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International Journal of Modeling, simulation, and scientific Computing 2020年第5期11卷 226-236页

作者： A.V.sedelnikov E.s.Khnyryova samara National Research University 34Moskowskoe ShosseSamara 443086Russia

This paper gives an interpretation of the quasispecies concept for an experiment of growing the Lymantria dispar artificial *** changes estimate in the population parameters for a significant change in environmental conditions at the stage of hatching caterpillars from the eggs was *** numerical and two random parameters were used for quantitative *** characterize the development of individuals of the population at this *** parameter changes significance was verified with using statistical *** results obtained do not contradict the quasispecies *** use of fuzzy sets describes the transition from one quasispecies to another at a significant change in environmental conditions.

关键词： Quasispecies evolution Lymantria dispar artificial population population development parameters fuzzy sets

strongα-cut and associated membership-based modeling for fuzzy time series forecasting

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International Journal of Modeling, simulation, and scientific Computing 2021年第1期12卷 53-72页

作者： Gunjan Goyal Dinesh C.s.Bisht Department of Mathematics Jaypee Institute of Information Technology NoidaIndia

In this paper,a method is proposed to deal with factors affecting the fuzzy time series forecasting.A new fuzzification process is used by considering all the fuzzy sets with nonzero membership values corresponding to the data points.A strong alpha-cut based method is presented to select appropriate fuzzy logical relationships that carry importance in analyzing the trend of time ***,a unique defuzzification approach based on weights is proposed to get crisp *** obtained variation is finally converted to the forecasted *** presented method is tested on the benchmark enrolment dataset of Alabama University and seven datasets of the Taiwan Capitalization Weighted stock *** comparing the results,it is observed that the presented method performs better than the existing ***,the statistical measures indicate the good forecasting results of the presented method.

关键词： Associated membership grade forecasting fuzzy logical relationship fuzzy time series strongα-cut

Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens

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World Journal of Gastroenterology 2018年第48期24卷 5418-5432页

作者： sandra Wagner Christina s Mullins Michael Linnebacher section of Molecular Oncology and Immunotherapy General SurgeryUniversity Medical Center

Therapeutic options for the treatment of colorectal cancer(CRC) are diverse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. substantial improvement in treatment outcome could be achieved by development of efficient patient-individual CRC vaccination strategies. This mini-review summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a variety of clinical studies examined the efficacy of different TAA-derived peptide vaccines. Combinations of several TAAs as the next step and the development of personalized TAA-based peptide vaccines are discussed. Improvements of peptidebased vaccines achievable by adjuvants and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusively neoantigens-which revealed promising results; particularly no severe adverse events were reported so far. Critical progress for clinical outcomes can be expected by individualizing neoantigen-based peptide vaccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest developments, truly personalized neoantigen-based peptide vaccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC.

关键词： Cancer vaccines Colorectal neoplasm Immunotherapy Neoplasm antigen tumor-associated antigens tumor-specific antigens Neoantigen(s)

Classifying Machine Learning Features Extracted from Vibration signal with Logistic Model Tree to Monitor Automobile Tyre Pressure

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structural Durability & Health Monitoring 2017年第2期11卷 191-208页

作者： P.s.Anoop V.sugumaran school of Mechanical and Building sciences(sMBs) Vellore Institute of Technology Chennai campusChennaiIndia

Tyre pressure monitoring system(TPMs)is compulsory in most countries like the United states and European *** existing systems depend on pressure sensors strapped on the tyre or on wheel speed sensor data.A difference in wheel speed would trigger an alarm based on the algorithm *** this paper,machine learning approach is proposed as a new method to monitor tyre pressure by extracting the vertical vibrations from a wheel hub of a moving vehicle using an *** obtained signals will be used to compute through statistical features and histogram features for the feature extraction *** LMT(Logistic Model Tree)was used as the classifier and attained a classification accuracy of 92.5%with 10-fold cross validation for statistical features and 90.5% with 10-fold cross validation for histogram *** proposed model can be used for monitoring the automobile tyre pressure successfully.

关键词： Machine learning Vibration accelerometer statistical Features Histogram Features Logistic model tree(LMT) Tyre pressure monitoring system

Einstein’s General Relativity and Pure Gravity in a Cosserat and De sitter-Witten spacetime setting as the Explanation of Dark Energy and Cosmic Accelerated Expansion

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International Journal of Astronomy and Astrophysics 2014年第2期4卷 332-339页

作者： Mohamed s. El Naschie Department of Physics University of Alexandria Alexandria Egypt

Ordinary energy and dark energy density are determined using a Cosserat-Cartan and killing-Yano reinterpretation of Einstein’s special and general relativity. Thus starting from a maximally symmetric space with 528 killing vector fields corresponding to Witten’s five Branes model in eleven dimensional M-theory we reason that 504 of the 528 are essentially the components of the relevant killing-Yano tensor. In turn this tensor is related to hidden symmetries and torsional coupled stresses of the Cosserat micro-polar space as well as the Einstein-Cartan connection. Proceeding in this way the dark energy density is found to be that of Einstein’s maximal energy mc2 where m is the mass and c is the speed of light multiplied with a Lorentz factor equal to the ratio of the 504 killing-Yano tensor and the 528 states maximally symmetric space. Thus we have E (dark) = mc2 (504/528) = mc2 (21/22) which is about 95.5% of the total maximal energy density in astounding agreement with COBE, WMAP and Planck cosmological measurements as well as the type 1a supernova analysis. Finally theory and results are validated via a related theory based on the degrees of freedom of pure gravity, the theory of nonlocal elasticity as well as ‘t Hooft-Veltman renormalization method.

关键词： General Relativity Cosserat Micro-Polar space Dark Energy Teleparellelism Witten’s M-Theory De sitter spacetime Killing-Yano Tensor Einstein-Cartan Relativity Pure Gravity Kaluza-Klein Theory Nonlocal Elasticity 't Hooft-Veltman Renormalization

Bioactive compounds in banana fruits and their health benefits

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Food Quality and safety 2018年第4期2卷 183-188页

作者： Jiwan s.sidhu Tasleem A.Zafar Department of Food science&Technology College of Life SciencesKuwait University13060-SafatKuwait

Banana is an edible fruit and is herbaceous flowering plant belonging to the genus Musa and the family *** is also eaten as cooked vegetable(and is then called plantains).All the edible banana fruits are seedless(parthenocarpic)and belong to two main species,Musa acuminata Colla and Musa balbisiana *** hybrid from these two species Musa x paradisiaca *** also available *** banana is native to Indomalaya and Australia,Papua New Guinea was the first to domesticate this *** has now spread to almost 135 countries around the *** per 2016 data,nearly 28 per cent of the total world’s banana production comes from India and *** group banana,being the main export item from the banana-exporting countries,usually refers to soft,sweet,and dessert banana in the Western countries,but the plantain bananas have firm,starchy fruit which is suitable for cooking as a *** is known to be rich not only in carbohydrates,dietary fibres,certain vitamins and minerals,but is also rich in many health-promoting bioactive *** composition including various bioactives and their health contributions has been reviewed in this paper.

关键词： banana fruit nutritional value phytochemicals bioactives phenolics biogenic amines.

A unified approximate reasoning theory suitable for both propositional calculus system L and predicate calculus system K

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science in China(series F) 2005年第1期48卷 1-14页

作者： WANGGuojun CHINK.s DANGC.Y. DepartmentofManufacturingEngineeringandEngineeringManagement CityUniversityofHongKongHongKongChina InstituteofMathematics ShaanxiNormalUniversityXi'an710062China//ResearchCenterforScienceXi'anJiaotongUniversityXi'an710049China

The concepts of metric R0-algebra and Hilbert cube of type RO are introduced. A unified approximate reasoning theory in propositional caculus system ? and predicate calculus system (?) is established semantically as w... 详细信息

关键词： metric R0-algebra Hilbert cube of type R0 metric Lindenbaum algebra of type R0 approximate reasoning complete theorem.

COUPLED VIBRATION OF sTRUCTURAL THIN-WALLED COREs

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Acta Mechanica solida sinica 2000年第1期13卷 81-88页

作者： shiu Cho NG J.s.Kuang Department of Civil Engineering Hong Kong University of Science and Technology

This paper presents an analysis of the coupled vibration of asymmetric core structures in tall buildings. The governing equation of free vibration and its corresponding eigenvalue problem, which is a set of equations for laterally flexural vibrations in two different directions coupled by a warping-st. Venant torsional vibration, are derived. Based on the Calerkin method, a generalized approximate method is developed for the analysis of coupled vibration and thus proposed for determining the natural frequencies and mode shapes of the structure in triply-coupled vibration. The results of the proposed method for the example structure show good agreement with those of the FEM analysis. The proposed method has been shown to provide a simple and rapid, yet accurate, means for coupled vibration analysis of core structures.

关键词： coupled vibration analysis asymmetric core structure Galerkin method natural frequency mode shape

Construction of Bode Envelopes Using REP Based Range Finding Algorithms

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International Journal of Automation and computing 2011年第1期8卷 112-121页

作者： P.s.V.Nataraj shanta sondur IDP in systems and Control Engineering Indian Institute of Technology Bombay Vivekanand Education society's Institute of Technology

The frequency domain analysis of systems is an important topic in control theory. Powerful graphical tools exist in classic control, such as the Nyquist plot, Bode plots, and Nichols chart. These methods have been widely used to evaluate the frequency domain behavior of system. A literature survey shows that various approaches are available for the computation of the frequency response of control systems under different types of parametric dependencies, such as affine, multi-linear, polynomial, etc. However, there is a lack of tools in the literature to construct the Bode envelopes for the general nonlinear type of parametric dependencies. In this paper, we address the problem of computation of the envelope of Bode frequency response of a non-rational transfer function with nonlinear parametric uncertainties varying over a box. We propose two techniques to compute the Bode envelopes：first, based on the natural interval extensions （NIE） combined with uniform subdivision and second, based on the existing Taylor model combined with subdivision strategy. We also propose the algorithms to further speed up both methods through extrapolation techniques.

关键词： Bode envelope asymptotic expansion extrapolation methods rep interval analysis approximation technique.

Multiple Extreme Learning Machines Based Arrival Time Prediction for Public Bus Transport

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Intelligent Automation & soft Computing 2023年第6期36卷 2819-2834页

作者： J.Jalaney R.s.Ganesh Department of Electronics and Communication Engineering Noorul Islam Centre for Higher EducationKumaracoil629180TamilnaduIndia Department of Electronics and Communication Engineering R.M.K.Engineering CollegeChennai601206Tamil NaduIndia

Due to fast-growing urbanization,the traffic management system becomes a crucial problem owing to the rapid growth in the number of vehicles The research proposes an Intelligent public transportation system where informa-tion regarding all the buses connecting in a city will be gathered,processed and accurate bus arrival time prediction will be presented to the *** linear and time-varying parameters such as distance,waiting time at stops,red signal duration at a traffic signal,traffic density,turning density,rush hours,weather conditions,number of passengers on the bus,type of day,road type,average vehi-cle speed limit,current vehicle speed affecting traffic are used for the *** proposed model exploits the feasibility and applicability of ELM in the travel time forecasting *** ELMs(MELM)for explicitly training dynamic,road and trajectory information are used in the proposed approach.A large-scale dataset(historical data)obtained from Kerala state Road Transport Corporation is used for *** are carried out by using MATLAB *** experiments revealed that the efficiency of MELM is independent of the time of day and day of the *** can manage huge volumes of data with less human intervention at greater learning *** is found MELM yields prediction with accuracy in the range of 96.7%to 99.08%.The MAE value is between 0.28 to 1.74 minutes with the proposed *** study revealed that there could be regularity in bus usage and daily bus rides are predictable with a better degree of *** research has proved that MELM is superior for arrival time pre-dictions in terms of accuracy and error,compared with other approaches.

关键词： Arrival time prediction public transportation extreme learning machine traffic density