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An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media

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Chinese Chemical Letters 2013年第9期24卷 793-796页

作者： fu-Jun Duan Jin-Chang Ding Hong-juan Deng Ding-Ben Chen Jiu-Xi Chen Miao-Chang Liu Hua-Yue wu College of Chemistry and Materials Engineering Wenzhou University Wenzhou Vocational and Technical College College of Pharmaceutical and Chemical Engineering Taizhou University

An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of β-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines （e.g., para-, metaor orthophenylenediamine） to construct bis-pyrrole or mono-pyrrole derivates.β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.

关键词： Pyrrole Paal-Knorr β-Cyclodextrin Water

A solitary annular plaque on the jaw:atypical presentation of secondary syphilis

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Chinese Medical Journal 2020年第11期133卷 1383-1384页

作者： juan wu Hao Chen fu-Quan Long Department of Sexually Transmitted Disease Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200443China Department of Pathology Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

To the Editor:Syphilis is a sexually transmitted disease caused by Treponema pallidum(***).Secondary syphilitic lesions usually occur within 3 months after the initial exposure to *** most frequent skin manifestations of secondary syphilis are macular and papular ***,other uncommon lesions,such as nodular,pustular,arcuate,and psoriasislike lesions,have been occasionally reported.[1,2]Annular syphilitic lesions are relatively rare and usually present as multiple lesions scattered over the body or are limited to local skin such as genital.[1,3]Herein,we report a solitary annular lesion of secondary syphilis on the face.

关键词： annular atypical solitary

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我国医疗机构结余药品管理现状及对策分析

中华医院管理杂志 2024年第6期40卷 444-447页

作者：吴广杰付伟裘琳李冬艳信凡雪郑鉴凌戴小喆陈倩刘燕谭莉刘东李娟华中科技大学同济医学院附属同济医院药学部武汉430030 华中科技大学同济医学院附属同济医院财务处武汉430030 华中科技大学同济医学院附属同济医院医疗保险办公室武汉430030 华中科技大学同济医学院附属同济医院审计处武汉430030 华中科技大学同济医学院附属同济医院感染管理科武汉430030

结余药品管理是药品管理的重要环节。目前,我国医疗机构在结余药品管理方面处于初步探索阶段。本研究通过分析医疗机构结余药品的产生原因、安全隐患、管理政策以及管理存在问题,提出针对性的对策建议,包括建立统一规范的管理办法、共... 详细信息

结余药品管理是药品管理的重要环节。目前,我国医疗机构在结余药品管理方面处于初步探索阶段。本研究通过分析医疗机构结余药品的产生原因、安全隐患、管理政策以及管理存在问题,提出针对性的对策建议,包括建立统一规范的管理办法、共识或指南,优化医疗机构内部管理,提高医务人员的管理意识,以及明确结余药品的利益问题,以期为医疗机构合理管理结余药品提供参考。

关键词：结余药品药品管理政策利益医疗机构

Polymer Waveguide Coupled Surface Plasmon Refractive Index Sensor:A Theoretical Study

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Photonic Sensors 2020年第4期10卷 353-363页

作者： Lanting JI Shuqing YANG Rongna SHI Yujie fu juan SU Chi wu Institute of Marine Science and Technology Shandong UniversityQingdao 266237China

A waveguide coupled surface plasmon sensor for detection of liquid with high refractive index(RI)is designed based on polymer *** effects of variation of the thickness of the Au film,polymethyl methacrylate(PMMA)buffer,and waveguide layer on the sensing performance of the waveguide are comprehensively investigated by using the finite difference *** simulations show that a thinner gold film gives rise to a more sensitive structure,while the variation of the thickness of the PMMA buffer and waveguide layer has a little effect on the *** liquid with high RI,the sensitivity of the sensor increases *** RI of liquid to be measured increases from 1.45 to 1.52,the sensitivity is as high as 4518.14 nm/RIU,and a high figure of merit of 114.07 is *** waveguide coupled surface plasmon RI sensor shows potential applications in the fields of environment,industry,and agriculture sensing with the merits of compact size,low cost,and high integration density.

关键词： Waveguide surface plasmon polaritons polymer refractive index sensor

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新农科背景下植物生理学实践课的现状及思考

嘉应学院学报 2024年第3期42卷 103-106页

作者：常金梅吴嘉嘉罗海华蓝木香付文娟嘉应学院广东省山区特色农业资源保护与精准利用重点实验室广东梅州514000

在“新农科”背景下,传统农业对资源约束和生态文明不断提出挑战,急需对相关专业人才的培养模式进行调整,以适应现代农业的发展,在此背景下,综述了植物生理学实践学习的现状,对传统植物生理学实践的现状以及不足之处进行了剖析,并在实... 详细信息

在“新农科”背景下,传统农业对资源约束和生态文明不断提出挑战,急需对相关专业人才的培养模式进行调整,以适应现代农业的发展,在此背景下,综述了植物生理学实践学习的现状,对传统植物生理学实践的现状以及不足之处进行了剖析,并在实践内容、实践方式、考核方法以及课程思政等方面提出了具体措施,利于提高新农科背景下应用型人才的创新能力,更好的达到培养目标.同时该论文为适应“新农科”创新型人才培养提供理论依据,有助于形成服务地方产业的人才队伍建设,培养一批高层次、高水平的应用型人才.

关键词：新农科创新能力植物生理学实践

不同温度和湿度对广陈皮色泽及挥发性成分的影响

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南方农业学报 2024年第7期55卷 2006-2020页

作者：李梦涵陈玉婷吴继军余元善温靖邹波刘昊澄徐玉娟傅曼琴广东海洋大学食品科技学院广东湛江524088 广东省农业科学院蚕业与农产品加工研究所/农业农村部功能食品重点实验室/广东省农产品加工重点实验室广东广州510610 梧州学院广西梧州543003

【目的】探究不同温湿度对广陈皮水分、色泽和挥发性成分的影响,为广陈皮的科学储藏和综合加工利用提供参考依据。【方法】以2022年广陈皮为研究对象,在高温高湿(35℃、85%)环境下处理5 d,然后在低温低湿(20℃、55%)环境下处理5 d,2种... 详细信息

【目的】探究不同温湿度对广陈皮水分、色泽和挥发性成分的影响,为广陈皮的科学储藏和综合加工利用提供参考依据。【方法】以2022年广陈皮为研究对象,在高温高湿(35℃、85%)环境下处理5 d,然后在低温低湿(20℃、55%)环境下处理5 d,2种环境下交替处理180 d,以室温条件(25℃、65%)为对照组,通过水分含量和水分活度分析其水分变化,通过色度值和褐变度分析其色泽变化,采用气相色谱—质谱联用法分析鉴定其挥发性成分。【结果】与对照组相比,高温高湿—低温低湿交替处理30~180 d的处理组广陈皮水分含量和水分活度显著提高(P<0.05,下同),正面的总色差值(ΔE*)极显著提高(P<0.01,下同),90~180 d褐变度显著增加。对照组和处理组共检测出80种挥发性成分,其中烯烃类28种、醛类14种、酯类12种、醇类14种、烷烃类1种、酮类5种、酚类2种和酸类4种。烯烃类和酯类化合物是广陈皮中的主要挥发性物质,相对含量分别为34.14%~57.18%和27.43%~46.62%,2组广陈皮中均以2-甲氨基-苯甲酸甲酯相对含量最高,D-柠檬烯次之。处理180 d时,处理组的酯类和酸类化合物相对含量分别显著和极显著高于对照组,醛类和酚类化合物相对含量极显著低于对照组,醇类化合物相对含量显著低于对照组,其中2-甲氨基-苯甲酸甲酯在处理组中相对含量(42.31%)高于对照组(36.49%),D-柠檬烯在处理组中相对含量(16.91%)低于对照组(18.80%)。肉豆蔻酸和γ-丝氨酸只在对照组中检出,亚油酸只在处理组中检出。【结论】高温高湿—低温低湿交替处理对广陈皮水分、色泽和挥发性成分影响显著,水分含量、水分活度和ΔE*显著提高,主要挥发性成分相对含量显著变化,在广陈皮实际仓储中可推广应用。

关键词：广陈皮温湿度水分色泽挥发性成分

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Analysis of asymmetry of the D_(α)emission spectra under the Zeeman effect in boundary region for D-D experiment on EAST tokamak

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Chinese Physics B 2021年第2期30卷 377-384页

作者： Wei Gao juan Huang Jianxun Su Jing fu Yingjie Chen Wei Gao Zhenwei wu EAST Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

In 2015 campaign,deuterium atomic emission spectra(D_(α))under the Zeeman effect in boundary region had been measured by a high resolution optical spectroscopic multichannel analysis(OSMA)system based on passive spectroscopy during the deuterium plasma discharge on EAST tokamak,and part of the works about the Zeeman effect on D_(α)spectra had already been ***,the asymmetric phenomena of D_(α)emission spectra under the Zeeman effect were observed in process of analyzing the spectral *** understand the asymmetric phenomena and acquire the useful local plasma information,an algorithm was proposed and used to analyze the asymmetry of the emission spectra under the Zeeman effect with all polarization components(πand±σ).In the algorithm,the neutral atoms were considered to follow the Maxwell distribution on EAST,and I+σ=I-σwas considered and *** of the line-averaged spectra along the viewing chord,the emission spectra were considered from two different regions:low-field side(LFS)and high-field side(HFS).Each spectral line was classified into three energy categories(the cold,warm,and hot)based on different atomic production processes in boundary *** viewing angleθ(between the magnetic field B and the viewing chord),magnetic field B at two spectral emission positions(HFS and LFS)and the Doppler shift of all three energy categories of each spectral line were all considered in the *** effect of instrument function was also included *** information of the boundary plasma were acquired,the reason for the asymmetric phenomena was discussed,and the boundary recycling during the discharge were studied in the *** on fitting a statistical data of acquired fitting results,an important conclusion was acquired that the ratio of the spectral line intensity in HFS and LFS was proportional to the square of that of the corresponding magnetic field.

关键词： Zeeman effect deuterium atom spectral lineshape plasma

Use of ^(18)F-FDG PET/CT to locate primary malignancies in patients with hepatic cirrhosis and malignant ascites

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Chinese Journal of Cancer Research 2013年第5期25卷 500-504页

作者： He-Bin Fan Ai-Jun Wang Dong-Liang Yang Jun Xiao Yun Ai Lu Huang Yong Guo Mu-Xiu Zhou juan-juan wu Zhi Li fu-Ming Yan Yi-Ming Wang Department of Infectious Diseases The People’s Liberation Army 161 Hospital Department of Radiology The People’s Liberation Army 161 Hospital Department of Infectious Diseases Union Hospital of Tongji Medical CollegeHuazhong University of Science and Technology Sanatorium for Zhaojiatiao 62101 Army for Retired Cadres Department of Pathology The People’s Liberation Army 161Hospital

Objective：Ascites in patients with hepatic cirrhosis is caused by cirrhosis in most *** most malignant ascites,the primary malignancy could be readily identified using conventional imaging methods,e.g.,computer tomography （CT） and magnetic resonance imaging （MRI）.However,in a small fraction of the patients,the primary malignancy remains occult even with these *** this retrospective study,we assessed the usefulness of 18F-FDG PET/CT in patients with hepatic cirrhosis and malignant ascites of otherwise unknown ***：Twenty-eight patients with malignant ascites of unknown primary sites after CT,MRI and ultrasound during the period of five years between January 2008 and December 2012 had received 18F-FDG PET/*** records of these patients were reviewed and ***：Elevated 18F-FDG absorption was found in 23 of 28 cases in the following sites：gastrointestinal tract （n=10,43.5％）,prostate （n=5,21.7％）,peritoneum （n=4,13.3％）,and ovary （n=4,13.3％）.Cancer was confirmed by pathology in 20 cases after open or laparoscopic *** patients were found to have benign ascites,among which,3 were found to be false positive due to *** values were significantly higher for tumors than for benign lesions （mean values,6.95 vs.2.94; P=0.005）.Conclusions：The 18F-FDG PET/CT can be as a powerful imaging tool in identifying tissue origin in liver cirrhosis patients suspected of cancers or with cancers of unknown primary sites.

关键词： PET/CT liver cirrhosis cancer, ascites

Serum Amyloid A Protein: A Potential Biomarker Correlated With Clinical Stage of Lung Cancer

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Biomedical and Environmental Sciences 2007年第1期20卷 33-40页

作者： DAN-HUI LIU XIAO-MIN WANG LI-juan ZHANG SONG-WEI DAI LI-YUN LIU JI-fu LIU SHAN-SHAN wu SHUAN-YING YANG SAM fu XUE-YUAN XIAO DA-CHENG HE Key Laboratory of Cell Proliferation and Regulation of Ministry of Education Beijing Normal University Beijing 100875 China Department of Thoracic Surgery General Hospital of Beijing Command PLA Beijing 100700 China Department of Respiratory Medicine Second Hospital of Xi＇an Jiaotong University Xi＇an 710004 Shaanxi China Ciphergen Biosystems Inc. Fremont CA 94555 USA

Objective To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis. Method Profiling analysis was performed on 450 sera collected from 213 patients with lung cancer, 19 with pneumonia, 16 with pulmonary tuberculosis, 65 with laryngeal carcinoma, 55 with laryngopharyngeal carcinoma patients, and 82 normal individuals. A new strategy was developed to identify the biomarkers on chip by trypsin pre-digestion. Results Profiling analysis demonstrated that an 11.6kDa protein was significandy elevated in lung cancer patients, compared with the control groups （P〈0.001）. The level and percentage of 11.6kDa protein progressively increased with the clinical stages Ⅰ-Ⅳ and were also higher in patients with squamous cell carcinoma than in other subtypes. This biomarker could be decreased after operation or chemotherapy. On the other hand, 11.6kDa protein was also increased in 50% benign diseases of lung and 13% of other cancer controls. After trypsin pre-digestion, a set of new peptide biomarkers was noticed to appear only in the samples containing a 11.6kDa peak. further identification showed that 2177Da was a fragment of serum amyloid A （SAA, MW 11.6kDa）. Two of the new peaks, 1550Da and 1611Da, were defined from the same protein by database searching. This result was further confirmed by partial purification of 11.6kDa protein and MS analysis. Conclusion SAA is a useful biomarker to monitor the progression of lung cancer and can directly identify some biomarkers on chip.

关键词： Lung cancer Serum amyloid A On chip identification Surface enhanced laser desorption/ionization Biomarker