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World Journal of Hepatology 2012年第12期4卷 402-405页

作者： Aloysious Aravinthan William Gelso Anita Limbu Rebecca Brais paul richardson Department of Hepatology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom Department of Hepatology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom n Department of Histopathology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom Department of Hepatology The Royal Liverpool and Broadgreen University Hospitals NHS TrustLiverpool L7 8XPUnited Kingdom

Hepatic sarcoidosis is usually asymptomatic but rarely leads to adverse liver-related ***-existence of viral hepatitis and hepatic sarcoidosis is a rare,but recognised *** a balance between immune suppression and anti-viral therapy may be *** in the presence of viral hepatitis can lead to rapid deterioration of liver ***,anti-viral therapy may exacerbate granulomatous *** we present two cases of viral hepatitis co-existing with sarcoidosis that illustrate successful management *** one,hepatitis B replication was suppressed with oral antiviral therapy before commencing *** the second,remission of hepatic sarcoidosis was achieved with prednisolone,before treating hepatitis C and obtaining a sustained virological response with pegylated interferon and ribavirin therapy.

关键词： Hepatic sarcoidosis Chronic hepatitis C infection Chronic hepatitis B infection Immune suppression Anti-viral therapy

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青藏高原东缘北川和彭灌断层的活动构造

世界地震译丛 2008年第2期39卷 1-22页

作者： A. L. Densmore M. A. Ellis G. S. Hancock N. richardson 王金艳中国地震局地壳应力研究所

青藏高原东缘地区地形陡峭、起伏大,经历了新生代的快速冷却和剥蚀,却没有显示出该前陆盆地产生过大量级地壳缩短或调解过程的证据。我们通过应用各种地貌观测结果对平行于该高原边缘的几条大断层的运动和滑动速率进行约束,来论述这一... 详细信息

青藏高原东缘地区地形陡峭、起伏大,经历了新生代的快速冷却和剥蚀,却没有显示出该前陆盆地产生过大量级地壳缩短或调解过程的证据。我们通过应用各种地貌观测结果对平行于该高原边缘的几条大断层的运动和滑动速率进行约束,来论述这一矛盾。北川和彭灌断层主要是右旋滑动的活动构造,沿该高原边缘可连续追踪达200km。这两条断层都断错了河流填充阶地,得到的宇宙成因核素10Be经继承校正后,暴露物的年龄少于15ka,说明了晚更新世的活动。彭灌断层沿走向的两个地点在全新世看来活动过。两条断层晚第四纪的视下落速率沿走向是变化的,但一般都小于1mm/a。走滑位移的速率很可能要高出几倍,可能约为1～10mm/a,但仍旧约束不好。四川盆地西缘特别是山前带,在晚第四纪也发生了褶皱和右旋走滑活动。这些观测证明了该高原东缘形成和保持的模式,没有发生大的上地壳缩短。这些也表明,与青藏高原东缘平行的断层的活动可能预示着人口密集的四川盆地存在很大的地震危险性。

关键词：活动构造龙门山冲积扇四川盆地西部断层崖晚第四纪北川断层断层作用青藏高原东缘晚新生代

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远去的胜利

pNpLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响

作者： (英)威廉·理查德森(William richardson) (英)西摩·弗雷德林(Seymour Freidlin)

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临床肝胆病杂志 2020年第10期36卷 2278-2278页

作者：朱倩牛俊奇 GELLERT-KRISTENSEN H richardson TG DAVEY SMITH G 吉林大学第一医院感染病中心肝病科不详

【据Hepatology 2020年3月报道】pNpLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响(作者Gellert-Kristensen H等)作者假设脂肪肝的遗传风险评分(GRS)可影响肝硬化和肝细胞癌(HCC)的患病风险。来自丹麦的Gellert... 详细信息

【据Hepatology 2020年3月报道】pNpLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响(作者Gellert-Kristensen H等)作者假设脂肪肝的遗传风险评分(GRS)可影响肝硬化和肝细胞癌(HCC)的患病风险。来自丹麦的Gellert-Kristensen等将3种遗传变异[含patatin样磷脂酶结构域蛋白3(pNpLA3)p.I148M;跨膜6,超家族成员2(TM6SF2)p.E167K;以及羟基类固醇17-β脱氢酶13(HSD17B13)rs72613567]组成危险因素评分(等位基因为0到6个).

关键词：患病风险普通人群变异体肝硬化磷脂酶脂肪肝肝癌类固醇

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贝沙罗汀对皮肤T细胞淋巴瘤的生物效应

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 36-37页

作者： Budgin J.B. richardson S.K. Newton S.B. 罗素菊冯义国 Ryan Veterinary Hospital University of Pennsylvania 3900 Delancey St Philadelphia PA 19104 United States Dr.

Objective: To determine the effects of bexarotene on malignant T cells isolated from the peripheral blood of patients with the leukemic variant of cutaneous T-cell lymphoma (Sé zary syndrome).Design, Setting, and participants: peripheral blood mononuclear cells from 9 patients with Sé zary syndrome and a high burden of circulating malignant T cells (>50% of peripheral blood mononuclear cells) and 6 healthy volunteers underwent evaluation at a university medical center, to test the effects of bexarotene on T cells. Main Outcome Measures: The capacity of bexarotene to induce apoptosis and its effects on T-cell cytokine production from peripheral blood lymphocytes isolated from patients with Sé zary syndrome. Results: Bexarotene produced dose-dependent apoptosis of peripheral blood T cells from patients with Sé zary syndrome. The T cells from approximately two thirds of patients were consistently sensitive to bexarotene, whereas those from the remaining one third of patients were consistently resistant to the apoptotic effects of bexarotene. Bexarotene inhibited mitogen-induced interleukin 4 production by the peripheral blood cells of patients with Sé zary syndrome, and this effect correlated with sensitivity of patients’ cells to apoptosis. In contrast to the retinoic acid receptor-specific retinoid, all-trans retinoic acid, bexarotene does not induce the augmentation of interferon γ production. Conclusions: Bexarotene induces apoptosis of malignant T cells from patients with Sé zary syndrome, but the cells from a proportion of patients are resistant to the apoptotic effects. Interleukin 4 production, which can play a role in the systemic immunosuppression that characterizes advancing Sé zary syndrome, may be inhibited by bexarotene.

关键词：生物效应淋巴瘤全反式维甲酸全身免疫大学医学中心 γ-干扰素类维生素特异性中起

舒马曲坦鼻腔喷雾治疗青少年偏头痛的长时程耐受性

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 25-26页

作者： Natarajan S. Jabbour J.T. Webster C.J. richardson M.S. 王英鹏 GlaxoSmithKline Research Triangle Park NC United States

Objective. - This 1- year, open- label, multicenter study was designed to assess the long- term tolerability and efficacy of sumatriptan nasal spray 20 mg in adolescent patients with migraine. Methods. - A prospective, multicenter, open- label study was conducted in patients aged 12 to 17 years who were allowed to treat an unlimited number of migraines at severe, moderate, or mild pain intensity with sumatriptan nasal spray for up to 1 year. All patients started the study at the 20- mg dose of sumatriptan nasal spray. Dose could be adjusted downward to 5 mg at the discretion of the investigator to optimize therapy. Results. - A total of 484 adolescent migraineurs treated 4676 migraines with sumatriptan nasal spray 20 mg (3593 during the first 6 months and 1083 during the second 6 months). A total of 3940 migraines and 699 migraines were treated with one and two 20- mg doses of sumatriptan nasal spray, respectively. Only 10 patients (treating 42 migraines) took the 5- mg dose of sumatriptan nasal spray. The overall percentage of migraines treated with either one 20- mg dose or one, two, or three 20- mg doses with at least 1 drug- related adverse event was 19% . The most common specific drug- related adverse event was unpleasant taste, reported in 17% of migraines. No other single drug- related adverse event was reported in more than 1% of migraines over the 1- year treatment period. When unpleasant taste was excluded from the adverse- event tabulations, the percentages of migraines with at least 1 drug- related adverse event after one or one, two, or three 20- mg doses declined to 4% and 3% , respectively. No patient experienced any drug- related changes in 12- lead ECGs, vital signs, or nasal assessments; and no clinically meaningful changes in clinical laboratory values were observed. Across all migraines with evaluable efficacy data (n = 4334), headache relief was reported in 43% of migraines at 1 hour and in 59% at 2 hours after dosing with sumatriptan nasal spra

关键词：头痛发作味觉感知舒马曲坦头痛程度功能评定生命征象数量限制

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机械有机器官

科技创业 2013年第9期 82-84页

作者：苏珊.杨肯.理查森

普林斯顿的科学家用3D打印机制造出了整合了电子元件的仿生耳。

关键词：器官机械电子元件普林斯顿打印机

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猪细小病毒疫苗的效力试验

贵州畜牧兽医 1997年第4期21卷 41-43页

作者： K.R.Edwards M.A.Emmerson p.R.Luff D.E.Wells J.C.Muskett.A.E.Wrtahall C.richardson B.N.J.parker D.H.Thornton 陈眷华

本次研究旨在调查和比较3种不同疫苗所提供的避免胎儿死亡的保护力,其中两种疫苗采用3个不同的剂量接种,以期能够获得不同的保护水平,以半数保护剂量(pD_(50))表示,由此获得的数据可以对其它疫苗作出评价。同时,对在已建立的细胞系上增... 详细信息

本次研究旨在调查和比较3种不同疫苗所提供的避免胎儿死亡的保护力,其中两种疫苗采用3个不同的剂量接种,以期能够获得不同的保护水平,以半数保护剂量(pD_(50))表示,由此获得的数据可以对其它疫苗作出评价。同时,对在已建立的细胞系上增殖病毒。

关键词：猪病细小病毒病疫苗免疫接种

The formation of autophagosomes at ER-pM contact sites in concert with the actin cytoskeleton and the endocytic machinery

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The formation of autophagosomes at ER-PM contact sites in co...