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Influence of rEV and ALV-J Co-Infection on Immunologic Function of T Lymphocytes and Histopathology in Broiler Chickens

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Agricultural Sciences in china 2010年第11期9卷 1667-1676页

作者： GUO Hui-jun, LI Hong-mei, CHENG Zi-qiang , LIU Jian-zhu and CUI Zhi-zhong Key Laboratory of animal Biotechnology and disease control and prevention, College of Veternary Medicine, Shandong Agricultural University, Tai’an 271018, p.r.china [a] Key Laboratory of animal Biotechnology and disease control and prevention College of Veternary Medicine Shandong Agricultural University Tai'an 271018 P.R. China

The aim of present investigation is to study the effect of single- and co-infection with rEV and ALV-J on T lymphocytes bioactivities and histopathology in broiler chickens. The bioactivities of blood and spleen T lymphocytes including lymphoproliferation responses, cytotoxicitic responses, and histopathology of spleen were detected in broiler chickens singly- or co-infected with rEV and ALV-J at different days post inoculation and the virus expressions in spleen of infected broiler chickens were detected with immunofluorescence assay （IFA）. The results indicated that blood and spleen T lymphocytes proliferation responses and cytotoxicity in broilers infected with rEV or/and ALV-J were inhibited in the whole observed period compared with controls. In the co-infected chickens they were highly inhibited than in the single-infected. The histopathology of spleen in infected chickens at 17 and 37 d post inoculation （dpi） indicated that cell interium increased, the numbers of lymphocytes decreased, and the regrowth were destroyed or decreased, especially more significantly at 17 than at 37 dpi. The different numbers of virus were detected in spleen lymphocytes in rEV- infected and/or ALV-J-infected chickens. In the spleen of co-infected chicken, both rEV and ALV-J were detected and the total numbers of viruses were more than in chickens singly-infected with rEV or ALV-J. Thus, the co-effect of rEV and ALV-J caused more immunosuppression on T lymphocytes bioactivities in broiler chickens than single-effect of ALV-J or rEV, which contributed to the sever histopathology and the product of tumor cells. This study will be helpful for understanding the effect of co-infection with many viruses and control them in poultry.

关键词： reticuloendotheliosis virus (rEV) J subgroup of avian leukosis virus (ALV-J) T lymphocyte activity,histopathology commercial broiler chickens

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Expression of pHGpx in mammalian cells and its antiviral effect against coxsackievirus group B

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progress in Natural Science:Materials International 2005年第7期15卷 665-668页

作者： ZHAO Wenran, ZHONG Xuekuan and ZHOU Lingwang (Institute of Keshan disease, Chinese research center for Endemic disease control, Harbin Medical University, Harbin 150086, china) Institute of Keshan disease Chinese Research Center for Endemic Disease Control Harbin Medical University Harbin 150086 China

To express human phospholipid hydroperoxide glutathione peroxidase (pHGpx) in eukaryotic cells and to study its antiviral effect against Coxsackievirus B3m (CVB3m) in vitro, pHGpx cDNA was amplified from a human testis library using specific primers and cloned into expression vector pcDNA3. I/His. Expression of pHGpx was performed in COS-1 cells. The antiviral effect was studied by the treatment of HeLa cells with the recombinant pHGpx. results showed that the activity of pHGpx expressed in COS-1 cells was 5-fold higher than that in control group, and it inhibited the cytopathic effect on HeLa cells caused by CVB3m. It can be concluded that recombinant pHGpx expressed in COS-1 cells has antiviral effect against CVB3m in vitro.

关键词： pHGpx gene expression coxsackievirus group B antiviral effect.

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Epidemiological Studies on Cystic Echinococcosis in china─A review

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Biomedical and Environmental Sciences 1995年第2期8卷 122-136页

作者： CHAI JUN-JIE(National Hydatid disease center of china, Xnjiang Institute for Endemic diseases control and research, Urumqi Xinjiang china 830002) National Hydatid disease center of china Xinjiang Institute for Endemic Diseases Control and Research.

In the four decades from 1951 to 1990, the six provinces or autonomous regions (Xinjiang, Gansu, Qinghai, Ningxia, Xizang and Nei Monggol) reported a total of 26 065surgical cases of hydatid disease, most of which were reported in the recent decade. About one third of the patients was children and adolescents under 15 years old. So far, cystic hydatid infections of local origin have been confirmed in 22 provinces, autonomous regions and municipalities in the whole nation. Findings of X-ray examination and real-time B-mode ultrasonography in agricultural and pastoral areas of Xinjiang, Gansu, Qinghai,Ningxia and Xizang showed that the morbidity rate of hydatidosis in human population varied between 0.5% and 4.5%. The main animal intermediate host in all these regions is sheep, the morbidity of which varied between 3.3% and 90%. The infection rate of adult Echinococcus granulosus in dogs varied between 7% and 71%. The high-risk period for humans contracting hydatid disease is the pre-school age. Direct contact of children with dogs and ingestion of water, vegetables and foods contaminated by worm eggs are the chief mode of transmission for human hydatidosis. The common practices of home slaughter and of feeding dogs on offal containing hydatid cysts facilitate the life cycIe of the *** the basis of hydatid control efforts for several years, the Ministry of public Health promulgated officially the '1992-1995 National programme for Hydatid disease control'in April, 1992, and pilot studies in which the control of hydatidosis is composed of extensive health education, sanitation of slaughtering and management and deworming of dogs are being *** echinococcosis has wide distribution in china and is a major public health problem in hyperendemic areas, poses a great threat against people's health and influences the development of livestock husbandry. This problem has received great attention from the medical and veterinary departments. In the rencent d

关键词： Epidemiological Studies on Cystic Echinococcosis in china A review

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Effects of red palm Oil on Serum Lipids and plasma Carotenoids Level in Chinese Male Adults

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Biomedical and Environmental Sciences 2003年第4期16卷 348-354页

作者： JIAN ZHANG , CHUN-rONG WANG, AN-NA XUE, AND KE-YOU GEInstitute of Nutrition and Food Safety, Chinese center for disease control and prevention, Beijing 100050, china Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 Chin

Objective Effects of red palm oil on major plasma carotenoids, tocopherol, retinol and serum lipids were evaluated when used in Chinese diet. Methods red palm oil group (rpO) composed of 20 male subjects(aged 18-32) and soybean oil group (SBO) composed of 22 male subjects (aged 18-32). Dietary fat provided about 28% of total calories, and the test oil accounted for about 60% of total dietary fat. In the 3 weeks of pretest period, diets were prepared with soybean oil, and then in the next 6 weeks subjects in each group consumed the diet prepared by test oil. results plasma α-carotene, β-carotene and lycopene concentration of rpO group significantly increased at the time of interim (21 days) and of the end (42 days) (ppherol concentration significantly increased at the time of the end (42 days) in this study. Though Chinese plasma retinol level was relatively low when compared with that of Westerners, red palm oil diet showed no significant effect on adult Chinese plasma retinol level. Serum concentration of total cholesterol, triglyceride, high density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B of all subjects showed no significant changes in rpO group during the study. Conclusions The data in our study suggest that red palm oil is a good source of carotenoids and vitamin E when used in Chinese diet preparation, and it can significantly increase plasma concentration of a-carotene, α-carotene, lycopene and β-tocopherol.

关键词： red palm oil retinal α-carotene β-carotene α-tocopherol Serum cholesterol Serum triglyeride Apolipoprotein AI Apolipoprotein B

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局部晚期非小细胞肺癌放疗靶区勾画和计划设计指南

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中华放射肿瘤学杂志 2024年第10期33卷 877-892页

作者：国家癌症中心/国家肿瘤质控中心朱广迎毕楠不详中日友好医院放射肿瘤科北京100029 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021

局部晚期非小细胞肺癌(NSCLC)占所有NSCLC患者总数的1/3,包括ⅢA期(可手术切除和不可手术切除)、ⅢB期、ⅢC期患者。放射治疗是局部晚期NSCLC的主要治疗之一。对于不可切除局部晚期NSCLC,以放疗为基础的综合治疗使得患者5年生存率达到42... 详细信息

局部晚期非小细胞肺癌(NSCLC)占所有NSCLC患者总数的1/3,包括ⅢA期(可手术切除和不可手术切除)、ⅢB期、ⅢC期患者。放射治疗是局部晚期NSCLC的主要治疗之一。对于不可切除局部晚期NSCLC,以放疗为基础的综合治疗使得患者5年生存率达到42.9%。对于可切除ⅢA期患者,放疗的价值受到挑战,但多项回顾性研究和真实世界研究的部分高危患者依然可以从术后放疗中获益,提高生存率。整体上该期患者由于异质性较大,预后的个体差异较大。中国不同放射治疗中心的NSCLC诊疗常规、靶区勾画规范、计划设计规范仍有较大差异,医生、物理师的具体工作标准也可能存在差异。精准靶区勾画是放疗获益的重要前提,为了促进肺癌临床放疗的规范化、便于开展多中心临床研究,国家肿瘤质控中心参考国内外已发布的相关标准制定此精准放疗技术下局部晚期NSCLC根治性同步放化疗和术后放疗路径、适应证、靶区勾画和计划评价指南,旨在为国内各放疗单位提供参考。

关键词：癌,非小细胞肺局部晚期术后放射疗法靶区勾画计划设计

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中国阿尔茨海默病蓝皮书(精简版)

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中华医学杂志 2024年第29期104卷 2701-2727页

作者：首都医科大学宣武医院国家神经疾病医学中心中国疾病预防控制中心慢性非传染性疾病预防控制中心国家卫生健康委能力建设和继续教育中心中国人口与发展研究中心《中国阿尔茨海默病蓝皮书》项目组首都医科大学宣武医院国家神经疾病医学中心中国疾病预防控制中心慢性非传染性疾病预防控制中心国家卫生健康委能力建设和继续教育中心中国人口与发展研究中心《中国阿尔茨海默病蓝皮书》项目组

随着中国人口老龄化程度不断加重, 阿尔茨海默病(AD)在我国的患病率和死亡率均不断上升, 已成为严重危害人民群众健康和影响社会可持续发展的重大疾病之一。为响应健康中国行动, 提高国民健康水平, 促进健康发展, 首都医科大学宣武医院... 详细信息

随着中国人口老龄化程度不断加重, 阿尔茨海默病(AD)在我国的患病率和死亡率均不断上升, 已成为严重危害人民群众健康和影响社会可持续发展的重大疾病之一。为响应健康中国行动, 提高国民健康水平, 促进健康发展, 首都医科大学宣武医院国家神经疾病医学中心、中国疾病预防控制中心慢性非传染性疾病预防控制中心、国家卫生健康委能力建设和继续教育中心、中国人口与发展研究中心等单位专家和学者联合编写《中国阿尔茨海默病蓝皮书(精简版)》(简称蓝皮书)。蓝皮书系统回顾了目前中国AD及其他认知障碍疾病的流行病学特征、诊疗现状、防治管理等情况, 旨在为人群AD疾病预防提供依据、为疾病规范化诊疗提供支持、为政府制定相关卫生政策提供参考。蓝皮书主要包括AD及其他认知障碍疾病的以下内容:(1)流行病学特征;(2)经济负担;(3)影响因素;(4)中国脑认知健康指数;(5)诊断现状;(6)治疗现状;(7)认知障碍诊疗中心建设;(8)社区防治;(9)AD患者的照料;(10)防治的公共卫生资源。

关键词：阿尔茨海默病流行病学诊断现状治疗现状社区防治照料负担

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2024年月中国甲乙丙类传染病疫情动态简介

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疾病监测 2024年第9期 1095-1095页

作者： Division of Infectious disease, Chinese center for disease control and prevention 中国疾病预防控制中心传染病预防控制处

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Interaction and Its Solution in Individual Matching Case-control Study

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Biomedical and Environmental Sciences 2003年第1期16卷 40-46页

作者： XIAO-XIN HE AND SHUI-GAO JINcenter for public Health Surveillance and Information Services, Chinese center for disease prevention and control, 27 Nan Wei road, Beijing 100050, china center for public Health Surveillance and Information Services Chinese Center for Disease Prevention and Control 27 Nan Wei Road 北京 100050

Objective To indicate the deficiency of the classical method for analyzing data on individual matching case-control study in consideration of the interaction between the study factor (exposure) and the matching factor, and to find out a proper method for handling this deficiency. Method First, experimental data with 50 pairs of cases and controls were used for strata analysis according to the values of a matching factor to illustrate the possible interaction between a risk factor (exposure) and the matching factor. Second, a detailed procedure was proposed for analyzing such data. results Interaction between the study factor and matching factor was demonstrated by using strata analysis and unconditional logistic regression analysis. Therefore the results from the classical analysis for such data might be incorrect. Conclusion Data from individual matching case-control study design should be dealt with strata analysis or multivariate analysis to explore and evaluate the possible interaction between the s

关键词： Interaction Individual matching case-control study Stratification analysis Multivariate analysis

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OBSErVATIONS ON EFFECT OF SODIUM SELENITE IN prEVENTION OF KESHAN disease

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中华医学杂志(英文版) 1979年第7期92卷 471-476页

作者： Keshan disease research Group of the Chinese Academy of Medical Sciences, Beijing Antiepidemic Station of sichuan province, chengdu Antiepidemic Station of Xichang District, sichuan Antiepidemic Station of Mianning County, sichuan Keshan disease research Group of the Chinese Academy of Medical Sciences Beijing Antiepidemic Station of sichuan province Chengdu Antiepidemic Station of Xichang District Sichuan Antiepidemic Station of Mianning County Sichuan

To evaluate the efficacy of sodium selenitein Keshan disease,a study was carried outamong children in Mianning county,sichuanprovince,from 1974 to 1977 *** of Keshan disease in Selenium(Se)supplemented children was found to be 2.2‰and 1.0‰ in 1974 and 1975 respectively whilethat in the control groups was 13.5‰ and 9.5‰,the difference being highly significant in *** 1976, both groups were given sodiumselenite and the rate was further decreased to0.32‰.In 1977,no new cases of Keshan diseasewere discovered among the treated *** 36,603 Se supplemented children,21 casesof the disease occurred during the 4 years *** these, only 3 died and 1 be-came a *** 9,642 children in thecontrol group,107 cases occurred, of which 53became fatal and 6 had insufficient heart *** results indicate that sodium sele-nite could not only lower the morbidity ofKcshan disease but also alleviate its clinicalsigns and improve its *** role of selenium in the etiology of Ke-shan disease and the possible mechanism ofsodium selenite in its prevention are discussed.

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A Flavobacterium lindanitolerans Strain Isolated from the Ascites Sample of a Chinese patient with EV71 Virus Infection

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Biomedical and Environmental Sciences 2011年第6期24卷 694-696页

作者： TIAN Guo Zhong1,△,pIAO Dong ri1,△,ZHAO Hong Yan1,△,JIANG Hai1,CUI Bu Yun1,and LI Jun Yan2,#1.State Key Laboratory for Infectious diseases prevention and control,National Institute for Communicable disease control and prevention,Chinese center for disease control and prevention,Beijing 102206,china 2.National Institute of Occupational Health and poison control,Chinese center for disease control and prevention,Beijing 100050,china [a] State Key Laboratory for Infectious diseases prevention and control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China [b] National Institute of Occupational Health and poison control Chinese Center for Disease Control and Prevention Beijing 100050 China

A strain of Flavobacterium lindanitolerans isolated from a sick child`s ascites was *** 16S rrNA gene of the strain was 100% identical to that of Flavobacterium lindanitolerans which was first identified in India in *** was first described that the isolate required X factor (Hemin) for growth in the optimal conditions of 37°C with 5% *** isolate produced indole and *** did not present hemolytic feature on blood agar.

关键词： Flavobacterium lindanitolerans 16S rrNA Biology

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