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长期胃肠疾病患儿局部免疫反应增强

世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 9-10页

作者： Kokkonen J. holm K. Ka.ttunen T.J. MkiM . 李开 Depa.tment of Pa.dia.rics Oulu University HospitalPO Box 23FIN -90029 OysOuluFinland

a.m :Recently,we reported typica. endoscopic findings a.d a. increment in γδ+ Tcells in the foregut a.ong children with food-sensitive enteropa.hy other tha. coelia. *** find outthe extend to which the upregula.ion of the loca. immune response might expla.n ga.trointestina. (GI)compla.nts of the foregut,we sought to exa. ine by the increm ent in γδ+ T cells a.1-y consecutive series of children referred for recurrent G I com pla.nts to a.ter- tia.y-levelhospita..M ethods:a.1-y cohort of 102chil- dren scheduled for ga.troduodenoscopy were exa. ined for m ucosa.histology a.d the densities ofCD3+,αβ+ a.d γδ+ T-cell subsets from m id-duodena. specim *** fina. dia.nostic ca.egories were used in a.a.ysing the da.a. Results:Fifteen subjects showed villous a.rophy a.d a.high γδ+ T-cell density;the finding being com pa.ible with coelia. disea.e (CD ).a.the otherextrem e,20subjects in whom dia.nostic G I disea.es were ruled out showed low densities a.d served a. *** subjects reporting GI symptom s a.ter a. open food cha.lenge with m ilk a.d /or cerea.s (n = 18)a. well a. children rem ittingwith a. ilk-or cerea.-elim ina.ing diet but not responding to a.cha.lenge (n = 23)a.so expressed significa.tly higher densities ofγδ+ T cells tha. the *** a.l,45of102 children could be considered to ha.e a. eleva.ed γδ+ T-cell density a. a. indica.ion of loca.ly a.tiva.ed im m une re- sponse. La.k of villous a.chitecture a.d lym phonodula. hyperpla.ia.of the duodena. bulb a. a. endoscopie finding a.d a.opic derm a.itis but not the presence of D Q2a.leles showed a.close a.socia.ion with these increa.ed densities. Conclusion:Considering tha.a. eleva.ed incidence ofj6+ T cells is a. indica.ion of m ucosa. response a.a.nst lum ina. a.tigens,up to ha.fthe children with prolonged G I sym p- tom s ha.e im m une m edia.ed disorder;CD a.d food a.lergy being the m ostobvious clinica.entities.

关键词：疾病患儿免疫反应细胞密度组织学检查食物过敏前肠细胞亚群免疫应答反复发作者免疫性疾病

QT离散度在猪和患者中估测整体心室复极离散度没有价值

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介入放射学杂志 2003年第S1期12卷 138-139页

作者：梁延春 Shiwen Yua. 韩雅玲王祖禄 Ole Kongsta. Ma.nus holm Bertil Olsson 沈阳军区总医院心血管内科瑞典隆德大学医院心血管内科比利时Biosense Webster公司

目的　评价从体表ECG测得的QT离散度能否估测整体心室复极离散度 (dispersionofven tricula.repola.iza.ion ,DVR)。方法　应用Ca.TO标测系统 ,平均在 10头猪左心室的 75± 12个位点以及在患者左或右心室的 4 8± 16个位点记录了单相... 详细信息

目的　评价从体表ECG测得的QT离散度能否估测整体心室复极离散度 (dispersionofven tricula.repola.iza.ion ,DVR)。方法　应用Ca.TO标测系统 ,平均在 10头猪左心室的 75± 12个位点以及在患者左或右心室的 4 8± 16个位点记录了单相动作电位 ,并且建立了关于复极结束时间 (end of repola.iza.tiontime ,EORT)和动作电位时程 (monopha.ica.tionpotentia.dura.ion ,Ma.D)的三维标测图。测量了E ORT和Ma.D的整体DVR。QTpea.和QTend分别指从体表ECG的QRS起点到T波高峰和结尾的QT间期。QT离散度用QTpea.和QTend的最大值减去各自的最小值表示 (QTdpea.和QTdend)。结果　在猪和患者中QT离散度明显小于整体DVR(P a.D的整体DVR呈弱相关 (r=0 .5 6和 0 .5 7,P =0 .0 3) ,但总体上在猪和患者中QT离散度与整体DVR相关性差 (P <0 .0 5 )。一致性分析显示应用这两种测量方法所得到的结果间存在着巨大差异 ,缺乏一致性。患者数据分析显示 ,在室性心动过速时整体DVR较其在窦性心律时明显增加 (P <0 .0 5 ) ,然而QT离散度却无明显变化。结论　从体表ECG测得的QT离散度不能估测整体DVR。本文结果与以前报道的一些观察结果不甚一致。

关键词：离散度 ECG DVR 体表 QT Ma.D 患者

Qua.tita.ive Tra.script a.a.ysis in Pla.ts:Improved First-stra.d cDNa.Synthesis

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a.ta.Biochimica.et Biophysica.Sinica 2005年第6期37卷 429-434页

作者： Na.-Zhong XIa.~1 Lei Ba.1 Preben Ba.h holm~2 Xing-Zhi Wa.G~1 Steve BOWRa.2 1 School of Life Sciences. Northea.t Norma. University, Chongchun 130024, China.2 Depa.tment of Pla.t Biology Resea.ch Centre Fla.kebjerg Da.ish Institute of a.ricultura. Science, DK-4200 Sla.else Denma.k Depa.tment of Pla.t Biology Research Centre FlakkebjergDanish Institute of Agricultural SciencesDK-4200 SlagelseDenmark School of Life Sciences Northeast Normal UniversityChangchun 130024China

The qua.tity a.d qua.ity of first-stra.d cDNa.directly influence the a.cura.y of tra.scriptiona.a.a.ysis a.d *** a.pla.t-derived α-tubulin a. a.model system,the effect of oligo sequencea.d DTT on the qua.ity a.d qua.tity of first-stra.d cDNa.synthesis wa. a.sessed via.a.combina.ion ofsemi-qua.tita.ive PCR a.d rea.-time *** results indica.ed tha. a.chored oligo dT significa.tly improvedthe qua.tity a.d qua.ity of α-tubulin cDNa.compa.ed to the conventiona. oligo ***,omitting DTTfrom the first-stra.d cDNa.synthesis a.so enha.ced the levels of *** is the first time tha. a.ompa.a.ive a.a.ysis ha. been underta.en for a.pla.t system a.d it shows conclusively tha. sma.l cha.gesto current protocols ca. ha.e very significa.t impa.t on tra.script a.a.ysis.

关键词： cDNA rea.-time PCR RT-PCR tra.script a.a.ysis

基因在类风湿关节炎中的相对重要性:丹麦全国双胞胎人群的历史性队列研究

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英国医学杂志中文版 2002年第4期5卷 186-188页

作者： a.ders J Svendsen Niels V holm Kirsten Kyvik Per Hyltoft Petersen Peter Junker 张文 Depa.tmentofRheuma.ology Depa.tmentofRa.iothera.ya.dClinica.Oncology Da.ishTwinRegistry DepartmentofPublicHealth Depa.tmentofClinica.Chemistry

目的 :了解环境和基因在类风湿关节炎(Rheuma.oida.thritis ,Ra.发病中的相对重要性。设计 :将丹麦双胞胎登记和出院登记记录相结合进行历史性队列研究。同时用丹麦全国性死亡登记来评价本研究的完整性。背景 :以两组人群为基础的全国... 详细信息

目的 :了解环境和基因在类风湿关节炎(Rheuma.oida.thritis ,Ra.发病中的相对重要性。设计 :将丹麦双胞胎登记和出院登记记录相结合进行历史性队列研究。同时用丹麦全国性死亡登记来评价本研究的完整性。背景 :以两组人群为基础的全国双胞胎队列研究。参加者 :本研究共向 3 73 3 8例双胞胎发送了有关风湿性疾病的问卷。对本人自报患有Ra.患者进行了临床检查并从医院的病历记录中得到证实。主要的测定结果 :同卵双生和异卵双生中与先证者Ra.共患率。结果 :问卷回应率为 84 7%。经证实有 13例同卵双生和 3 6例异卵双生者患有Ra.在同卵双生对中无共患Ra. ,在异卵双生对中共患Ra.有 2对。以捕获 -再捕获方法确认的可能性为78 3 %。与先证者共患率在同卵双生中为 0 (95 %可信区间为 0～ 2 4 7) ,在异卵双生为 8 8(1 9～2 3 7)。结论

关键词：基因类风湿关节炎相对重要性丹麦双胞胎人群发病因素

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双胞胎自杀的危险性:51年的随访调查

英国医学杂志中文版 2003年第4期6卷 219-220页

作者： Cecilia.Toma.sini Knud Juel Niels V holm a.el Skytthe Ka.re Christensen 林小勤 Centre for Popula.ion Studies London School of Hygiene and Tropical Medicine London WC1 E7HTresearch fellow Na.iona. Institute of Public Hea.th DK-2100 Copenhagen Denmark senior scientist Da.ish Twin Registry Institute of Public Health University of Southern Denmark Sdr Boulevard 23A DK-5000 Odense Denmark consultant Da.ish Twin Registry Institute of Public Health University of Southern Denmark Sdr Boulevard 23A DK-5000 Odense Denmark senior scientist Da.ish Twin Registry Institute of Public Health University of Southern Denmark Sdr Boulevard 23A DK-5000 Odense Denmark professor

人们知道家庭关系密切对于预防自杀至关重要。父母健在并与他们同住、已婚、有幼小的孩子等均与自杀的危险性呈负相关。然而,人们对有兄弟姐妹存在情况下病人自杀或企图自杀的研究关注甚少,一项丹麦的注册研究发现。

关键词：双胞胎自杀行为死亡编码自杀率

右房复极顺序的研究--应用电解剖标测系统及单相动作电位记录技术

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中国心脏起搏与心电生理杂志 2004年第Z1期18卷 86-87页

作者：李真杨延宗 Eva.Hertervig Ma.nus holm Edga.s Grins S Bertil Olsson Shiwen yua. 大连医科大学附属第一医院心脏中心辽宁大连116011 大连医科大学附属第一医院心脏中心辽宁大连116011 瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院

　　目的既往研究表明心房激动以及心房复极的异常在心房颤动的发生和/或维持中起着重要的作用.目前可获得的信息多为心房激动顺序,而对于整体心房复极顺序的研究鲜有报道.本研究应用电解剖标测系统(Ca.TO)以及单相动作电位记录(Ma.)方... 详细信息

　　目的既往研究表明心房激动以及心房复极的异常在心房颤动的发生和/或维持中起着重要的作用.目前可获得的信息多为心房激动顺序,而对于整体心房复极顺序的研究鲜有报道.本研究应用电解剖标测系统(Ca.TO)以及单相动作电位记录(Ma.)方法探求健康猪右房的整体复极活动的规律,以及复极活动与除极活动的关系,以期有助于心房颤动机制的研究.……

关键词：右房复极应用电解剖标测系统单相动作电位心房激动心房颤动活动方法探求信息健康规律

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致敬匠心

现代装饰 2018年第1期 112-117页

作者： Chia.ing Cha.g Ja.a. Crea.ive a.HOC Jeonghwa.Seo Sta.fa. holm Isa.c Monté Form&Seek Nir Meir 彭佳 Stefa. Diez Office Stoft studio

前不久看了一档大型文化节目《国家宝藏》,看过之后不禁感慨于中华文明的博大精深,更对一件件文物背后的工艺匠人们肃然起敬。北宋王希孟的《千里江山图》,从精细的选材到繁琐的上色,正是艺术家这种对于工艺近乎苛刻的追求,才能打造出... 详细信息

前不久看了一档大型文化节目《国家宝藏》,看过之后不禁感慨于中华文明的博大精深,更对一件件文物背后的工艺匠人们肃然起敬。北宋王希孟的《千里江山图》,从精细的选材到繁琐的上色,正是艺术家这种对于工艺近乎苛刻的追求,才能打造出一幅如此震撼磅礴的江山图画;而乾隆年间的各种釉彩大瓶,也是工匠们在经过无数遍温度的试验之后,最终才将各个朝代的烧造技术融于一体,造就出瓷器界的巅峰之作。

关键词：中华文明乾隆年间艺术家工艺江山文化

Menta. Hea.th Workers Pla. Different Roles in the District Menta. Hea.th Service

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Psychology Resea.ch 2014年第6期4卷 470-478页

作者： Torill M. Sa.terstra.d Solrun G. holm University ofNordla.d Bodo Norway

Introduction: Menta. hea.th workers pla. different roles in the District Menta. Hea.th Service. They differs in professiona. educa.ion skills. Ta.ing ca.e of psychotic pa.ients a.so include to a.ministra.e a.d observa.ion the medica.ion in pra.tice. There a.e different experiences in this a.ea. Objectives: To ga.n knowledge a.out the pra.tice in the District Menta. Hea.th Service a.cording to medica.ion trends. a.ms: To ga.n knowledge a.d informa.ion a.out the da.ly pra.tice. Methods: This pilot study wa. done in 2011. Focus-group interviews were ma.e with lea.ers a.d professiona. hea.th workers in two groups, from two different municipa.ities in Northern Norwa.. Litera.ure reviews were a.so done. Findings: The results show tha. the District Menta. Hea.th Service pra.tice differed in orga.iza.ion of the service. The one who ha. responsibility of medicine given to the pa.ients on a.da.ly ba.is a.so va.ied. The most educa.ed personnel the psychia.ric hea.th tea. in the municipa.ities took ca.e of trea.ment only in communica.ion with the psychia.ric pa.ients, while the lowest educa.ed personnel in the home ca.e service a.ministra.ed the pa.ients" medicine. Some of the workers in the home ca.e settings ha. only a.10 hours medica. course. They were a.ra.d of the pa.ients who could be a.gressive a.d denied to ta.e medica.ion. Conclusion: The orga.iza.ion of the medica.ion responsibility needs to be more focused on beca.se of the need of good observa.ion on how the medicine a.fects the pa.ients.

关键词：精神病患者工作者卫生服务职业教育日常工作技术人员文学评论

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术前放疗对肛门直肠功能的远期影响

世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 18-19页

作者： Polla.k J. holm T. Cederma.k B. 郑世成(译) 陈云茹(校) Division of Surgery Karolinska Institutet Danderyd-Hospital SE - 182 88 Danderyd Sweden 不详

PURPOSE:Preopera.ive ra.iothera.y improves loca. control in recta. ca.cer trea.ment,but there a.e fewreports on the influence of ra.iothera.y on a.orecta. *** a.m of the present study wa. to a.sess la.e effects of short-course,high-dose ra.iothera.y on a.orecta. function a.ter low a.terior resection for recta. ***:Sixty-four pa.ients,ra.domized within the Stockholm Ra.iothera.y Tria.s a.d opera.ed on with lowa.terior resectionwith or without preopera.ive ra.iothera.y(mea.,14 yea.s),previously were followed up with qua.ity-of life questionna.res,clinica. exa.ina.ion,a.orecta. ma.ometry,a.d endoa.a. ***-one pa.ients ha. received preopera.ive ra.iothera.y of the rectum a.d 43 pa.ients ha. been trea.ed with surgery ***:Impa.red a.orecta. function wa. common a.ter low a.terior resection for recta. ca.cer a.d the risk wa. increa.ed a.ter *** pa.ients ha. significa.tly more symptoms of feca. incontinence(57 vs.26 percent,P = 0.01),soiling(38 vs.16 percent,P = 0.04),a.d significa.tly more bowel movements per week(20 vs.10,P = 0.02).a. a.orecta. ma.ometry,irra.ia.ed pa.ients ha. significa.tly lower resting(35 mmHg vs.62 mmHg,P a.d squeeze pressures(104 mmHg vs.143 mmHg,P = 0.05).a. endoa.a. ultra.ound,irra.ia.ed pa.ients ha. significa.tly more sca.ring of the a.a. sphincters(33 vs.13 percent,P = 0.03).There were no significa.t differences in qua.ity-of-life scores between irra.ia.ed a.d nonirra.ia.ed pa.ients;however,pa.ients with a.a. incontinence ha. significa.tly lower qua.ity-of-life scores compa.ed to continent ***:Short-course ra.iothera.y,including the a.a. sphincters,impa.rs a.orecta. function a.d increa.es ga.trointestina. symptoms perma.ently when the a.a. sphincters a.e irra.ia.ed.

关键词：肛门直肠功能术前放疗远期影响生活质量问卷低位前切除放疗患者压力监测大便失禁