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Effect of PKCα on the gene expression related with proliferation and activity of transcription factor AP-1

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Chinese Science Bulletin 1997年第23期42卷 1986-1989页

作者： WANG Xiangyang and LIU HuituKey Laboratory of Cell Proliferation and Regulation Biology, department of Biology, beijing normal university, beijing 100875, China Key Laboratory of Cell Proliferation and Regulation Biology Department of Biology Beijing Normal University Beijing China

PROTEIN kinase C (PKC) is a serine/thronine kinase, which plays a major role in cell sig-nalling, growth control and tumorigenesis. PKC is encoded by a multigene family, which havebeen identified as consisting of at least 12 members in mammalian tissues. PKC isoforms differin their biochemical properties, tissue-specific expression and intracellular localization. Thedifferences imply that the individual PKC isoforms have a distinct physiological function. Inorder to study the role of specific PKC subtype in cell proliferation and transformation, weconstructed the human embryonic lung cell (2BS) model stably overexpressing PKC_α andfound that the overexpression of PKC_α promoted the growth rate and caused the transform-

关键词： protein kinase Cα 2BS cell transcription factor AP-1.

Weighted Boundedness for a Class of Rough Multilinear Operators

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Acta Mathematica Sinica,English Series 2001年第3期17卷 517-526页

作者： Yong DING Shan Zhen LU department of Mathematics,beijing normal university,beijing 100875,P.R.China E-mail:dingy@*** lusz@*** department of Mathematics Beijing Normal University Beijing 100875 P. R. China

In this paper we give the (L^p(ω~p),L^q(ω~q)) boundedness for a class of multilinear operators, which is similar to the higher-order commutator for the rough fractional *** our results the kernel function is merely ... 详细信息

关键词： Multilinear operator Fractional integral Rough kernel BMO A(p,q) weight

Ergodicity of Reversible Reaction Diffusion Processes with General Reaction Rates

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Acta Mathematica Sinica,English Series 1994年第1期10卷 99-112页

作者： Chen Mufa Ding Wanding Zhu Dongjin department of Mathematics beijing normal university beijing,100875 China department of Mathematics Animi normal university Wuhu,24.000 China department of Mathematics Beijing Normal University Beijing China department of Mathematics Anhui Normal University Wuhu China

In this paper,a class of reaction diffusion processes with general reaction rates is studied.A necessary and sufficient condition for the reversibility of this calss of reaction diffusion processes is given,and then t... 详细信息

关键词： Ergodicity of Reversible Reaction Diffusion Processes with General Reaction Rates

Ab initio studies on the pyrolysis mechanism of 2-haloacetic acids in the gas phase

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Chinese Journal of Chemistry 1995年第1期13卷 10-18页

作者： CHEN, Li-Tao CHEN, Guang-Ju FU, Xiao-YuanChemistry department, beijing normal university, beijing 100875, China Chemistry department Beijing Normal University Beijing 100875 China

The dehydrohalogenation mechanism of 2-haloacetic acids (XCH2CO2H, X=F, Cl and Br) has been studied theoretically by HF/3-21G and AM1 methods. The results indicate that these reactions are most probably proceeded in terms of a polar five-membered cyclic transition state in the gas phase. Their microscopic processes are beleived to be a stepwise reaction and the rate-determining step is the first one. By comparing the energy barriers of different 2-haloacetic acids, it can be realized that 2-fluoroacetic acid is easier to react than 2-chloroacetic and 2-bromoacetic acids.

关键词： 2-Haloacetic acid pyrolysis reaction mechanism transition state.

^(14.C dating of moss peat banks in Fildes Peninsula, Antarctica

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Chinese Science Bulletin 1999年第19期44卷 1817-1819页

作者： ZHAO Ye and LI Rongquandepartment of Resource and Environmental Sciences , beijing normal university , beijing 100875 , China department of Resource and Environmental Sciences Beijing Normal University Beijing China

Based on the radiocarbon data of the moss peat banks in Fildes Peninsula, Antarctica, it was calculated that the mean rates of peat accumulation in the upper layer and the lower layer are 0.195 and 0.069 4.mm·a-1 respectively. Based on the radiocarbon date (3 265 ± 120 aBP) and the mean rate of peat accumulation in the lower peat layer, it was calculated that

关键词： Antarctica moss peat bank 14. dating environmental change.

Superprocesses arising from interactive stochastic flows

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Science China Mathematics 2006年第4期49卷 451-476页

作者： YAN Guojun & LI Zhanbing Medical School, Shantou university, Shantou 515063, China department of Mathematics, Bejing normal university,{4., China Medical School Shantou University Shantou China department of Mathematics Bejing Normal University Beijing China

In this paper, we give a unified construction for superprocesses with dependent spatial motion constructed by Dawson, Li, Wang and superprocesses of stochastic flows constructed by Ma and Xiang. Furthermore, we also g... 详细信息

关键词： superprocess, interactive stochastic flows, martingale problem, dual processes.

Ab initio studies on the thermolysis of azetidine

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Chinese Journal of Chemistry 1992年第3期10卷 193-199页

作者： CHEN, Guang-Ju FU, Xiao-Yuan TANG, Ao-Qing Chemistry department, beijing normal university, beijing 100875 Chemistry department Beijing Normal University Beijing 100875

The reaction mechanism of the thermolysis of azetidine to form ethylene and methylen- imine has been studied by ab initio SCF MO method at STO--3G and 3-21G levels. Two possible step- wise pathways are explored. One is the breaking of C--C bond as the first step, while the other is the breaking of C--N bond. All the stationary points on the potential energy surface (PES) are fully optimiz- ed. MP2 / 3-21G single point calculations on all stationary points and MCSCF / STO-3G computations for some stationary points are also carried out. The calculations indicate that azetidine decomposes via biradicaloid intermediates and the cleavage of C--N bond is preferable to that of C--C bond.

关键词： Ab initio studies on the thermolysis of azetidine STO

Theoretical study on the reaction mechanism of(CH_3)_3CO+CO

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Science China Chemistry 2005年第1期48卷 18-24页

作者： ZHAO Hongmei1,2,3, SUN Chengke1,4. ZHANG Rongchang3, XI Hongmin3 & LI Zonghe1 1. department of Chemistry, beijing normal university, beijing 100875, China 2. The Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, beijing 100080, China 3. department of Chemistry, Beihua university, Jilin 132013, China 4. department of Chemistry, Qujing normal university, Yunnan 655000, China department of Chemistry Beijing Normal University Beijing China The Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing China department of Chemistry Beihua University Jilin China department of Chemistry Qujing Normal University Yunnan China

The reaction mechanism of (CH3)3CO with CO has been theoretically investigated using density-functional theory (DFT) calculations at B3LYP/6-31G* level. In order to get more reliable energy values the single-point energy is evaluated at CCSD (T)/6-31++G** level. The results show that the reaction is multi-channel and the reaction of (CH3)3CO radical with CO mostly produces (CH3)3C + CO2. The reaction could play a role in eliminating air pollution.

关键词： DFT, B3LYP, (CH3)3CO, radical.

Electrochemical Studies of Paclitaxel Interaction with Tubulin

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Chinese Chemical Letters 2000年第4期11卷 351-352页

作者： Yong YU Qi Long LI (department of Chemistry, beijing normal normal {4.. beijing 100873) department of Chemistry Beijing Normal University Beijing 100875 China

A highly sensitive linear sweep voltammetric method was developed for the determination of paclitaxel and the mechanism of the binding of paclitaxel to tubulin was studied. Tubulin dimer formed with paclitaxel an electrochemically nonactive complex with a combination ratio of 2:2. Its stability constant was 2.85 x 10(22). So the tubulin dimer had two binding sites for paclitaxel. The experiment showed that the binding sites of paclitaxel to tubulin dimer were different from that of Ca2+ to tubulin dimer.

关键词： paclitaxel tubulin linear sweep voltammetry