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Very Low, Real-Time Rate of Urinary Retention after Intradetrusor Botox<sup>&reg</sup>for Non-Neurogenic Overactive Bladder

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Open Journal of Obstetrics and Gynecology 2017年第8期7卷 915-921页

作者： Kirin K. Syed Christopher S. Gomez Angelo E. gousse Bladder Health and Reconstructive Urology Institute Miramar FL USA Female Urology Neurourology Voiding Dysfunction and Reconstruction Department of Urology University of Miami Miami FL USA

Introduction: According to the most recent AUA/SUFU guidelines, intradetrusor onabotulinumtoxinA (BTN/A) is a standard, evidence strength grade B, third line treatment option for refractory non-neurogenic overactive bladder (OAB). Urinary retention is the most common clinically significant reported side effect ranging from 5.4% to 43% in previous studies. The aim of this study was to investigate the real-time rate of urinary retention in patients treated with BTN/A for refractory non-neurogenic OAB in a multi-institutional study. Methods: Retrospective chart review identified 71 patients who were treated with 100U BTN/A for refractory non-neurogenic OAB from August 2011 to July 2015 at two institutions. Using a flexible cystoscope, 100U Botox® reconstituted with 10 ml normal saline was administered. Injections of 1 ml (10 units/ mL) were administered in 10 evenly distributed sites sparing the trigone. Pre and post BTN/A post-void residuals (PVR) were reviewed. Urinary retention was defined as PVR > 200 mL requiring clean intermittent catheterization (CIC). Results: After exclusion, the study group consisted of 66 patients with a mean age of 67 years and 30% were men. Mean pre and post-procedural PVR were 14.06 mL and 69.21 mL. Eight patients (12.12%) were noted to have elevated PVR > 200 mL post injection however only one patient (female) required initiation of CIC. The rate of urinary retention was 1.5% (N = 1). There was no correlation with age, history of previous radiation, diabetes or prior use of a neuromodulator device. Conclusions: To the best of our knowledge, this is the first study to demonstrate a very low risk of real-time urinary retention rates in appropriately selected patients treated with BTN/A for refractory non-neurogenic OAB outside of a clinical trial setting.

关键词： Intradetrusor OnabotulinumtoxinA Refractory Non-Neurogenic Overactive Bladder Urinary Retention OAB Urinary Retention Rate Botox®

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脊髓损伤后残存自主神经功能载录国际标准

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中华物理医学与康复杂志 2010年第4期32卷 310-315页

作者： MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green a gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望刘楠 S Charlifue University of Alabama BirminghamALUSA Baylor College of Medicine HoustonTXUSA International Collaboration On Repair Discoveries (ICORD) University of British Columbia and Vancouver Coastal HealthVancouverBritish ColumbiaCanada James A Haley VA Hospital TampaFLUSA Shepherd Center AtlantaGAUSA University of Miami MiamiFLUSA McKay Urology Carolinas HealthcareCharlotteNCUSA Sahlgrenska University Hospital GothenburgSweden Rigshospitalet and University of Copenhagen CopenhagenDenmark Aarhus University Hospital AarhusDenmark Kessler Institute for Rehabilitation West OrangeN JUSA Thomas Jefferson University PhiladelphiaPAUSA Imperial College St Mary's HospitalLondonUK Stanford Uni-versity Palo AltoCAUSA James J Peters Veterans Affairs Medical Center BronxNYUSA University Hospital Balgrist ZurichSwitzerland Herlev Hospi-tal University of CopenhagenCopenhagenDenmark Veterans Affairs Puget Sound Health Care SeattleWAUSA Case Western Re-serve University ClevelandOHUSA Mayo Clinic RochesterMSUSA and University Hospital Antwerp University AntwerpAntwerpBelgium 北京大学第三医院康复医学科 Craig Hospital EnglewoodCOUSA

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的... 详细信息

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的标准出版时，曾进行了较大的修订，修订内容包括完全性损伤与不完全性损伤的定义，

关键词：国际标准脊髓损伤自主神经功能不完全性损伤残存修订内容神经学分类 ards

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