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GeDiPNet: Online resource of curated gene-disease associations for polypharmacological targets discovery

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Genes & Diseases 2023年第3期10卷 647-649页

作者： Indra kundu Mridula Sharma Ram Shankar Barai Khushal Pokar Susan Idicula-Thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbai 400012India

There are numerous online databases dedicated to genes associated with human *** redundancy and lack of consistency of disease terms in these databases pose a significant impediment in high throughput data *** address this,we developed GeDiPNet by compiling data available on gene-disease associations from six popular open access sources namely DisGeNET,1 ClinGen.

关键词： databases online analysis.

Dose and duration dependent cytotoxicity of aroclor 1254 in the testis of mice

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Asian pacific Journal of Reproduction 2017年第3期6卷 112-115页

作者： Shweta Pathak Jalpa Raja Rahul kundu UGC-CAS Department of Biosciences Saurashtra UniversityRajkot-360005GujaratIndia

Objective:To evaluate the dose and duration dependent cytotoxicity of aroclor 1254 on mice ***: The study tests the hypothesis that in vivo exposure of very low dose aroclor 1254, comparable to that of possible human exposure from different environmental sources, will provoke dose and duration dependent histological damage in the mice testis. Male mice were orally administered with the two doses 0.1 and 1 mg/kg b.w /d. of aroclor 1254 for 7, 14, 21 and 28 ***:Results showed the degenerative changes in the testis of mice, namely, atrophied seminiferous tubules, expanded space in interstitial and necrosis in the germinal epithelial cells of seminiferous tubules, of the seminiferous tubules and deceleration of ***: Therefore, the results of the present study suggested that the sub-acute exposure of very low doses of aroclor 1254, can subsequently mediate the cytoskeleton dysfunction in the testis of mice.

关键词： PCBs Aroclor 1254 Histopathology Testis Mice

Cu-water nanofluid flow induced by a vertical stretching sheet in presence of a magnetic field with convective heat transfer

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Propulsion and Power Research 2017年第3期6卷 206-213页

作者： Kalidas Das Amit Sarkar Prabir Kumar kundu Dept.of Mathematics A.B.N.Seal CollegeCooch Behar 736101West BengalIndia Dept.of Mathematics Jadavpur UniversityKolkata 700032West BengalIndia

The convective heat transfer performance of nanofluid over a permeable stretching sheet with thermal convective boundary condition in presence of magnetic field and slip velocity is studied in the present ***-water nanofluid is used to investigate the effect of nanoparticles on the flow and heat transfer *** numerical results are compared with published results and are found in an excellent *** influences of various relevant parameters on the velocity and temperature as well as the rate of shear stress and the rate of heat transfer are elucidated through graphs and *** is observed that nanoparticles volume fraction and surface convection parameter both increase the thickness of thermal boundary layer.

关键词： Nanofluid Slip velocity Magnetic field Convective boundary condition

Influence of linearly varying density and rigidity on torsional surface waves in inhomogeneous crustal layer

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Applied Mathematics and Mechanics(English Edition) 2012年第10期33卷 1239-1252页

作者： S.GUPTA S.KVISHWAKARMA D.K.MAJHI S.kundu Department of Applied Mathematics Indian School of Mines

The present work deals with the possibility of propagation of torsional surface wave in an inhomogeneous crustal layer over an inhomogeneous half space. The layer has inhomogeneity which varies linearly with depth whereas the inhomogeneous half space exhibits inhomogeneity of three types, namely, exponential, quadratic, and hyperbolic discussed separately. The dispersion equation is deduced for each case in a closed form. For a layer over a homogeneous half space, the dispersion equation agrees with the equa- tion of the classical case. It is observed that the inhomogeneity factor due to linear variation in density in the inhomogeneous crustal layer decreases as the phase velocity increases, while the inhomogeneity factor in rigidity has the reverse effect on the phase velocity.

关键词： torsional wave phase velocity crustal layer exponential quadratic,hyperbolic

Crystallization kinetics of Sn_(40)Se_(60) thin films for phase change memory applications

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Journal of Semiconductors 2015年第6期36卷 17-20页

作者： Joshua M.kundu Patrick M.Karimi Walter K.Njoroge Department of Physics Kenyatta University

The crystallization kinetics of Sn4oSe6o thin films has been successfully investigated using sheet resis- tance versus temperature measurements. Thermal evaporation was used to deposit the films on ordinary glass sub- strates. The crystallization temperature for Sn4oSe60 thin film was found to be 156.6 -t- 0.3 ~C. In the as-deposited state, the sheet resistance was found to be 195 Mf2/[2, this value declined to 1560 f2/[2] upon annealing. The value of activation energy obtained from the Kissinger plot was 0.62 ＋ 0.07 eV. From the results obtained, SnaoSe60 is a promising alloy for PCM application because of its high electrical contrast, high crystallization temperature, and relatively high activation energy.

关键词： crystallization temperature activation energy electrical contrast phase change memory

Movable Au Microplates as Fluorescence Enhancing Substrates for Live Cells

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Nano Research 2010年第10期3卷 738-747页

作者： Boya Radha Mohammed Arif Ranjan Datta Tapas K.kundu Giridhar U.Kulkarni Chemistry and Physics of Materials Unit and DST Unit on Nanoscience Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bangalore 560064India Molecular Biology and Genetics Unit Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bangalore 560064India International Centre for Materials Science Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bangalore 560064India

Hexagonal and triangular Au microplates extending over an area of~12,000μm^(2) with thickness in the range 30-1000 nm have been synthesized using a single step thermolysis of(AuCl_(4))^(-)-tetraoctylammonium bromide complex in *** microplates are self-supporting and can be easily manipulated using a sharp pin,a property which enables them to serve as substrates for living *** microplate surface is non-toxic to living cells and can enhance the fluorescence signal from fluorophores residing within the cell by an order of *** addition,the microplates are smooth and single-crystalline,and ideal as microscopy substrates and molecular *** growth of the microplates in the initial stages is interesting in that they seem to grow perpendicular to the substrate,as evidenced by in situ microscopy.

关键词： Au microplates synthesis cell substrate metal enhanced fluorescence manipulation

Propagation of Love waves in non-homogeneous substratum over initially stressed heterogeneous half-space

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Applied Mathematics and Mechanics(English Edition) 2013年第2期34卷 249-258页

作者： S.GUPTA D.K.MAJHI S.kundu S.K.VISHWAKARMA Department of Applied Mathematics Indian School of Mines

The paper studies the propagation of Love waves in a non-homogeneous substratum over an initially stressed heterogeneous half-space. The dispersion equation of phase velocity is derived. The velocities of Love waves are calculated numerically as a function of kH and presented in a number of graphs, where k is the wave number, and H is the thickness of the layer. The case of Gibson＇s half-space is also considered. It is observed that the speed of Love waves is finite in the vicinity of the surface of the half-space and vanishes as the depth increases for a particular wave number. It is also observed that an increase in compressive initial stresses causes decreases of Love waves velocity for the same frequency, and the tensile initial stress of small magnitude in the half-space causes increase of the velocity.

关键词： Love waves initial stress heterogeneous half-space Gibson's half-space,dispersion equation phase velocity

Self-adaptive bulk/surface engineering of Bi_(x)O_(y)Br_(z) towards enhanced photocatalysis:Current status and future challenges

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Journal of Energy Chemistry 2023年第7期82卷 387-413,I0009页

作者： Zhiwei Wu Bidyut Kumar kundu Wanqiong Kang Lei Mao Sen Zhang Lan Yuan Fen Guo Chuang Han Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Chemistry University of CincinnatiCincinnatiOH 45221United States The PLA Rocket Force Command College Wuhan 430012HubeiChina Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074HubeiChina

The bulk/surface states of semiconductor photocatalysts are imperative parameters to maneuver their performance by significantly affecting the key processes of photocatalysis including light absorption,separation of charge carrier,and surface site *** years have witnessed the encouraging progress of self-adaptive bulk/surface engineered Bi_(x)O_(y)Br_(z) for photocatalytic applications spanning various ***,despite the maturity of current research,the interaction between the bulk/surface state and the performance of Bi_(x)O_(y)Br_(z) has not yet been fully understood and *** this regard,a timely tutorial overview is quite urgent to summarize the most recent key progress and outline developing obstacles in this exciting ***,the structural characteristics and fundamental principles of Bi_(x)O_(y)Br_(z)for driving photocatalytic reaction as well as related key issues are firstly ***,we for the first time summarized different self-adaptive engineering processes over Bi_(x)O_(y)Br_(z)followed by a classification of the generation approaches towards diverse Bi_(x)O_(y)Br_(z)*** features of different strategies,the up-to-date characterization techniques to detect bulk/surface states,and the effect of bulk/surface states on improving the photoactivity of Bi_(x)O_(y)Br_(z)in expanded applications are further ***,the present research status,challenges,and future research opportunities of self-adaptive bulk/surface engineered Bi_(x)O_(y)Br_(z)are *** is anticipated that this critical review can trigger deeper investigations and attract upcoming innovative ideas on the rational design of Bi_(x)O_(y)Br_(z)-based photocatalysts.

关键词： Bismuth oxybromide Self-adaptive engineering Pollutant degradation Energy application Photocatalysis

1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells

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World Journal of Gastroenterology 2013年第42期19卷 7374-7388页

作者： Dipon Das Ranjan Preet Purusottam Mohapatra Shakti Ranjan Satapathy Chanakya Nath kundu Cancer Biology Division KIIT School of BiotechnologyKIIT UniversityBhubaneswarOdisha 751024India

AIM:To study the mechanism of 5-fluorouracil(5-FU)resistance in colon cancer cells and to develop strategies for overcoming such resistance by combination ***:We established and characterized a 5-FU resistance(5-FU-R)cell line derived from continuous exposure(25μmol/L)to 5-FU for 20 wk in 5-FU sensitive HCT-116 *** proliferation and expression of different representative apoptosis and anti-apoptosis markers in 5-FU sensitive and 5-FU resistance cells were measured by the MTT assay and by Western blotting,respectively,after treatment with Resveratrol(Res)and/or 1,3-Bis(2-chloroethyl)-1-nitrosourea(BCNU).Apoptosis and cell cycle arrest was measured by 4',6'-diamidino-2-phenylindole hydrochloride staining and fluorescence-activated cell sorting analysis,*** extent of DNA damage was measured by the Comet *** measured the visible changes in the DNA damage/repair cascade by Western ***:The widely used chemotherapeutic agents BCNU and Res decreased the growth of 5-FU sensitive HCT-116 cells in a dose dependent *** application of BCNU and Res caused more apoptosis in5-FU sensitive cells in comparison to individual *** addition,the combined application of BCNU and Res caused a significant decrease of major DNA base excision repair components in 5-FU sensitive *** established a 5-FU resistance cell line(5-FU-R)from 5-FU-sensitive HCT-116(mismatch repair deficient)cells that was not resistant to other chemotherapeutic agents(e.g.,BCNU,Res)except *** 5-FU resistance of 5-FU-R cells was assessed by exposure to increasing concentrations of 5-FU followed by the MTT *** was no significant cell death noted in5-FU-R cells in comparison to 5-FU sensitive cells after5-FU *** resistant cell line overexpressed anti-apoptotic[e.g.,AKT,nuclear factorκB,FLICE-like inhibitory protein),DNA repair(e.g.,DNA polymerase beta(POL-β),DNA polymerase eta(POLH),protein Flap endonuclease 1(FEN1),DNA dam

关键词： 5-fluorouracil 1,3-Bis(2-chloroethyl)-1-nitrosourea Resveratrol Colon cancer Combination therapy