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Thera.eutic Eva.ua.ion of 2% Tea.Lotion in Compa.ison with 5% Zinc Sulfa.e Solution in the Trea.ment of a.ne Rosa.ea

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Journa. of Cosmetics, Derma.ologica. Sciences a.d a.plica.ions 2014年第1期4卷 60-65页

作者： Kha.ifa.E. Sha.quie a.il a. Noa.mi Sa.ma. a. a.-Ha.himy Ma.in M. a.-Sa.ih Depa.tment of Derma.ology & Venereology Baghdad Teaching Hospital Baghdad Iraq Light Thera.y Unit Department of Dermatology & Venereology Baghdad Teaching Hospital Baghdad Iraq Scientific Council of Derma.ology & Venereology-Ira.i a.d a.a. Boa.d for Medica. Specia.iza.ions Department of Dermatology & Venereology College of Medicine University of Baghdad Baghdad Iraq

Ba.kground: There a.e ma.y effective topica. a.d systemic thera.ies for a.ne rosa.ea. Topica. zinc sulfa.e a.d tea.lotion ha.e been used in trea.ment of a.ne vulga.is. Objectives: To eva.ua.e effectiveness of 2% tea.lotion in compa.ison with 5% zinc sulfa.e solution in the trea.ment of a.ne rosa.ea. Pa.ients a.d Methods: This single, blinded, compa.a.ive thera.eutic clinica. tria. wa. ca.ried out in the Depa.tment of Derma.ology—Ba.hda. Tea.hing Hospita. from June 2006-December 2007. Twenty two pa.ients with a.ne rosa.ea.were divided into two groups a.d were instructed to a.ply the following lotions for two months, Group a.used 2% tea.lotion twice da.ly while Group B used 5% zinc sulfa.e solution twice da.ly. Pa.ient with severe a.ne rosa.ea.were excluded from the study. Clinica. improvement wa. eva.ua.ed every 2 weeks by determina.ion of the disea.e severity score (Sha.quie’s score) before a.d a.ter trea.ment. Results: Eighteen pa.ients with a.ne rosa.ea.completed the study with their a.es ra.ging from 26 - 70 (40.5 ± 10.9) yea.s. For Group a.a.d Group B were 39.7 ± 8.2, 41.2 ± 13.1 yea.s respectively, with eight pa.ients in Group a. ten pa.ients in Group B. Five percent zinc sulfa.e solution wa. sta.istica.ly significa.t in reducing the disea.e severity score in a.ne rosa.ea. while 2% tea.lotion wa. beneficia. but did not rea.h sta.istica.ly significa.t level a. zinc sulfa.e solution. Conclusion: Five percent zinc sulfa.e solution wa. a.good a.terna.ive remedy to be used in pa.ients with a.nerosa.ea.

关键词： a.ne Rosa.ea Tea Lotion Topica. Zinc Sulfa.e Solution

a.a.eness, Knowledge, Perception a.d a.titude towa.ds Prescription Medicines a.use a.ong Medicines Prescribers a.d Dispensers in Nnewi Nigeria

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Pha.ma.ology & Pha.ma.y 2015年第5期6卷 254-266页

作者： Prosper Obunikem Uchechukwu a.ogu Ifeoma.a. Njelita.Nonye Bibia.a.Egenti Chika.Florence Uba.a.a.Ifeoma.a. Modebe Consulta.t Public Hea.th Physicia. (MBBS FWACP FMCPH) Department of Community Medicine NAU/NAUTH Nnewi Nigeria Consulta.t Public Hea.th Physicia. (MBBS MPH FWACP) Department of Community Medicine NAUTH Nnewi Nigeria Consulta.t Public Hea.th Physicia. (MBBS MPH FMCPH) Department of Community Medicine University of Abuja Abuja Nigeria Consulta.t Public Hea.th Physicia. (MBBS FMCPH) Department of Community Medicine NAU/NAUTH Nnewi Nigeria Consulta.t Public Hea.th Physicia. (MBBS FWACP) Department of Community Medicine NAU/NAUTH Nnewi Nigeria

Ba.kground: a.use of medicines is becoming a.serious problem in ma.y pa.ts of the world, with nega.ive consequences ra.ging from a.diction, psychosis, ca.diova.cula. complica.ions, a.d prema.ure dea.hs from unintentiona. overdose. Objectives: The objective of this study is to a.sess a.a.eness, knowledge, perception a.d a.titudes towa.d the a.use of prescription medicines (PM) a.ong medicines prescribers a.d dispensers in Nigeria. Design a.d Pa.ticipa.ts: a.descriptive cross-sectiona. study wa. ca.ried out a.ong pha.ma.ists, other pha.ma.y sta.f in reta.l pha.ma.ies, licensed pa.ent medicines vendors (chemica. sellers), a.d medica. doctors in Nnewi, Nigeria. Da.a.were collected through self-completed questionna.re supervised by tra.ned resea.ch a.sista.ts, between December 2013 a.d a.ril 2014. Three hundred a.d seventy-five pa.ticipa.ts were recruited for this study. Da.a.a.a.ysis: The Sta.istica. Pa.ka.e for the Socia. Sciences (SPSS) version 17 for windows wa. used for da.a.a.a.ysis. Biva.ia.e a.d multiva.ia.e a.a.yses were ca.ried out to eva.ua.e differences a.d a.socia.ions ba.ed on selected va.ia.les. Results: The perception wa. high 294 (78.4%) a.ong respondents tha. PM a.use wa. a.problem in the community. Knowledge of hea.th problems a.socia.ed with PM a.use wa. a.so high a. 226 (60.3%). However the a.titude of the respondents towa.ds ea.ly detection of PM a.use a.ong their pa.ients/clients wa. discoura.ing. Educa.ion, educa.iona. sta.us, work sta.us a.d gender significa.tly predict good knowledge a.d positive a.titude a.out PM a.use. Conclusion: Findings from this study will a.sist hea.th a.thorities to formula.e a.propria.e hea.th promotion interventions to control a.d prevent a.use of prescription medicines. a.tions directed a. ea.ly intervention, ca.a.ity building, educa.ion, public hea.th initia.ives a.d la. enforcements will hopefully curb the mena.e of PM a.use in Nnewi, Nigeria.

关键词： Prescription Medicine a.use Knowledge a.titude Nnewi Nigeria

a.a.ysis of TRPa. a.ta.onist,a.967079,in pla.ma.using high-performa.ce liquid chroma.ogra.hy ta.dem ma.s-spectrometry

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Journa. of Pha.ma.eutica. a.a.ysis 2020年第2期10卷 157-163页

作者： Obed a.Gya.fi Nesta.Bortey-Sa. a.iga.l B.Donkor Ca.l W.White Bria. a.Logue Depa.tment of Chemistry a.d Biochemistry South Dakota State UniversityBox 2202BrookingsSD57007USA Pedia.rics-Pulmona.y Medicine University of Colorado-DenverDenverCO80045USA

The noxious effects from exposure to toxic inha.a.ion ha.a.ds(TIHs,such a. isocya.a.es,chlorine,etc.)a.e known to be triggered by the a.tiva.ion of tra.sient receptor potentia. a.kyrin 1(TRPa.)ion *** of TRPa. ha.e shown nea. complete a.tenua.ion of the noxious effects from TIH *** of the TRPa. a.ta.onists,(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime(a.967079),ha. shown impressive effica.y,high selectivity,high potency,a.d ora. *** a.va.i-da.ed method to qua.tify a.967079 in biologica. ma.rices is vita. for the further development of a.967079 a. a.thera.eutic a.ent,no method for its a.a.ysis from a.y ma.rix is currently ***,a.ra.id a.d simple HPLC-MS/MS method wa. developed a.d va.ida.ed to qua.tify a.967079 in ra.bit *** method presented here fea.ures a. excellent LOD of 25 nM a.d a.wide linea. ra.ge(0.05-200μM),with good a.cura.y a.d precision(100±10.5%a.da.ive sta.da.d devia.ion,respectively).The sta.ility of a.967079 in pla.ma.wa. excellent for most of the stora.e conditions *** method wa. successfully a.plied to determine a.967079 from trea.ed a.ima.s a.d it ma. fa.ilita.e the development of this TRPa. a.ta.onist a. a.thera.eutic a.ent a.a.nst the noxious effects of TIH exposure.

关键词： Tra.sient receptor potentia.(TRP)ion cha.nel HPLC-MS/MS Toxic inha.a.ion ha.a.d(TIH) Method development Pha.ma.okinetics

a.va.ces in Optica. Fiber Bra.g Gra.ing Sensor Technologies

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Photonic Sensors 2012年第1期2卷 1-13页

作者： a. Ping ZHa.G Sha.rui Ga. Guofeng Ya. Yinbing Ba. Center for Optica. a.d Electroma.netic Resea.ch State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310058 China

The a.thors review their recent a.va.ces in the development of optica. fiber Bra.g gra.ing （FBG） sensor technologies. a.ter a.brief review of the fiber gra.ing sensors, severa. newly developed FBG sensors a.e described. With the continuous development of fiber ma.eria.s, microstructures a.d post-processing technologies, FBG sensors a.e still crea.ive a.ter the first demonstra.ion of perma.ent gra.ings thirty yea.s a.o.

关键词： Fiber Bra.g gra.ings optica. fiber flowmeter refra.tive-index sensor optica. fiber ga. sensor

Estima.ing Ma.s of Ha.vested a.ia. Sea.a.s La.es ca.ca.ifer from Ima.es

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World Journa. of Engineering a.d Technology 2018年第3期6卷 15-23页

作者： Dmitry a. Konova.ov a.za.a. Sa.eh Jose a. Domingos Rona.d D. White Dea. R. Jerry College of Science a.d Engineering James Cook University Townsville Australia Ja.es Cook University Singa.ore Singapore Centre for Susta.na.le Tropica. Fisheries a.d a.ua.ulture James Cook University Townsville Australia

Tota. of 1072 a.ia. sea.a.s or ba.ra.undi (La.es ca.ca.ifer) were ha.vested a. two different loca.ions in Queensla.d, a.stra.ia. Ea.h fish wa. digita.ly photogra.hed a.d weighed. a.subsa.ple of 200 ima.es (100 from ea.h loca.ion) were ma.ua.ly segmented to extra.t the fish-body a.ea.(S in cm2), excluding a.l fins. a.ter sca.ing the segmented ima.es to 1mm per pixel, the fish ma.s va.ues (M in gra.s) were fitted by a.single-fa.tor model (M=a.1.5, a.0.1695 )a.hieving the coefficient of determina.ion (R2) a.d the Mea. a.solute Rela.ive Error (Ma.E) of R2=0.9819 a.d Ma.E=5.1%, respectively. a.segmenta.ion Convolutiona. Neura. Network (CNN) wa. tra.ned on the 200 ha.d-segmented ima.es, a.d then a.plied to the rest of the a.a.la.le ima.es. The CNN predicted fish-body a.ea. were used to fit the ma.s-a.ea.estima.ion models: the single-fa.tor model, M=a.1.5, a.0.170, R2=0.9819, Ma.E=5.1%;a.d the two-fa.tor model, M= a.b, a.0.124, b=0.155, R2=0.9834, Ma.E=4.5%.

关键词： a.ua.ulture a.ia. Sea.a.s Ba.ra.undi La.es ca.ca.ifer Computer Vision Ima.e Processing Weight Estima.ion

PWa.Doped SiO2 PEG Hybrid Ma.eria.s of Cla.s II

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Ma.eria.s Sciences a.d a.plica.ions 2010年第5期1卷 285-291页

作者： S. Gra.di P. Musta.elli a. Ca.ollo C. Toma.i E. Qua.ta.one a. Ma.istris 不详

Sol-gel is a.promising technique for the synthesis of orga.ic-inorga.ic hybrid ma.eria.s of cla.s II. One of the most interesting a.plica.ions for these hybrid ma.eria.s is a. solid polymer electrolytes (SPEs). In pa.ticula., when doped with proton species they ha.e potentia. a.plica.ions in fuel cells. In this pa.er SiO2–PEG1500 hybrids of cla.s II were prepa.ed with different contents of SiO2 a.d phosphotungstic a.id. The influence of the SiO2 content in the ma.rix ha. been studied. The sa.ples were investiga.ed by therma. a.a.ysis (TGa.a.d DSC), X-ra. diffra.tion, infra.ed spectros-copy (IR), sca.ning electron microscopy (SEM) a.d Impeda.ce Spectroscopy.

关键词： Hybrid Ma.eria.s Sol-Gel Protonic Conduction Phosphotungistic a.id Polymer Electrolyte

5-Methylcytosine RNa.Methyla.ion in a.a.idopsis Tha.ia.a

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Molecula. Pla.t 2017年第11期10卷 1387-1399页

作者： Xuea. Cui Zhe Lia.g Lisha.Shen Qia. Zha.g Shengjie Ba. Yuke Geng Bin Zha.g Vonny Leo Lea. a. Va.dy Tiega.g Lu Xia.feng Gu Ha. Yu Biotechnology Resea.ch Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Depa.tment of Biologica. Sciences a.d Tema.ek Life Sciences La.ora.ory National University of Singapore 117543 Singapore Singapore Institute of Medica. Biology Agency for Science Technology and Research (A^+STAR) 8A Biomedical Grove #06-06 Immunos 138648 Singapore Singapore

5-Methylcytosine （m^5C） is a.well-cha.a.terized DNa.modifica.ion, a.d is a.so predomina.tly reported in a.unda.t non-coding RNa. in both proka.yotes a.d euka.yotes. However, the distribution a.d biologica. functions of m^5C in pla.t mRNa. rema.n la.gely unknown. Here, we report tra.scriptome-wide profiling of RNa.m^5C in a.a.idopsis tha.ia.a.by a.plying m^5C RNa.immunoprecipita.ion followed by a.deep- sequencing a.proa.h （m^5C-RIP-seq）. LC-MS/MS a.d dot blot a.a.yses revea. a.dyna.ic pa.tern of m^5C mRNa.modifica.ion in va.ious tissues a.d a. different developmenta. sta.es, m^5C-RIP-seq a.a.ysis identified 6045 m^5C pea.s in 4465 expressed genes in young seedlings. We found tha. m^5C is enriched in coding sequences with two pea.s loca.ed immedia.ely a.ter sta.t codons a.d before stop codons, a.d is a.socia.ed with mRNa. with low tra.sla.ion a.tivity. We further demonstra.ed tha. a. RNa.（cytosine-5）-methyl- tra.sfera.e, tRNa.specific methyltra.sfera.e 4B （TRM4B）, exhibits m^5C RNa.methyltra.sfera.e a.tivity. Muta.ions in TRM4B displa. defects in root development a.d decrea.ed m^5C pea.s. TRM4B a.fects the tra.script levels of the genes involved in root development, which is positively correla.ed with their mRNa.sta.ility a.d m^5C levels. Our results suggest tha. m^5C in mRNa.is a.new epitra.scriptome ma.ker ina.a.idopsis, a.d tha. regula.ion of this modifica.ion is a. integra. pa.t of gene regula.ory networks underlying pla.t development.

关键词： 5-methylcytosine (m^5C) a.a.idopsis RNa.methyla.ion TRM4B root development

Exposure to dieta.y mercury a.ters cognition a.d beha.ior of zebra.finches

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Current Zoology 2017年第2期63卷 213-219页

作者： John R SWa.DLE Tessa.R. DIEHL Ca.well E, Ta.LOR a.ron S. Fa.a.E Jessica.L. BENSON Neil R. HUCKSTEP Da.iel a. CRISTOL Biology Depa.tment College of William and Mary Institute for Integrative Bird Behavior Studies Williamsburg VA 23187-8795 USA Biologica. Sciences Virginia Tech 1405 Perry Street Blacksburg VA 24061 USA

Environmenta. stressors ca. nega.ively a.fect a.ia. cognitive a.ilities, potentia.ly reducing fitness, for exa.ple by a.tering response to preda.ors, displa. to ma.es, or memory of loca.ions of food. We expa.d on current knowledge by investiga.ing the effects of dieta.y mercury, a.ubiquitous en- vironmenta. polluta.t a.d known neurotoxin, on a.ia. cognition. Zebra.finches Ta.niopygia.gut- ta.a.were dosed for their entire lives with sub-letha. levels of mercury, a. the environmenta.ly rele- va.t dose of 1.2 pa.ts per million. In our first study, we compa.ed the dosed birds with controls of the sa.e a.e using tests of three cognitive a.ilities： spa.ia. memory, inhibitory control, a.d color a.socia.ion. In the spa.ia. memory a.sa., birds were tested on their a.ility to lea.n a.d remember the loca.ion of hidden food in their ca.e. The inhibitory control a.sa. mea.ured their a.ility to ig- nore visible but ina.cessible food in fa.or of a.lea.ned beha.ior tha. provided the sa.e rewa.d. Fina.ly, the color a.socia.ion ta.k tested ea.h bird＇s a.ility to a.socia.e a.specific color with the presence of hidden food. Dieta.y mercury nega.ively a.fected spa.ia. memory a.ility but not inhibi- tory control or color a.socia.ion. Our second study focused on three beha.iora. a.sa.s not tied to a.specific skill or problem-solving： a.tivity level, neophobia. a.d socia. domina.ce. Zebra.finches exposed to dieta.y mercury throughout their lives were subordina.e to, a.d more a.tive tha., con- trol birds. We found no evidence tha. mercury exposure influenced our metric of neophobia. Together, these results suggest tha. sub-letha. exposure to environmenta. mercury selectively ha.ms neurologica. pa.hwa.s tha. control different cognitive a.ilities, with complex effects on be- ha.ior a.d fitness.

关键词： a.ima. beha.ior ecotoxicology cognition mercury spa.ia. memory zebra.finch.

The exp(-&a.p;phi;(&a.p;xi;))-Expa.sion Method a.d Its a.plica.ion for Solving Nonlinea. Evolution Equa.ions

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Interna.iona. Journa. of Modern Nonlinea. Theory a.d a.plica.ion 2015年第1期4卷 37-47页

作者： Ma.moud a. E. a.delra.ma. Ema. H. M. Za.ra. Mosta.a.M. a. Kha.er Depa.tment of Ma.hema.ics Faculty of Science Mansoura University Mansoura Egypt Depa.tment of Ma.hema.ica. a.d Physica. Engineering College of Engineering Shubra Benha University Egypt

The exp(-φ(ξ))-expa.sion method is used a. the first time to investiga.e the wa.e solution of a.nonlinea. dyna.ica. system in a.new double-Cha.n model of DNa.a.d a.diffusive preda.or-prey system. The proposed method... 详细信息

关键词： Dyna.ica. System in a New Double-Cha.n Model of DNA A Diffusive Preda.or-Prey System Tra.eling Wa.e Solutions Solita.y Wa.e Solutions Kink-a.ti Kink Sha.ed