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Dental pulp stem cells and BonelikeVR for bone regeneration in ovine model

Regenerative Biomaterials 2019年第1期6卷 49-59页

作者： J.m.Campos A.C.Sousa A.R.Caseiro S.S.Pedrosa P.O.Pinto m.V.Branquinho I.Amorim J.D.Santos T.Pereira C.m.mendonca A.Afonso L.m.Atayde A.C.maurı´cio Departamento de Clı´nicas Veterina´rias Instituto de Cieˆncias Biome´dicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreirano 2284050-313 PortoPortugal Centro de Estudos de Cieˆncia Animal(CECA) Instituto de CieˆnciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IIApartado 551424051-401 PortoPortugal Escola Universita´ria Vasco da Gama(EUVG) Hospital Veterina´rio Universita´rio de Coimbra(HVUC)Campo Universita´rio–Bloco BLordem~aoCoimbraPortugal REQuimTE/LAQV–U.Porto–Porto/Portugal Departamento de Engenharia Metalu´rgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRuaDr.Roberto Friass/n4200-465 PortoPortugal Faculdade de Engenharia da Universidade do Porto(FEUP) Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Pathology and molecular Immunology of the Institute of Biomedical Sciences Abel Salazar(ICBAS) University of Porto4050-313 PortoPortugal Institute for Research and Innovation in Health (i3S)University of PortoPortoPortugal Institute of molecular Pathology and Immunology of the University of Porto(IPATImUP) 4200-135 PortoPortugal Faculdade de medicina Denta´ria da Universidade do Porto(FmDUP) 4200-393 PortoPortugal

Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone *** an ovine model,the present pre-clinical study presents a synthetic bone graft(BonelikeVR)in combination with a cellular system as an alternative for the regeneration of non-critical *** association of biomaterials and cell-based therapies is a promising strategy for bone tissue *** stem cells(mSCs)from human dental pulp have demonstrated both in vitro and in vivo to interact with diverse biomaterial systems and promote mineral deposition,aiming at the reconstruction of osseous ***,these cells can be found and isolated from many ***-critical bone defects were treated with BonelikeVR with or without mSCs obtained from the human dental *** showed that BonelikeVR and mSCs treated defects showed improved bone regeneration compared with the defects treated with BonelikeVR ***,it was observed that the biomaterial matrix was reabsorbed and gradually replaced by new bone during the healing *** therefore propose this combination as an efficient binomial strategy that promotes bone growth and vascularization in non-critical bone defects.

关键词： biomaterial BonelikeVR bone regeneration,dental pulp human bone hydroxyapatite mesenchymal stem cells ovine model tissue regeneration tricalcium phosphate

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Superiority of Prothrombin Complex Concentrate versus Frozen Fresh Plasma in Cardiology Patients with Warfarin Intoxication–Observational Study

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Open Journal of Emergency medicine 2017年第2期5卷 75-84页

作者： Alexandre de matos Soeiro maria Cristina César Bruno Biselli Aline Siqueira Bossa T. de Carvalho Andreucci Torres Leal maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Ludhmila Abraã o Hajjar múcio Tavares Oliveira Emergency Unit–Heart Institute–University of Sã o Paulo medical School S&atilde o Paulo Brazil

Objective: The objective of this study was to analyse the reversibility of the anticoagulant effect of warfarin by comparing prothrombin complex concentrate (PCC) versus frozen fresh plasma (FFP) in cardiology patients with serious warfarin intoxication. methods: This was an observational and retrospective study comprising 67 patients (18 in group I [PCC] and 49 in group II [FFP]). The primary endpoint was the reversal of anticoagulant effect of warfarin after 2 and 24 hours of PCC or FFP administration. Comparisons between the groups were made using T-test and Q-square. multivariate analyses were conducted using logistic regression, and the results were considered significant when p Results: The medium dose used was 27.6 ui/kg of PCC and 14.5 ml/kg of FFP. Significant differences were observed between groups I and II in the INR reversibility measurements after 2 hours (33.3% vs. 6.1%, p = 0.001) and 24 hours (38.9% vs. 12.2%, p = 0.009) as well as in the occurrence of pulmonary edema (5.6% vs. 42.9%, OR = 11.10, p = 0.04). The AUC for PCC was 0.891 (CI 95% [0.72 - 1.0]), and for FFP, it was 0.291 (CI 95% [0.09 - 0.49]). Conclusions: PCC is better than FFP treatment in reversing the warfarin intoxication after 2 and 24 hours of administration. Furthermore, PCC showed lower pulmonary edema in cardiology patients.

关键词： Intoxication Warfarin Fresh Frozen Plasma Prothrombin Complex Concentrate

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Pre-treatment prediction of response to peginterferon plus ribavirin in chronic hepatitis C genotype 3

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World Journal of Hepatology 2015年第4期7卷 703-709页

作者： Sebastian marciano Silvia m Borzi melisa Dirchwolf Ezequiel Ridruejo manuel mendizabal Fernando Bessone maria E Sirotinsky Diego H Giunta Julieta Trinks Pablo A Olivera Omar A Galdame marcelo O Silva Hugo A Fainboim Adrian C Gadano Liver Unit Hospital Italiano de Buenos Aires Hepatology Section Hospital R. Rossi La Plata Buenos Aires Argentina Liver Infectious Disease Unit Hospital F.J Muniz Uspallata 2272 Buenos Aires Argentina Hepatology Section Department of Medicine Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Avenida Galvan 4102 Buenos Aires Argentina Hepatology and Liver Transplant Unit Hospital Universitario Austral Hepatology Unit Sanatorio del Parque Rosario Argentina HEPATOSUR group Comodoro Rivadavia Chubut Argentina Internal medicine Research Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina Basic Science and Experimental medicine Institute Hospital Italiano de Buenos Aires Internal medicine Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Buenos Aires Argentina

AIm: To evaluate pre-treatment factors associated with sustained virological response(SVR) in patients with hepatitis C virus(HCV) genotype 3 treated with peginterferon and ribavirin(RBV). mETHODS: We retrospectively analyzed treatment naive, mono-infected HCV genotype 3 patients treated with peginterferon and RBV. Exclusion criteria included presence of other liver disease, alcohol consumption and African American or Asian ethnicity. The variables collected and compared between patients who achieved an SVR and patients who did not were as follows: gender, age, fibrosis stage, diabetes, body mass index,steatosis, INFL3 polymorphism, pre-treatment HCVRNA, type of peginterferon, RBV dose and adherence. RESULTS: A total of 107 patients treated between June, 2004 and march, 2013 were included. mean treatment duration was 25.1(± 1.8) wk. Overall, 58%(62/107) of the patients achieved an SVR and 42%(45/107) did not. In the multivariate logistic regression analysis, pre-treatment HCV-RNA ≥ 600000 ui/m L(OR = 0.375, 95%CI: 0.153-0.919, P = 0.032) and advanced fibrosis(OR = 0.278, 95%CI: 0.113-0.684,P = 0.005) were significantly associated with low SVR rates. In patients with pre-treatment HCV-RNA ≥600000 ui/m L and advanced fibrosis, the probability of achieving an SVR was 29%(95%CI: 13.1-45.2).In patients with pre-treatment HCV-RNA ui/m L and mild to moderate fibrosis, the probability of achieving an SVR was 81%(95%CI: 68.8-93.4).CONCLUSION: In patients with HCV genotype 3infections the presence of advance fibrosis and high pre-treatment viral load might be associated with poor response to peginterferon plus RBV. These patients could benefit the most from new direct antiviral agentsbased regimes.

关键词： Sustained virological response Direct antiviral agents Sofosbuvir Cirrhosis Viral load

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慢性高肌酸激酶症对于临床正常人群的诊断价值

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 60-60页

作者： Fernandez C. De Paula A.m. Figarella- Branger D. J.- F. Pellissier 朱振中 Laboratoire D' Anatomie Pathologique et Neuropathologie Hpitalde la Timone 264 rue Saint- Pierre 13385 Marseille Cedex 05 France Dr.

The authors analyzed muscle biopsy specimens of 104 patients with creatine kinase activity greater than 500 ui/L (normal 10 to 170 ui/L) without signs of muscle weakness. They achieved a definite or probable diagnosis in 55% of cases. The most frequently identified diseases were glycogen storage diseases, muscular dystrophies, and inflammatory myopathies. The probability of making a diagnosis was higher in children and when creatine kinase level was greater than 2,000 ui/L.

关键词：肌酸激酶丙酮酸激酶患者

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CT监控睾丸癌病人辐射诱发癌风险评估的误区:时间悖论

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国际医学放射学杂志 2013年第3期 269-269页

作者： P.V.Pandharipande J.D.Eisenberg R.J.Lee m.E.Gilmore E.A.Tu-ran S.Singh 张业坡 massachusetts General Hospital Institute for Technology Assessment

目的阐明在睾丸癌监测过程中终生辐射诱发癌风险评估的局限性,尤其是没有考虑辐射诱发癌的发生时间滞后于病人的生命周期。材料与方法本研究中CT辐射剂量测定数据的使用得到伦理委员会的批准,无须知情同意书,符合HIPAA。建立一个马尔科... 详细信息

目的阐明在睾丸癌监测过程中终生辐射诱发癌风险评估的局限性,尤其是没有考虑辐射诱发癌的发生时间滞后于病人的生命周期。材料与方法本研究中CT辐射剂量测定数据的使用得到伦理委员会的批准,无须知情同意书,符合HIPAA。建立一个马尔科夫模型来评估睾丸癌病人睾丸切除术后10年中CT监测的预后。早期风险与滞后风险效应的定量化,睾丸癌病人预期减寿及生命死亡率风险与CT辐射诱发癌症相关风险的比较。不同于终生风险评估,预期减寿的推测涵盖了整个生命周期的时间风险,这使得终生风险评估的局限性得以显现。马氏链蒙特卡罗方法被用来评估结果的不确定性。结果以33岁精原细胞瘤Ⅰ期病人进行CT监测为例,睾丸癌生命死亡率风险[5.98×10-3;95%不确定区间(ui):302～894]仅稍高于辐射诱导癌风险(5.05×10-3;95%ui:280～730)。但是,归因于睾丸癌的预期减寿(83d;95%ui:42～124)比辐射诱导癌(24d;95%ui:13～35)大3倍。模拟情景的趋势是一致的。结论在做决策时,相对于短期的健康风险,终生辐射风险的评估可能过于强调了辐射诱发癌的风险。

关键词：睾丸癌风险评估辐射诱导病人 CT

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