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Car.iac r.habilitation by Pulmonar. ar.er. Banding after.Induced Dilated Car.iomyopathy:a Pilot Study on a r.dent model

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Congenital Hear. Disease 2024年第5期19卷 473-487页

作者： Domenico crea ar.en Dedja matteo Ponzoni Stefania r.zzo alber.o Cipr.ani r.ccar.o Bar.ani Kalliopi Pilichou mar.a Bueno mar.nas Danila azzolina massimo a.Padalino Pediatr.c and Congenital Car.iac Sur.er. Department of Cardiothoracic and Vascular Sciences and Public HealthUniversity of PadovaPadova35128Italy Division of Car.iac Sur.er. The Sick Children’s HospitalTorontoON M5G 1E8Canada Car.iovascular.Pathology Department of Cardiothoracic and Vascular Sciences and Public HealthUniversity of PadovaPadova35128Italy Car.iology Clinic Department of Cardiothoracic and Vascular Sciences and Public HealthUniversity of PadovaPadova35128Italy Depar.ment of Envir.nmental and Pr.ventive Science University of FerraraFerrara44121Italy Depar.ment Pr.cision and r.gener.tive medicine and Jonian ar.a University of Bari“Aldo Moro”Bari70124Italy

Backgr.und:Since 2015,the pulmonar. ar.er. banding(PaB),following the Giessen pr.tocol,has tr.ated endstage hear. failur. in selected infants with pr.ser.ed r.ght ventr.cular.function,acting as a br.dge to tr.nsplant or.r.cover.,as a r.sult of ventr.cular.ventr.cular.***:To elucidate whether.PaB is a feasible and r.pr.ducible pr.cedur. in a r.dent model of phar.acologically induced dilated car.iomyopathy(DCm)and to evaluate PaB-induced ventr.cular.***:We used 49 Spr.gue-Dawley r.ts divided into four.gr.ups:a sham sur.er. contr.l gr.up,a healthy animal gr.up under.oing PaB,a doxor.bicin(DOX)-tr.ated contr.l gr.up,and a DOX+PaB-tr.ated *** under.ent echocar.iogr.phic,histological,and molecular.***:Pr.liminar. r.sults showed high mor.ality in r.ts with DOX-induced DCm,with contr.ctile dysfunction confir.ed by 2D *** of damage wer. detected thr.ugh tr.nsmission electr.n micr.scopy,but not via standar. histological/molecular.*** after.DOX impr.ved contr.ctile function,enhancing ejection fr.ction(p=0.01)and fr.ctional shor.ening(p=0.03).Conclusion:The DOX-induced DCm model,while r.pr.ducible,may not r.flect DCm’s tr.e *** mor.ality and individual var.ability limited the *** r.sear.h is needed to find alter.ative models with lower.mor.ality and to explor. the PaB-induced molecular.signaling pathways and car.iac pr.lifer.tion potential.

关键词： Dilated car.iomyopathy doxor.bicin pulmonar. ar.er. banding

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Guillain–Bar.é syndr.me, tr.nsver.e myelitis and infectious diseases

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Cellular.& molecular.Immunology 2018年第6期15卷 547-562页

作者： Yhojan r.dr.guez manuel r.jas Yovana Pacheco Yeny acosta-ampudia Car.lina r.mír.z-Santana Diana m monsalve m Er.c Ger.hwin Juan-manuel anaya Center.for.autoimmune Diseases r.sear.h(crea) School of Medicine and Health SciencesUniversidad del RosarioBogotaColombia Division of r.eumatology Allergy and Clinical ImmunologyUniversity of California DavisSchool of MedicineDavisCAUSA

Guillain–Bar.ésyndr.me(GBS)and tr.nsver.e myelitis(Tm)both r.pr.sent immunologically mediated polyneur.pathies of major.clinical *** ar. thought to have a genetic pr.disposition,but as of yet no specific genetic r.sk loci have been clear.y *** ar. consider.d autoimmune,but again the etiologies r.main *** may be induced via molecular.mimicr.,par.icular.y fr.m infectious agents and vaccines,but clear.y host factor.and co-founding host r.sponses will modulate disease susceptibility and natur.l *** is an acute inflammator. immune-mediated polyr.diculoneur.pathy char.cter.zed by tingling,pr.gr.ssive weakness,autonomic dysfunction,and *** injur. specifically takes place at the myelin sheath and r.lated Schwann-cell components in acute inflammator. demyelinating polyneur.pathy,wher.as in acute motor.axonal neur.pathy membr.nes on the ner.e axon(the axolemma)ar. the pr.mar. tar.et for.immune-r.lated *** of GBS have been r.por.ed,most fr.quently r.lated to Campylobacter.jejuni infection,however.other.agents such as Zika Vir.s have been str.ngly *** with GBS r.lated to infections fr.quently pr.duce antibodies against human per.pher.l ner.e *** contr.st,Tm is an inflammator. disor.er.char.cter.zed by acute or.subacute motor.sensor.,and autonomic spinal cor. *** is inter.uption of ascending and descending neur.anatomical pathways on the tr.nsver.e plane of the spinal cor. similar.to *** has been suggested to be tr.gger.d by infectious agents and molecular.*** this r.view,we will focus on the putative r.le of infectious agents as tr.gger.ng factor. of GBS and Tm.

关键词： bacter.al infections disease outbr.aks Guillain-Bar.ésyndr.me tr.nsver.e myelitis vir.s diseases Zika vir.s

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3D Echocar.iogr.m r.constr.ction Employing a Flip Dir.ctional Textur. Pyr.mid

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Computer.Systems Science & Engineer.ng 2023年第6期45卷 2971-2988页

作者： C.Pr.ethi m.mohamed Sathik S.Shajun Nisha PG&r.sear.h Depar.ment of Computer.Science SadakathullahAppa CollegeAffiliation of Manonmaniam Sundaranar UniversityTirunelveli627012Tamil NaduIndia

Thr.e dimensional(3D)echocar.iogr.m enables car.iologists to visua-lize suspicious car.iac str.ctur.s in *** r.cent year.,this thr.e-dimensional echocar.iogr.m car.ies impor.ant clinical value in vir.ual sur.ical ***,this 3D echocar.iogr.m involves a tr.de-off difficulty between accu-r.cy and efficient computation in clinical *** paper.pr.sents a novel Flip Dir.ctional 3D Volume r.constr.ction(FD-3DVr.method for.the r.con-str.ction of echocar.iogr.m *** pr.posed method consists of two main steps:multiplanar.volumetr.c imaging and 3D volume *** the crea-tion of multiplanar.volumetr.c imaging,two-dimensional(2D)image pixels ar. mapped into voxels of the volumetr.c *** the obtained slices ar. discontin-uous,ther. ar. some missing voxels in the volume *** r.stor. the str.ctur.l and textur.l infor.ation of 3D ultr.sound volume,the pr.posed method creates a volume pyr.mid in par.llel with theflip dir.ctional textur. ***,the near.st neighbor. of missing voxels in the multiplanar.volumetr.c imaging ar. identified by 3D aNN(appr.ximate Near.st Neighbor.patch matching ***,aflip dir.ctional textur. pyr.mid is pr.posed and aggr.gated with distance in patch matching tofind out the most similar.*** the r.con-str.ction step,str.ctur.l and textur.l infor.ation obtained fr.m differ.ntflip angle dir.ctions can r.constr.ct 3D volume well with the desir.d ***-par.d with existing 3D r.constr.ction methods,the pr.posed Flip Dir.ctional 3D Volume r.constr.ction(FD-3DVr.method pr.vides super.or.per.or.ance for.the mean peak signal-to-noise r.tio(40.538 for.the pr.posed method I and 39.626 for.the pr.posed method II).Exper.mental r.sults per.or.ed on the car.i-ac datasets demonstr.te the efficiency of the pr.posed method for.the r.constr.c-tion of echocar.iogr.m images.

关键词： Thr.e-dimensional echocar.iogr.m 3D aNN patch matching volume pyr.mid flip dir.ctional textur. pyr.mid 3D volume r.constr.ction

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Which ar. the most favour.ble conditions for.r.ducing soil CO_(2)emissions with no-tillage?r.sults fr.m a meta-analysis

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Inter.ational Soil and Water.Conser.ation r.sear.h 2022年第3期10卷 497-506页

作者： Simone Br.gaglio Gabr.ele mongiano r.ssana m.Fer.ar. Fabr.zio Ginaldi alessandr. Lagomar.ino Gianfr.nco r.na crea-Council for.agr.cultur.l r.sear.h and Economics Research Centre for Agriculture and EnvironmentI-40128BolognaItaly crea-Council for.agr.cultur.l r.sear.h and Economics Research Centre for Plant Protection and CertificationSS 11 km 2500I-13100VercelliItaly crea-Council for.agr.cultur.l r.sear.h and Economics Research Centre for Agriculture and EnvironmentI-70125BariItaly crea-Council for.agr.cultur.l r.sear.h and Economics Research Centre for Agriculture and EnvironmentI-50125FirenzeItaly

No-tillage pr.ctices have a r.cognised beneficial impact on soil and water.conser.ation while r.ducing er.sion pr.cesses and enhancing soil or.anic matter.***,scientists continue to debate the effectiveness of no-tillage in r.ducing soil car.on dioxide(CO_(2))emissions fr.m *** the same line of inquir. pur.ued by the author. who r.viewed the impact of conser.ative pr.ctices on dir.ct CO_(2)emissions,we applied meta-analytic and machine lear.ing techniques to unr.vel the effect of no-tillage under.contr.sting pedo-envir.nmental conditions and agr.cultur.l *** analysed fifty-six exper.mental studies investigating dir.ct soil CO_(2)emissions fr.m no-tillage and conventional tillage pr.ctices(102 pair.d obser.ations),consider.ng pedological(soil textur.,soil or.anic car.on content),envir.nmental(climate type),and management(cr.p r.tation,exper.ment dur.tion)*** estimated the effect of differ.nt pr.ctices on the daily amount of soil CO_(2)emissions,and the impact of tillage in the per.od immediately following the *** main insights of this study ar.:(i)the conditions leading to the highest r.duction of CO_(2)emissions due to no-tillage wer. long-ter. exper.ments(standar.ised mean differ.nceβ=0.64)conducted in ar.d envir.nments(β=0.76)and clay soils(β=0.81),with low or.anic car.on content(β=0.79)wher. cr.p r.tations(β=0.65)wer. per.or.ed;(ii)the same conditions wer. associated with the lowest absolute CO_(2)emissions,ir.espective of soil management;(iii)the highest contr.bution to the var.ability of absolute soil CO_(2)emissions was associated with soil textur.(mean decrease in accur.cy of r.ndom For.st models,mDa=4.57),r.tation(mDa=3.07),exper.ment dur.tion(mDa=2.93)and soil or.anic car.on content(mDa=2.24),r.ther.than to tillage pr.ctices;(iv)soil CO_(2)emissions almost doubled in the fir.t day after.a tillage event,consistently acr.ss studies(p=0.001).This meta-analysis offer. quantitative figur.s on the impact of tillage

关键词： agr.cultur.l soils Gr.enhouse gases Global war.ing Net-zer. agr.cultur.

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Synthetic biology identifies the minimal gene set r.quir.d for.paclitaxel biosynthesis in a plant chassis

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molecular.Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang Lor.nz Wiese Hao Fang Saleh alseekh Leonar.o Per.z de Souza Feder.co Scossa John molloy mathias Chr.stmann alisdair.r.Fer.ie max-Planck-Institut fur.molekular. Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center.of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Institute of Chemistr. and Biochemistr. Freie Universitat BerlinTakustraBe 314195 BerlinGermany Depar.ment of Biomolecular.Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany r.sear.h Center.for.Genomics and Bioinfor.atics(crea-GB) Via Ardeatina 54600178 RomeItaly

The diter.enoid paclitaxel(Taxol)is a chemother.py medication widely used as a fir.t-line tr.atment against sever.l types of solid *** supply of paclitaxel fr.m natur.l sour.es is ***,missing knowledge about the genes involved in sever.l specific metabolic steps of paclitaxel biosynthesis has r.nder.d it difficult to engineer.the full *** this study,we used a combination of tr.nscr.ptomics,cell biology,metabolomics,and pathway r.constitution to identify the complete gene set r.quir.d for.the heter.logous pr.duction of *** identified the missing steps fr.m the cur.ent model of paclitaxel biosynthesis and confir.ed the activity of most of the missing enzymes via heter.logous expr.ssion in Nicotiana ***,we identified a new C4β-C20 epoxidase that could over.ome the fir.t bottleneck of metabolic *** used both pr.viously char.cter.zed and newly identified oxomutases/epoxidases,taxane 1β-hydr.xylase,taxane 9aα-hydr.xylase,taxane 9α-dioxygenase,and phenylalanine-Coa ligase,to successfully biosynthesize the key inter.ediate baccatin Ill and to conver. baccatin Ill into paclitaxel in *** combination,these appr.aches establisha metabolic r.ute to taxoidbiosynthesis and pr.vide insights into the unique chemistr. that plants use to gener.te complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biology baccatin Ill biosynthesis Taxus

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Exploiting Natur.l Var.ation in Tomato to Define Pathway Str.ctur. and metabolic r.gulation of Fr.it Polyphenolics in the Lycoper.icum Complex

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molecular.Plant 2020年第7期13卷 1027-1046页

作者： Takayuki Tohge Feder.co Scossa r.gina Wendenbur. Pier.e Fr.sse llse Balbo mutsumi Watanabe Saleh alseekh Sagar.Sudam Jadhav Jay C.Delfin mar. Lohse Patr.ck Giavalisco Bjoer. Usadel Youjun Zhang Jie Luo mondher.Bouzayen alisdair.r.Fer.ie max-Planck-lnstitut fiir.molekular. Pflanzenphysiologie Am Muehlenberg 114476 Potsdam-Golm.Germany Gr.duate School of Biological Science Nara Institute of Science and TechnologyIkoma 630-0192 Japan Council for.agr.cultur.l r.sear.h and Economics(crea) Research Centre for Genomics and Bioinformaticsvia Ardeatina 54600178 RomeItaly Univer.ite de Toulouse INP-ENSA ToulouseGenomique et Biotechnologie des FruitsCastanet-Tolosan 31326France Institute of Plant Systems Biology 4000 PlovdivBulgaria max Planck Institute for.Biology of ageing Joseph Stelzmann Strasse 9b50931 CologneGermany Institute of Botany and molecular.Genetics BioSCRWTH Aachen University52056 AachenGermany National Key Labor.tor. of Cr.p Genetic Impr.vement and National Center.of Plant Gene r.sear.h(Wuhan) Huazhong Agricultural UniversityWuhan 430070China

While the str.ctur.s of plant pr.mar. metabolic pathways ar. gener.lly well defined and highly conser.ed acr.ss species,those defining specialized metabolism ar. less well char.cter.zed and mor. highly var.able acr.ss *** this study,we investigated polyphenolic metabolism in the lycoper.icum complex by char.cter.zing the under.ying biosynthetic and decor.tive r.actions that constitute the metabolic networ. of polyphenols acr.ss eight differ.nt species of *** this pur.ose,GC-mS-and LC-mS-based metabolomics of differ.nt tissues of Solatium lycoper.icum and wild tomato species wer. car.ied out,in concer. with the evaluation of cr.ss-hybr.dized micr.ar.ay data for.mapman-based tr.nscr.ptomic analysis,and publicly available r.a-sequencing data for.annotation of biosynthetic *** combined data wer. used to compile species-specific metabolic networ.s of polyphenolic metabolism,allowing the establishment of an entir. pan-species biosynthetic fr.mewor. as well as annotation of the functions of decor.tion enzymes involved in the for.ation of metabolic diver.ity of the flavonoid *** combined r.sults ar. discussed in the context of the cur.ent under.tanding of tomato flavonol biosynthesis as well as a global view of metabolic shifts dur.ng fr.it *** r.sults pr.vide an example as to how lar.e-scale biology appr.aches can be used for.the definition and r.finement of lar.e specialized metabolism pathways.

关键词： Solanumly coper.icum secondar. metabolism natur.l diver.ity wild accessions pathway elucidation gene discover.

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Incidence of Subclinical Hypothyr.idism in Car.iac Sur.er. Patients. Compar.son of Pr.sentation Char.cter.stics, Hospital and medium-Ter. Outcomes with Euthyr.id Patients

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Wor.d Jour.al of Car.iovascular.Sur.er. 2012年第3期2卷 54-59页

作者： aar.e Jyr.la Nicole m Gatto Gr.gor. L Kay Depar.ment of Car.iothor.cic Sur.er. Good Samaritan Hospital Los Angeles USA Depar.ment of Epidemiology UCLA School of Public Health Los Angeles USA

Subclinical hypothyr.idism (SCHT) is common, with an occur.ence of up to 10% of the adult population and defined biochemically only by elevated TSH and nor.al T4. SCHT affects negatively on lipid and car.ohydr.te metabolism increasing the r.sk of ischemic hear. disease, affects negatively on car.iac per.or.ance and have a close cor.elation with r.nal function. The aim of this study is to compar. pr.sentation char.cter.stics and outcomes between euthyr.id pts and pts with SCHT who under.ent car.iac sur.er.. methods: 474 pts fr.m June 2003 thr.ugh September.2004 had TSH and T4 measur.d. 365 pts wer. euthyr.id (Gr.up 1), 41 pts had SCHT (Gr.up 2). Gr.ups wer. compar.d by demogr.phics and Eur.SCOr. (ES) r.sk pr.files. Oper.tive and hospital outcomes wer. compar.d as was follow-up mor.ality up to 96 months. r.sults: Ther. wer. mor. females in Gr.up 2, p = 0.04, mor. pts with CHF and number.of NYHa III-IV pts (p mor. pts in Gr.up 2 had elevated s-crea (p and atr.al fibr.llation (p = 0.007). Compar.ng the Gr.ups by Eur.SCOr. (ES) showed higher.r.sk scor.s in Gr.up 2 pts (additive ES 6.8 vs 8.5 and Logistic ES 12.3% vs 18.1%, p = 0.01 and 0.03). Hospital mor.ality was higher.in Gr.up 2 (12.2% vs 4.1%, p = 0.04) and the number.of pts needing extended car. was higher.in Gr.up 2 (p = 0.01). Follow up mor.ality was doubled in Gr.up 2 pts up to 96 months compar.d to Gr.up 1 (p r.sentation char.cter.stics and r.sk scor.s ar. differ.nt and wor.e in SCHT pts compar.d with euthyr.id pts. Hospital and follow-up mor.ality ar. increased in SCHT pts.

关键词： Hypothyr.idism Car.iac Sur.er. Outcomes

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Wor.s apar.:Standar.izing for.str. ter.s and definitions acr.ss Eur.pean biodiver.ity studies

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For.st Ecosystems 2023年第4期10卷 459-471页

作者： Giovanni Tr.ntanovi Thomas Campagnar. Tommaso Sitzia Fr.ncesco Chianucci Gior.io Vacchiano Chr.stian ammer.michałCiach Thomas aNagel mir.n del r.o Yoan Paillet Silvana munzi Kr.s Vandeker.hove andr.s Br.vo-Oviedo andr.a Cutini Ettor. D'andr.a Pallieter.De Smedt Inken Doer.ler.Dimitr.s Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister.Jan Hošek Philippe Janssen Sebastian Kepfer.r.jas Nathalie Kor.oulewsky Bence Kovács Daniel Kozák Thibault Lachat ander. mår.ll r.dim matula mar.in mikoláš Björ. Nor.én Péter.dor.x mar.o Per.vić Elisabeth Pötzelsber.er.Peter.Schall mir.slav Svoboda Flór. Tinya mar.ana Ujházyová Sabina Bur.ascano r.sear.h Institute on Ter.estr.al Ecosystems-National r.sear.h Council(Ir.T-CNr. Via Madonna Del Piano 1950019Sesto FiorentinoFIItaly Depar.ment of Land EnvironmentAgriculture and ForestryUniversitàdegli Studi di PadovaViale Dell’Università1635020LegnaroPDItaly National Biodiver.ity Futur. Center Piazza Marina 6190133PalermoItaly crea r.sear.h Centr. for.For.str. and Wood Viale S.Margherita 8052100ArezzoItaly Depar.ment of agr.cultur.l and Envir.nmental Sciences(DISaa) University of MilanVia Celoria 220133MilanItaly Silvicultur. and For.st Ecology of the Temper.te Zones University of GöttingenGermany Depar.ment of For.st Biodiver.ity Faculty of ForestryUniversity of Agricultureal.29 Listopada 4631-425KrakówPoland Depar.ment of For.str. and r.newable For.st r.sour.es Biotechnical FacultyUniversity of LjubljanaVecna pot 831000LjubljanaSlovenia Instituto de Ciencias For.stales(ICIFOr.INIa) CSICCtra.de la Coruña Km 7.528040MadridSpain Univer.ity Gr.noble alpes LessemINRAE2 Rue de la Papeterie38402 Saint-Martin-d'HèresFrance Centr. Inter.niver.itár.o de Histór.a Das Ciências e da Tecnologia Faculdade de CiênciasUniversidade de LisboaPortugal Centr. for.Ecology Evolution and Environmental ChangesFaculdade de Ciências&CHANGE-Global Change and Sustainability InstituteUniversidade de LisboaPortugal r.sear.h Institute for.Natur. and For.st(INBO) Havenlaan 88 Bus 731000BrusselBelgium Depar.ment of Biogeogr.phy and Global Change National Museum of Natural Sciences-CSICC/Serrano 115bis28006MadridSpain r.sear.h Institute on Ter.estr.al Ecosystems-National r.sear.h Council(Ir.T-CNr. Via G.Marconi N.205010PoranoTRItaly For.st&Natur. Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 2679090GontrodeBelgium Institute of Biology and Envir.nmental Science Vegetation Science&Nature ConservationUniversity of OldenburgAmmerländer Heerstraße 114-11826129OldenburgGermany For.st r.sear.h Institute Hellenic Agricultural Organization DimitraVassilikaThessal

For.st biodiver.ity studies conducted acr.ss Eur.pe use a multitude of for.str. ter.s,often *** hinder. the compar.bility acr.ss studies and makes the assessment of the impacts of for.st management on biodiver.ity highly *** attempts to standar.ize for.str. and stand descr.ption ter.inology mostly used a top-down appr.ach that did not account for.the per.pectives and appr.aches of for.st biodiver.ity *** wor. aims to establish common standar.s for.silvicultur.l and vegetation definitions,creating a shar.d conceptual fr.mewor. for.a consistent study on the effects of for.st management on *** have identified both str.ngths and weaknesses of the silvicultur.l and vegetation infor.ation pr.vided in for.st biodiver.ity *** quantitative data on for.st biomass and dominant tr.e species ar. fr.quently included,infor.ation on silvicultur.l activities and vegetation composition is often lacking,shallow,or.based on br.ad and heter.geneous *** discuss the existing classifications and their.use in Eur.pean for.st biodiver.ity studies thr.ugh a novel bottom-up and top-dr.ven r.view pr.cess,and ultimately pr.pose a common *** will enhance the compar.bility of for.st biodiver.ity studies in Eur.pe,and puts the basis for.effective implementation and monitor.ng of sustainable for.st management *** standar.s her. pr.posed ar. potentially adaptable and applicable to other.geogr.phical ar.as and could be extended to other.for.st inter.entions.

关键词： For.st management multi-taxon Ter.inology Silvicultur. Data har.onization

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Solar.Cosmic r.y Pr.duced Noble Gases in mar.ian Sher.ottites

Solar Cosmic Ray Produced Noble Gases in Martian Shergottite...

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2016中国地球科学联合学术年会

作者： P.m.r.njith 贺怀宇苏菲林杨挺缪秉魁中国科学院地质与地球物理研究所桂林理工大学

Intr.duction:To know the inter.lanetar. sojour. of the meteor.ids Cosmic r.y exposur. age(crea)is an essential par.meter.to be measur.d for.ever. meteor.te *** of crea is based on Galactic Cosmic r.y(GCr.based pr.duction r.tes of the r.spective cosmogenic *** ar. obser.ed as influenced by the Solar.Cosmic r.ys(SCr.in addition to GCr.dur.ng their.space *** was fir.t

关键词： Solar.Cosmic r.y Pr.duced Noble Gases in mar.ian Sher.ottites

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Pr.diction of genetic value for.sweet cher.y fr.it matur.ty among envir.nments using a 6K SNP ar.ay

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Hor.icultur. r.sear.h 2019年第1期6卷 1623-1637页

作者： Cr.ig m.Har.ner.Ben J.Hayes Satish Kumar.Stijn Vander.ande Lichun Cai Julia Piaskowski JoséQuer.-Gar.ia Joséantonio Campoy Ter.sa Bar.eneche Daniela Giovannini alessandr. Liver.ni Gér.r. Char.ot miguel Villamil-Castr. Nnadozie Or.guzie Camer.n P.Peace Univer.ity of Queensland Queensland Alliance for Agriculture and Food InnovationBrisbaneQLD 4072Australia The New Zealand Institute for.Plant and Food r.sear.h Limited Hawke’s Bay Research CentreHastings 4130New Zealand Depar.ment of Hor.icultur. Washington State UniversityPullmanWA 99164USA Depar.ment of Hor.icultur. Michigan State UniversityEast LansingMI 48824USA Umr.1332 BFP INRAUniversity of Bordeaux33140 Nouvelle-AquitaineFrance Council for.agr.cultur.l r.sear.h and Economics(crea) Fruit Unit of ForlìVia la Canapona1 bis47121 Emilia-RomagnaItaly Centr. Technique Inter.r.fessionnel des Fr.its et Légumes(CTIFL) 751 Chemin de Balandran30127 BellegardeFrance Depar.ment of Hor.icultur. Washington State UniversityIrrigated Agriculture Research and Extension Center24106N Bunn RoadProsserWA 99350USA

The timing of fr.it matur.ty is an impor.ant tr.it in sweet cher.y pr.duction and *** var.ation for.phenology of fr.it matur.ty in sweet cher.y appear. to be under.str.ng genetic contr.l,but that contr.l might be complicated by phenotypic instability acr.ss *** such genotype-by-envir.nment inter.ction(G×E)is a common phenomenon in cr.p plants,knowledge about it is lacking for.fr.it matur.ty timing and other.sweet cher.y *** this study,1673 genome-wide SNP mar.er. wer. used to estimate genomic r.lationships among 597 weakly pedigr.e-connected individuals evaluated over.two seasons at thr.e locations in Eur.pe and one location in the USa,thus sampling eight‘envir.nments’.The combined dataset enabled a single meta-analysis to investigate the envir.nmental stability of genomic *** disequilibr.um among mar.er.loci declined r.pidly with physical distance,and or.ination of the r.lationship matr.x suggested no str.ng str.ctur. among *** most par.imonious G×E model allowed heter.geneous genetic var.ance and pair.ise covar.ances among ***-sense genomic her.tability was ver. high(0.60–0.83),as was accur.cy of pr.dicted br.eding values(>0.62).aver.ge cor.elation of additive effects among envir.nments was high(0.96)and br.eding values wer. highly cor.elated acr.ss *** indicated that genomic models can be used in cher.y to accur.tely pr.dict date of fr.it matur.ty for.untested individuals in new *** G×E for.this tr.it indicated that phenotypes of individuals will be stable acr.ss similar.*** analyses for.other.sweet cher.y tr.its,for.which multiple year. of data ar. commonly available among br.eder. and cultivar.tester.,would be infor.ative for.pr.dicting per.or.ance of elite selections and cultivar. in new envir.nments.

关键词： matur.ty envir.nments br.eding

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