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World Journal of Gastroenterology 2024年第32期30卷 3730-3738页

作者： Ming-Shuang Lai Xi-Peng Yan Donald R branch Melika Loriamini Li-Min Chen The Joint Laboratory on Transfusion-Transmitted Diseases(TTDs)Between Institute of Blood Transfusion Chinese Academy of Medical Sciences and Nanning Blood CenterNanning 530003Guangxi Zhuang Autonomous RegionChina Department of Medicine and Laboratory Medicine and Pathobiology Centre for InnovationCanadian Blood ServicesHamilton 397086Canada Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory for Transfusion-transmitted Infectious Diseases of the Health Commission of Sichuan ProvinceChengdu 610052Sichuan ProvinceChina

This editorial discusses a recently published paper in the World Journal of *** research focuses on p53's regulatory mechanism for controlling ferroptosis,as well as the intricate connection between ferroptosis and liver *** is a specific form of programmed cell death that is dependent on iron and displays unique features in terms of morphology,biology,and genetics,distinguishing it from other forms of cell *** can affect the liver,which is a crucial organ responsible for iron storage and *** evidence indicates a robust correlation between ferroptosis and the advancement of liver disorders.P53 has a dual effect on ferroptosis through various distinct signaling ***,additional investigations are required to clarify the regulatory function of p53 metabolic targets in this complex association with *** the future,researchers should clarify the mechanisms by which ferroptosis and other forms of programmed cell death contribute to the progression of liver *** and controlling important regulatory factors associated with ferroptosis present a promising therapeutic strategy for liver disorders.

关键词： Liver disease P53 Programmed cell death Ferroptosis Therapeutic target

Temperature distribution in the tool-chip-workpiece system during the orthogonal cutting process

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International Journal of Minerals,Metallurgy and Materials 1997年第3期11卷 30-34页

作者： ZHENG Chun GU Tong (Department of Mechanical Engineering, McMaster University, canada) (Applied science School, University of science and technology Beijing, Beijing 100083, China) McMaster Univ Canada

The temperature distribution in the tool, chip and workpiece was studied during the orthogonal cuttingprocess Under several different cutting conditions. The temperature distribution is calculated by the finite differencemethod. and the variation of the material properties with temperature was taken was taken into account The results obtained arecoincident with both previous published results and experimental measurements.

关键词： temperature distribution orthogonal cutting FDM tool-chip-workpiece system

Correlations between recombination rate and intron distributions along chromosomes of ***

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Progress in Natural science:Materials International 2009年第4期19卷 517-522页

作者： Hong Li a,b, Guoqing Liu a, Xuhua Xia b a School of Physical science and technology, Inner Mongolia University, Hohhot 010021, China b Department of Biology, University of Ottawa, Ottawa, Ont., canada K1N 6N5 School of Physical science and technology Inner Mongolia University Hohhot 010021 China Department of Biology University of Ottawa Ottawa Ont. Canada K1N 6N5

Generally speaking, the intron size positively correlates with recombination rate in Caenorhabditis elegans genome. Here, we analyze the correlations between recombination rate and some measures of different intron lengths so as to know whether the recombination influences the introns of different lengths in the same way. Results show that the correlation between the recombination rate and the percentage of short introns (<100 bp) is negative, but the correlation between the recombination rate and the percentage of introns that are larger than 500 bp is positive. Average intron length correlates positively with the recombination rate for introns whose length is in the range of 100-1000 bp. We speculate that the recombination mainly exerts impact on introns whose length ranges from 100-1000 bp. We also show that the average intron number per gene correlates negatively with the recombination rate.

关键词： Recombination rate Percentage of introns Intron length Intron number per gene C. elegans

The evolution and morphological stability of a spherical crystal

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science China(Technological sciences) 2008年第3期51卷 225-243页

作者： CHEN MingWen1,2, WANG ZiDong2 & XU JianJun3,4 1 School of Applied sciences, University of science and technology Beijing, Beijing 100083, China 2 School of Materials science and Engineering, University of science and technology Beijing, Beijing 100083, China 3 School of Mathematical sciences, Nankai University, Tianjin 300071, China 4 Department of Mathematics and Statistics, McGill University, Montreal H3A 2K6, canada School of Applied sciences University of Science and Technology Beijing Beijing China School of Materials science and Engineering University of Science and Technology Beijing Beijing China School of Mathematical sciences Nankai University Tianjin China Department of Mathematics and Statistics McGill University Montreal Canada

The growth model of a spherical crystal in the undercooled melt including the surface energy, interfacial kinetics and convective flow is established. The effect of the convective flow induced by a small far field flow on the evolution and morphological stability of the interface of the spherical crystal is studied. The interface shape of the spherical crystal, which is affected by the far field flow, and the dispersion relation of the growth rate of amplitude of the perturbed interface are derived. It is shown that the convection induced by the far field flow makes the interface of the growing spherical crystal further grow in the upstream direction of the far field flow and inhibit growth in the downstream direction; the interface of the decaying spherical crystal further decays in the upstream direction and inhibits decay in the downstream direction. The theoretical result suggests that both the growth of the sphere in the upstream direction and the decay of the sphere in the downstream direction make the spherical crystal tend to evolve into an oval; the morphological stability of the interface depends on a certain radius R c such that the spherical crystal is unstable when its radius is greater than R c and stable when its radius is less than R c . The surface energy and interfacial kinetics have strong stabilizing effects on the growth of the spherical crystal. In the meantime interfacial kinetics is a table factor of the interface when the interface of the sphere is growing; it is an unstable factor of the interface when the interface is decaying.

关键词： solid-liquid interface spherical crystal convective flow crystal growth morphological stability

The steady-state solution of dendritic growth from the undercooled binary alloy melt with the far field flow

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science China(Technological sciences) 2009年第8期52卷 2280-2287页

作者： CHEN MingWen1,2, WANG ZiDong2 & XU JianJun2,3,4 1 School of Applied sciences, University of science and technology Beijing, Beijing 100083, China 2 School of Materials science and Engineering, University of science and technology Beijing, Beijing 100083, China 3 School of Mathematical sciences, Nankai University, Tianjin 300071, China 4 Department of Mathematics and Statistics, McGill University, Montreal H3A 2K6, canada School of Applied sciences University of Science and Technology Beijing Beijing China School of Materials science and Engineering University of Science and Technology Beijing Beijing China School of Mathematical sciences Nankai University Tianjin China Department of Mathematics and Statistics McGill University Montreal Canada

The steady-state dendritic growth from the undercooled binary alloy melt with the far field flow is considered. By neglecting the interface energy, interface kinetics and buoyancy effects in the system, we obtaine the steady-state solution for the case of the large Schmidt number, in terms of the multiple variable expansion method. The changes of the temperature and concentration fields, the morphology of the interface, the normalization parameter and the Peclet number of the system induced by uniform external flow are derived. The results show that, compared with the system of dendritic growth from undercooled pure melt, the convective flow in the system of growth from undercooled binary alloy has stronger effects on the morphology of the interface. Nevertheless, the shape of the interface still remains nearly a paraboloid.

关键词： binary alloy melt convection dendritic growth interfaces steady-state solution multiple variable expansion method

Levels and profiles of PBDEs in the atmosphere of Harbin

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Levels and profiles of PBDEs in the atmosphere of Harbin

Jackknifed random weighting for Cox proportional hazards model

持久性有机污染物论坛2009暨第四届持久性有机污染物全国学术研讨会

作者： Hong Qi,~1 Yi-Fan Li,~(1,2*),Wan-Li Ma~1 (1 International Joint Research Center for Persistent Toxic Substances(IJRC-PTS),State Key Laboratory of Urban Water Resource and environment,Harbin Institute of technology,China 2 science and technology branch,environment canada

*** Polybrominated diphenylethers(PBDEs) are a class of additive brominated flame retardants(BFRs) used in plastics,foams,fabrics and other materials to prevent *** have been ubiquitous in the environment through long-range transport(LRT),even in Arctic biotic and abiotic samples.(de et al,2006;Verreault et al,2007).It is important to assess levels of PBDEs in the air because the atmosphere is the

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science China Mathematics 2012年第4期55卷 775-786页

作者： LI Xiao 1 ,WU YaoHua 2,& TU DongSheng 1 1 Cancer Research Institute,Queen’s University,Kingston,Ontario K 7L 3N6,canada 2 Department of Finance and Statistics,University of science and technology of China,Hefei 230026,China Cancer Research Institute Queen’s University Kingston Canada Department of Finance and Statistics University of Science and Technology of China Hefei China

The Cox proportional hazards model is the most used statistical model in the analysis of survival time ***,a random weighting method was proposed to approximate the distribution of the maximum partial likelihood estimate for the regression coefficient in the Cox *** method was shown not as sensitive to heavy censoring as the bootstrap method in simulation studies but it may not be second-order accurate as was shown for the bootstrap *** this paper,we propose an alternative random weighting method based on one-step linear jackknife pseudo values and prove the second accuracy of the proposed *** Carlo simulations are also performed to evaluate the proposed method for fixed sample sizes.

关键词： Cox proportional hazards model jackknife random weighting second-order accuracy simulations survival data

Molecular and quantum mechanical studies on the monomer recognition of a highly-regular β-helical antifreeze protein

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science China Chemistry 2004年第1期47卷 34-40页

作者： YANG Zuoyin, JIA Zongchao, LIU Ruozhuang & CHEN GuangjuDepartment of Chemistry, Beijing Normal University, Beijing 100875, China Faculty of science, Beijing University of Chemical technology, Beijing 100029, China Department of Biochemistry, Queen’s University, Kingston, Ontario K7L 3N6, canada Department of Chemistry Beijing Normal University Beijing China Faculty of science Beijing University of Chemical Technology Beijing China Department of Biochemistry Queenś University Kingston Canada

The possible interaction models for an antifreeze protein from Tenebrio molitar (TmAFP) have been systematically studied using the methods of molecular mechanics, molecular dynamics and quantum chemistry. It is hoped that these approaches would provide insights into the nature of interaction between protein monomers through sampling a number of interaction possibilities and evaluating their interaction energies between two monomers in the course of recognition. The results derived from the molecular mechanics indicate that monomer? β-sheets would be involved in interaction area and the side chains on two p-faces can match each other at the two-dimensional level. The results from molecular mechanics and ONIOM methods show that the strongest interaction energy could be gained through the formation of H-bonds when the twoβ-sheets are involved in the interaction model. Furthermore, the calculation of DFT and analysis of van der Waals bond charge density confirm further that recognition between the two TCTs mainly depends on inter-molecular hydroxyls. Therefore, our results demonstrate that during the course of interaction the most favorable association of TmAFPs is via their β-sheets.

关键词： antifreeze protein, recognition, dynamics simulation, molecular mechanics, quantum chemistry.

Isomer of Dechlorane Plus in Surfacial Water,Soil and Sediment in a Northern Chinese Wetlands

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Isomer of Dechlorane Plus in Surfacial Water,Soil and Sedime...