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Stress Echocardiography for Chronic Coronary Syndrome:Clinical Practice Guidelines(2023)

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Journal of Geriatric Cardiology 2024年第5期21卷 475-505页

作者： Peng-Fei ZHANG Jia-Wei TIAN Tian-Gang ZHU Jue-Fei WU Xiao-Ping LENG Yi WANG Meng-Meng LI Xin-Hao LI Qian-Qian WANG Xiao-Peng FENG Jia-Yan LV Li-Xue YIN Yun ZHANG Mei ZHANG chinese Society of Echocardiography,Superficial Tissue and Vascular Group of chinese Society of Ultrasound in medicine,Ultrasound Professional Committee of chinese medicine Education Association State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina The Second Affiliated Hospital of Harbin Medical University HaerbinChina Peking University People's Hospital BeijingChina Sichuan Province People's Hospital ChengduChina Nanfang Hospital Southern Medical UniversityGuangzhouChina Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijingChina 不详

In the context of the People's Republic of china,coronary artery disease(CAD)presents a sig-nificant clinical challenge,with over 11.3 mil-lion patients ***,the diagnos-is of CAD has predominantly relied on invasive coronary angiography.[1]However,recent advances in clinical research have revealed a notable trend:a substantial 82% of patients subjected to such invas-ive diagnostics do not necessitate interventional therapy.

关键词： coronary clinical patients

Inhibiting pain with pain——A basic neuromechanism of acupuncture analgesia

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chinese Science Bulletin 2001年第17期46卷 1485-1494页

作者： LIU XiangInstitute of Acupuncture and Moxibustion, china academy of traditional chinese medicine, beijing 100700, china Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine Beijing China

(i) The structure and function of the meridian (channel and collateral) described by ancient medical doctors may correspond to the blood circulation, nerve control and neurohumoral modulation of modern medicine. (ii) The needling, which can injure the tissue, is a noxious stimulation inducing pain. Acupuncture manipulation, such as lifting and thrusting, twisting and twirling, or electroacupuncture (EA) with the sufferable biggest intensity for patients should be a stronger pain stimulation. The needling sensation of soreness, numbness, distension and heaviness is a deep pain. (iii) There is an intrinsic analgesic system in brain, which centers around the periventricular and periaqueductal grey matter, contains endorphins as possible mediators, goes through the descending inhibition system in medulla oblon-gata, and acts on the gating mechanism in spinal cord. Itcould be producing analgesia while the system is activated. (iv) NRM might be a supraspinal center modulating pain, and the R-S neurons could

关键词： acupuncture analgesia Inhibiting pain with pain negative feedback mechanism of pain nucleus raphe magnus afferent C fiber capsaicm.

Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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chinese Journal of Cancer Research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing Rongsheng Zhao the Steering Committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of chinese Pharmaceutical Association(CPA) Hospital Pharmacy Professional Committee of chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of china Anti-Cancer Association(CACA) chinese Society of Hematology of chinese Medical Association(CMA) Hospital Pharmacy Professional Committee of Cross-Straits medicine Exchange Association(SMEA) Department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

2023 Guideline for the management of hypertension in the elderly population in china

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Journal of Geriatric Cardiology 2024年第6期21卷 589-630页

作者： Hypertension Branch of chinese Geriatrics Society,beijing Hypertension Association,National Clinical Research Center of the Geriatric Diseases Qi HUA Li FAN Zeng-Wu WANG Jing LI 不详 Xuanwu Hospital Capital Medical UniversityBeijingChina chinese PLA General Hospital BeijingChina Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Preamble Hypertension is one of the most common chronic diseases and the primary risk factor for stroke,myocardial infarction and even cardiovascular *** than half of the elderly population has high blood *** people are a unique group,and strategies for the prevention,diagnosis,evaluation,and treatment of hypertension in elderly individuals differ significantly from those in the general population.

关键词： hypertension prevention diagnosis

Inhibition of ATP-regulated potassium channels by agmatine in RINm5F insulin secreting cells

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中国药理学与毒理学杂志 1998年第2期12卷 70-71页

作者： LIANG　RiXin(Institute of chinese Materia Medica, china academy of traditional chinese medicine, beijing 100700) 中国中医研究院中药所北京

ＩｎｈｉｂｉｔｉｏｎｏｆＡＴＰ┐ｒｅｇｕｌａｔｅｄｐｏｔａｓｉｕｍｃｈａｎｎｅｌｓｂｙａｇｍａｔｉｎｅｉｎＲＩＮｍ５ＦｉｎｓｕｌｉｎｓｅｃｒｅｔｉｎｇｃｅｌｓＬＩＡＮＧＲｉ－Ｘｉｎ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｉｎｅｓ... 详细信息

ＩｎｈｉｂｉｔｉｏｎｏｆＡＴＰ┐ｒｅｇｕｌａｔｅｄｐｏｔａｓｉｕｍｃｈａｎｎｅｌｓｂｙａｇｍａｔｉｎｅｉｎＲＩＮｍ５ＦｉｎｓｕｌｉｎｓｅｃｒｅｔｉｎｇｃｅｌｓＬＩＡＮＧＲｉ－Ｘｉｎ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｉｎｅｓｅＭａｔｅｒｉａＭｅｄｉｃａ，Ｃｈ...

关键词： patchclamp technique agmatine ion channels, potassium

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笔谈:透视台湾地区2024年“两项选举”

台湾研究 2024年第1期 1-14页

作者： Institute of Taiwan Studies, chinese academy of Social Sciences 中国社会科学院台湾研究所

2024年1月13日,台湾地区领导人和立法机构“二合一”选举落下幕。民进党籍候选人赖清德、萧美琴当选台湾地区正副领导人。台湾地区立法机构总额113席中,中国国民党获52席,民进党获51席,民众党获8席,无党籍及未经政党推荐者获2席.

关键词：中国国民党民进党立法机构台湾地区民众党推荐者二合一候选人

A new evolutionary theory deduced mathematically from entropy amplification

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chinese Science Bulletin 2000年第1期45卷 91-96页

作者： CHEN JimingInstitute of Virology, chinese academy of Preventive medicine, beijing 100052, china Institute of Virology Chinese Academy of Preventive Medicine Beijing China

A new evolutionary theory which is able to 黱ite the present evolutionary debates is deduced mathematically from the principle of entropy amplification. it suggests that the extensive evolution is driven by the amplification of entropy, or microscopic diversity, and the biological evolution is driven by the amplification of biodiversity. Forming high hierarchies is the most important way for the amplification and brings out spontaneously three kinds of selection. This theory has some positive cultural meanings.

关键词： evolutionary theory mathematics entropy biodiversity selection cultural meanings.

多剂量包装中药配方颗粒调剂管理上海共识（2023）

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上海中医药大学学报 2024年第5期 1-9页

作者： Clinical chinese Materia Medica Group of Hospital Pharmacy Professional Committee of Shanghai Pharmaceutical Association Hospital Pharmacy Branch of Shanghai Association of traditional chinese medicine Writing Group of"Shanghai Consensus on Dispensing Management of Multi-dose Packaged traditional chinese medicine Formula Granules (2023)" 上海市药学会医院药学专业委员会临床中药学组上海市中医药学会医院药学分会《多剂量包装中药配方颗粒调剂管理上海共识（2023）》编写组

多剂量包装中药配方颗粒利用设备进行调剂，在上海各医疗机构使用广泛，但药品的调剂质量受多方面因素影响较大，管理要求亟待完善提高。为此，上海市药学会医院药学专业委员会临床中药学组等单位组织专家，根据有关政策法规要求，参考... 详细信息

多剂量包装中药配方颗粒利用设备进行调剂，在上海各医疗机构使用广泛，但药品的调剂质量受多方面因素影响较大，管理要求亟待完善提高。为此，上海市药学会医院药学专业委员会临床中药学组等单位组织专家，根据有关政策法规要求，参考相关标准规范和近5年的文献报道，结合上海市实际情况，围绕与多剂量包装中药配方颗粒调剂相关的人员要求、温湿度控制、设备要求、清洁污染、效期管理、发药交待等管理问题，以“陈述”形式形成上海地区多剂量包装中药配方颗粒调剂管理专家共识，以期进一步规范中药配方颗粒的临床调剂工作，加强应用的安全性、合理性和可控性。

关键词：中药配方颗粒多剂量包装调剂专家共识上海

Direct Optimization of Low-thrust Many-revolution Earth-orbit Transfers

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chinese Journal of Aeronautics 2009年第4期22卷 426-433页

作者： Gao Yang academy of Opto-Electronics,chinese academy of Sciences,beijing 100190,china [a]academy of Opto-Electronics Chinese Academy of Sciences Beijing 100190 China

Low-thrust Earth-orbit transfers with 10^- 5-order thrust-to-weight ratios involve a large number of orbital revolutions which poses a real challenge to trajectory optimization. This article develops a direct method to optimize minimum-time low-thrust many-revolution Earth-orbit transfers. A parameterized control law in each orbit, in the form of the true optimal control, is proposed, and the time history of the parameters governing the control law is interpolated through a finite number of nodal values. The orbital averaging method is used to significantly reduce the computational workload and the trajectory optimization is conducted based on the orbital averaging dynamics expressed by nonsingular equinoctial elements. Furthermore, Earth＇s shadowing and perturbation effects are taken into account. The optimal transfer problem is thus converted to the parameter optimization problem that can be solved by nonlinear programming. Taking advantage of the mapping between the parameterized control law and the Lyapunov control law, a technique is proposed to acquire good initial guesses for optimization variables, which results in enlarged convergence domain of the direct optimization method. Numerical examples of optimal Earth-orbit transfers are presented.

关键词： low thrust orbital transfer optimization direct method orbital averaging Lyapunov method