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Hair follicles as a target structure for nanoparticles

Journal of Innovative Optical Health Sciences 2015年第4期8卷 2-9页

作者： J.Lademann F.Knorr H.Richter S.Jung M.C.Meinke E.Rühl U.alexiev M.Calderon A.Patzelt Center of Experimental and Applied Cutaneous Physiology Department of Dermatology Venereology and Allergology Charite-Universitatsmedizin Berlin Chariteplatz 1Berlin 10117Germany Physical Chemistry Institute of Chemistry and Biochemistry Freie Universitat Berlin Takustr.3Berlin 14195Germany Department of Physics Freie Universitat Berlin Arnimallee 14Berlin 14195Germany

For at least two decades,nanoparticles have been investigated for their capability to deliver topically applied substances through the skin *** on findings that nanoparticles are highly suitable for penetrating the blood--brain barrier,their use for drug delivery through the skin has become a topic of intense *** spite of the research efforts by academia and industry,a commercial product permitting the nanoparticle-assisted delivery of topically applied drugs has not yet been ***,nanoparticles of approximately 600 nm in diameter have been shown to penetrate fficiently into the hair fllieles where they can be stored for several *** successful loading of nanoparticles with drugs and their triggered release inside the hair fllile may present an ideal method for localized drug *** on the particle size,such a method would permit targeting specific structures in the hair fllicles such a stem ells or immune cells or blood vessels found in the vicinity of the hair follicles.

关键词： Skin barrier penetration stratum corrneum hair fllicles triggered release

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Mayaro virus infection, the next epidemic wave after Zika?Evolutionary and structural analysis

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 194-201页

作者： Eleonora Cella Marta Giovanetti Teresa Milano Marta Fogolari Francesco Garilli Ivailo alexiev Riccardo Bazzardi Marco Salemi Luiz Carlos Junior Alcantara Silvia Angeletti Stefano Pascarella Massimo Ciccozzi Public Health and Infectious Diseases Sapienza University Unit of Clinical Laboratory Science University Campus Bio-Medico of Rome Fundao Oswaldo Cruz University of Rome"Tor Vergata" Dipartimento di Scienze Biochimiche"A.Rossi Fanelli" Universita La Sapienza Department of Medicine University Campus Bio-Medico of Rome National Reference Laboratory of HIV National Center of Infectious and Parasitic Diseases Department of Food Hygiene Experimental Zooprophylactic Institute of Sardinia Emerging Pathogens Institute Unirersity of Florida

Objective: To evaluate the evolution of the pathogen Mayaro virus, causing Mayaro fever(a mosquito-borne disease) and to perform selective pressure analysis and homology ***: Nine different datasets were built, one for each protein(from protein C to non-structural protein 4) and the last one for the complete genome. Selective pressure and homology modelling analyses were applied. Results: Two main clades(A and B) were pointed in the maximum likelihood tree. The clade A included five Brazilian sequences sampled from 1955 to 2015. The Brazilian sequence sampled in 2014 significantly clustered with the Haitian sequence sampled in 2015. The clade B included the remaining 27 sequences sampled in the Central and Southern America from 1957 to 2013. Selective pressure analysis revealed several sites under episodic diversifying selection in envelope surface glycoprotein El, non-structural protein 1 and nonstructural protein 3 with a posterior probability P≤0.01. Homology modelling showed different sites modified by selective pressure and some protein-protein interaction sites at high interaction propensity. Conclusion: Maximum likelihood analysis confirmed the Mayaro virus previous circulation in Haiti and the successful spread to the Caribbean and USA. Selective pressure analysis revealed a strong presence of negatively selected sites, suggesting a probable purging of deleterious polymorphisms in functional genes. Homology model showed the position 31, under selective pressure, located in the edge of the ADP-ribose binding site predicting to possess a high potential of protein-protein interaction and suggesting the possible chance for a protective vaccine,thus preventing Mayaro virus urbanization as with Chikungunya virus.

关键词： Mayaro virus Proteins Evolutionary analysis

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Locoregional IL-2 low dose applications for gastrointestinal tumors

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World Journal of Gastroenterology 2005年第35期11卷 5525-5529页

作者： Zachary Krastev V Koltchakov R Tomova S Deredjian a alexiev D Popov B Tomov Jan-Willem Koten John Jacobs Willem Den Otter Clinic of Gastroenterology Faculty of Medicine University Hospital Blvd. Iv.Geshov 15Sofia 1431Bulgaria Department of Pathobiology PO Box 80.178 3508 TD Utrecht The Netherlands Clinic of Gastroenterology Faculty of Medicine Univeisity Hospital Blvd. Iv.Geshov 15Sofia 1431Bulgaria

AIM： To explore the feasibility of local interleukin 2 （IL-2） in patients with different forms of abdominal cancer. This required experimentation with the time interval between IL-2 applications and the methods of application. METHODS： Sixteen patients with stages Ⅲ and Ⅳ of gastrointestinal malignancies （primary or metastatic） who were admitted to our Department of Gastroenterology were treated with Iocoregionally applied IL-2 in low doses. RESULTS： No major problems applying Iocoregional IL-2 were encountered. In 6 out of 16 patients, a modest but clinically worthwhile improvement was obtained. Adverse effects were minimal. The therapeutic scheme was well tolerated, even in patients in a poor condition. CONCLUSION： This study demonstrates the feasibility of low dose Iocoregional IL-2 application in advanced abdominal cancer. Local IL-2 therapy gives only negligible adverse effects. The results suggest that it is important to apply intratumorally. Local IL-2 may be given adjunct to standard therapeutic regimes and does not imply complex surgical interventions. These initial results are encouraging.

关键词： Interleukin-2 Local IL-2 therapy Gastrointestinalcancer

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