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Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

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Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan yu Shang Jiang Hai-dong yu bi-yu Pang Xin Dong Yi-qian Wang School of Mathematical Sciences Soochow UniversitySuzhou215006China beijing Institute of Astronautical System Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction *** and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various *** this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well *** conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted *** in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet *** with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag *** obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further *** compare turbulent statistics of the scalloped riblet case with those of the triangular riblet *** mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the *** also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex *** Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be bene

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

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Numerical investigations of the interactions between bubble induced shock waves and particle based on OpenFOAM

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Journal of Hydrodynamics 2024年第2期36卷 355-362页

作者： Jia-xin yu Jin-sen Hu yu-hang Liu Yi-fan Liu Dan Gao yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of EducationSchool of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The presence of particles and the shock waves generated by the cavitation bubbles can significantly affect the safety and the performance of hydrodynamic *** the present paper,the shock waves generated by cavitation bubble collapsing near the particle are numerically investigated based on the OpenFOAM together with the numerical schlieren for the shock wave *** numerical results reveal that the stand-off distance is one of the paramount factors affecting the interactions between the particle and the shock *** different kinds of shock waves(e.g.,bubble-inception,jet formation,particle reflected and jet-split shock waves)are observed during the bubble collapsing near the *** stand-off distance smaller than 0.5 or larger than 1.1,the maximum pressure at particle surface generated by the bubble growth can surpass those of the collapse stage.

关键词： Particle-bubble interaction shockwaves jetdynamics

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Current status and trends in small nucleic acid drug development:Leading the future

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Acta Pharmaceutica Sinica b 2024年第9期14卷 3802-3817页

作者： yuxi Miao Chen Fu Zhaojin yu Lifeng yu yu Tang Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based *** agents function by selectively targeting specific genes or their corresponding messenger RNAs(mRNAs),further modulating gene expression and regulating translation-related *** examples within this category include antisense oligonucleotides(ASO),small interfering RNAs(siRNAs),micro-RNAs(miRNAs),and *** emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity,facile design,abbreviated development cycles,expansive target spectrum,and prolonged *** challenges such as poor stability,immunogenicity,and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery *** review provides an overview of the current status and prospective trends in small nucleic acid drug *** with a historical context,we introduce the primary classifications and mechanisms of small nucleic acid ***,we delve into the advantages of the *** and Drug Administration(FDA)approved drugs and mainly discuss the challenges encountered during their *** from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues,promoting endosomal escape is a critical scientific question and important research direction in siRNA drug *** directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development

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Effect of platelet-derived growth factor-bb on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells

Effect of platelet-derived growth factor-BB on gap junction ...

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首届男性大健康中西医协同创新论坛暨第三届全国中西医结合男科青年学术论坛

作者： Zhao F Huang X yu b Lv b Huang W Department of Urology and Andrology The Second Affiliated Hospital of Zhejiang Chinese Medical University

We explored whether platelet-derived growth factor(PDGF)-bb regulates corpus cavernosum smooth muscle cell gap junctions and can ameliorate erectile dysfunction and how it modulates connexin43(CX43)after bilateral cavernous neurectomy. Primary cultured rat corpus cavernosum smooth muscle cells were treated with PDGF-bb with or without a PDGFR inhibitor, Akt siRNA or the depletion or promotion ofβ-catenin. PDGF-bb improved CCSMCs gap junction coupling and increased CX43 and PDGFRβ expression;inhibition of PDGFR activity down-regulated CX43 and decreased Akt and nuclear β-*** or promotion of β-catenin down-regulated and up-regulated CX43 expression respectively. Moreover, β-catenin activation induced CX43 nuclear accumulation, which impeded CX43 down-regulation induced by PDGFR inhibition, suggesting that CX43 expression is positively correlated with nuclear β-catenin expression. Furthermore,CX43 promoter luciferase and chromatin immunoprecipitation assays indicated that β-catenin regulates CX43 transcription by directly interacting with its promoter. Male rats underwent bilateral cavernous neurectomy. After 12 weeks, they were injected with PDGF-bb, CX43 and PDGFRβ expression was significantly lower than in the control group,which was reversed by PDGF-bb injection. These results suggested that PDGF-bb contributed to the improvement of gap junction intracellular communication among corpus cavernosum smooth muscle cells,increased CX43 through PDGFRβ/Akt/nuclear β-catenin signalling, and ameliorated cavernous nerve injury-induced erectile dysfunction.

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Effect of platelet-derived growth factor-bb on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells

Effect of platelet-derived growth factor-BB on gap junction ...

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2019年浙江省医学会泌尿外科学、男科学学术大会

作者： Zhao F Huang X yu b Lv b Huang W Department of Urology and Andrology The Second Affiliated Hospital of Zhejiang Chinese Medical University

We explored whether platelet-derived growth factor(PDGF)-bb regulates corpus cavernosum smooth muscle cell gap junctions and can ameliorate erectile dysfunction and how it modulates connexin43(CX43)after bilateral cavernous neurectomy. Primary cultured rat corpus cavernosum smooth muscle cells were treated with PDGF-bb with or without a PDGFR inhibitor, Akt siRNA or the depletion or promotion of β-catenin. PDGFbb improved CCSMCs gap junction coupling and increased CX43 and PDGFRβ expression;inhibition of PDGFR activity down-regulated CX43 and decreased Akt and nuclear β-catenin. Knockdown or promotion of β-catenin down-regulated and up-regulated CX43 expression respectively. Moreover, β-catenin activation induced CX43 nuclear accumulation, which impeded CX43 down-regulation induced by PDGFR inhibition, suggesting that CX43 expression is positively correlated with nuclear β-catenin expression. Furthermore, CX43 promoter luciferase and chromatin immunoprecipitation assays indicated that β-catenin regulates CX43 transcription by directly interacting with its promoter. Male rats underwent bilateral cavernous neurectomy. After 12 weeks, they were injected with PDGF-bb, CX43 and PDGFRβ expression was significantly lower than in the control group, which was reversed by PDGF-bb injection. These results suggested that PDGF-bb contributed to the improvement of gap junction intracellular communication among corpus cavernosum smooth muscle cells, increased CX43 through PDGFRβ/Akt/nuclear β-catenin signalling, and ameliorated cavernous nerve injury-induced erectile dysfunction.

关键词： Akt Effect of platelet-derived growth factor-bb on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells

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Effectiveness of urban distributed runoff model for discharge and water depth calculation in urban drainage pipe networks

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Journal of Hydrodynamics 2024年第3期36卷 582-591页

作者： Yang Zhou Yi-ling Leng Peng-yu Wang Shang-hong Zhang yu-long Zhu yu-jun Yi School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing102206China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing100875China

Effective urban land-use re-planning and the strategic arrangement of drainage pipe networks can significantly enhance urban flood defense *** at reducing the potential risks of urban flooding,this paper presents a straightforward and efficient approach to an urban distributed runoff model(UDRM).The model is developed to quantify the discharge and water depth within urban drainage pipe networks under varying rainfall intensities and land-use *** Nash efficiency coefficient of UDRM exceeds 0.9,which indicates its high computational efficiency and potential benefit in predicting urban *** prediction of drainage conditions under both current and re-planned land-use types is achieved by adopting different flood recurrence *** findings reveal that the re-planned land-use strategies could effectively diminish flood risk upstream of the drainage pipe network across 20-year and 50-year flood recurrence ***,in the case of extreme rainfall events(a 100-year flood recurrence),the re-planned land-use approach fell short of fulfilling the requirements necessary for flood disaster *** these instances,the adoption of larger-diameter drainage pipes becomes an essential requisite to satisfy drainage ***,the proposed UDRM effectively combines land-use information with pipeline data to give practical suggestions for pipeline modification and land-use optimization to combat urban ***,this methodology warrants further promotion in the field of urban re-planning.

关键词： Stormwater runoff water depth urban distributed runoff model urban drainage pipe networks urban land-use re-planning

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A conservative Fourier pseudospectral algorithm for a coupled nonlinear Schrdinger system

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Chinese Physics b 2013年第6期22卷 135-140页

作者：蔡加祥王雨顺 Jiangsu Key Laboratory for NSLSCS School of Mathematics ScienceNanjing Normal University School of Mathematics Science Huaiyin Normal University

We derive a new method for a coupled nonlinear Schr/Sdinger system by using the square of first-order Fourier spectral differentiation matrix D1 instead of traditional second-order Fourier spectral differentiation matrix D2 to approximate the second derivative. We prove the proposed method preserves the charge and energy conservation laws exactly. In numerical tests, we display the accuracy of numerical solution and the role of the nonlinear coupling parameter in cases of soliton collisions. Numerical experiments also exhibit the excellent performance of the method in preserving the charge and energy conservation laws. These numerical results verify that the proposed method is both a charge-preserving and an energy-preserving algorithm.

关键词： Schroedinger equation Fourier pseudospectral method conservation law energy

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Epidemic spreading on a scale-free network with awareness

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Chinese Physics b 2012年第10期21卷 44-48页

作者：鲁延玲蒋国平宋玉蓉 College of Computer Nanjing University of Posts and Telecommunications College of Automation Nanjing University of Posts and Telecommunications

This paper presents a modified susceptible-infected-recovered（SIR） model with the effects of awareness and vaccination to study the epidemic spreading on scale-free networks based on the mean-field *** this model,when susceptible individuals receive awareness from their infected neighbor nodes,they will take vaccination *** theoretical analysis and the numerical simulations show that the existence of awareness and vaccination can significantly improve the epidemic threshold and reduce the risk of virus *** addition,regardless of the existence of vaccination,the awareness can increase the spreading threshold and slow the spreading speed *** a given awareness and a certain spreading rate,the total number of infections reduces with the increasing vaccination rate.

关键词： scale-free network awareness vaccination epidemic threshold

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A Strong,Tough,and Self-Healing Strengthening Thioctic Acid-based Elastomer for Highly Reliable Flexible Strain Sensor

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Chinese Journal of Polymer Science 2024年第10期42卷 1610-1618,I0016页

作者： Xin-yu Chen yu-bing Fu Xue-Ling Yan Lan Liu School of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Polymer MaterialsSouth China University of TechnologyGuangzhou510641China

Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a *** this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis *** strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good *** PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.

关键词： Thioctic acid Ion clusters Multiple dynamic networks Self-healing strengthening Flexible strain sensor

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The Logarithmic Sobolev Inequality for a Submanifold in Manifolds with Nonnegative Sectional Curvature

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Chinese Annals of Mathematics,Series b 2024年第3期45卷 487-496页

作者： Chengyang YI yu ZHENG School of Mathematical Sciences East China Normal UniversityShanghai 200241China

The authors prove a sharp logarithmic Sobolev inequality which holds for compact submanifolds without boundary in Riemannian manifolds with nonnegative sectional curvature of arbitrary dimension and *** the Michael-Simon Sobolev inequality,this inequality includes a term involving the mean *** extends a recent result of brendle with Euclidean setting.

关键词： Logarithmic Sobolev inequality Nonnegative sectional curvature Submanifold

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