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Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma

World Journal of Gastroenterology 2008年第24期14卷 3879-3883页

作者： Mansour S al-Moundhri a al-shukaili M al-Nabhani B al-Bahrani IA Burney A Rizivi SS Ganguly Medical Oncology Unit Department of MedicineCollege of Medicine and Health SciencesSultan Qaboos University Department of Microbiology and Immunology (SQU) National Cancer Institute Royal Hospital Department of Epidemiology and Medical Statistics (SQU)

AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P all stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.

关键词： Gastric cancer Serum Vascular endothelialgrowth factor Oman

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Antimicrobial and cytotoxic potential of seeds and flowers crude extracts of sunflower

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Grain & Oil Science and Technology 2019年第4期2卷 103-108页

作者： Nuzha Bint Mahdi Bin ali al-shukaili Mohammad Amzad Hossain College of Pharmacy and Nursing University of Nizwa

Oil-producing crops,including Helianthus annuus L.(***,Sunflower),have been used for the treatment of different human diseases since ancient *** study aims to determine the antimicrobial and cytotoxic potential of different polarities of seeds and flower extracts of locally grown *** by well-established *** achieve the objects,the plant extracts were prepared from both flowers and seeds powder samples individually with methanol solvent by using a Soxhlet extraction *** antimicrobial and cytotoxic potential of the flowers and seed extracts were determined by the in vitro diffusion and brine shrimp method(BSL).The results of the antimicrobial potential of both prepared flower and seed extracts of various polarities at different concentrations showed promising potential against the gram-positive and gram-negative bacterial strains,within the range of inhibition zone 0–20 *** the flower extracts,the highest potential was obtained in water extract and the lowest potential was in butanol extract followed by water>ethyl acetate>hexane>methanol>chloroform>butanol ***,from the seed extracts,the highest potential was obtained in water extract and the lowest potential was in the methanol extract followed by water>hexane>butanol>ethyl acetate>chloroform>methanol *** the other hand,the results of cytotoxicity among the flowers extracts against the brine shrimp method where the highest LC50 against brine shrimp nauplii were found to be 31.25μg/mL in water extract and the lowest LC50 was 1345.86μg/mL in chloroform extract followed by water>ethyl acetate>hexane>butanol>methanol>chloroform ***,different polarities of seed extracts,the highest LC50 against brine shrimp nauplii was shown to be 109.56μg/mL in butanol extract and the lowest LC50 was 1513.56μg/mL in ethyl acetate extract followed by butanol>hexane>water>methanol>chloroform>ethyl acetate *** conclusion,the results showed that both flowers and s

关键词： Helianthus annuus Sunflower Antimicrobial potential Cytotoxic potential Agar gel diffusion method BSL method

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