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Peripapillary and macular vascular densities in healthy,ocular hypertensive,and different stages of glaucomatous eyes

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2018-2026页

作者： Caner Ozturk Sirel Gur gungor Umit Eksioglu Almila Sarıgul Sezenoz Meric Colak Comparison of vascular densities in glaucoma patients 1Department of Ophthalmology Minister of Health Hitit University Erol Olcok Education and Research HospitalCorum 19030Turkey Department of Ophthalmology Baskent UniversityFaculty of MedicineAnkara 06170Turkey Department of Biostatistics Baskent UniversityFaculty of MedicineAnkara 06300Turkey

AIM:To investigate vascular changes in different stages of glaucoma and to evaluate the role of optical coherence tomography angiography(OCTA)in the early diagnosis of ***:Glaucoma patients and healthy controls(n=29 eyes)were investigated in this cross-sectional comparative *** patients were grouped as ocular hypertension(n=44 eyes),preperimetric glaucoma(PPG;n=32 eyes),early glaucoma(EG;n=35 eyes),moderate stage glaucoma(MG;n=36 eyes),and advanced glaucoma(AG;n=35 eyes).Peripapillary and macular vascular densities(VDs)of all participants were compared and correlations of VDs and retinal nerve fiber layer thickness(RNFLT),ganglion cell analysis(GCA),and visual field(VF)tests were *** under the receiver operation characteristic curves(AUC)of the peripapillary and macular VD parameters were ***:VD values decreased with the progression of *** peripapillary and macular VD parameters of PPG and EG groups were lower than healthy controls(P<0.001).There was no significant difference in RNFLT between the PPG and EG groups,but most peripapillary and macular VDs were found to be lower in EG group than in PPG group(P<0.05).In most disease group,VDs were significantly correlated with OCT parameters(P<0.001)and VF index(P<0.05).There were no significant correlations between VF and RNFLT indices in the AG group,but significant correlations were found between VF and VD values(P<0.05).AUC for discriminating between healthy and glaucomatous eyes were highest in whole image peripapillary VD(AUC:0.865,0.929,and 0.986,respectively in EG,MG,and AG groups).CONCLUSION:OCTA can be used in the early diagnosis of glaucoma and can be useful in follow-up of the advanced *** cases where limitations or suspicions in structural and functional tests are present,OCTA can be used as a supportive diagnostic test,both in EG and AG.

关键词： glaucoma optical coherence tomography angiography vascular density early diagnosis

Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2013年第4期10卷 310-316页

作者： Ahmet Ekmekci Mahmut Uluganyan Fatif Tufan Huseyin Uyarel Gurkan Karaca Seref Kul Barl(s) gungor Department of Cardiology Dr.Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital Tibbiye Caddesi 34000 Istanbul Turkey Department of Cardiology Kadirli State Hospital Toki Caddesi 8075 Osmaniye Turkey Department of Geriatric Istanbul University Medical Hospital Vatan Cadddessi 34000 Istanbul Turkey Department of Cardiology Bezmialem Vakif University Medical Hospital Vatan Caddesi 34000 Istanbul Turkey

OBJECTIVE:Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events。 We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients >65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction。 METHODS:We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 ±5.4)。 Patients were divided into two groups according to admission blood glucose levels。 Group : low glucose group (LLG), glucose 168 mg/dL。 RESULTS:In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P 1, post-thrombolysis in MI <3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P <0.001)。 CONCLUSIONS:Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality。

关键词： Admission hyperglycemia Elderly patients In-hospital mortality Long-term mortality Major adverse cardiac events

Effect of 0.05% topical cyclosporine for the treatment of symptomatic subepithelial infiltrates due to adenoviral keratoconjunctivitis

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 634-635页

作者： Ilkay Kilic Muftuoglu Yonca A.Akova Sirel G.gungor Department of Ophthalmology Istanbul Training and Research Hospital Department of Ophthalmology Bayindir Kavaklidere Hospital Department of Ophthalmology Baskent University

Dear Sir,Iam Yonca ***,MD-from the Department of Ophthalmology,Bayindir Kavaklidere Hospital,Turkey.I wrote this letter to evaluate the efficacy of 0.05%topical cyclosporine A（CsA）eye drops（Restasis Allergan,Irvine,USA）in symptomatic patients with recurrent subepithelial infiltrates（SEIs）due to adenoviral keratoconjunctivitis following steroid eye drops tapering or discontinuation.

关键词： subepithelial Effect of 0.05 cyclosporine symptomatic steroid letter Irvine drops recurrence corneal

Atherogenic indices in non-arteritic ischemic optic neuropathy

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1041-1046页

作者： Nurullah Kocak Volkan Yeter Mustafa Turunc Merve Bayrambas Bilge Eraydın inci gungor Department of Ophthalmology Ondokuzmayıs University HospitalAtakum 55200SamsunTurkey Department of Ophthalmology CankırıState HospitalCankırı18100Turkey Department of Ophthalmology Erbaa State HospitalTokat 60500Turkey

AIM:To evaluate the atherogenic indices and the relationship with visual acuity and bilateral sequential involvement in patients with non-arteritic ischemic optic neuropathy(NAION).METHODS:A total of 65 patients with NAION and 48 age-sex matched healthy individuals were included in this retrospective *** demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical *** atherogenic indices were calculated using the lipid *** association between visual acuity,bilateral sequential involvement,and atherogenic indices was ***:The mean age was 63.8±12.5 y in the NAION group and 64.7±10.1 y in control group(P=0.707).Although there were no significant differences in terms of total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-c)between two groups(P=0.089,0.091),all the nontraditional serum lipid ratios were significantly higher in NAION group(P20/200(P=0.032,0.025,0.032,respectively).The values for the atherogenic indices were higher in NAION patients with bilateral sequential involvement in comparison to those with unilateral involvement(P=0.271,0.127,0.197,0.128,0.127,respectively).CONCLUSION:The study reveals a relationship between NAION and the non-traditional lipid *** indices may predict the visual loss severity and second eye involvement in patients with NAION.

关键词： atherosclerosis atherogenic index lipid profile non-arteritic ischemic optic neuropathy second eye involvement

Determination of sedimentation rates in Izmir Bay using ^(210)Pb radionuclide

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Nuclear Science and Techniques 2017年第11期28卷 266-270页

作者： Mutlu Ichedef gungor Yener Hasan Baha Buyukisik Ebru Yesim Ozkan Institute of Nuclear Sciences Ege University35100 IzmirTurkey Faculty of Fisheries Ege University35100 IzmirTurkey

In this study, using the constant rate of supply model, sedimentation rates of Izmir Bay were calculated and discussed. For this purpose, eight sediment cores were collected from inner part of the bay and sedimentation rates were calculated from vertical distribution of^(210)Pb.^(210)Pb activities were determined indirectly from ^(210)Po *** rates ranged from 0.10 to 0.52 cm/year. The highest sedimentation rates were determined in stations close to the Poligon stream. It was concluded that main transporting mechanism for sediments is river and streams in the area. In addition, sediment cores taken from the harbor were mixed due to bioturbation, water circulation and/or other factors.

关键词： Sedimentation rates I˙zmir Bay ^(210)Pb ^(210)Po

Inappropriate use of digoxin in patients presenting with digoxin toxicity

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Journal of Geriatric Cardiology 2015年第2期12卷 143-146页

作者： Mustafa Adem Tatlisu Kazim Serhan Ozcan Baris gungor Ahmet Zengin Mehmet Baran Karatas Zekeriya Nurkalem Department of Cardiology Sivas Numune State Hospital Rahmi Crunay Street Sivas 58000 Turkey Department of Cardiology Kocaeli Derince Education and Research Hospital ibni Sina Street Kocaeli 41900 Turkey Department of Cardiology Dr.Siyami Ersek Cardiovascular Surgery Education and Research Hospital Tlbbiye street lstanbul 34668 Turkey Department of Cardiology Istanbul Medipol University Kosuyolu Istanbul 34718 Turkey

Background Digoxin remains widely used today despite its narrow therapeutic index and toxicity. The objective of this study was to investigate the percentage of inappropriate use of digoxin and long-term outcomes of elderly patients hospitalized for digoxin toxicity. Methods The study included 99 consecutive patients hospitalized for digoxin toxicity. The other study criteria for the inappropriate use of digoxin was regarded if participants having depressed left ventricular systolic function （ejection fraction 〈 45%） who were not on optimal medical therapy including beta-blocker and angiotensin-converting-enzyme inhibitor therapy or if participants having permanent AF who were not on optimal beta-blocker therapy. Results Appropriate digoxin usage was confirmed in 33 of patients in spite of its narrow therapeutic index. A total of 16 of 99 patients died, with a mean follow-up time of 22.1 ± 10.3 months. Conclusions Contrary to popular belief, the rate of inappropriate digoxin usage remains high. On account of its narrow therapeutic index and toxicity, digoxin should be used more carefully according to the current evidence and guidelines.

关键词： Digoxin Ejection fraction Indications Toxicity

Boldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats:Role of oxidative stress,inflammation and caspase-3

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BIOCELL 2022年第9期46卷 2111-2122页

作者： NERGIZ HACER TURGUT HUSEYIN gungor MEHMET EKICI MUMIN ALPER ERDOGAN MEHMET ONDER KARAYIGIT HAKI KARA Department of Pharmacology Faculty of PharmacyIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pharmacology and Toxicology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of MedicineIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pathology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey

Side effects of cisplatin,especially dose-dependent nephrotoxicity,are major factors limiting its use in ***((S)-2,9-dihydroxy-1,10-dimethoxy-aporphine)is a natural alkaloid known for its strong antioxidant activity present in leaves/bark of boldo tree(Peumus boldus Molina),a native tree in ***,we aimed to investigate the nephroprotective effect of boldine and its underlying mechanisms on cisplatin-induced rat renal *** Wistar albino rats divided into 5 groups(Control,Cis,Bold.40,Cis+Bold.20,Cis+Bold.40 groups)were *** received boldine(20 or 40 mg/kg/day),or vehicle(saline)intraperitoneal for 14 days and a single dose cisplatin(7 mg/kg,ip)was applied on the 10th day to induce *** and kidney tissue were weighed to determine kidney *** urea nitrojen(BUN)and creatinine levels,the amount of thiobarbituric acid reactive substances(TBARS,an index of lipid peroxidation),superoxide dismutase(SOD),glutathione peroxidase(GPx)enzyme activities and tumor necrosis factor alpha(TNF-α)levels were measured and histopathologic examination was *** nitric oxide synthase(iNOS)and caspase-3 expressions were detected *** induced by cisplatin was apparent by elevated levels of BUN,creatinine,kidney index,TBARS and TNF-α,and decreased body weight,SOD and GPx enzyme *** with boldine protected the renal function at both boldine doses by fixing the renal damage markers,oxidative stress,caspase-3 and iNOS *** findings supported biochemical *** together these findings indicate that boldine has promising protective effect against cisplatin nephrotoxicity by improving oxidative stress,inflammation,histopathological alterations and by alleviating caspase 3 expression.

关键词： Boldine Caspase-3 Cisplatin nephrotoxicity Inflammation Oxidative stress

Effectivity of intraoperative adjustable suture technique in horizontal strabismus

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 492-497页

作者： Ayse Gul Kocak Altintas Hasan Basri Arifoglu Inci Kocak Midillioglu Elif Damar gungor Saban Simsek S.B.Ulucanlar Eye Training and Education Hospital No:59 06340 AltindagAnkaraTurkey Department of Ophthalmology S.B.Kayseri Training and Education HospitalSanayi Mah.Atatürk Boulevard Hastane Street No:78 38010 KayseriTurkey Davis Eye Clinic 4860 Y St.Suite 2400SacramentoCA 95817USA Department of Ophthalmology S.B.Malatya State HospitalAnkara cd.zalper mh.No:4MalatyaTurkey Department of Ophthalmology S.B.Haydarpasa Numune Training and Education HospitalTibbiye Cad.No:40 sküdaristanbulTurkey

AIMTo compare the long-term effectivity of intraoperative adjustable suture technique with traditional non-adjustable strabismus surgery.

关键词： adjustable suture strabismus surgery esodeviation exodeviation

Digoxin intoxication： An old enemy in modern era

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Journal of Geriatric Cardiology 2012年第3期9卷 237-242页

作者： Bahadir Kirilmaz Serkan Saygi Hasan gungor Ugur Onsel Turk Emin Alioglu Serdar Akyuz Fatih Asgun Istemihan Tengiz Ertugrul Ercan Department of Cardiology Canakkale Onsekiz Mart University Medical Faculty Canakkale 17100 Turkey Department of Cardiology Odemis State Hospital Izmir 35750 Turkey Department of Cardiology Central Hospital Izmir 35580 Turkey Department of Cardiology Yunus Emre State Hospital Eskisehir 26190 Turkey Department of Cardiovascular Surgery Canakkale Onsekiz Mart University Medical Faculty Canakkale 17100 Turkey

Objectives Although development of new treatment modalities limited digoxin usage, digoxin intoxication is still an important issue which could be easily overlooked. In this report, we analyzed a case series definitively diagnosed as digoxin intoxication in the modern era. Methods We analyzed 71 patients hospitalized with digoxin intoxication confirmed by history, complaints, clinical and electrocardiograph （ECG） findings, and serum digoxin levels 〉 2.0 ng/mL, during a five year period. The demographic and clinical data, indications for digoxin use, digoxin dosage, concurrent medications, laboratory data, hospital monitoring, and ECG findings were obtained from all patients. Results Thirty-eight of 71 patients （53.5%） had symptoms of heart failure during admission or later. Sixty-four percent of patients were older than 75 years. The percentage of females was 67%. Atrial fibrillation, hypertension and gastrointestinal complaints were more frequent in the females （64% in females, 30% in males, P = 0.007; 81% in female, 52% in males, P = 0.01; 50% in female, 17.3% in males, P = 0.008, respectively）. The mortality rate during the hospital course was 7%. Conclusions This report demonstrated the reduced mortality rates in patients with digoxin intoxication over the study period. Gastrointestinal complaints are the most common symptoms in this population.

关键词： Digoxin intoxication Digitalis Heart failure Arrhythmia