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The role of Mc1R gene in buffalo coat color

Science china(Life sciences) 2010年第2期53卷 267-272页

作者： MIAO YongWang1,2,WU GuiSheng3,WANG Lei2,LI DaLin4,TANG ShouKun5.LIANG JianPing2,MAO HuaMing2,LUO HuaiRong3 & ZHANG YaPing1,6 1 Laboratory for conservation and Utilization of Bio-resource,Yunnan University,Kunming 65.091,china 2 Faculty of Animal Science and Technology,Yunnan Agricultural University,Kunming 65.201,china 3 Kunming institute of Botany,c.inese ac.demy of {5.,Kunming 65.204,china 4 Yunnan institute of Buffalo Science and Technology,Kunming 65.021,china 5.Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,china 6 State Key Laboratory of Genetic Resources and Evolution,Kunming institute of Zoology,c.inese ac.demy of {5.,Kunming 65.223,china 1. Laboratory for conservation and Utilization of Bio-resource Yunnan University Kunming 650091 China2. Faculty of Animal Science and Technology Yunnan Agricultural University Kunming 650201 China3. Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China4. Yunnan Institute of Buffalo Science and Technology Kunming 650021 China5. Animal Husbandry and Veterinary Station of Luxi city Luxi 678400 China6. State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

Melanocortin-1 receptor (Mc1R) plays a major role in pigmentation in many *** investigate if the Mc1R gene is associated with coat color in water buffalo,the coding region of Mc1R gene of 216 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp *** the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I128M changes,*** Individuals carrying homozygote EBR/EBR were *** genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of *** in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of *** results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.

关键词： Buffalo coat color Mc1R

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Simulation of freezing and melting of soil on the northeast Tibetan Plateau

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c.inese Science Bulletin 2011年第20期56卷 2145-2155页

作者： XIA Kun 1,2,3,LUO Yong 2,4,5.& LI WeiPing 2 1 institute of Atmospheric Physics,c.inese ac.demy of sciences,Beijing 100029,china 2National climate center,china Meteorological Administration,Beijing 100081,china 3Graduate University of c.inese ac.demy of sciences,Beijing 100049,china 4 center for Earth System Science,Tsinghua University,Beijing 100084,china 5.ey Laboratory of Earth System Numerical Simulation,Ministry of Education,Beijing 100084,china institute of Atmospheric Physics Chinese Academy of Sciences National climate center China Meteorological Administration Graduate University of c.inese ac.demy of sciences center for Earth System Science Tsinghua University Key Laboratory of Earth

Using observational data spanning the period from February to December 2009 and recorded at the Suli station in Qinghai Province,the land-surface model cLM3.0 was employed to simulate the freezing and melting of *** results indicate that the simulated soil temperature is higher than the observed soil temperature and the ultimate thawing date is earlier than the observed date during the melting *** the freezing period,the simulated soil temperature is lower than the observed soil temperature and the ultimate freezing of the deep soil is earlier than that ***,the simulation of freezing is better than that of melting,and the simulation of a shallow layer is better than that of a deeper *** the original cLM3.0,it is assumed that frozen soil begins to melt when the soil temperature exceeds 0c,which is inconsistent with *** critical freeze-thaw temperature was calculated according to thermodynamics equations and the freeze-thaw condition was *** this work,the melting rate for frozen soil was reduced using the modified scheme,and the simulated soil temperature was lowered. Meanwhile,the refreezing of soil during the melting season was well simulated and more closely matched ***,it was found that the rates of melting and freezing differ,with the former being slower than the latter,but refreezing during the melting season is rather quick.

关键词：土壤温度冻结期青藏高原东北部模拟融化观测数据热力学方程表面模型

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A novel model-free approach for reconstruction of time-delayed gene regulatory networks

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中国科学：生命科学英文版 2006年第2期49卷 190-200页

作者： JIANG Wei1,2, LI Xia1,2,3,4, GUO Zheng1,2,3, LI chuanxing1, WANG Lihong1 & RAO Shaoqi1,5.1. Department of Bioinformatics, Harbin Medical University, Harbin 15.086, china 2. Department of computer Science, Harbin institute of Technology, Harbin 15.080, china 3. School of Life Science and Technology, Tongji University, Shanghai 200092, china 4. Biomedical Engineering institute, capital University of Medical {5., Beijing 10005., china 5. Departments of cardiovascular Medicine and Molecular cardiology, cleveland clinic Foundation, cleveland, Ohio 44195. USA Department of Bioinformatics Harbin Medical University Harbin 150086 China Department of computer Science Harbin Institute of Technology Harbin 150080 China School of Life Science Technology Tongji University Shanghai 200092 China Biomedical Engineering institute Capital University of Medical Sciences Beijing 100054 China Departments of cardiovascular Medicine Molecular cardiology Cleveland Clinic Foundation Cleveland Ohio 44195 USA

Reconstruction of genetic networks is one of the key scientific challenges in functional genomics. This paper describes a novel approach for addressing the regulatory dependencies be-tween genes whose activities can be delayed by multiple units of time. The aim of the proposed ap-proach termed TdGRN (time-delayed gene regulatory networking) is to reversely engineer the dy-namic mechanisms of gene regulations, which is realized by identifying the time-delayed gene regu-lations through supervised decision-tree analysis of the newly designed time-delayed gene expres-sion matrix, derived from the original time-series microarray data. A permutation technique is used to determine the statistical classification threshold of a tree, from which a gene regulatory rule(s) is ex-tracted. The proposed TdGRN is a model-free approach that attempts to learn the underlying regula-tory rules without relying on any model assumptions. compared with model-based approaches, it has several significant advantages: it requires neither any arbitrary threshold for discretization of gene transcriptional values nor the definition of the number of regulators (k). We have applied this novel method to the publicly available data for budding yeast cell cycling. The numerical results demonstrate that most of the identified time-delayed gene regulations have current biological knowledge supports.

关键词： gene regulatory networks, time delayed, decision tree.

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POLYMERIZATION OF p-DIETHYNYLBENZENE INITIATED BY Ni(c≡cc_6H_4c≡cH)_2(PPH_3)_2

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c.inese Journal of Polymer Science 2001年第3期19卷 303-309页

作者： Mu-jie Yang Xiao-wei Zhan Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027, china Present address: institute of chemistry, c.inese ac.demy of sciences, Beijing 100080, china 浙江大学浙江杭州

Homogeneous polymerization of p-diethynylbenzene initiated by nickel acetylide Ni(c ≡ c c_6H_4 c ≡ cH)_2(PPh_3)_2has been investigated in terms of different solvents, addition agents, atmosphere gases, catalyst concentrations, monomerconcentrations and polymerization temperatures. The yield and catalytic efficiency approach 88% and 11. 1 kg polymer/molNi, respectively, under the optimum conditions: [cat] = 0.01 mol/L, [M] = 1.0 mol/L, NEt_3/cat (mol ratio) = 3～5. 1,4-dioxane/toluene (volume ratio) = 1 and T = 25. for 5.h. The polymerization rate equation can be expressed as R_p =k_p[M][cat]~2, where k_p= 0.47 L^2. mol^(-2)·S^(-1) (25.). The overall polymerization activation energy was found to be203 kJ·mol^(-1). Poly(p-diethynylbenzene) so obtained is soluble in THF, cHcl_3 and toluene with weight-average molecularweights as high as 27, 100 and a rich-trans extended π-conjugated polyene chain structure with pendent groups ofp-c_6H_4c≡cH.

关键词： Polymerization p-Diethynylbenzene Nickel acetylide catalyst

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David c Bartlett Robert P Sutcliffe Nikolaos A chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom college of Medical and Dental sciences University of BirminghamBirmingham B152TTUnited Kingdom institute of clinical sciences University of BirminghamBirmingham B152TTUnited Kingdom

BacKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dccA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dccA and present the experience of a highvolume tertiary-centre managing dccA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dccA who received *** patients from 2017 to 2022 who were referred for NAT for dccA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dccA was *** studies reported outcomes for 9 patients who received NAT for dccA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dccA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 5.-74 years,male:female 5.4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 5. months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dccA is *** propose using the established National-comprehensive-cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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Study on the Reaction of Proteins with 5.Nitrosalicylfluorone-molybdenum(Ⅵ) complex by Spectrophotometry in PVA 124 Microemulsion

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c.inese Journal of chemistry 2004年第7期22卷 714-718,615页

作者：魏琴吴丹杜斌张慧欧庆瑜Lanzhou institute of chemical Physics c.inese ac.demy of sciences Lanzhou Gansu 730000 china School of chemistry & chemical Engineering Jinan University Jinan Shandong 250022 China Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou Gansu 730000 China School of chemistry & chemical Engineering Jinan University Jinan Shandong 250022 China

The application of 5.-nitrosalicylfluorone (5.-NSF)-molybdenum(VI) complex as a spectroscopic probe was studied. In the buffer medium of HOac-NaOac at 3.45.and in the presence of PVA 124 microemulsion, 5.-NSF-Mo(VI) complex combines protein rapidly to form a stable compound, leading to an absorbance decrease at 5.5.nm of 5.-NSF-Mo(VI) complex. according to this change, microdetermination of protein has been described. Bovine serum albumin (BSA) could be determined in the linear range of 0—16 g昺L-1 with the detection limit of 11 ngmL-1. Many amino acid and metal ions studied do not interfere with the assay. The method possesses high sensitivity as well as high selectivity. It can be used to determine protein in human urine and milk powder successfully. The relative standard deviations are in all instances less than 4.7%, and the recoveries are between 97.6% and 106.0%. Moreover, the binding number of BSA with the complex, which is determined by using molar ratio, Rosenthanl graphic and slope ratio methods, is in good agreement with each other.

关键词： protein spectrophotometry 5.-NSF-Mo(VI) complex microemulsion

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Distinct Pattern of Human Vδ1 γδ T cells Recognizing MIcA

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cellular & Molecular Immunology 2005年第4期2卷 253-258页

作者： Jianqiang Li~1 Lianxian cui~1 Wei He~(1,2) ~1Department of Immunology,institute of Basic Medical sciences,c.inese ac.demy of Medical sciences and School of Basic Medicine,Peking Union Medical college,5.Dong Dan San Tiao,Beijing 100005.{5. Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China.

γδT cells represent one unique recognition pattern,the limited recognition,which distinguishes from the specificrecognition for αβT cells and pattern recognition for macrophages.Vδ1 γδT cell is the major subset of human γδT cells,which predominates in mucosal tissue including the intestinal ***,a few antigens thathuman Vδ1TcR can recognize have been *** them,MHc class I chain-related molecules A (MIcA)have been studied most *** Vδ1TcR,MIcA is also the ligand of NKG2D,a c-type lectin-likeactivating *** human,only Vδ1 cells can simultaneously express both types of receptors of MIcAwhile NK cells,αβT cells and other subsets of γδT cells likewise express *** the precisemechanisms are still enigmatic,this distinct pattern of Vδ1 cells recognizing MIcA predicts unique biologicalsignificance of Vδ1 cells in immune *** years,some progresses have been made in this *** thisreview we summarize the related reports and put forward some novel views based on our group’s ***& Molecular Immunology.2005.2(4):25.-25..

关键词： Vδ1TcR MIcA NKG2D γδ T cell

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Studies on rickettsia-like organism (RLO) disease of tropical marine pearl oyster-Epidemiological investigation of RLO disease in juvenile populations of maricultured Pinctada maxima

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acta Oceanologica Sinica 2003年第3期22卷 421-435页

作者： Xinzhong Wu , Dengfeng Li, Jinpei Pan, Jingbo Jiang college of Animal sciences,Zhejiang University,Hangzhou 310029,china. Email: wuxz@zju.edu.cnSouth china Sea institute of Oceanology, c.inese ac.demy of sciences,Guangzhou 5.0301,chinaSchool of Life sciences,SUN YAT-SEN University,Guangzhou 5.0275.china Zhejiang Univ Coll Anim Sci Hangzhou 310029 Peoples R China c.inese acad Sci S China Sea Inst Oceanol Guangzhou 510301 Peoples R China Sun Yat Sen Univ Sch Life Sci Guangzhou 510275 Peoples R China

The death which occurred in juvenile population was a severe problem in the course ofPinctada maxima artificial culture. With the methods of field investigation, histological study and statistic analyses, the epidemiological study was carried out on the disease and death in juvenile populations of Pinctada maxima in the Xinying Pearl Oyster Mariculture Farm of Lingao county (for the A, B and c batches of cultured juveniles hanged in the sea) and the Xincun Pearl Oyster Mariculture Farm of Lingshui county (for the D batch of cultured juvenile hanged in the pond), Hainan Province from November 1993 to April *** results show that the deaths which occurred in juvenile populations of Pinctada maxima presented an outbreak pattern. The peak of mortality rates, in general, occurred in 4-to 6-month old pearl oyster juveniles, and the mortality rates gradully declined with the extention of pearl oyster age after cul-turing 8 months. The correlation between the mortality rates of juvenile populations and mean body lengths of juvenile populations show that the mortality rate become higher under 4 cm of mean body lengths of juvenile population and become obvious declined over 5.cm of mean body lengths. The peak of mortality rate occurred in 1-3 cm of mean body lengths. The results of histological observation showed that rickettsia-like organism inclusions were common, histological widespread infective agent among every batches (A, B, c and D) of cultured juvenile populations. The mean severity indices (SI) of rickettsia-like organism (RLO) infection were positively correlated with mortality rates of juvenile populations. After or within every peaks of RLO infection were all accompanied with the peaks of mortality rates of host populations and the mortality rates declined with decreased RLO infection. So the evidences of histological observation and epidemiology in this study indicated that rickettsia-like organism (RLO) may be as an important pathogenic organism of disease

关键词： Pinctada maxima rickettsia-like organism epidemiology juvenile population

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Use-wear evidence confirms the earliest hafted chipped-stone adzes of Upper Palaeolithic in northern china

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c.inese Science Bulletin 2010年第3期55卷 268-275页

作者： ZHANG XiaoLing1,2,3, SHEN chen1,2,4 GAO Xing1,2 cHEN FuYou1,2 & WANG chunXue1,2,3 1institute of Vertebrate Paleontology and Paleoanthropology, c.inese ac.demy of sciences, Beijing 100044, china 2Laboratory of Human Evolution and Archaeometry, c.inese ac.demy of sciences, Beijing 100044, china 3Graduate University of c.inese ac.demy of sciences, Beijing 100049, china 4The Royal Ontario Museum, Toronto M5. 2c6, canada institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China Laboratory of Human Evolution and Archaeometry Chinese Academy of Sciences Beijing 100044 China Graduate University of c.inese ac.demy of sciences Beijing 100049 China Royal Ontario Museum Toronto M5S 2C6 Canada

chipped-stone "adze-shaped objects" (ASOs) were identified from a few Upper Palaeolithic sites in northern china. Its morpho- logical form resembles to ground-stone type-specific adze, but the function of the ASO has never been assessed. The objective of this study is to investigate the use function of this particular tool type recovered from the Hutouliang site in the Nihewan Basin of northern china. In this study, the lithic use-wear analysis is applied to examining microscopically edge-damages and sur- face-rounding of the tools in order to assess how they were employed. The result suggests that the ASO might have been used as woodworking tools with a hafted shaft, providing evidence for the appearance of the earliest hafted chipped-stone adzes prior to 10000 years ago in northern china. This study also demonstrates that the use-wear technique is an innovated and effective analytic appraoch to the study of stone tool functions that has been conventionally treated by typo-technological analyses. Stone tool use-patterns revealed by use-wear evidence would shed new insights on prehistoric adaptive strategies of modern human in northern china.

关键词：旧石器时代晚期中国北方磨损证据石材加工工具木工工具中国网站技术分析

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Multiparty simultaneous quantum identity authentication with secret sharing

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Science china(Physics,Mechanics & Astronomy) 2008年第3期51卷 321-327页

作者： YANG YuGuang1,2,WEN QiaoYan3 & ZHANG Xing4,5.1 college of computer Science and Technology,Beijing University of Technology,Beijing 100022,china 2 State Key Laboratory of Information Security (Graduate University of the c.inese ac.demy of sciences),Beijing 100049,china 3 School of Science,Beijing University of Posts and Telecommunications,Beijing 100876,china 4 institute of Electronic Technology,Information Engineering University,Zhengzhou 45.004,china 5.Trusted computing Laboratory,Beijing University of Technology,Beijing 100022,china college of computer Science Technology Beijing University of Technology Beijing 100022 China State Key Laboratory of Information Security [Graduate University of the c.inese ac.demy of sciences] Beijing 100049 China School of Science Beijing University of Posts Telecommunications Beijing 100876 China institute of Electronic Technology Information Engineering University Zhengzhou 450004 China Trusted computing Laboratory Beijing University of Technology Beijing 100022 China

Two multiparty simultaneous quantum identity authentication (MSQIA) protocols based on secret sharing are presented. All the users can be authenticated by a trusted third party (TTP) simultaneously. In the first protocol,the TTP shares a random key K with all the users using quantum secret sharing. The ith share acts as the authentication key of the ith user. When it is necessary to perform MSQIA,the TTP generates a random number R secretly and sends a sequence of single photons encoded with K and R to all the users. according to his share,each user performs the corresponding unitary operations on the single photon sequence sequentially. At last,the TTP can judge whether the impersonator exists. The sec-ond protocol is a modified version with a circular structure. The two protocols can be efficiently used for MSQIA in a network. They are feasible with current technol-ogy.

关键词： quantum identity authentication secret sharing quantum cryptography

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