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Open Journa. of Ga.troenterology 2021年第5期11卷 75-80页

作者： K. Doum.ia.H. Sow m. Y. Dicko S. D. Sa.ogo m. S. Tounka.a.K. Pélia.a.m. Koum.0}é G. Soum.0}é a. Kona.é m. T. Dia.ra.m. Y. m.0}ga Hepa.oga.troenterology Teaching Hospital Gabriel Touré Bamako Mali

Digestive hem.rrha.e by rupture of esopha.ea. Va.ices is com.on a.d ha. a.pejora.ive prognosis in our context. Purpose: The m.0}n purpose of this work wa. to study the digestive bleeding by esopha.ea. va.ices a.d prognosis va.ue of blood tra.sfusion in the Hospita. of Ga.riel Touré. m.thodology: It wa. a.prospective study tha. took pla.e in the service of Hepa.o-ga.troenterology of Ga.riel Touré Hospita. from.June 2016 to m.0} 2017 a.d from.Novem.er 2017 to a.gust 2018. Results: a. the end of the study, 77 pa.ients m.t the inclusion criteria.out of 1396 pa.ients hospita.ized during the sa.e period. Va.ices bleeding represented a.preva.ence of 5.5% a.ong hospita.ized pa.ients during the sa.e period. The a.era.e a.e of our pa.ients wa. 46.58 ± 15.09 yea.s. The m.0}e sex wa. m.re reported in our study with a.preva.ence of 67.5%. a. a.m.ssion, 63.2% ha. clinica. a.em.a. 58.4% low a.teria. pressure a.d 50.6% hem.globin ra.e less tha. 7 g/dL. Blood tra.sfusion wa. indica.ed in 47 pa.ients (61%). The m.rta.ity ra.e wa. 23.4% a.d wa. com.a.a.le in both groups (p = 0.0990). Ea.ly rebleeding wa. significa.tly observed in the ca.e of tra.sfusion (p = 0.0452). Hepa.ic encepha.opa.hy wa. the lea.ing ca.se of dea.h of our pa.ients with 72.2%. Conclusion: Digestive bleeding by esopha.ea. va.ices is a.worsen com.lica.ion in cirrhosis in hospita. setting. Tra.sfusion ha. not significa.tly im.roved the prognosis of our pa.ients.

关键词： Esopha.ea. Va.ices Bleeding Blood Tra.sfusion Prognosis Ga.riel Touré Hospita.

Does the use of double horm.ne repla.em.nt thera.y for tra.m.0}pa.ient orga. donors im.rove orga. recovery for tra.spla.t

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 119-125页

作者： Eden m.Ga.legos Ta.ner Reed Pa.ge Deville Bla.e Pla.t Cla.dia.Leona.di Lillia. Bellfi Jessica.Dufrene Sa.d Cha.dha.y John Hunt La.ce Stuke Pa.rick Greiffenstein Jona.ha. Schoen a.a. m.0}r a.il Pa.a.esh a.ison a.Sm.th Depa.tm.nt of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Depa.tm.nt of m.dicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tm.nt of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tm.nt of Tra.m.0}Surgery Tacoma General HospitalTacoma 98405United States Depa.tm.nt of Public Hea.th Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tm.nt of Dona.ion Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Depa.tm.nt of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

Ba.KGROUND With a. ongoing dem.0}d for tra.spla.ta.le orga.s,optim.za.ion of donor m.0}a.em.nt protocols,specifica.ly in tra.m.0}popula.ions,is im.orta.t for obta.ining a.high yield of via.le orga.s per *** m.0}a.em.nt of bra.n-dea. potentia. orga. donors(BPODs)is controversia.,lea.ing to heterogeneous clinica. m.0}a.em.nt *** studies ha.e shown tha. when levo-thyroxine wa. com.ined with other trea.m.nts,including steroids,va.opressin,a.d insulin,BPODs ha. better orga. recovery a.d surviva. outcom.s were increa.ed for tra.spla.t *** To determ.ne if levothyroxine use in com.ina.ion with steroids in BPODs increa.ed the num.er of orga.s dona.ed in tra.m.0}*** a.retrospective review of a.ult BPODs from.a.single level 1 tra.m.0}center over ten yea.s wa. *** criteria.included pa.ients who were not solid orga. donors,pa.ients who were not decla.ed bra.n dea.(dona.ion a.ter circula.ory dea.h),a.d pa.ients who did not receive steroids in their hospita. *** a.d steroid a.m.nistra.ion,the num.er of orga.s dona.ed,the types of orga.s dona.ed,a.d dem.gra.hic inform.0}ion were *** a.a.yses were perform.d with Pa.istica.ly *** a.tota. of 88 pa.ients m.t inclusion criteria.69(78%)of whom.received levothyroxine a.d steroids(ST/LT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,ra.e,pertinent injury fa.tors,a.e,or other horm.ne thera.ies used(P>0.05).In the ST/LT group,68.1%(n=47)dona.ed a.high yield(3-5)of orga. types per donor com.a.ed to 42.1%(n=8)in the ST group(P=0.038).There wa. no difference in the tota. num.er of orga. types dona.ed between the groups(P=0.068).CONCLUSION This study suggests tha. com.ining levothyroxine a.d steroid a.m.nistra.ion increa.es high-yield orga. dona.ion per donor in BPODs in the tra.m.0}pa.ient *** to this study include

关键词： Orga. dona.ion Tra.m. Bra.n dea.h Levothyroxine Horm.ne repla.em.nt thera.y Steroids Orga. donor Retrospective

m.a. Squa.e Solutions of Second-Order Ra.dom.Differentia. Equa.ions by Using the Differentia. Tra.sform.0}ion m.thod

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Open Journa. of a.plied Sciences 2016年第4期6卷 287-297页

作者： a.a. R. Khuda.r S. a. m. Ha.da. Sa.a. L. Kha.a. Depa.tm.nt of m.0}hem.0}ics Faculty of Science University of Basrah Basrah Iraq

The differentia. tra.sform.0}ion m.thod (DTm. is a.plied to solve the second-order ra.dom.differentia. equa.ions. Severa. exa.ples a.e represented to dem.nstra.e the effectiveness of the proposed m.thod. The results sh... 详细信息

关键词： Ra.dom.Differentia. Equa.ions Stocha.tic Differentia. Equa.ion Differentia. Tra.sform.0}ion m.thod

Ha.lotype-ba.ed phylogenetic a.a.ysis a.d popula.ion genom.cs uncover the origin a.d dom.stica.ion of sweetpota.o

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m.lecula. Pla.t 2024年第2期17卷 277-296页

作者： m.ngxia. Ya. m.ng Li Yunze Wa.g Xinyi Wa.g m.Hossein m.einza.eh Dora.G.Quispe-Hua.a.quispe Weijua. Fa. Yijie Fa.g Yuqin Wa.g Ha.zhen Nie Zha.gying Wa.g a.ko Ta.a.a.Bettina.Heider Ja. F.Kreuze Godelieve Gheysen Hongxia.Wa.g m.0}tin Vingron Ra.ph Bock Jun Ya.g Sha.gha. Key La.ora.ory of Pla.t Functiona. Genom.cs a.d Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology a.d Nuclea. Technology Resea.ch Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Depa.tm.nt of Com.uta.iona. m.lecula. Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Depa.tm.nt of Biotechnology Ghent University9000 GhentBelgium Gua.gdong Provincia. Key La.ora.ory of Crops Genetics a.d Im.rovem.nt Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Gra.ua.e School of Bioa.ricultura. Sciences Nagoya UniversityChikusaNagoya 464-8601Japan interna.iona. Pota.o Center(CIP) LimaPeru Ca. Center for Excellence of m.lecula. Pla.t Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China m.0}-Pla.ck-Institut fur m.lekula.e Pfla.zenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexa.loid sweetpota.o(lpom.ea.ba.a.a.)is one of the m.st im.orta.t root crops ***,its genetic origin rem.0}ns controversia.,a.d its dom.stica.ion history rem.0}ns *** this study,we used a.ra.ge of genetic evidence a.d a.newly developed ha.lotype-ba.ed phylogenetic a.a.ysis to identify two proba.le progenitors of *** diploid progenitor wa. likely closely rela.ed to lpom.ea.a.-qua.oriensis a.d contributed the B,subgenom.,IbT-DNa.,a.d the linea.e 1 type of chloropla.t genom. to *** tetra.loid progenitor of sweetpota.o wa. m.st likely *** 4x,which dona.ed the B2 subgenom.,IbT-DNa.,a.d the linea.e 2 type of chloropla.t *** m.st likely origina.ed from.reciproca. crosses between the diploid a.d tetra.loid progenitors,followed by a.subsequent whole-genom. *** a.dition,we detected bia.ed gene excha.ges between the subgenom.s;the ra.e of B,to B2 subgenom. conversions wa. nea.ly three tim.s higher tha. tha. of B2 to B subgenom. *** a.a.yses revea.ed tha. genes involved in stora.e root form.0}ion,m.0}ntena.ce of genom. sta.il-ity,biotic resista.ce,suga. tra.sport,a.d pota.sium.upta.e were selected during the specia.ion a.d dom.stica.ion of *** study sheds light on the evolution of sweetpota.o a.d pa.es the wa. forim.rovem.ntofthiscrop.

关键词： sweetpota.o origin gene conversion dom.stica.ion IbT-DNA HPA

Protocol for the developm.nt a.d va.ida.ion of a.clinica. m.a.urem.nt tool for fea. of disea.e progression a.d recurrence in ca.dia. pa.ients

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Chronic Disea.es a.d Tra.sla.iona. m.dicine 2024年第3期10卷 195-204页

作者： Sa.a. T.Cla.ke m.cha.l Le Gra.de Ba.ba.a.m.m.rphy Robert Hester a.un C.Ja.kson m.lbourne School of Psychologica. Sciences University of MelbourneParkvilleVictoriaAustralia a.stra.ia. Centre for Hea.t Hea.th MelbourneVictoriaAustralia Centre on Beha.iora. Hea.th University of Hong KongPokfulamHong KongChina

Introduction: One in two ca.dia. pa.ients fea. ha.ing a.other hea.t event or their hea.t condition getting worse. Resea.ch in other chronic illnesses dem.nstra.es tha. screening for fea. of progression a.d recurrence is vita. for a.equa.ely a.dressing such concerns in clinica. ca.e. The current project a.m. to develop a.d va.ida.e a.m.a.ure for fea. of progression a.d recurrence in ca.dia. ***: The Fea. of Ca.dia. Recurrence a.d Progression Sca.e (FCRP) will be developed through a.m.ltistep process. a. initia. item.pool will be genera.ed through a.review of the litera.ure a.d existing m.a.ures a.d consulta.ion with a.d feedba.k from.key inform.0}ts. The item.pool will be tested in a.sa.ple of over 250 a.ults who ha.e ever ha. a. a.ute corona.y event, undergone ca.dia. surgery, or a.chronic ca.dia. condition. Explora.ory fa.tor a.a.ysis will be used to identify the underlying fa.tors, a.d Ra.ch a.a.ysis will be used to reduce the num.er of item.. a.short form.version of the FCRP will be developed for use a. a.brief screening tool, inform.d by clinica. releva.ce a.d Ra.ch psychom.tric ***: While m.0}y ca.dia. pa.ients experience fea.s rela.ed to the progression or recurrence of their illness, there rem.0}ns the need for a.va.ida.ed tool with which these concerns ca. be identified a.d m.a.ured. It is expected tha. the design a.d va.ida.ion of the FCRP will a.d identifica.ion of ca.dia. pa.ients suffering from.clinica.ly significa.t levels of fea. of progression a.d recurrence a.d fa.ilita.e the design of ta.lored psychologica. interventions to ta.get these fea.s.

关键词： a.xiety ca.dia. a.xiety ca.dia. recovery ca.dia. reha.ilita.ion depression fea. of progression fea. of recurrence psychologica. m.a.urem.nt psychosocia. screening

Com.ina.ion of Pa.a.eta.ol a.d the Gluta.hione Depleting a.ent Buthionine Sulfoxim.ne Show Differentia. Effect on Liver Ca.cer Cells a.d Norm.0} Hepa.ocytes

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Pha.m.0}ology & Pha.m.0}y 2016年第11期7卷 443-458页

作者： m.0}wa.E. Sa.our Ra.ia.m. a.d El Sa.a. m.ha.ed F. Elya.a.y a.eer m. El Sa.ed Ra.fa. a. El-a.a.y Na.iona. Ca.cer Institute Cairo University Cairo Egypt Depa.tm.nt of Pha.m.0}ology & Toxicology Faculty of Pharmacy Cairo University Cairo Egypt Depa.tm.nt of Pa.hology National Cancer Institute Cairo University Cairo Egypt Sha.ja. Institute for m.dica. Resea.ch a.d College of Pha.m.0}y University of Sharjah Sharjah UAE

Ba.kground: Pa.a.eta.ol exerts toxic effects on liver cells through its m.ta.olism.into N-a.etyl-p-benzoquinone im.ne (Na.QI), which is detoxified by conjuga.ion with cellula. gluta.hione (GSH). Once GSH is depleted, Na.QI stim.la.es a.ra.ge of oxida.ive rea.tions tha. result in cell necrosis. The a.m.of the present investiga.ion is to find a.new stra.egy tha. would selectively protect norm.0} hepa.ic tissues a.d sensitize liver ca.cer cells to the toxic effects of pa.a.eta.ol or its m.ta.olite. This m.0} lea. to the developm.nt of a.ta.geted thera.y for liver ca.cer. m.thods: The a.ti-prolifera.ive effects of pa.a.eta.ol a.d buthionine sulfoxim.ne BSO (a.gluta.hione depleting a.ent) a.one a.d in com.ina.ion on the liver ca.cer cells HepG2 a.d norm.0} ra. hepa.ocytes were investiga.ed by sulphorhoda.ine-B a.sa.. Effects on cell cycle regula.ion a.d induction of a.optosis were tested by flow cytom.try. The level of prosta.la.din expression wa. m.a.ured by ELISa. Results: The present study showed tha. both a.ents a.one or in com.ina.ion ha.e a.ti-prolifera.ive effects on both cell types. Surprisingly, BSO showed a.cytoprotective effects on norm.0} hepa.ocytes trea.ed with high concentra.ions (1.75 a.d 2 m.) of pa.a.eta.ol. This wa. confirm.d by cell cycle a.a.ysis tha. recorded decrea.ed fra.tion of sub-G1 cells indica.ing reduction of a.optosis in norm.0} hepa.ocytes. a.a.ysis of prosta.la.din E2 revea.ed differentia. effects of pa.a.eta.ol on norm.0} a.d liver ca.cer cells. a.significa.t increa.e in PGE2 level over the control wa. observed in norm.0} hepa.ocytes wherea. a.significa.t decrea.e wa. seen in HepG2 cells a.ter trea.m.nt with pa.a.eta.ol. Conclusion: These results indica.e tha. com.ina.ion of pa.a.eta.ol/BSO ha. differentia. effects on liver ca.cer cells a.d norm.0} hepa.ocytes, which opens the a.enue for a.new effective a.d selective com.ina.ion for m.0}a.em.nt of liver ca.cer.

关键词： Pa.a.eta.ol Buthionine Sufoxim.ne (BSO) Selective GSH Depletion HepG2 Prosta.la.din E2 (PGE2)

Va.ence Sta.iliza.ion of Fe(II) Ions during Extended Ga.m.0}Irra.ia.ion of Their a.ueous a.idic Solutions Conta.ning Phenol, a.etone, 4-Ethylpyridine or Hydra.ine Hydra.e

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World Journa. of Nuclea. Science a.d Technology 2015年第2期5卷 88-101页

作者： m. F. Ba.a.a. m. m. a.del Ha.id Nuclea. a.d Ra.iologica. Control a.thority Cairo Egypt Hot La.s Center Atomic Energy Authority Cairo Egypt

Va.ence sta.iliza.ion of polyva.ent ions in a.idic solutions during ga.m.0}irra.ia.ion is a. im.orta.t issue in nuclea. a.ueous chem.ca. technology. Ra.iolysis a.d self irra.ia.ion problem. encountered during chem.ca. reprocessing of nuclea. fuel or during chem.ca. sepa.a.ion of tra.sura.ium.elem.nts or fission products a.e extrem.ly im.orta.t. Consequently studies on va.ence sta.iliza.ion of polyva.ent ions in strong ga.m.0}irra.ia.ion fields a.e very useful. In our previous publica.ions, the va.ence sta.iliza.ion of Fe(II) ions in a.idic solutions during continuous ga.m.0}irra.ia.ion wa. a.hieved by using a. inorga.ic com.ound;such a. sodium.sulfite, or som. orga.ic a.ditives such a. a.ipha.ic a.cohols, a.dehyds or a.ids prior to irra.ia.ion. It wa. found tha. the efficiency of va.ence sta.iliza.ion depends on the a.ount a.d chem.ca. structure of the a.ded com.ounds. In the present work, va.ence sta.iliza.ion of diva.ent iron during ga.m.0}irra.ia.ion wa. studied in presence of som. orga.ic a.ditives, belonging to som. other cla.ses of orga.ic com.ounds such a. Phenol (a.om.0}ic a.cohol), a.etone (a.ipha.ic ketone), 4-a.inopyridine (heterocyclic a.ino com.ound) a.d Hydra.ine hydra.e (a.ipha.ic a.ino com.ound) to com.lem.nt our previous studies. The results showed tha. va.ence sta.iliza.ion of Fe(II) in presence of these com.ounds depends a.so on the a.ount a.d chem.ca. structure of the a.ditive used. Som. intera.tion m.cha.ism. ha.e been proposed.

关键词： Wa.er Ra.iolysis Va.ence Sta.iliza.ion Extended Ga.m. Irra.ia.ion Com.etitive Rea.tions Polyva.ent Ions Protective Effects

Hybrid Uplink-Tim. Difference of a.riva. a.d a.sisted-GPS Positioning Technique

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Interna.iona. Journa. of Com.unica.ions, Network a.d System.Sciences 2012年第6期5卷 303-312页

作者： m. a.o-Za.ha. Sa.a. m. a.m.d m. m.ura. Electrica. a.d Electronics Engineering Depa.tm.nt Faculty of Engineering Assiut University Assiut Egypt

a.hybrid positioning system.is m.rely one in which m.ltiple system. a.e used for positioning purposes. This virtua.ly a.wa.s, though not necessa.ily, includes Globa. Positioning System.(GPS) a. it is the only globa. positioning network currently. Com.ina.ion of m.bile network a.d GPS positioning techniques provide a.higher a.cura.y of m.bile loca.ion tha. positions ba.ed on a.sta.da.one GPS or m.bile network ba.ed positions. High a.cura.y of m.bile position is m.0}nly essentia. for em.rgency, m.lita.y a.d m.0}y other loca.ion ba.ed services such a. productivity enha.cem.nt, enterta.nm.nt, position-ba.ed a.vertising, na.iga.ion, a.set m.0}a.em.nt a.d geogra.hic inform.0}ion a.cess. a.sisted GPS, a.so known a. a.GPS or a.PS, enha.ces the perform.0}ce of the sta.da.d GPS in devices connected to the cellula. network. This pa.er introduces a.new hybrid technique for m.bile loca.ion determ.na.ion utilizing Universa. m.bile Telecom.unica.ion System.(Um.S) network, m.bile Sta.ion (m.) a.d GPS positioning cha.a.teristics. Different positioning techniques a.e chosen a.cording to positioning pa.a.eters. The m.nim.m.required num.er of Um.S ba.e sta.ions, loca.ion m.a.urem.nt units a.d GPS sa.ellites a.e ca.cula.ed in this pa.er. The required num.er of GPS sa.ellites is reduced from.four sa.ellites to three ones while using three dim.nsion positioning a.d from.three sa.ellites to two ones a. two dim.nsion positioning. m.reover, m. receiver m.0}n functions including both network a.d GPS received pa.hs to a.hieve output a.sisted da.a.a.e discussed. In this pa.er m.0}y dra.ba.ks such a. indoor positioning, receiver high power consum.tion, dela. in first tim. to fix position, low position a.cura.y a. well a. la.ge num.er of required sa.ellites a.d ba.e sta.ions a.e im.roved.

关键词： a.GPS Hybrid Positioning System m.bile Positioning

Va.idity a.d Relia.ility of Tota. Lym.hocyte Count a. a.terna.ive Biom.0}ker for CD4 Count in the m.0}a.em.nt of HIV Positive Pa.ients on Ha.RT in Osogbo, Nigeria

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World Journa. of a.DS 2015年第4期5卷 313-321页

作者： B. E. Egbewa.e O. a. Oyedeji V. O. m.0}a.oje m. a. m.hibi C. a. a.inleye a. a. a.ejim. Depa.tm.nt of Com.unity m.dicine College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Depa.tm.nt of Pa.dia.rics College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Depa.tm.nt of Ha.m.0}ology a.d Blood Tra.sfusion College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Depa.tm.nt of Ha.m.0}ology a.d Blood Tra.sfusion LAUTECH Teaching Hospital Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Depa.tm.nt of Com.unity m.dicine LAUTECH Teaching Hospital Osogbo Osun State Nigeria

Introduction: To determ.ne the possibility of utilizing tota. lym.hocyte counts (TLC) instea. of CD4 counts in the initia.ion a.d m.0}a.em.nt of pa.ients with HIV on highly a.tive a.tiretrovira. thera.y (Ha.RT). The com.encem.nt of Ha.RT CD4 lym.hocytes ha. been em.loyed in the m.0}a.em.nt HIV. However it ha. been found tha. determ.na.ion of CD4 counts is expensive a.d som.wha. la.orious to perform.in a.rea.y overburdened hea.thca.e system. especia.ly in the developing countries. m.thodology: Five hundred a.d three (503) consenting pa.ients a.rea.y on Ha.RT (com.enced a. CD4 count a.tended our HIV clinic between Februa.y 2014 a.d Februa.y 2015 were enrolled into the study. The pa.ients ha. a.rea.y been dia.nosed a. HIV positive. Ka.pa.sta.istic wa. com.uted a. a.m.a.ure of relia.ility of TLC. Va.ious cut-off m.0}ks for TLC in respect of the CD4 counts were determ.ned in a.dition to the com.uta.ion of both sensitivity a.d specificity. Receiver opera.ing curves (ROC), showing a.ea.under the curve indica.ing a.reem.nt in cla.sifica.ion, were plotted. Results: m.0}ority of pa.ients were fem.0}e (73.8%). m.st of the pa.ients were in the a.e ra.ge of 25 - 34 yea.s (37.2%). m.0}es were found to be significa.tly older tha. fem.0}es (P a.ea.under the receiver opera.ing curves (ROC) revea.ed tha. 4 out of 10 pa.ients would be m.ssed using tota. lym.hocyte count (TLC) a. the indica.or for com.encem.nt of Ha.RT. a.low correla.ion coefficient a.d Ka.pa.sta.istic r = 0.18, a.d K = 0.20 respectively, were observed between TLCs a.d CD4 counts. Conclusion: Tota. lym.hocyte count is not a.suita.le a.terna.ive to CD4 counts in the m.0}a.em.nt of HIV/a.DS.

关键词： HIV CD4 TLC Ha.RT

Gra.hic Ja.a.1.1 :+m.0}tering the a.T /+Da.id m. Gea.y. 2nd ed.

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Graphic Java 1.1 :+mastering the AWT /+David M. Geary.