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复方碘口腔喷雾原位膜的制备及促口腔溃疡修复评价

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中国药科大学学报 2024年

作者：张小军黄山芩郭潇涵季梦菲沈雁陈大全许颖 1.江苏大学药学院 2.中国药科大学药学院 3.烟台大学药学院江苏大学药学院中国药科大学药学院烟台大学药学院

采用原位凝胶技术，制备了新型复方碘口腔喷雾原位膜，用于发挥缓释作用，并促进口腔溃疡创面修复。首先以喷雾状态和成膜时间为指标，对喷雾药液的处方和工艺进行优化。以成膜时间和药膜黏附性为评价指标对药液混合比例进行考察。并对... 详细信息

采用原位凝胶技术，制备了新型复方碘口腔喷雾原位膜，用于发挥缓释作用，并促进口腔溃疡创面修复。首先以喷雾状态和成膜时间为指标，对喷雾药液的处方和工艺进行优化。以成膜时间和药膜黏附性为评价指标对药液混合比例进行考察。并对最优处方制备的复方碘口腔喷雾药液的药物含量、稳定性、pH、喷雾效果，及原位膜的成膜时间、溶解性、吸湿性、保湿性、体外释放等理化性质进行考察；此外，通过细胞实验考察了成膜材料的生物相容性及复方碘口腔喷雾原位膜的促迁移效果；采用兔口腔溃疡模型，对复方碘口腔喷雾在体成膜效果及促修复效果进行评价。实验结果显示，最优处方制备的药液A和药液B的pH分别为6.21 ± 0.02和 6.42 ± 0.03.符合正常口腔黏膜pH范围；稳定性好，具有良好的喷雾状态；药液B中碘含量为（1.96 ± 0.01）mg/mL；原位膜体外成膜时间为（118.3.± 3.6）s，口腔内成膜时间为（13..3.± 4.6）s；24 h溶解率为（87.3. ± 1.74）%，吸湿率为（124.17 ± 7.13.%，保湿率为（26.85 ± 2.50）%；复方碘口腔喷雾原位膜中碘含量为（47.42 ± 0.3.）mg/g；具有良好的柔韧性和黏附性，并具有一定的缓释效果。细胞实验中，原位膜表现出良好的促成纤维细胞迁移作用。兔口腔溃疡实验表明，复方碘口腔喷雾在体可快速成膜，并可显著促进口腔溃疡修复。本研究所开发的复方碘口腔喷雾原位膜，制备工艺稳定，并可有效促进口腔溃疡创面修复，为口腔黏膜制剂的研究和开发提供了新思路，并具有良好的转化前景。

关键词：口腔喷雾原位膜复方碘口腔溃疡缓释促修复

Surface effects of monolayer-protected gold nanoparticles on the redox reactions between ferricyanide and thiosulfate

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Science China Chemistry 2005年第5期48卷 424-430页

作者： LI Di1, SUN Chunyan1, HUANG Yunjie1, LI Jinghong1,2 & CHEN Shaowei3.1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 13.022, China 2. department of Chemistry, Tsinghua university, Beijing 100084, China 3. department of Chemistry, university of California, Santa Cruz, Santa Cruz, CA 95064, USA 1. State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences 130022 Changchun China 2. department of Chemistry Tsinghua University 100084 Beijing China 3. department of Chemistry University of California 95064 Santa Cruz Santa Cruz CA USA

Electron transfer through the self-assembled monolayers (SAMs) on gold nanopar-ticles is investigated by using the monolayer protected gold nanoclusters (MPCs) as elec-tron-transfer mediators. 3.Mercaptopropionic acid (MPA) and 11-meraptoundecanoic acid (MUA) MPCs were employed to catalyze the redox reaction between potassium ferricyanide and sodium thiosulfate. The catalytic mechanism was proposed that the MPCs act as diffusing elec-tron-mediators and electron transfers to and from the MPCs surface. Therefore the electron transfer rate through the capping layers would be proportional to the MPCs catalyzed reaction rate, which was monitored by the UV absorbance of ferricyanide. The calculated apparent rate constant was orders of magnitude smaller than that of the maximum of tunneling current, which was attributed to the splited energy level of the nanoscale particles.

关键词： electron transfer, three-dimensional self-assembled monolayers, redox reaction, electron transfer mediator, surface effect.

EFFECTS OF TRACE Zr ON FATIGUE CRACK GROWTH RATE OF HIGH DAMPING Zn-Al ALLOY

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中国有色金属学会会刊：英文版 1996年第3期6卷 92-95页

作者： Zhou Shanchu Luo Binghui (department of Materials Science and Engineering,Central south university of Technology, Changsha 410083. CENT S UNIV TECHNOL DEPT MAT SCI & ENGNCHANGSHA 410083PEOPLES R CHINA

ＥＦＦＥＣＴＳＯＦＴＲＡＣＥＺｒＯＮＦＡＴＩＧＵＥＣＲＡＣＫＧＲＯＷＴＨＲＡＴＥＯＦＨＩＧＨＤＡＭＰＩＮＧＺｎ－ＡｌＡＬＬＯＹ￥ＺｈｏｕＳｈａｎｃｈｕ；ＬｕｏＢｉｎｇｈｕｉ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓ... 详细信息

ＥＦＦＥＣＴＳＯＦＴＲＡＣＥＺｒＯＮＦＡＴＩＧＵＥＣＲＡＣＫＧＲＯＷＴＨＲＡＴＥＯＦＨＩＧＨＤＡＭＰＩＮＧＺｎ－ＡｌＡＬＬＯＹ￥ＺｈｏｕＳｈａｎｃｈｕ；ＬｕｏＢｉｎｇｈｕｉ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｅ...

关键词： Zr Zn-Al alloy fatigue crack growth rate internal friction

Petrogenesis of Songshugou dunite body in the Qinling orogenic belt, Central China: Constraints from geochemistry and melt inclusions

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Science China Earth Sciences 2005年第8期48卷 1146-1157页

作者： SU Li1,2, SONG Shuguang3.& ZHOU Dingwu1 1. Key Laboratory of Continental Dynamics of the Ministry of Education, department of Geology, Northwestern university, Xi’an 710069, China 2. The Geological Lab Center, China university of Geosciences (Beijing), Beijing 100083. China 3. Key Laboratory of Orogenic Belts of the Ministry of Education, department of Geology, Peking university, Beijing 100871, China 1. Key Laboratory of Continental Dynamics of the Ministry of Education Department of Geology Northwestern University 710069 Xi’an China 2. The Geological Lab Center China University of Geosciences 100083 (Beijing)Beijing China 3. Key Laboratory of Orogenic Belts of the Ministry of Education Department of Geology Peking University 100871 Beijing China

The Songshugou dunite body, which occupies an area of about 20 km2, is the largest ultramafic massif in the eastern Qinling orogenic belt, Central China. The major compo-nent of this body is dunitic rocks including mylonitic dunite and coarse-grained dunite; they oc-cupy about 95 vol% of the total body. Petrography, mineral composition, major and trace ele-ments and primitive melt inclusions have been investigated in this paper; all revealed that this dunite body is the product of melt-rock interaction by porous percolation flow. In comparison with dunite sills or veins in harzburgite from the basal part of Oman ophiolite, this dunite body is characterized by lower contents of Al2O3. CaO and HREE but higher content of highly incom-patible elements and Zr and Hf. The LREE enriched patterns and primitive mantle normalized spidergrams of trace elements are also different from the Oman dunite. Combining with melt in-clusions observed in olivines, we conclude that this dunite body is the product of large- scale porous percolation flow of high-MgO melts within depleted mantle peridotites. The high-MgO magma, in essence, was most probably produced at the hot head of an upwelling mantle plume. The occurrence of the Songshugou dunite body is closely associated with the activity of mantle super-plume in Neo-Proterozoic era in the Yangtze Craton.

关键词： Songshugou dunite body, geochemistry, melt inclusion, mantle plume, Qinling orogenic belt.

STRUCTURE AND PROPERTY OF SINTERED MOLYBDENUM DOPED WITH La_2O_3

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中国有色金属学会会刊：英文版 1995年第4期5卷 100-103页

作者： Liu Xinyu Wang Dezhi(department of Materials Science and Engineering Central south university of Technology,Changsha 410083. Central south Univ of Technology Changsha China

ＳＴＲＵＣＴＵＲＥＡＮＤＰＲＯＰＥＲＴＹＯＦＳＩＮＴＥＲＥＤＭＯＬＹＢＤＥＮＵＭＤＯＰＥＤＷＩＴＨＬａ_２Ｏ_３ＬｉｕＸｉｎｙｕ；ＷａｎｇＤｅｚｈｉ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇ... 详细信息

ＳＴＲＵＣＴＵＲＥＡＮＤＰＲＯＰＥＲＴＹＯＦＳＩＮＴＥＲＥＤＭＯＬＹＢＤＥＮＵＭＤＯＰＥＤＷＩＴＨＬａ_２Ｏ_３ＬｉｕＸｉｎｙｕ；ＷａｎｇＤｅｚｈｉ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｅｒｉｎｇＣｅｎｔｒａｌＳｏ...

关键词： molybdenum La2O3 microstructure mechanical property

TiC－PHASE　DIFFUSION　LAYER　FORMATION　IN　TITANIUM　CLAD　STEEL　COMPOSITE　HAVING　AN　INTERMEDIATE　LAYER　OF　α－Fe

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中国有色金属学会会刊：英文版 1996年第2期6卷 76-80页

作者： Xia Changqing Jin Zhanpeng(department of Materials Science and Engineering,Central south university of Technology, Changsha 410083. CENT S UNIV TECHNOL DEPT MAT SCI & ENGNCHANGSHA 410083PEOPLES R CHINA

ＴｉＣ－ＰＨＡＳＥＤＩＦＦＵＳＩＯＮＬＡＹＥＲＦＯＲＭＡＴＩＯＮＩＮＴＩＴＡＮＩＵＭＣＬＡＤＳＴＥＥＬＣＯＭＰＯＳＩＴＥＨＡＶＩＮＧＡＮＩＮＴＥＲＭＥＤＩＡＴＥＬＡＹＥＲＯＦα－ＦｅＸｉａＣｈａｎｇｑｉｎｇ；ＪｉｎＺ... 详细信息

ＴｉＣ－ＰＨＡＳＥＤＩＦＦＵＳＩＯＮＬＡＹＥＲＦＯＲＭＡＴＩＯＮＩＮＴＩＴＡＮＩＵＭＣＬＡＤＳＴＥＥＬＣＯＭＰＯＳＩＴＥＨＡＶＩＮＧＡＮＩＮＴＥＲＭＥＤＩＡＴＥＬＡＹＥＲＯＦα－ＦｅＸｉａＣｈａｎｇｑｉｎｇ；ＪｉｎＺｈａｎｐｅｎｇ（Ｄｅｐａｒｔｍｅｎ...

关键词： TiC-phase carbon activity stationary diffusion