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Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?

World Journal of Clinical Oncology 2016年第2期7卷 234-242页

作者： Gilles Houvenaeghel Agnès Tallet Aurélie jalaguier-coudray Monique Cohen Marie Bannier Camille Jauffret-Fara Eric Lambaudie Institut Paoli Calmettes and CRCM Aix Marseille Université

The incidence of multifocal(MF) and multicentric(MC) carcinomas varies widely among clinical studies,depending on definitions and methods for pathological *** resonance imaging is increasingly used because it can help identify additional and conventionally occult tumors with high ***,false positive lesions might incorrectly influence treatment ***,preoperative biopsies must be performed to avoid unnecessary *** studies have shown higher lymph node involvement rates in MF/MC tumors than in unifocal ***,the rate of local recurrences is usually low after breast conservative treatment(BCT) of MC/MF *** has been suggested that BCT is a reasonable option for MC/MF tumors in women aged 50-69 years,with small tumors and absence of extensive ductal carcinoma in situ.A metaanalysis showed an apparent decreased overall survival in MC/MF tumors but data are *** should achieve both acceptable cosmetic results and negative margins,which requires thorough preoperative radiological workup and localization of *** radiotherapy techniques must be evaluated since double boosts might result in increased toxicity,namely *** conclusion,BCT is feasible in selected patients with MC/MF but the choice of surgery must be discussed in a multidisciplinary team comprising at least radiologists,surgeons and radiotherapists.