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Equilibrium *** melting relations in the Higher Himalayan Crystalline(HHC) pelitic migmatites,Sikkim Himalaya

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Geoscience Frontiers 2011年第4期2卷 539-549页

作者： Bhaskar kundu National Geophysical Research Institute Council of Scientific and Industrial ResearchUppal RoadHyderabad 500007India

Higher Himalayan Crystalline（HHC） complex of the Sikkim Himalaya predominantly consists of high-grade pelitic *** this study,reaction textures,mineral/bulk rare earth elements （REE）,trace element partition coefficients and trace element zoning profiles in garnet are used to demonstrate a complex petrogenetic process during crustal *** the help of equilibrium REE and trace element partitioning model,it is shown that strong enrichment of Effective Bulk Composition（EBC） is responsible for the zoning in garnet in these *** data strongly support disequilibrium element partitioning and suggest that the anatectic melts associated with mafic selvedges are likely produced by disequilibrium melting because of fast melt segregation process.

关键词： Pelitic migmatites Crustal anatexis Mafic selvedge Disequilibrium melting

Quantitative analysis of the interaction of heterologous viruses with Plum pox virus in C5 HoneySweet transgenic plums

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Journal of Integrative Agriculture 2019年第10期18卷 2302-2310页

作者： Khushwant Singh Tereza Neubauerová Jiban Kumar kundu Plant Virus and Vector Interactions Group Division of Crop Protection and Plant Health Crop Research Institute

Stone fruits are an important crop in most parts of the world and are heavily challenged by several viruses including Plum pox virus (PPV), Prune dwarf virus (PDV), Prunus necrotic ringspot virus (PNRSV), and Apple chlorotic leaf spot virus (ACLSV). We validated the PPV resistance in C5 plum plants (commercially known as HoneySweet) grown in the Czech Republic for more than 16 years in a field trial experiment under natural environmental conditions. We quantified single (PPV-Rec) and mixed viruses (PPV-Rec+ACLSV, PPV-Rec+PDV and PPV-Rec+ACLSV+PDV) in C5 transgenic plums inoculated for the period 2016 to 2018. The accumulation of PPV-Rec was high (~5.43E+05 copies) compared with that of ACLSV (~8.70E+04 copies) in the inoculated graft of C5 transgenic plants. Leaves close to the inoculum sources showed a differential level of virus titre in single and mixed infections (~10 to ~5×10^2 copies). C5 plants with permanent virus pressure showed 103- to 105-fold fewer copies of viruses than those of the inoculated graft. We observed high accumulation of conserved miRNAs such as miR167, miR69 and miR396 in C5 plants co-infected with PPV, ACLSV and PDV that are associated with its resistance against viruses. Overall, i) C5 transgenic plums showed high resistance to PPV infection, and a low level (~32 copies) of PPV only accumulated in some grafted plants, ii) high accumulation of PPV was found in inoculated grafts in single PPV infection and mixed infections, iii) heterologous virus infection sustained by ACLSV or PDV did not suppress PPV resistance, and iv) high and low conserved microRNAs accumulated in C5 plants.

关键词： PPV PDV ACLSV C5 HoneySweet resistance

Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle

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Journal of Integrative Medicine 2022年第5期20卷 463-472页

作者： Asmita Pal Sucharita Das Soumalee Basu Rita kundu Department of Botany University of CalcuttaKolkataWest Bengal 700019India Department of Microbiology University of CalcuttaKolkataWest Bengal 700019India

Objective‘Multi-targeting’drugs can prove fruitful to combat drug-resistance of multifactorial disease—cervical *** study envisioned to reveal if Thuja homeopathic mother tincture(MT)and its bioactive component could combat human papillomavirus(HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated *** Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species(ROS)generation by 2’,7’-dichlorodihydrofluorescein diacetate(DCFDA)staining and loss in mitochondrial membrane potential(MMP)by rhodamine(Rh)123 *** and autophagy inductions were studied by acridine orange(AO)ethidium bromide(EB)staining and immunoblot analyses of marker *** bioactive component of Thuja MT detected by gas chromatography-mass spectrometry was studied for antiproliferative and antimigratory properties along with in silico prediction of its cellular targets by molecular docking and oral drug forming *** Thuja MT showed significant antiproliferative and antimigratory potential in SiHa cells at a 50%inhibitory concentration(IC50)dosage of 17.3μL/*** increase in DCFDA fluorescence and loss in Rh123 fluorescence prove that Thuja MT acted through the burst of ROS and loss in MMP ***/EB-stained cells under the microscope and immunoblot analyses supported Thuja-induced cellular demise via dual pathways—apoptosis and *** showed cleavage of caspase-3 and poly adenosine diphosphate-ribose polymerase-1(PARP-1)along with upregulation of Beclin-1,microtubule-associated protein 1 light chain 3B(LC3B)-II,and p62 ***,the apoptotic cascade followed a caspase-3-dependent pathway supported by PARP-1 cleavage,while autophagic death was Beclin-1-dependent and mediated by accumulation of LC3BII and p62 ***,detected as the bioactive principle of Thuja MT showed greater anti-pro

关键词： Thuja Homeopathy Thujone Cervical cancer Apoptosis-autophagy crosstalk

Interplay between genome organization and epigenomic alterations of pericentromeric DNA in cancer

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Journal of Genetics and Genomics 2021年第3期48卷 184-197页

作者： Subhadip kundu M.D.Ray Ashok Sharma Laboratory of Chromatin and Cancer Epigenetics Department of BiochemistryAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Surgical Oncology IRCHAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

In eukaryotic genome biology,the genomic organization inside the three-dimensional(3D)nucleus is highly complex,and whether this organization governs gene expression is poorly *** lamina(NL)is a filamentous meshwork of proteins present at the lining of inner nuclear membrane that serves as an anchoring platform for genome *** chromatin domains termed as lamina-associated domains(LADs),play a major role in silencing genes at the nuclear *** interaction of the NL and genome is dynamic and ***,many genes change their positions during developmental processes or under disease conditions such as cancer,to activate certain sorts of genes and/or silence *** heterochromatin(PCH)is mostly in the silenced region within the genome,which localizes at the nuclear *** show that several genes located at the PCH are aberrantly expressed in *** interesting question is that despite being localized in the pericentromeric region,how these genes still manage to overcome pericentromeric *** epigenetic mechanisms control the expression of the pericentromeric region,recent studies about genome organization and genome-nuclear lamina interaction have shed light on a new aspect of pericentromeric gene regulation through a complex and coordinated interplay between epigenomic remodeling and genomic organization in Cancer.

关键词： LADs Pericentromere Heterochromatin Gene regulation Epigenetics Cancer Genome organization

Dispersion and attenuation of torsional wave in a viscoelastic layer bonded between a layer and a half-space of dry sandy media

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Applied Mathematics and Mechanics(English Edition) 2017年第9期38卷 1313-1328页

作者： P.ALAM S.kundu S.GUPTA Department of Applied Mathematics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004JhrkhandIndia

Propagation of a torsional wave in a doubly-layered half-space structure of an initially stressed heterogeneous viscoelastic layer sandwiched between a layer and a half-space of heterogeneous dry sandy media is studied. A closed form complex expression for the velocity profile is obtained under effective boundary conditions. The real part of the complex expression provides a dispersion equation, and the imaginary part yields a damping equation. The derived dispersion and damped equations are in well agreement with the classical Love wave condition. In addition, to study the effect of the dissipation factor, the attenuation coefficient, the sandy parameters, the initial stress, the hetero- geneity parameters, and the thickness ratio parameter, some noteworthy contemplations are made by numerical calculations and graphical visuals. The results of this paper may present a deeper insight into the behaviour of propagation phenomena in heterogeneous viscoelastic and heterogeneous dry sandy materials that can provide a theoretical guide for the design and optimization in the field of earthquake engineering. The study also reveals that the presence of a damping part due to viscoelasticity affects the torsional wave propagation significantly.

关键词： attenuation dissipation viscoelastic sandy heterogeneous initial stress,phase damping

Production of biodiesel from unused algal biomass in Punjab, India

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Petroleum Science 2018年第1期15卷 164-175页

作者： Rachan Karmakar Anita Rajor Krishnendu kundu Nitin Kumar School of Energy and Environment Thapar University Department of Biofuel CSIR CMERI Co EFM Department of Mechanical Engineering Thapar University

Biodiesel from inedible sources has become prominent in last few decades. But it is economically incompatible with petroleum diesel. At the same time, both petro-diesel and biodiesels are concerned with environmental pollution, global warming, etc. Algae, on the other hand, utilize CO2 for their growth and can minimize some sort of pollution level and results in carbon credit for a country. In Punjab, India, algae are seen to grow in many water bodies. But all those are taken away and dumped in vats. Some of this huge biomass was used for production of biodiesel in this work. Extraction of oil from algae was conducted by using Soxtherm（solvent extraction）. An amount of 9 wt% of algal oil was extracted by comparatively costly hexane, whereas 8% extraction was done by cheaper acetone. In the transesterification reaction, molar ratio（methanol： oil） of 6：1, catalyst（KOH） concentration of 3 wt%, reaction temperature of 60 °C, 60 min reaction time and a settling time of 2.5 h were found to be optimum conditions to get maximum ester with minimum free fatty acid content and viscosity. A statistical analysis for the transesterification procedure also showed a methanol-to-oil molar ratio of 6：1 and catalyst concentration of 3 wt% to be the optimum. Characterization of biodiesel was done and compared with ASTM/BIS standards. Most important properties of biodiesel ester like viscosity（3.12 c St or 3.12 mm2/s）, cloud and pour point（-1 and-6 °C, respectively）, flash and fire point（153 and 158 °C）, carbon residue content（0.03%）, acid number（0.36 mg of KOH/gm） were within the range of concerned standards.

关键词： Algae Biodiesel Biodiesel properties Transesterification Oil extraction

Effect of magnetic field on Oldroyd-B type nanofluid flow over a permeable stretching surface

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Propulsion and Power Research 2018年第3期7卷 238-246页

作者： Kalidas Das Tanmoy Chakraborty Prabir Kumar kundu Department of Mathematics A.B.N.Seal CollegeCooch BeharWest Bengal 736101India Department of Engineering Science Academy of TechnologyHooghly 712121India Department of Mathematics Jadavpur UniversityKolkataWest Bengal 700032India

This article is conceded to explore the influence of magnetic flux on a two dimensional incompressible Oldroyd-B type nanofluid past a heat generating/absorbing permeable expanding *** by some appropriate similarity transformations,the fundamental PDEs are converted into a self similar system of coupled,non-linear *** findings are gained by taking the help of the Runge–Kutta Gill based Shooting *** visualize the influences of related parameters concerning the flow,on velocity,temperature and concentration distributions are represented through *** fallouts for the local Nusselt number and Sherwood number are charted for various parametric situations to offer interesting aspects of the *** existence of magnetic flux the momentum boundary layer width declines rapidly with relaxation time and velocity slip whereas,the temperature boundary layer width enhances significantly with heat source,Brownian motion and thermophoresis *** Nusselt number falls a lot with heat source,velocity slip and Brownian motion parameter but reverse result is notified for Sherwood number for the ***,the obtained numerical outcomes for particular cases are compared with those of the existing data in the open literature and,are found in excellent harmony.

关键词： Oldroyd-B type nanofluid Slip velocity Magnetic field Heat generation/absorption Suction/injection

Seismoelectric wave propagation modeling in a borehole in water-saturated porous medium having an electrochemical interface

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Chinese Physics B 2017年第12期26卷 345-354页

作者：丁浩然刘金霞崔志文 Tribikram kundu Department of Acoustics and Microwave Physics College of Physics Jilin University Department of Civil Engineering and Engineering Mechanics University of Arizona

Water-saturated porous media often exhibit a seismoelectric effect due to the existence of an electrical double layer and a relative flow of pore fluid. Here we consider the seismoelectric waves in an open borehole surrounded by water-saturated porous formation which exhibits discontinuity of electrochemical properties at a cylindrical interface. We carefully analyze the seismoelectric interface response since these signals show sensitivity to contrasts in electrochemical properties across an interface. Both coupled and approximate methods are used to compute borehole seismoelectric fields. The simulation results show that the radiated electromagnetic wave from the electrochemical interface is generated due to the change of salinity in pore fluid in the porous formation. However, the elastic properties of the formation remain unchanged across such an electrochemical interface. As a result it is difficult to recognize such a change in electrochemical properties using only elastic waves. Therefore, the seismoelectric interface response is potentially used to detect the changes of the electrochemical properties in the formation.

关键词： seismoelectric effect interface response porous formation borehole

An analytical study on the Rayleigh wave generation in a stratified structure

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1039-1054页

作者： A.MANDI S.kundu P.PATI P.C.PAL Department of Mathematics and Computing Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India

In this paper,an analytical method is used to investigate the Rayleigh wave generation in a stratified structure and the wave generation in a dry sandy layer constrained between the couple stress and inhomogeneous orthotropic *** study is devoted to analyzing the impact of various effective parameters associated with the media on the phase velocities of the *** displacement components for each medium are derived by implementing the separable variable *** frequency equa-tion is secured by using the displacement components in the boundary conditions,imposed at the interfaces between the layer and ***,the secured equation is the relation between the phase velocity and the wave *** computations are performed,and graphical representations are demonstrated between the phase velocity and the wave number for both phase velocities with different values of the *** comparison between the phase velocities is observed for the same value of each pa-rameter.

关键词： Rayleigh wave dry sandy layer couple stress orthotropic phase velocity wave number