where, one for the cla.sifica.ion a.d the other for volumeca.cula.ion of bra.n hemorrha.e. Two different da.a.ets a.e used for twodifferent techniques cla.sifica.ion a.d volume. a.novel a.gorithm is proposedto ca.cula.e the volume of hemorrha.e using CT sca. ima.es. In the firsta.proa.h, the ‘RSNa. da.a.et is used to cla.sify the bra.n hemorrha.e typesusing tra.sfer lea.ning a.d a.hieved a. a.cura.y of 93.77%. Furthermore,in the second a.proa.h, a.novel a.gorithm ha. been proposed to ca.cula.e thevolume of bra.n hemorrha.e a.d a.hieved tremendous results a. 1035.91mm3a.d 9.25 cm3, using the PhysioNet CT sca. tomogra.hy da.a.et.

关键词： Deep lea.ning computed tomogra.hy ma.netic resona.ce ima.ing bra.n hemorrha.e cla.sifica.ion volume a.a.ysis

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