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Screening of GJB2 mutations in Chinese population

Journal of Otology 2007年第1期2卷 18-22页

作者： HAN Ming-kun1, HAN Dong-yi1, GUO Yu-fen2, LI Qing-zhong3, ZHAO Ya-li1, 4, RAO Shao-qi1, 5, 6, YUAN Hu1, ZONG Liang1, GUAN Jing2, XU Bai-cheng2, WANG Da-yong1, LAN lan1, WANG Qiu-ju1, 7 1 Department of Otorhinolaryngology/ Head and Neck Surgery, and Institute of Otolaryngology, china People Liberation Army General Hospital, beijing, china 2 Department of Otorhinolaryngology/ Head and Neck Surgery, the Second Affiliated Hospital of LanZhou University, Lanzhou, china 3 Deparment of Otlolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, china 4 Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, beijing, china 5 Departments of Cardiovascular Medicine and Molecular Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA 6 Department of Bioinformatics, Harbin Medical University, Harbin, china 7 china national human genome center, beijing, china Department of Otorhinolaryngology/ Head and Neck Surgery and Institute of Otolaryngology China People Liberation Army General Hospital Beijing China Department of Otorhinolaryngology/ Head and Neck Surgery the Second Affiliated Hospital of LanZhou University Lanzhou China Deparment of Otlolaryngology Eye and ENT Hospital of Fudan University Shanghai China Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Departments of Cardiovascular Medicine and Molecular Cardiology the Cleveland Clinic Foundation Cleveland Ohio USA Department of Bioinformatics Harbin Medical University Harbin China china national human genome center Beijing China

The GJB2 gene(connexin 26) has been shown to be responsible for DFNB1 and DFNA3. We screened the GJB2 gene in 488 patients with prelingual deafness(Group 1), 124 with postlingual deafness(Group 2), and 117 normal hearing subjects(Group 3). We found that, in Group 1, 65 patients(13.32%) were homozygotes or compound heterozygotes and 51 patients (10.45%) carried a single pathogenic mutation. The 235delC mutation was the most frequent mutation, accounting for 73.22% of the known pathogenic alleles in Group 1. No homozygotes or compound heterozygotes were detected in Group 2 or Group 3. Some postlingual deaf patients (2.42%) and normal hearing subjects(4.27%) were 235delC carriers. Our preliminary data indicate that 235delC, the most frequent mutation identified in this study, is a major cause for prelingual deafness.

关键词： prelingual deafness postlingual deafness, GJB2 235delC Chinese

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Report on Cardiovascular Health and Diseases in china 2023:An Updated Summary

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Biomedical and Environmental Sciences 2024年第9期37卷 949-992页

作者： national center for Cardiovascular Diseases The Writing Committee of the Report on Cardiovascular Health and Diseases in china Shengshou Hu .

Since 1990,china has made considerable progress in resolving the problem of“treatment difficulty”of cardiovascular diseases(CVD).The prevalent unhealthy lifestyle among Chinese residents has exposed a massive proportion of the population to CVD risk factors,and this situation is further worsened due to the accelerated aging population in *** remains one of the greatest threats to the health of Chinese *** terms of the proportions of disease mortality among urban and rural residents in china,CVD has persistently ranked *** 2021,CVD accounted for 48.98%and 47.35%of deaths in rural and urban areas,*** out of every five deaths can be attributed to *** implement a national policy“focusing on the primary health institute and emphasizing prevention”and truly achieve a shift of CVD prevention and treatment from hospitals to communities,the national center for Cardiovascular Diseases has organized experts from relevant fields across china to compile the“Report on Cardiovascular Health and Diseases in china”annually since *** 2024 report is established based on representative,published,and high-quality big-data research results from cross-sectional and cohort population epidemiological surveys,randomized controlled clinical trials,large sample registry studies,and typical community prevention and treatment cases,along with data from some projects undertaken by the national center for Cardiovascular *** firsthand data not only enrich the content of the current report but also provide a more timely and comprehensive reflection of the status of CVD prevention and treatment in china.

关键词： Cardiovascular disease Risk factor Prevalence Mortality Rehabilitation Basic research Medical device development Health economics

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Real-World Treatment Adherence to Smoking Cessation Medications and Association with Treatment Outcome—27 centers,china,2017–2022

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china CDC weekly 2024年第22期6卷 522-529,I0001-I0003页

作者： Anqi Cheng Zhao Liu Xinmei Zhou Zheng Su Dan Xiao Chen Wang the china national Tobacco Cessation Cohort Study(CNTCCS)Study Group Department of Tobacco Control and Prevention of Respiratory Disease Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/National Center for Respiratory Medicine/National Clinical Research Center for Respiratory Diseases/Institute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/China National Center for Respiratory Medicine/China National Clinical Research Center for Respiratory DiseasesBeijingChina Chinese Academy of Medical Sciences and Peking Union Medical College BeijingChina 不详

What is already known about this topic?Medication non-adherence significantly impedes smoking cessation *** effective smoking cessation medications are accessible in china,realworld adherence and its correlation with treatment outcomes remain largely *** is added by this report?From December 2017 to January 2022,1,120 participants were recruited from 27 centers in all seven geographical regions of *** revealed that only 38.2%of smokers adhered to the prescribed 12-week smoking cessation treatment and those with a higher education level were more likely to be *** addition,smokers with good adherence were more likely to successfully quit *** are the implications for public health practice?The data obtained could enhance our understanding of smoking cessation practices in *** adherence is a crucial strategy to enhance the effectiveness of smoking cessation treatments and management provided to smokers.

关键词： china smoke likely

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2023 Guideline for the management of hypertension in the elderly population in china

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Journal of Geriatric Cardiology 2024年第6期21卷 589-630页

作者： Hypertension Branch of Chinese Geriatrics Society,beijing Hypertension Association,national Clinical Research center of the Geriatric Diseases Qi HUA Li FAN Zeng-Wu WANG Jing LI 不详 Xuanwu Hospital Capital Medical UniversityBeijingChina Chinese PLA General Hospital BeijingChina Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Preamble Hypertension is one of the most common chronic diseases and the primary risk factor for stroke,myocardial infarction and even cardiovascular *** than half of the elderly population has high blood *** people are a unique group,and strategies for the prevention,diagnosis,evaluation,and treatment of hypertension in elderly individuals differ significantly from those in the general population.

关键词： hypertension prevention diagnosis

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Community-based prevention and treatment of cardiovascular diseases

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Journal of Geriatric Cardiology 2024年第3期21卷 315-322页

作者： Sheng-Shou HU The Writing Committee of the Report on Cardiovascular Health and Diseases in china Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on Cardiovascular Health and Diseases in china(2022)intricate landscape of cardiovascular health in *** is the third section of the report with a specific focus on community-based prevention and treatment of cardiovascular diseases(CVD).This section of the report underscores the importance of initiatives outlined in the"Healthy china 2030 Plan,"emphasizing the comprehensive prevention and control strategy for chronic diseases.A key aspect of this plan involves the establishment of national demonstration areas aimed at comprehensive prevention and control of chronic *** 2020,488 such areas had been set up across china,surpassing the initial target and covering a significant proportion of counties and *** report highlights the successful implementation of these strategies in Lishan district,Anshan city,where demonstration areas for comprehensive prevention and control of chronic diseases were launched in *** the course of seven years,the number of healthy units increased substantially,leading to improvements in managing risk factors for CVD among *** reductions in prevalence rates of overweight,obesity,smoking,passive smoking,and drinking were observed,along with the development of healthier behaviors among ***,Qiaokou district in Wuhan City,designated as a national demonstration area in 2014,implemented comprehensive public health promotion ***,special clinics for hypertension intervention were established,contributing to an increase in self-reported rates of hypertension,a slight decrease in prevalence,and a remarkable improvement in the control rate among treated ***,these efforts underscore the effectiveness of community-based approaches in driving positive health outcomes and advancing the comprehensive prevention and control of chronic diseases,particularly cardiovascular diseases,in china.

关键词： prevention district treatment

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Cardiovascular Risk Factors in china

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Journal of Geriatric Cardiology 2024年第2期21卷 153-199页

作者： Sheng-Shou HU the Writing Committee of the Report on Cardiovascular Health and Diseases in china Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 不详

The Annual Report on Cardiovascular Health and Diseases in china(2022) intricate landscape of cardiovascular health in china. This section dissects cardiovascular risk factors in china which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in china,with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia,have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in china,with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in

关键词： landscape adding spite

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Heart failure in china:epidemiology and current management

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Journal of Geriatric Cardiology 2024年第6期21卷 631-641页

The Annual Report on Cardiovascular Health and Diseases in china(2022)intricate landscape of cardiovascularhealth in *** connection with the previous section,this sixth section of the report offers a comprehensive analysis of heart failure(HF)in *** is one of the most important cardiovascular disease in the 21st *** mortality is equivalent to that of *** is an important public health problem that seriously affects the health of Chinese *** recent years,with the deepeningof understanding,the change of treatment principles,the innovation of treatment methods and the update of treatment guidelines,the in-hospital mortality of HF patients has declined,and the long-term prognosis is also ***,there are stilldifferences in the management level of HF among different hospitals in *** to improve the standardized diagnosis andtreatment level of HF in china remains an important challenge.

关键词： epidemiology diagnosis treatment

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国家药品不良反应监测年度报告（2023年）

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中国病毒病杂志 2024年第3期 204-210页

作者： national center for ADR Monitoring,china 国家药品不良反应监测中心

为全面反映2023年我国药品不良反应监测情况，提高安全用药水平，更好地保障公众用药安全，国家药品不良反应监测中心组织编撰《国家药品不良反应监测年度报告（2023年）》。1药品不良反应监测工作情况2023年，国家药品不良反应监测中... 详细信息

为全面反映2023年我国药品不良反应监测情况，提高安全用药水平，更好地保障公众用药安全，国家药品不良反应监测中心组织编撰《国家药品不良反应监测年度报告（2023年）》。1药品不良反应监测工作情况2023年，国家药品不良反应监测中心在国家药品监督管理局的领导下，全面贯彻党的二十大精神，认真落实“四个最严”要求，按照“讲政治、强监管、保安全、促发展、惠民生”的工作思路，扎实有效开展各项工作，为药品监管提供科学有力支撑，切实保护和促进公众健康。一是体系能力建设纵深推进。贯彻落实《国务院办公厅关于全面加强药品监管能力建设的实施意见》《“十四五”国家药品安全及促进高质量发展规划》，加强对基层监测机构和医疗机构指导，督促药品上市许可持有人（以下简称“持有人”）落实主体责任，持续强化“一体两翼”工作格局。

关键词：药品不良反应监测统计

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Pulmonary embolism and deep venous thrombosis in china

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Journal of Geriatric Cardiology 2024年第8期21卷 775-778页

The Annual Report on Cardiovascular Health and Diseases in china(2022) intricate landscape of cardiovascular health in *** connection with the previous section,this eighth section of the report offers a comprehensive analysis of pulmonary embolism and deep venous *** recent years,research in the field of pulmonary vessel in china has made great progress.A number of nationwide multi-center registry research results have filled the gaps in the epidemiology,diagnosis and treatment of pulmonary hypertension and venous *** types of pulmonary hypertension still need attention to the identification of risk factors and/or risk stratification,and venous thromboembolism needs attention in the prevention and the overall management inside and outside *** the future,we look forward to the publication of more high-quality research in china,which could be able to improve relevant guidelines for pulmonary vascular diseases both domestically and inter-nationally.

关键词： epidemiology prevention diagnosis

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中国政治经济学年度发展报告（2023）（下）

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政治经济学评论 2024年第3期 90+207-208页

作者： center for Studies of Contemporary Political Economy,Research Institute for 21st-Century Marxism,Nankai University·University of Chinese Academy of Social Science center for Teaching and Research on Capital,Renmin University of china national Institute of Socialist Political Economy with Chinese Characteristics,Renmin University of china 南开大学·中国社会科学院大学21世纪马克思主义研究院当代政治经济学研究中心中国人民大学《资本论》教学与研究中心中国人民大学全国中国特色社会主义政治经济学研究中心

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，...

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，取得系列代表性成果。为准确刻画学界研究进展和轨迹，推动中国经济学理论体系的构建和完善，本刊精选议题如期奉上《中国政治经济学年度发展报告（2023）》。自2010年起，本刊连续十四年发布《中国政治经济学年度发展报告》，“年度发展报告”专栏已成为本刊标志性特色栏目。2023年报告聚焦12个专题，分为（上）（下）两篇，其中专题1—6于报告（上）篇刊登，专题7—12由报告（下）篇刊登。2023年报告（下）选题如下：

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