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放疗后胆管炎和慢性胰腺炎并发胆管上皮癌

世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 33-33页

作者： Rebours v. Lé vy P. Hammel P. 张诗峰 Fé dé ration mé dico-chirurgicale d'Hé pato- gastroenté rolog-ie H pital Beaujon 92118 Clichy Cedex France

There are no reports of cholangiocarcinoma complicating post radiotherapy cholangitis. We report the case of a 40 year old patient who had undergone thoracoabdominal radiotherapy for Hodgkin’s disease, 22 years ago. This radiotherapy was complicated, many years later, by chronic pancreatitis and cholangitis. Recurrent angiocholangitis led us to schedule a biliodigestive anastomosis. during surgery, cholangiocarcinoma was discovered. The patient died from his carcinoma some months later.

关键词：慢性胰腺炎胆管上皮霍奇金病胆肠吻合术

为耐用和可靠而设计的4．5kv压接式封装IGBT(英文)

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电力电子 2004年第5期2卷 56-63页

作者： S.埃克尔 m.雷西莫 E.齐普拉柯夫 d.施内德 U.施拉普巴赫 E.卡洛尔 ABB公司半导体分部

介绍了额定电压达4500v、额定电流达2000A的新型压接式封装IGBT(PPI)。在这种新器件的开发期间,特别强调系统制造商易于使用的可选用性。为了便于把压接式封装的IGBT紧固在长的骨架上,其机械设计是精心优化的。即使在骨架上的紧固会发... 详细信息

介绍了额定电压达4500v、额定电流达2000A的新型压接式封装IGBT(PPI)。在这种新器件的开发期间,特别强调系统制造商易于使用的可选用性。为了便于把压接式封装的IGBT紧固在长的骨架上,其机械设计是精心优化的。即使在骨架上的紧固会发生某些不均匀现象,这种压接式封装的IGBT因其独特的设计,对每个芯片都用单独的压针压紧,因而它们都会发挥其完善的功能。进而,材料的选择也得到优化,以保证在野外也能达到极高的可靠性。在功率循环次数及在故障情况下运行之间的折衷平衡点亦已被推向新的限界。这里的IGBT和二极管二者的芯片都基于SPT(软穿通)技术。先进的IGBT平面元胞设计与二极管精密的寿命控制工程相结合,这样的芯片就具备了崭新的安全工作区。这就大大便利了系统的设计,使原先使用的夹具或减振器成为过时。

关键词： IGBT 压接式封装压接式封装IGBT 功率循环短路失效模式模块化率安全工作区

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针刺治疗紧张型头痛患者的随机、对照试验

世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 1-1页

作者： melchart d. Streng A. Hoppe A. 郭俊 Centre for Complementary medicine Research Department of Internal Medicine II Technische Universitt München Kaiserstr 9 80801 Munich Germany

Objective: To investigate the effectiveness of acupuncture compared with minimal acupuncture and with no acupuncture in patients with tension-type headache. design: Three armed randomised controlled multicentre trial. Setting: 28 outpatient centres in Germany. Participants: 270 patients (74%women, mean age 43 (Sd 13) years) with episodic or chronic tension-type headache. Interventions: Acupunc- ture, minimal acupuncture (superficial needling at non-ac- upuncture points), or waiting list control. Acupuncture and minimal acupuncture were administered by specialised physicians and consisted of 12 sessions per patient over eight weeks. main outcome measure: difference in numbers of days with headache between the four weeks before randomisation and weeks 9-12 after randomisation, as recorded by participants in headache diaries. Results: The number of days with headache decreased by 7.2 (Sd 6.5) days in the acupuncture group compared with 6.6 (Sd 6.0) days in the minimal acupuncture group and 1.5 (Sd 3.7) days in the waiting list group (difference: acupuncture v minimal acupuncture, 0.6 days, 95%confidence interval -1.5 to 2.6 days, P = 0.58; acupuncture v waiting list, 5.7 days, 3.9 to 7.5 days, P ders (at least 50%reduction in days with headache) was 46%in the acupuncture group, 35%in the minimal acupuncture group, and 4%in the waiting list group. Conclusions: The acupuncture intervention investigated in this trial was more effective than no treatment but not significantly more effective than minimal acupuncture for the treatment of tension-type headache.

关键词：紧张型头痛对照试验针灸穴位专科医师中所

血流研究和血清学实验评价青光眼的诊断:一项先导性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 46-46页

作者： Greenfield d.S. Bagga H. 肖颖 Bascom Palmer Eye Institute 71 08 Fairway Drive Palm Beach Gardens FL 33418 United States Dr.

BACKGROUNd ANd OBJECTIvE: To evaluate the prevalence of hemodynamically signif icant carotid artery stenosis, peripapillary blood flow, and serologic abnormali ties in a pilot study among patients with glaucoma. PATIENTS ANd mETHOdS:All sub jects underwent complete eye examination, standard automated perimetry, carotid doppler ultrasonography, serum laboratory testing, and scanning laser doppler fl owmetry (SLdF). Subjects were subdivided into two groups based on glaucoma subty pe (normal-tension vs primary openangle glaucoma) and severity (mild vs moderat e-advanced). RESULTS: Twenty eyes of 20 patients with associated glaucomatous v isual field loss were enrolled. No significant differences in age, gender, intra ocular pressure, systemic comorbidity, number of antiglaucoma medications, and p rior filtration surgery were observed between the groups based on the type and s everity of glaucoma. The prevalence of clinically significant (>70%) carotid st enosis, mean peripapillary blood flow assessed by SLdF, mean erythrocyte sedimen tation rate, mean hematocrit, mean hemoglobin, and positive FTA-ABS was similar in both groups. Severity of glaucomatous damage as determined by visual field m ean defect did not correlate with the degree of carotid artery stenosis (R2d flow derived from mean SLdF (R2=0.000 5, P =0.92). CONCLUSION: data from this pilot study demonstrate that the prevalence o f hemodynamically significant carotid stenosis, peripapillary blood flow, and se rologic abnormalities are similar in patients with normal-tension and primary o pen-angle glaucoma, and do not correlate with glaucoma severity.

关键词：血清学实验评价颈动脉狭窄正常眼压视野缺损滤过手术全自动视野计乳头周围用药量实验室检测

关于含有石灰石、粒化高炉矿渣和粉煤灰为主要组分的水泥性能的新发现

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关于含有石灰石、粒化高炉矿渣和粉煤灰为主要组分的水泥性能的新...

胎盘免疫调节因子对子宫内膜异位症大鼠免疫功能的影响

2011国内外水泥粉磨新技术交流大会暨展览会

作者： Ing.Ch.müller Ing.K.Severins Ing.B.Hauer 曾晓辉傅子诚 Forschungsinstitut der Zementindustrie DüsseldorfGermany

应用石灰石和粒化高炉矿渣作为CEmⅡ/A-LL或CEmⅡ-S和CEmⅢ水泥的主要组分在德国已经是一个长期而成功的传统,且业已证明这两种主要组分的组合用于波特兰水泥也是成功的。22个关于应用CEmⅡ/B-m(S-LL)水泥和CEmⅡ/B-m(v-LL)水泥的国家...

应用石灰石和粒化高炉矿渣作为CEmⅡ/A-LL或CEmⅡ-S和CEmⅢ水泥的主要组分在德国已经是一个长期而成功的传统,且业已证明这两种主要组分的组合用于波特兰水泥也是成功的。22个关于应用CEmⅡ/B-m(S-LL)水泥和CEmⅡ/B-m(v-LL)水泥的国家技术使用许可,已于2003年夏天在德国颁布[1,2]。含粉煤灰的水泥可能越来越重要,当前有趣的问题是硅酸盐水泥熟料、粒化高炉矿渣、粉煤灰和石灰石等主要组分的不同组合或比例制成的水泥性能如何。这个问题直接关系到全球气候保护日益增长的需求,并且水泥和混凝土原始材料的供应有时候是有波动的。作为题为"带多种主要组分的水泥生态和技术优化"[3]研究项目的一部分,生产了德国标准dIN EN 197-1之外的标准组分水泥[3]。,这些水泥配制的混凝土性能特点(如抗压强度和耐久性)已在实验室测试了,这项工作是作为且由联邦教育和研究部支持(支持代码01LK0502)的题为"气候保护和气候影响防护措施"(***)[4]项目的一部分的。所取得的成果,其中一些转载如下,它们虽不能适用于所有领域,但可以作为进一步研究开发工作的基础。

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中国组织工程研究与临床康复 2007年第27期11卷 5328-5331页

作者：张学荣刘海涛韦敏石庆秋班建东苏建家舒雨雁广西医科大学医学科学实验中心蛇毒研究所广西壮族自治区南宁市530021 广西肿瘤防治研究所广西壮族自治区南宁市530021

目的:观察胎盘免疫调节因子对大鼠子宫内膜异位症动物模型的治疗效果和对大鼠免疫功能的影响。方法:实验于2005-10/2006-12在广西医科大学医学科学实验中心及广西肿瘤防治研究所实验病理室完成。①实验材料:健康6个月龄雌性Sd大鼠60只,... 详细信息

目的:观察胎盘免疫调节因子对大鼠子宫内膜异位症动物模型的治疗效果和对大鼠免疫功能的影响。方法:实验于2005-10/2006-12在广西医科大学医学科学实验中心及广西肿瘤防治研究所实验病理室完成。①实验材料:健康6个月龄雌性Sd大鼠60只,体质量为200～250g;健康产妇胎盘在经广西医科大学第一附属医院伦理委员会同意和产妇知情同意后获得。②实验干预及分组:利用自体子宫组织移植的方法,建立雌性子宫内膜异位症大鼠模型40只,随机分为胎盘免疫调节因子小剂量组、中剂量组、高剂量组和模型对照组,分别肌注胎盘免疫调节因子剂量为0.375,0.75,1.5mg/kg和等体积生理盐水,1次/d,连续8周。③用两脚规测量移植物的体积(v=长×宽×高/mm3),采用ATP生物荧光法测定大鼠脾细胞增殖能力;采用中性红法测定腹腔巨噬细胞的吞噬功能。采用ELISA法检测治疗后各组大鼠血清中白细胞介素2水平。结果:建模成功40只,均进入结果分析。①各组移植物外观及体积:用药后8周,各胎盘免疫调节因子组移植物体积不同程度缩小(P<0.05),呈扁平状,粘连受到明显的抑制。②各组大鼠脾细胞增殖试验、腹腔巨噬细胞吞噬功能及血清白细胞介素2水平的变化:胎盘免疫调节因子中,高剂量用药组脾细胞增殖能力较模型对照组升高(P<0.05);各剂量胎盘免疫调节因子组腹腔巨噬细胞吞噬功能、白细胞介素2水平均较模型对照组升高(P<0.05)。结论:胎盘免疫调节因子治疗大鼠子宫内膜异位症显示了较好的疗效,可显著缩小子宫异位内膜的体积,提高大鼠的免疫功能。

关键词：免疫因子子宫内膜异位症大鼠组织构建

3例曾接受米托蒽醌治疗的多发性硬化症患者的严重迟发性心力衰竭

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 33-33页

作者： Goffette S. van Pesch v. vanoverschelde J.L. 袁海峰 Service de Neurologie Cliniques Universitaires Saint Luc UCL 10 Avenue Hippocrate 1200 Brussels Belgium.Dr

mitoxantrone is an approved drug for patients with worsening relapsing-remitting, secondary progressive and progressive relapsing multiple sclerosis (mS). From a cohort of 820 mS patients, 52 (6%) were treated with this drug between december 1991 and April 2003. mitoxantrone was administered at a dose of 12 mg/m2 once a month for three months and then at three-month intervals to reach a total cumulative dose of 144 mg/m2. The left ventricular ejection fraction was checke d by radionuclide ventriculography prior to treatment and every six months. Trea tment was stopped if the ejection fraction was below 50%in two consecutive vent riculographies performed one to three months apart. Cardiotoxicity during the co urse of the treatment was not observed. However, three patients developed conges tive heart failure 24, 39 and 80 months after the last dose of mitoxantrone. Oth er cardiac causes were excluded. Two of these patients had been treated previous ly with cyclophosphamide. All patients first recovered on medical treatment, but two worsened a few months later. One patient remained severely symptomatic in s pite of optimal medical treatment. Although mitoxantrone is generally well toler ated and reduces progression of disability and clinical exacerbations, our obser vation of a delayed cardiotoxicity makes necessary a long-term follow-up of mS patients treated with this drug.

关键词：多发性硬化症米托蒽醌治疗后患者

Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression

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World Journal of Biological Chemistry 2013年第4期4卷 119-130页

作者： duygu dee Harrison-Findik Sizhao Lu Emily m Zmijewski Jocelyn Jones matthew C Zimmerman department of Internal medicine University of Nebraska Medical Center department of Cellular and Integrative Physiology University of Nebraska Medical Center

AIm: To understand the role of mitochondrial-produced superoxide(O 2 ?) in the regulation of iron-regulatory hormone, hepcidin by alcohol in the liver. mETHOdS: For alcohol experiments, manganese superoxide dismutase knockout mice heterozygous for Sod2 gene expression(Sod2 +/) and age-matched littermate control mice(LmC), expressing Sod2 gene on both alleles, were exposed to either 10%(w/v) ethanol in the drinking water or plain water(control) for 7 d. Total cellular O 2 ? levels in hepatocytes isolated from the livers of mice were measured by electron paramagnetic resonance spectroscopy. The mitochondrial-targeted, O 2 ?-sensitive fluorogenic probe, mitoSOX Red and flow cytometry were utilized to measure O 2 ? in mitochondria. Gene and protein expression were determined by Taqman Real-time quantitative PCR and Western blotting, respectively. RESULTS: Sod2 +/- mice expressed 40% less mnSOd protein(SOd2) in hepatocytes compared to LmC mice. The deletion of Sod2 allele did not alter the basal expression level of hepcidin in the liver. 10% ethanol exposure for 1 wk inhibited hepatic hepcidin mRNA expression three-fold both in Sod2 +/ and LmC mice. O 2 ? levels in hepatocytes of untreated Sod2 +/ mice were three-fold higher than in untreated LmC mice, as observed by electron paramagnetic resonance spectroscopy. O 2 ? levels in mitochondria of Sod2 +/ mice were four-fold higher than in mitochondria of untreated LmC mice, as measured by mitoSOX Red fluorescence and flow cytometry. Alcohol induced a two-fold higher increase in O 2 ? levels in hepatocytes of LmC mice than in Sod2 +/ mice compared to respective untreated counterparts. In contrast, 1 wk alcohol exposure did not alter mitochondrial O 2 ? levels in both Sod2 +/- and control mice. CONCLUSION: mitochondrial O2 ? is not involved in the inhibition of liver hepcidin transcription and thereby regulation of iron metabolism by alcohol. These findings also suggest that short-term alcohol consumption significantly elevat

关键词： Hepcidin Alcohol Iron Superoxide Superoxide dismutase Liver mitochondria manganese superoxide dismutase Electron paramagnetic resonance

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脉冲光泵远红外激光器中泵浦脉冲宽度的作用

中国激光 1984年第7期 403-406页

作者：韩绍平秦毅潘承志后其国刘秀云北京真空电子器件研究所

实验研究了光泵浦脉冲宽度对受激喇曼发射型d2O激光器和激光发射型CH3F496微米激光器的激光能量和转换效率的影响,宽的脉冲泵浦将显著改善输出能量和转换效率。

关键词：激光器转换效率光转换光泵光激射器电子器件输出能量泵浦脉冲脉冲宽度脉冲特性远红外激光泵浦激光