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CT关节成像研究肩袖损伤,影像采集前行外展外旋(ABER)位检查的必要性

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国际医学放射学杂志 2010年第4期 399-399页

作者： H.Cochet S.Couderc E.Pelé N.Amoretti m.H.moreau-durieux O.Hauger 赵芳 Unité d'imagerie thoracique et cardiovasculaire Hopital cardiologique du Haut-LévêqueCHU BordeauxPessacFrance

目的评价CT关节成像之前行外展外旋(ABER)位检查对于肩袖损伤评价的影响。方法对27例临床怀疑有肩袖损伤的病人,先行肩关节正中位CT关节成像,在下一次正中位CT影像采

关键词：肩袖损伤外旋 ABER 外展关节运动器官影像采集 CT

IGRT技术在肺癌SBRT治疗靶区位置误差测定中的应用

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中国临床医学 2016年第6期23卷 841-845页

作者：王昌民胡伟刚彭佳元蔡旭伟傅小龙许青复旦大学附属肿瘤医院放疗科复旦大学上海医学院肿瘤学系上海200032 上海交通大学附属胸科医院放疗科上海200030

目的:探讨图像引导放射治疗(image guided radiation therapy,IGRT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,SBRT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14... 详细信息

目的:探讨图像引导放射治疗(image guided radiation therapy,IGRT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,SBRT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14例肺部恶性肿瘤并接受SBRT的患者。每次治疗前后均进行千伏级锥形束CT(kv-CBCT)扫描,与计划CT图像进行在线配准,校正误差后进行治疗。治疗后再次进行CBCT扫描并配准。分别记录治疗前后靶区位置误差。根据临床靶区(CTv)-计划靶区(PTv)外放公式mPTv(外放)=2.5Σ+0.7σ计算PTv外扩大小。结果:治疗前靶区位置左右、头脚、腹背方向误差最大值分别为10.0mm、16.9mm、8.7mm,误差平均值分别为(2.4±2.8)mm、(3.4±4.6)mm、(2.9±3.4)mm。在线校正并治疗后,靶区位置左右、头脚、腹背方向的误差最大值分别为7.6mm、4.6mm、7.0mm,误差平均值分别为(2.1±2.0)mm、(1.5±1.6)mm、(1.7±2.0)mm。无图像引导PTv外扩大小为左右7.96mm、头脚11.72mm、腹背9.63mm,有图像引导并在线校正PTv外扩大小为左右6.65mm、头脚4.87mm、腹背5.65mm。结论:IGRT技术可即时校正SBRT治疗前由摆位引起的靶区位置误差,并测定治疗过程中的靶区位置移动,能提高治疗精度,并有助于PTv外扩的制定。

关键词：图像引导放射治疗体部立体定向放射治疗误差计划靶区

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Axillary Surgery in Breast Cancer - Primary Results of the INSEmA Trial

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The New England journal of medicine 2024年第12期46卷 2024 Dec 12页

作者： Toralf Reimer Angrit Stachs Kristina veselinovic Thorsten Kühn Jörg Heil Silke Polata Frederik marmé Thomas müller Guido Hildebrandt david Krug Beyhan Ataseven Roland Reitsamer Sylvia Ruth Carsten denkert Inga Bekes dirk-michael Zahm marc Thill michael Golatta Johannes Holtschmidt michael Knauer valentina Nekljudova Sibylle Loibl Bernd Gerber From the department of Obstetrics and Gynecology University of Rostock Rostock Germany (T.R. A.S. B.G.) University Hospital Ulm Ulm Germany (K.V. I.B.) Hospital Esslingen Esslingen Germany (T.K.) University Hospital Heidelberg Heidelberg Germany (J. Heil M.G.) the Breast Unit Sankt Elisabeth Hospital Heidelberg Germany (J. Heil M.G.) Evang. Waldkrankenhaus Spandau Berlin (S.P.) the Faculty of medicine mannheim Department of Obstetrics and Gynecology University of Heidelberg Mannheim Germany (F.M.) the department of Obstetrics and Gynecology Hanau City Hospital Hanau Germany (T.M.) the department of Radiation Oncology University Hospital Rostock Rostock Germany (G.H.) the department of Radiotherapy and Radiation Oncology University Hospital Hamburg-Eppendorf (UKE) Hamburg Germany (D.K.) the department of Radiation Oncology University Medical Center Schleswig-Holstein Kiel Germany (D.K.) medical School and University medical Center OWL Department of Gynecology and Obstetrics Bielefeld University Klinikum Lippe Detmold Germany (B.A.) Salzburg Regional Hospital Salzburg Austria (R.R.) Johanniter-Hospital Genthin-Stendal Genthin Germany (S.R.) the Institute of Pathology Philipps-University Marburg and University Hospital Marburg (UKGM) Marburg Germany (C.D.) Breast Center St. Gallen Kantonsspital St. Gallen Switzerland (I.B.) SRH Wald-Klinikum Gera Gera Germany (D.-M.Z.) the department of Gynecology and Gynecologic Oncology Agaplesion Markus Hospital Frankfurt am Main Germany (M.T.) the German Breast Group Neu-Isenburg Germany (J. Holtschmidt V.N. S.L.) and the Tumor and Breast Center Eastern Switzerland St. Gallen Switzerland (M.K.).

BACKGROUNd:Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear.mETHOdS:In this prospective, randomized, noninferiority trial, we investigated the omission of axillary surgery as compared with sentinel-lymph-node biopsy in patients with clinically node-negative invasive breast cancer staged as T1 or T2 (tumor size, ≤5 cm) who were scheduled to undergo breast-conserving surgery. We report here the per-protocol analysis of invasive disease-free survival (the primary efficacy outcome). To show the noninferiority of the omission of axillary surgery, the 5-year invasive disease-free survival rate had to be at least 85%, and the upper limit of the confidence interval for the hazard ratio for invasive disease or death had to be below 1.271.RESULTS:A total of 5502 eligible patients (90% with clinical T1 cancer and 79% with pathological T1 cancer) underwent randomization in a 1:4 ratio. The per-protocol population included 4858 patients; 962 were assigned to undergo treatment without axillary surgery (the surgery-omission group), and 3896 to undergo sentinel-lymph-node biopsy (the surgery group). The median follow-up was 73.6 months. The estimated 5-year invasive disease-free survival rate was 91.9% (95% confidence interval [CI], 89.9 to 93.5) among patients in the surgery-omission group and 91.7% (95% CI, 90.8 to 92.6) among patients in the surgery group, with a hazard ratio of 0.91 (95% CI, 0.73 to 1.14), which was below the prespecified noninferiority margin. The analysis of the first primary-outcome events (occurrence or recurrence of invasive disease or death from any cause), which occurred in a total of 525 patients (10.8%), showed apparent differences between the surgery-omission group and the surgery group in the incidence of axillary recurrence (1.0% vs. 0.3%) and death (1.4% vs. 2.4%). The safety analysis indicates that patients in the surgery-omission group had a lower incidence

关键词： trial surgery axillary breast cancer-primary insema results

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André didier Auguste Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin david Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti di Lorenzo daniele Corti Flavio dal Corso Olivia dalager Christophe de La Taille 邓智邓子艳 Wilfried depnering marco diaz Xuefeng ding 丁雅韵 Bayu dirgantara Sergey dmitrievsky Tadeas dohnal dmitry dolzhikov Georgy donchenko 董建蒙 Evgeny doroshkevich marcos dracos Frédéric druillole 杜然杜书先 Stefano dusini martin dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 marco Fargetta dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Christian Grewing vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di milano and dipartimento di Fisica dell Universitàdi milano MilanoItaly department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance department of Physics National Taiwan UniversityTaipei dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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CEPC Technical design Report

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Radiation detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella d'Anzi Ling-Yun dai Xinchen dai Xuwen dai Antonio de maria Nicola de Filippis Christophe de La Taille Francesca de mori Chiara de Sio Elisa del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio di micco Ran ding Siqin dingl Yadong ding Haiyi dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTd Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&Tv Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille dalian minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron dESY Hamburg dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(dLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 Gev Linac,a 1.1 Gev damping Ring,a Booster capable of achieving energies up to 180 Gev,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TdR)follows the Preliminary Conceptual design Report(Pre-CdR,2015)and the Conceptual design Report(CdR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&d and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise