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医院传染病应急管理中"医院感染专盯"岗位的实践探索

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中华医院感染学杂志 2024年第12期34卷 1885-1888页

作者：荆晓红周童何明张志云谢美莲金荣华卢联合首都医科大学附属北京地坛医院感染管理处北京100015 首都医科大学附属北京地坛医院护理部北京100015 首都医科大学附属北京地坛医院医院办公室北京100015

目的探讨"医院感染专盯"岗位在医疗机构应对传染病疫情应急中的实践及应用效果.方法以首都医科大学附属北京地坛医院隔离病房医护人员为研究对象,通过对比"医院感染专盯"岗位设立前后医院感染管理重点监测指标及医院感染发生率等,结... 详细信息

目的探讨"医院感染专盯"岗位在医疗机构应对传染病疫情应急中的实践及应用效果.方法以首都医科大学附属北京地坛医院隔离病房医护人员为研究对象,通过对比"医院感染专盯"岗位设立前后医院感染管理重点监测指标及医院感染发生率等,结合定量、定性分析方法验证该岗位设置在感染控制管理工作中的实践效果和应用意义.结果 "医院感染专盯"岗位设立后,应急区医护人员感染知识、医院感染知识评分较设立前提升(P<0.05);手卫生依从率,口罩佩戴及防护服穿脱合格率较前改善(P<0.05),医护及患者感染风险也有所降低.结论在新冠等呼吸道传染病应急管理中,医院结合实际情况设置并推进"医院感染专盯"岗位,对于保证应急区医疗安全质量、降低医院感染事件发生具有重要应用价值,也对未来不明呼吸道传染病的应急处置管理提供借鉴与思考.

关键词：医院感染专盯岗位医院感染管理呼吸道传染病应急管理

Ultrawide dynamic modulation of perfect absorption with a Friedrich–Wintgen BIC

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Photonics Research 2023年第3期11卷 456-462页

作者： ENDUO GAO rong jin ZHENCHU FU GUANGTAO CAO YAN DENG JIAN CHEN GUANHAI LI XIAOSHUANG CHEN HONGJIAN LI School of Physics and Electronics Central South UniversityChangsha 410083China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410004China School of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Dynamical control of perfect absorption plays an indispensable role in optical switch and ***,it always suffers from the limited modulation range,small depth,and susceptible absorption ***,we propose a new strategy based on Friedrich–Wintgen bound states in the continuum(F–W BICs)to realize a tunable perfect absorber with large dynamic modulation *** proof of concept,we demonstrate a pentaband ultrahigh absorption system consisting of graphene gratings and graphene sheets through elaborately tuning F–W *** nature of the F–W BIC arises from the destructive interference between Fabry–Perot resonance and guided mode resonance modes in the coherent phase-matching *** radiation channels are avoided from *** BIC can be dynamically modulated by engineering the Fermi level of graphene gratings,which breaks the traditional modulation methods with an incidence ***,the perfect absorber with this F–W BIC approach achieves the largest modulation range of up to 3.5 *** believe that this work provides a new way to dynamically engineer perfect absorption and stimulates the development of multiband ultracompact devices.

关键词： tuning absorption perfect

Development and Future Trends of Traditional Kampo Medicine in Japan

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Chinese Medicine and Culture 2022年第1期5卷 58-64页

作者： Risa Shibata Gui-Xiang Chu Xun Lin jin-rong Fu Gynaecology Department of TCM Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China International Office Shanghai University of Traditional Chinese MedicineShanghai 201203China

Traditional Kampo medicine is based on traditional Chinese medicine,which spread to Japan via the Korean Peninsula in the 5th *** practice of Kampo developed gradually under the influence of local Japanese culture and prospered until the Meiji *** appeared in schools successively,such as the School of Later Developments,the School of Classic Methods,the School of Textual Research,and the Integrated ***,the practice of Kampo gradually declined after the Meiji ***,through the continuous efforts of knowledgeable Japanese Kampo practitioners,the practice of Kampo has entered a new era as an indispensable aspect of contemporary Japanese medicine.

关键词： Medical history History Japan Kampo Traditional Chinese medicine

血清PSA、EGF在不同类型良性前列腺增生患者中表达意义及其与术后疾病转归的相关性分析

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现代生物医学进展 2024年第5期24卷 961-965页

作者：林鑫曾宪华唐荣金李勇平刘平桂林医学院附属医院外科广西桂林541001

目的:分析血清前列腺特异抗原(PSA)、表皮生长因子(EGF)在不同类型良性前列腺增生患者中低表达意义及其与术后疾病转归的相关性。方法:选择自2020年1月至2022年12月在我院接受手术治疗的128例良性前列腺增生患者作为研究对象,根据术后... 详细信息

目的:分析血清前列腺特异抗原(PSA)、表皮生长因子(EGF)在不同类型良性前列腺增生患者中低表达意义及其与术后疾病转归的相关性。方法:选择自2020年1月至2022年12月在我院接受手术治疗的128例良性前列腺增生患者作为研究对象,根据术后病理活检结果进行分组,间质结节组(16例)、腺肌性结节组(32例)、纤维腺瘤性结节组(12例)、腺性结节组(30例)和混合结节组(38例),其中以间质增生为主60例、以腺体增生为主68例。检测所有患者血清PSA、EGF的表达水平,以术后6个月的国际前列腺症状评分(IPSS评分)<8分判定为预后良好,分析血清PSA、EGF在预后良好组与预后不良组之间的差异性及与IPSS评分的关系。结果:血清PSA、EGF表达水平在间质结节组、腺肌性结节组、纤维腺瘤性结节组、腺性结节组和混合结节组间比较有差异(P<0.05);以腺体增生为主的良性前列腺增生患者血清PSA、EGF表达水平均明显高于以间质增生为主的患者(P<0.05);经ROC曲线分析,血清PSA联合EGF预测以腺体增生为主的良性前列腺增生的敏感度为86.42%,特异度为65.34%,AUC为0.930;所有患者均获得随访6个月,预后良好98例、预后不良30例;预后不良组血清PSA、EGF表达水平均明显高于预后良好组(P<0.05);经Pearson相关性分析,良性前列腺增生患者血清PSA、EGF表达水平均与IPSS评分呈负相关(r值分别为-0.348、-0.417,P值均为0.000)。结论:血清PSA、EGF在不同病理类型良性前列腺增生患者中表达差异显著,以间质增生为主的患者,以腺体增生为主的患者血清PSA、EGF表达水平更高,两者均与术后疾病转归密切相关,值得临床予以重视。

关键词：良性前列腺增生前列腺特异抗原表皮生长因子病理类型疾病转归

SQSTM1/p62 regulate breast cancer progression and metastasis by inducing cell cycle arrest and regulating immune cell infiltration

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Genes & Diseases 2022年第5期9卷 1332-1344页

作者： Jia-Long Qi jin-rong He Cun-Bao Liu Shu-Mei jin Xu Yang Hong-Mei Bai Yan-Bing Ma Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunmingYunnan 530102PR China Kunming Medical University Institute of Medical BiologyKunmingYunnan 650500PR China Yunnan Institute of Materia Medical Department of PathologyKunmingYunnan 650111PR China

The autophagy adaptor protein SQSTM1/p62 is overexpressed in breast cancer and has been identified as a metastasis-related ***,the mechanism by which SQSTM1/p62 contributes to breast cancer progression and tumor microenvironment remains *** study revealed that silencing SQSTM1/p62 expression suppressed breast cancer progression via regulating cell proliferation and reshaping the tumor microenvironment(TME).Here,we found that SQSTM1/p62 was overexpressed in multiple human cancer tissue types and that was correlated with poor patient overall survival(OS)and disease-free survival(DFS).Moreover,we found that short-hairpin RNA(shRNA)-mediated knockdown of p62 expression significantly inhibited cell proliferation,migration,and invasion,and promoted cell death in vitro,as well as suppressed breast cancer growth and lung metastasis in *** addition,flow cytometry analysis of splenocytes and tumor infiltrating lymphocytes(TILs)indicated that the numbers of CD8α+interferon(IFN)-γ+cells(CTLs)and CD4+IFN-γ+(Th1)cells were increased while those of CD4+IL-4+(Th2)cells,tumor-associated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs)were ***-PCR analyses showed that the gene expression of Th1/Th2 cytokines changed in the tumor *** SQSTM1/p62 suppressed tumor cell lung ***,our results provide strong evidence that silencing tumor cell SQSTM1/p62 inhibited tumor growth and metastasis through cell cycle arrest and TME *** finding provides a novel molecular therapeutic strategy for breast cancer progression and metastasis treatment.

关键词： Breast cancer Cell cycle Metastasis SQSTM1/p62 Tumor microenvironment

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慢性心力衰竭临床治疗的回顾及展望

广东医学 2024年第6期45卷 794-800页

作者：李家昊陈文亮陈庞何许锦荣广东医科大学第一临床医学院广东湛江524000 广东医科大学附属第二医院心血管内科二区广东湛江524000

慢性心力衰竭通常标志着大部分心血管疾病进入其终末阶段,具有患病率高、预后极其不利等特点。在药物治疗上,“金三角”方案被普遍视为治疗慢性心力衰竭的经典策略,近年来,随着大量的临床研究数据的公布,慢性心衰“新四联”疗法及可溶... 详细信息

慢性心力衰竭通常标志着大部分心血管疾病进入其终末阶段,具有患病率高、预后极其不利等特点。在药物治疗上,“金三角”方案被普遍视为治疗慢性心力衰竭的经典策略,近年来,随着大量的临床研究数据的公布,慢性心衰“新四联”疗法及可溶性鸟苷酸环化酶激动剂维立西呱等新型治疗药物开始应用于临床。一系列的生物标志物被发现,它们与慢性心衰患者的预后密切相关,如SERCA2a、中性粒细胞明胶酶相关脂质运载蛋白、生长分化因子15等。这些新疗法及生物标志物的发现有助于提高慢性心力衰竭患者的临床疗效及更好地预测其预后。本文就慢性心力衰竭临床治疗及生物标志物的研究及展望作一综述。

关键词：慢性心力衰竭新四联疗法鸟苷酸环化酶激动剂 SERCA2a

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Influences of pore fluid on gas production from hydrate-bearing reservoir by depressurization

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Petroleum Science 2023年第2期20卷 1238-1246页

作者： Yi-Fei Sun Bo-Jian Cao Hong-Nan Chen Yin-Long Liu jin-rong Zhong Liang-Liang Ren Guang-jin Chen Chang-Yu Sun Dao-Yi Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Division of Ocean Science and Technology Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China School of Chemistry and Food Engineering Changsha University of Science&TechnologyChangshaHunan 410114China Oilfield Chemicals R&D Institute COSLHebei 065201China

In addition to the temperature and pressure conditions,the pore fluid composition and migration behavior are also crucial to control hydrate decomposition in the exploitation *** this work,to investigate the effects of these factors,a series of depressurization experiments were carried out in a visible one-dimensional reactor,using hydrate reservoir samples with water saturations ranging from 20%to 65%.The results showed a linear relationship between gas production rates and gas saturations of the reservoir,suggesting that a larger gas-phase space was conducive to hydrate decomposition and gas ***,the rapid water production in the early stage of hydrate exploitation could release more gas-phase space in the water-rich reservoir,which in turn improved the gas production ***,the spatiotemporal evolution of pore fluids could lead to partial accelerated decomposition or secondary formation of *** the unsealed reservoir,the peripheral water infiltration kept reservoir at a high water saturation,which hindered the overall production process and caused higher water ***,depressurization assisted with the N2 sweep could displace the pore water *** to the results,it is recommended that using the short-term N2 sweep as an auxiliary means in the early stage of depressurization to expand the gas-phase space in order to achieve the highest production efficiency.

关键词： CH4 hydrate Water saturation Depressurization Gas-phase space N2 sweep

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分子印迹技术在大环内酯类药物检测中的应用

饲料研究 2024年第5期47卷 172-176页

作者：王瑜刘岑杨智翔段二珍赵银丽乔汉桢王金荣河南工业大学生物工程学院河南郑州450001

分子印迹技术是模拟酶-底物、抗原-抗体之间的相互作用,对印迹分子进行专一识别的技术,能够特异性识别模板或类似物,常被用于分析样品的预处理,可对样品进行高效提取和净化。大环内酯类药物是畜牧业中常用抗生素之一,广泛用于畜禽呼吸... 详细信息

分子印迹技术是模拟酶-底物、抗原-抗体之间的相互作用,对印迹分子进行专一识别的技术,能够特异性识别模板或类似物,常被用于分析样品的预处理,可对样品进行高效提取和净化。大环内酯类药物是畜牧业中常用抗生素之一,广泛用于畜禽呼吸道、胃肠道感染等疾病的预防与治疗,但不规范使用可能导致其在动物产品及环境中残留,对人类健康产生威胁。文章针对分子印迹技术对大环内酯类药物残留检测的预处理技术研究进展进行综述,重点对分子印迹固相萃取和磁性分子印迹固相萃取进行介绍,并对分子印迹技术在大环内酯类药物残留分析预处理的应用前景进行展望,为优化大环内酯类抗生素检测前处理方法提供参考。

关键词：分子印迹技术大环内酯类抗生素分子印迹固相萃取磁性分子印迹固相萃取

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Ultra-robust Metallosupramolecular Hydrogels with Unprecedented Self-recoverability using Asymmetrically Distributed Carboxyl-Fe3+Coordination Interactions

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Chinese Journal of Polymer Science 2023年第2期41卷 250-257页

作者： Zhao-Yang Yuan Zhen-Xing Cao Rui Wu Hui Li Qiong-Jun Xu Hai-Tao Wu jing Zheng jin-rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China

Recently,numerous mechanically robust synthetic hydrogels have been ***,unlike natural loading-bearing materials such as cartilages and muscles,most hydrogels have inherently contradictory requirements,obstructing the design of hydrogels with characteristics of robustness and rapid ***,we present a facile strategy for constructing mechanically robust and rapidly self-recoverable *** linear poly(acrylamide-co-itaconic acid)chains crosslink via coordination bonds and minimal chemical crosslinkers to form the hydrogel *** design endows the coordination interactions to be asymmetrically *** deformation,the coordination interactions exhibit a reversible dissociation-and-reorganization property,demonstrating a new mechanism for energy dissipation and stress ***,the hydrogels possess tensile strength up to 12.5 MPa and toughness up to 28.2 MJ/***,the inherent dynamic nature of the coordination bonds imparts these hydrogels with stretch rate-and temperature-dependent mechanical behavior as well as excellent self-recovery *** method employed in this study is universal and is applicable to other polymers with load-bearing yet rapid recovery *** study will facilitate diverse applications of most metallosupramolecular hydrogels.

关键词： Metallosupramolecular hydrogels Coordination interactions Self-recoverability